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NOVEMBER 2010, Vol. 28

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HEADLINES

Clinical Research Career Development Awards – Getting Started

Monday, November 29, 2010
1:00 - 3:00 PM
Palmer Commons, Forum Hall

Career Development Awards are an important first step toward becoming an independent researcher. Please join the Michigan Institute for Clinical & Health Research (MICHR) and Medical School Grants Review and Analysis office for an introduction to submitting clinical research career development awards. This presentation will provide all the necessary information for getting started on a proposal. Attendees will hear advice on finding great mentors; understanding the importance of research methods, interventions and outcomes; completing budgets; and designing your career development program. Presenters include MICHR faculty and staff with extensive experience in research design and methodology, grant writing, budget development, and grant administration. Bring your lunch.

Register for this workshop.

One attendee of this workshop valued the "pearls... good rules of the trade and tips for career development grant writing."

Another attendee felt that, "Most helpful for me was identifying all of the resources available and how to proceed with applying for these awards, because I was previously overwhelmed by the thought of getting funding and did not realize so much help is available free of charge here at the UM. Also, the handouts with application and mentor letter examples will be extremely useful."

MICHR K Writing Workshop –
3 Part Series Beginning December 1, 2010

Wednesday, December 1, 2010
Wednesday, December 15, 2010
Wednesday, January 5, 2011
5:00 - 7:00 PM
Danto Auditorium, CVC

NOTE: This event occurs over 3 days. Participants MUST attend all three days

This structured three-part workshop is designed to assist junior faculty and fellows who are preparing competitive career development grant applications for February or June 2011 submission. Receive peer critique and feedback from senior faculty experienced in NIH study section thinking. Attendance is strictly limited to those preparing a grant.

Register for this workshop.

"Getting together and reading the work of your peers was the most valuable part to me.  Small group sessions were very effective in providing personal direct feedback."

NIH Therapeutics for Rare and Neglected Diseases (TRND) Program
Deadline: December 6, 2010 (for the first cycle)

The National Institutes of Health (NIH) Therapeutics for Rare and Neglected Diseases (TRND) program is a new Congressionally mandated program that performs preclinical and early clinical development of new drugs for rare and neglected diseases, and develops new technologies and paradigms to improve the efficiency of therapeutic development for these diseases.  The operational model of TRND is collaboration between intramural NIH drug development scientists and partners having promising leads and disease/target knowledge but lacking the expertise or resources to develop these projects into clinical stage programs attractive to biopharmaceutical or other suitable organizations.  TRND is establishing collaborations with researchers in the public and private sectors to together “de-risk” Rare and Neglected disease drug development projects by accomplishing lead optimization through an FDA Investigational New Drug (IND) application and, when needed, proof-of-concept human studies.

TRND collaborative projects will be initiated at any stage during preclinical development.  Projects of interest will be at one of the following stages:

  • Lead optimization including clear structure-activity relationships (SAR) in at least two structurally distinct chemical series or well defined biological lead, reproducible activity in primary and orthogonal assays, efficacy in an accepted animal model (or when not available, cellular model) of the disease, and initial indications of favorable Absorption, Distribution, Metabolism, and Excretion (ADME) properties.
  • High-quality New Molecular Entity (NME) lead(s) with clear efficacy, good DMPK properties and initial non-GLP safety studies demonstrating absence of gross toxicities.
  • NME clinical candidates with incomplete IND-enabling PK/PD/toxicology/formulation studies.
  • A drug previously approved for another indication by FDA with efficacy in an animal (or when not available, cellular) model of a rare or neglected disease, making it a candidate for repurposing but in need of formulation, dose-finding, disease-specific toxicology, or other studies to allow clinical testing to commence.

The TRND program will partner with academic laboratories, not-for-profit organizations, and for-profit companies.  Foreign organizations may also apply. Applications are made through the online grants management website ProposalCentral. Submitted research proposals will be reviewed for scientific merit and technical feasibility, as well as program balance and availability of resources.  Successful applicants will collaborate with TRND to create and implement a therapeutic development project plan.  Note this is not a grant or contract program.

To apply to the TRND program, please visit the TRND webpage at (http://trnd.nih.gov).

Call for Design Projects for Biomedical Engineering Class

The UM Biomedical Engineering Capstone Design class, BME 450, seeks faculty and physicians who have ideas for medical devices to sponsor student team design projects. Project sponsors mentor upper-class student teams during the process of biomedical problem identification, solution design, prototype building and testing.

Projects should have known problems and device requests but should also be open-ended enough to allow the students to explore possible innovative solutions. For more information, contact Rachael Schmedlen (shope@umich.edu) or call 734-763-0575.

URC Partners Showcase Innovation News in New E-Publication

Michigan's University Research Corridor partners are showcasing innovation, business and research news through a new monthly e-publication, ResearchCorridor.com. The URC universities — University of Michigan, Michigan State University and Wayne State University — formed the alliance in 2006 to transform, diversify and strengthen the state's economy.


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Human Research

IRBMED Holiday Season Schedule

As the weather grows colder and the holiday season approaches, the IRBMED Office would like to remind you that:

  • IRBMED review boards do not meet on Thursday, November 25, 2010, Thanksgiving Day, nor on Friday, November 26, 2010, the day following Thanksgiving.
  • IRBMED review boards do not meet during the holiday closure (12/24/10 through 1/3/11).  The last meetings of 2010 are Friday, December 17, 2010, and Thursday, December 23, 2010.  The first meeting of 2011 will be Thursday, January 6, 2011 (Boards B1 and B2).
  • The IRBMED Office is not open for regular business during the holiday closure beginning the afternoon of December 23.  The office will reopen on Monday, January 3, 2011, at 8:30 AM.  The drop-box outside our offices at 2800 Plymouth Road will remain open to receive submissions, though mail will not be opened until January 3, 2011.  In addition, campus mail will not be delivered during the holiday closure.

Happy Holidays!

 

Animal Research

UCUCA and OSEH Animal Handler Medical Surveillance Questionnaire Compliance

It is the University Committee on Use and Care of Animals’ (UCUCA) mission to foster and oversee the humane use and care of all animals at the University.  It is Occupational Safety and Environmental Health’s (OSEH) responsibility to assure safety of all personnel working with animals.  Together these departments have created the OSEH Animal Handler Program and the UCUCA Policy on Participation in the OSEH Animal Handler Program.  This policy includes mandatory involvement in the OSEH Hazards program, the OSEH Medical Surveillance Program and the requirement of completing the annual OSEH Medical Surveillance Questionnaire.  This form evaluates an animal user’s safety regarding exposure to animals or possible hazards and is required annually of every person that is listed on a protocol and handling animals.

Recently, the UCUCA Office contacted all animal users who had not completed the OSEH Animal Handler medical surveillance annual questionnaire and brought the program to an almost 100% compliance rate.  The UCUCA Office wants to thank all who helped us reach this high level of compliance with the program.

The UCUCA Office will continue to assist OSEH with tracking personnel as their annual questionnaires come due each year.  When you are contacted to renew your annual questionnaire, please do so in a timely manner.  This will help to avoid the possibility of being reported to the UCUCA Committee for noncompliance, with consequences ranging from removal of access to animal areas to protocol suspension.

If you have questions regarding your annual questionnaire, please contact OSEH at (oseh_contact@umich.edu) or the UCUCA Office at 734-763-8028 or (ucuca.office@umich.edu).


EDUCATIONAL OPPORTUNITIES


Using EndNote for Grant Writing

EndNote can help you tackle the many hurdles of writing a grant. The program can help you format references according to the grant instructions for the initial funding application, the annual progress reports and the biosketches. EndNote makes complying with the National Institutes of Health (NIH) requirements to add the PMCID (PubMed Central Identification) number to citations easy. Sponsored by the Taubman Health Sciences Library.

Friday, December 3, 2010
9:30 - 10:30 AM
Taubman Learning Center, 2802 Medical Sciences Building II
Register for this workshop.


BIOSAFETY


Updated Policy and Procedures Regarding Minors in Labs

The participation of minors in research work is an important experiential element for some and should be accommodated where appropriate; but under-18 young people wishing to gain experience in various research settings may be exposed to inherent research risks.  These potential exposures to chemicals, biologics or radioactivity pose a risk to the individual and the university.  Occupational Safety & Environmental Health (OSEH) has updated policy/procedures on “Minors in Labs” in order to provide research PIs with a more direct process for arranging to have minors participate in their laboratory research operations (http://www.oseh.umich.edu/minors.html).

This new policy is not meant to address minors who participate in university-sanctioned, short-term, “research opportunity” programs.  Instead, it is focused upon minors who make private arrangements for research experience with individual researchers they are acquainted with – or through other university facilitators – in order to gain research experience over the course of weeks or even months.  The policy recognizes that UM Medical Center has an orientation policy and procedures already in place for volunteers, whether they plan to be active in the clinical setting or a research setting.  The UMMC orientation allows individuals to receive red volunteer ID badges.  It goes beyond that and identifies prudent steps that must be followed in order to protect the interests of the volunteer, their parents/guardians, and the university.

The “Minors in Labs” policy is focused on ensuring that the minor and their parents are aware of the risks that are inherent in modern research laboratories and that all the necessary steps are taken to reduce or eliminate those risks to the greatest extent possible.  Awareness of the risks is documented through the use of specific disclosure forms, and risk-reduction is achieved through rigorous, documented training on the part of the minor.  Laboratory Directors are responsible for filing the necessary disclosures and permissions with their departmental chairs’ offices for internal review and filing purposes.  OSEH is available with technical assistance on any specific safety or training aspects involving minors in labs.  If there are any questions concerning this policy and procedures, please contact OSEH directly at 734-763-6973.


KUDOS


Jean Nemzek Receives AALAS 2010 Nathan R. Brewer Scientific Achievement Award
Jean Nemzek

The American Association of Laboratory Animal Science selected Jean Nemzek, D.V.M., M.S., from the Unit for Laboratory Animal Medicine as the recipient of the 2010 Nathan R. Brewer Scientific Achievement Award. This award honors research relevant to laboratory animal science and comparative medicine that advances current knowledge and makes a major contribution to the existing literature in those fields. To be recognized, a portion of the research must have been generated and presented by trainees or other personnel within the laboratory. The award was presented on October 10, 2010 at the 61st National AALAS meeting in Atlanta, GA.

Nemzek is a graduate of University of Minnesota College of Veterinary Medicine, a boarded specialist in veterinary surgery, and joined the ULAM faculty in 2000. Her research focuses on sepsis and inflammation. One branch of her research has specifically examined the welfare of animals used in these areas of investigation. Her publications stress the use of scientific methods to seek refinements in animal studies that will improve animal welfare but still yield sound research results. The work produced in the Nemzek Laboratory has generated significant discussion among researchers and begun to impact current research practices.


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains information on email alert groups, internal grant programs, upcoming limited submissions, and links to extramural funding search engines.


Internal Submissions

Center for Computational Medicine and Bioinformatics (CCMB) Pilot Research Grant Program
Deadline: December 15, 2010

The goals of the Pilot Grant program are to bring together research faculty in different fields (computational/mathematical/statistical/informatics and biological/translational) in joint projects which will foster successful future proposals to NIH or other funding agencies and to enhance the development of the CCMB. Grant proposals may be in the areas of genomics, proteome and metabolome informatics with emphasis on innovative integration of different types of high throughput molecular data and computational networks.

Proposals for the Pilot Research Grant Program require a pairing of a computational/mathematical/statistical/informatics PI and a biological/translational PI. The two primary collaborators must be from the two different domains, and both must make substantive research contributions.  At least one investigator must be on the roster of CCMB Affiliate Faculty. The compelling and feasible research aims should combine use of computational and informatics capabilities with an important biological or biomedical problem. Innovation on both computational and experimental sides is strongly encouraged. Support can be requested for 12-18 months with total funding up to $50,000. For complete application guidelines and instructions, visit (http://www.ccmb.med.umich.edu/funding).


External Limited Submissions


These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

Edward Mallinckrodt, Jr. Foundation Grant Program
Internal Deadline: December 2, 2010

The basic aim of the Edward Mallinckrodt, Jr. Foundation is to advance knowledge in the various fields of medical and health research. It is further the general aims to (1) confine contributions to those worthy projects that are in need of initial start-up funding to move the projects forward to the point of other independent support or (2) support highly promising young investigators (e.g. have not been a PI on an R01) at the time when start-up funds are limited and initial progress is dependent on additional funding. The Foundation is most interested in basic research with upstream potential for impacting disease.

Eligibility:
The applicant must have a permanent appointment in the Medical School. For example: Those with titles of Clinical Lecturer or Clinical Instructor would not qualify for this funding program, as these are not permanent appointments. Those with titles of Research Investigators  and Research Assistant Professor are eligible for this award, as these are permanent positions.

It is not the intent to support projects that are already under way and are already receiving significant grant support to provide long-range funding beyond an initial three-year period of support. The Foundation will not fund overhead, and grants will be made and restricted to domestic institutions.

Grants are made in the amount of $50,000 - $75,000 per year for a period of one to three years and are contingent upon a yearly progress report by the applicant. The Foundation reviews applications three times a year. The next Foundation deadline is February 1, 2011. The University of Michigan may submit a maximum of two proposals.

For consideration as an institutional nominee, submit the following electronically in a single PDF document – in the order listed – by December 2, 2010 to (limitedsubmissions@umich.edu):

  • Cover sheet (downloaded from the website below)
  • Nominating letter from the department chair
  • 3-page research plan
  • NIH formatted biosketch

We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions. Please visit this website to download the cover sheet and view complete Foundation guidelines.

Mary Kay Foundation Grants for Innovative Translational Cancer Research
Internal Deadline: December 3, 2010

The Mary Kay Foundation is accepting grant applications for innovative translational research in ovarian, uterine, breast or cervical cancer. Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately such research would lead to improvements in diagnosis, prognosis, prevention, or treatment of cancer. The award will be up to $100,000 (combined direct and indirect costs) for a two-year period. The University of Michigan may submit TWO applications: one through the Medical School and one through the School of Public Health. Deadline for submission of an application to the Foundation is February 4, 2011.

For consideration as an institutional nominee, submit the following electronically in a single PDF document - in the order listed – by December 3, 2010:

We acknowledge receipt of all electronic submissions.

For applications through the Medical School: send to (limitedsubmissions@umich.edu). For applications through the School of Public Health: send to (philbert@umich.edu). Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions. Visit (http://www.mkacf.org/Pages/CancerGrantProgram.aspx) for complete information.

Fred Hutchinson Cancer Research Center Harold M. Weintraub Graduate Student Award
Deadline: December 15, 2010

The Harold M. Weintraub Graduate Student Award recognizes outstanding achievement during graduate studies in the biological sciences. Awardees will participate in a scientific symposium honoring Hal Weintraub and his commitment to innovative science. The award symposium will consist of scientific presentations by the graduate student awardees and informal gatherings of students and faculty. The graduate student awardees are expected to be advanced students near the completion of their studies. Nominated students should not have graduated before September 2010. The Fred Hutchinson Weintraub and Groudine Fund, established to foster intellectual exchange through the promotion of programs for graduate students, fellows and visiting scholars, will cover expenses for the graduate student awardees. Only one nomination may be submitted per department or program. Visit (http://www.fhcrc.org/science/basic/weintraub/index.html) for complete information.


External Open Submissions

Doris Duke Clinical Research Fellowship for Medical Students
Deadline: January 12, 2011

The Doris Duke Clinical Research Fellowship provides support for one year of full-time clinical research training. The main goal of the program is to encourage medical students to pursue careers in clinical research.

Students matriculated at any U.S. medical school who are in good academic standing and have completed two or more years of medical school prior to the start of the fellowship are eligible to apply. Interested medical students must be willing to take a year out from school and conduct fellowship research and training at one of 12 hosting medical schools. A stipend plus other benefits are offered as part of this program.

Experiments that utilize animals or primary tissues derived from animals are not eligible for support through this program.

Full details and application instructions are available at (http://www.ddcf.org/mrp-crf).


Deadline Watch

Click here to view.

Distinguished University Innovator Award
Deadline: November 12, 2010

http://research.umich.edu/ovpr/innovator
Contact Jane Ritter at 734-763-1290 or (ritterj@umich.edu) with any questions.


UMMS AWARDED GRANTS

External Awarded Grants

An asterisk next to a name means that they are the Contact PI for the program, since some projects are awarded with multiple PIs.

Click here to view.

Biological Chemistry

PI: *Goldstrohm,Aaron
Title: Regulation of Gene Expression by the Deadenylase Nocturnin
Sponsor: Mallinckrodt, Edward, Jr.,  Foundation
Project Dates and Amount of Award: 10/01/10-09/30/11; $60,000

Cell & Developmental Biology

PI: *Joglekar,Ajit
Title: CAREER AWARD AT THE SCIENTIFIC INTERFACE
Sponsor: Burroughs Wellcome Fund
Project Dates and Amount of Award: 01/01/11-06/30/13; $219,000

Emergency Medicine

PI: *Stanley,Rachel
Title: Progesterone for Traumatic Brain Injury in Children: Planning a Safety and Efficacy Trial
Sponsor: HRSA 1 H34 MC 19353 01
Project Dates and Amount of Award: 09/01/10-08/31/12; $599,759

Family Medicine

PI: *Ruffin,Mack
Title: CORRELATES OF ABNORMAL PAP SMEARS IN APPALACHIA (SUPPLEMENT)
Sponsor: NIH - Subcontracts TO Ohio State University  P50 CA 105632
Project Dates and Amount of Award: 04/01/10-03/31/11; $9,577

Human Genetics

PI: *Antonellis,Anthony
Title: Non Canonical Function of Glycyl tRNA Synthetase: Role in c-Jun  regulation and in inherited neurodegenerative diseases
Sponsor: US-Israel Binational Science Foundation
Project Dates and Amount of Award: 10/01/10-09/30/11; $48,000

Internal Medicine

PI: *Bernal-Mizrachi,Ernesto
Co-I: Cras-Meneur, Corentin (Metabolism, Endo & Diabetes)
Title: Nutrient Signals and Programming of Pancreas Development
Sponsor: NIH  1 R01 DK 084236 01 A2
Project Dates and Amount of Award: 09/30/10-08/31/14; $1,328,394

PI: *Day,Sharlene
Title: Using Genetics for Early Phenotyping and Prevention of Hypertrophic Cardiomyopathy
Sponsor: NIH - Subcontracts TO Brigham and Women's Hospital  P20 HL 101408
Project Dates and Amount of Award: 04/01/10-03/31/11; $43,500

PI: *Erba,Harry
Title: A Phase 2 Study of SCH 727965 in Subjects With Relapsed and Refractory Acute Myelogenous Leukemia and Acute Lymphoblastic Leukemia
Sponsor: Schering Corporation
Project Dates and Amount of Award: 08/27/10-11/27/10; $12,368

PI: *Herman,William
Title: Michigan Diabetes Research and Training Center -- Core Consolidation
Sponsor: NIH  3 P60 DK 020572 33 S1
Project Dates and Amount of Award: 09/15/10-08/31/11; $458,000

PI: *Higgins,Peter
Title: IBD School: A Series of Patient Education Videos about Inflammatory Bowel Disease
Sponsor: Centocor, Inc.
Project Dates and Amount of Award: 10/14/10-12/31/11; $37,000

PI: *Jakubowiak,Andrzej
Title: Noxa-Mediated Apoptosis Helps Predict Response to Treatment in Myeloma Cells Treated with Novel Proteasome Inhibitor
Sponsor: American Society of Hematology
Project Dates and Amount of Award: 07/06/10-12/31/10; $4,000

PI: *Lawrence,Daniel
Title: ROLES OF PLASMINOGEN ACTIVATOR INHIBITOR-1 AND VITRONECTIN IN FAILURE OF CORONARY REVASCULARIZATION
Sponsor: NIH - Subcontracts TO University of Missouri
Project Dates and Amount of Award: 09/01/10-07/31/11; $38,625

PI: *Richardson,Bruce
Co-I: Strickland, Faith (Int Med-Rheumatology) / Warner, Roscoe (Pathology Department)
Title: Assessment of Drug(s) for Lupus Prevention and Therapy
Sponsor: Cerenis Therapeutics
Project Dates and Amount of Award: 08/01/10-11/30/10; $168,780

PI: *Sekiguchi,Joann
Title: Roles of the Artemis Nuclease in DNA Repair and Disease
Sponsor: NIH  3 R01 AI 063058 05 S1
Project Dates and Amount of Award: 09/01/10-08/31/11; $142,664

PI: *Smith,David
Title: 2010.039:  Phase II Trial of Carboplatin and RAD001 in Metastatic Castrate Resistant Prostate Cancer (CRPC) Pretreated with Docetaxel Therapy
Sponsor: Novartis TO Karmanos Cancer Institute
Project Dates and Amount of Award: 07/26/10-01/06/13; $40,000

PI: *Wiggins,Roger
Co-I: Gadegbeku, Crystal (Int Med-Nephrology)
Title: The University of Michigan George M. O'Brien Renal Core Center - Supplement
Sponsor: NIH  3 P30 DK 081943 03 S2
Project Dates and Amount of Award: 09/29/10-09/28/11; $50,000

PI: *Zimmermann,Ellen
Title: A NON-INTERVENTIONAL LONG-TERM POST-MARKETING REGISTRY OF PATIENTS TREATED WITH CERTOLIZUMAB PEGOL (CIMZIA) FOR CROHN'S DISEASE
Sponsor: UCB TO Schwarz Biosciences
Project Dates and Amount of Award: 10/08/10-02/28/20; $87,800

Michigan Nanotechnology Institute for Medicine and Biological Sciences

PI: *Baker Jr,James
Co-I: Hemmila, Mark (General Surgery Section) / Lipuma, John (Pediatrics-Infectious Diseases) / Makidon, Paul (Allergy MNiMBS) / Smith, Douglas (Allergy MNiMBS)
Title: Nanoemulsion-Based Anti-Microbials for Protection Against Burn and Wound Infections
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 10/15/10-11/14/13; $1,476,040

Microbiology and Immunology

PI: *Laouar,Yasmina
Title: Role of TGFbeta in the Control of Autoimmune Encephalomyelitis
Sponsor: National Multiple Sclerosis Society
Project Dates and Amount of Award: 10/01/10-09/30/13; $435,049

Molecular & Behavioral Neuroscience Institute

PI: *Sutton,Michael
Title: Homeostatic Regulation of Presynaptic Function by Dendritic mTORC1
Sponsor: NIH  1 F31 MH 093112 01
Project Dates and Amount of Award: 03/01/11-02/28/14; $95,690

Neurology

PI: *Feldman,Eva
Title: Human Pluripotent Stem Cells for Modeling and Studying the Pathophysiology of ALS
Sponsor: US-Israel Binational Science Foundation
Project Dates and Amount of Award: 10/01/10-09/30/14; $81,500

Obstetrics & Gynecology

PI: *Fenner,Dee
Title: An Investigation of the TReatment of FecAl IncontiNence using the TOPAS Sling system FOR WoMen (TRANSFORM)
Sponsor: American Medical Systems
Project Dates and Amount of Award: 04/10/10-09/30/15; $356,164

PI: *Harris,Lisa
Co-I: Watkins, Daphne C (School of Social Work)
Title: Women's Pregnancy and Contraceptive Decisions During Economic Recession
Sponsor: Buffett Foundation
Project Dates and Amount of Award: 08/01/10-06/30/11; $69,821

Orthopaedic Surgery

PI: *Kozloff,Kenneth
Title: Susceptibility of OI Bone to Microdamage, and Implications for Bisphosphonate Treatment
Sponsor: American Society for Bone and Mineral Research (ASBMR)
Project Dates and Amount of Award: 01/01/11-12/31/11; $55,000

Pathology

PI: *Johnson,Kent
Title: A 12-Month, Multi-Center, Randomized, Open-Label, Non Inferiority SStudy
Sponsor: Novartis
Project Dates and Amount of Award: 07/15/10-02/28/13; $61,864

PI: *Kleer,Celina
Co-I: Banerjee, Mousumi (Biostatistics Department) / Newman, Lisa (General Surgery Section)
Title: The Function of EZH2 in Estrogen Receptor Negative Breast Cancer in Women of African Ancestry
Sponsor: NIH  1 U01 CA 154224 01
Project Dates and Amount of Award: 09/27/10-07/31/15; $1,862,494

PI: *Kunkel,Steven
Title: Systems Pathology
Sponsor: Centocor, Inc.
Project Dates and Amount of Award: 10/08/10-10/07/11; $124,862

PI: *Miller,Richard
Title: Two New Methods That Extend Maximal Lifespan in Mice
Sponsor: Ellison Medical Foundation
Project Dates and Amount of Award: 09/01/10-08/31/14; $930,894

Pediatrics & Communicable Diseases

PI: *Freed,Gary
Co-I: Dombkowski, Kevin (Pediatrics-Ambulatory Care Pgm)
Title: Vaccination Information Program
Sponsor: CDC-Subcontracts TO Association for Prevention Teaching and Research
Project Dates and Amount of Award: 09/30/10-09/29/11; $200,000

PI: *Russell,Mark
Title: AN OPEN LABEL PILOT STUDY EVALUATING THE SAFETY AND EVIDENCE OF THERAPEUTIC EFFECT OF A 96-HOUR CONTINUOUS INTRAVENOUS ADMINISTRATION OF 2-0, 3-0 DESULFATED HEPARIN (ODSH) FOR THE TREATMENT OF EXACERBATION OF PROTEIN LOSING ENTEROPATHY (PLE) ASSOCIATED WITH SINGLE VENTRICLE PALLIATIVE SURGERY. (PGX-ODSH-2009-PLE)
Sponsor: ParinGenix, Inc
Project Dates and Amount of Award: 09/01/10-08/31/11; $44,387

Pharmacology

PI: *Neubig,Richard
Title: Evaluation of RGS Modulators
Sponsor: Bristol-Myers Squibb
Project Dates and Amount of Award: 10/22/10-10/21/11; $29,900

Psychiatry

PI: *Giordani,Bruno
Title: NEUROPSYCHOLOGICAL BENEFITS OF COGNITIVE TRAINING WITH UGANDAN HIV CHILDREN
Sponsor: NIH - Subcontracts TO Michigan State University  R34 MH 084782
Project Dates and Amount of Award: 04/05/10-02/28/11; $13,574

PI: *Taylor,Stephan
Co-I: Gipson, Debbie (Pediatrics-Nephrology)
Title: Data Management Plan for the National of Depression Centers
Sponsor: National Network of Depression
Project Dates and Amount of Award: 08/23/10-08/22/12; $197,002

Radiation Oncology

PI: *Pierce,Lori
Co-I: Moran, Jean (Radiation Oncology - Ann Arbor)
Title: A Randomized Comparison of IMRT and 3D Radiotherapy in Node Positive Breast Cancer
Sponsor: Breast Cancer Research Fdn
Project Dates and Amount of Award: 10/01/10-09/30/11; $223,000

Radiology

PI: *Kilbourn,Michael
Title: GE - Offsite Production
Sponsor: General Electric Company
Project Dates and Amount of Award: 10/01/10-09/30/13; $720,000

PI: *Piert,Morand
Title: 18F-Fluoride PET/CT Versus 99mTc-MDP Scanning for Detecting Bone Metastases
Sponsor: American College of Radiology
Project Dates and Amount of Award: 10/11/10-05/11/13; $50,000

Surgery

PI: *Bolling,Steven
Title: Restore-SR 12-Month Follow-up Study
Sponsor: AtriCure, Inc.
Project Dates and Amount of Award: 09/01/10-03/31/11; $7,650

PI: *Campbell Jr,Darrell
Title: Removing Barriers to Disclosure-and-Offer Models
Sponsor: Health and Human Services, Department of-Agency for Health Care Research and Quality-Subcontracts TO Harvard University  R21 HS 019537
Project Dates and Amount of Award: 08/01/10-01/31/11; $13,905

PI: *Carlozzi,Noelle
Co-I: Tulsky, David (Physical Medicine & Rehab Dept)
Title: Microgravity Effects on Pro-Thrombotic Microparticles (MPs): Physical Characterization and Evaluation
Sponsor: NIH  7 R03 NS 065194 02
Project Dates and Amount of Award: 08/03/10-04/30/11; $62,488

PI: *Cherry-Bukowiec,Jill
Title: Hepcidin and Anemia in Surgical Critical Care
Sponsor: Surgical Infection Society
Project Dates and Amount of Award: 07/01/10-06/30/11; $50,000

PI: *Hirsch,Jennifer
Title: CryoValve SG Pulmonary Valve Post-Clearance Study
Sponsor: CryoLife, Inc.
Project Dates and Amount of Award: 04/01/10-12/31/11; $13,000

PI: *Magee,John
Title: A 24-month Randomized, Multicenter Study Evaluating Efficacy, Safety, Tolerability and Pharmacokinetics of Sotrastaurin (STN)Combined with Tacrolimus (TAC) vs a Tacrolimus/Mycophenolate Mofetil (MMF)-Based Control Regimen in De Novo Liver Transplant Recipients (Clinical Study Protocol CAEB071B2201)
Sponsor: Novartis
Project Dates and Amount of Award: 09/27/10-09/30/13; $236,375

PI: *Sung,Randall
Title: TOL 101
Sponsor: Tolera Therapeutics, Inc
Project Dates and Amount of Award: 09/01/10-07/31/12; $215,186

PI: *Zheng,Pan
Co-I: Liu, Yang (General Surgery Section)
Title: MTOR, Inflammation and Senescence of Hematopoietic Stem Cells
Sponsor: NIH  1 R01 AG 136690 01 A1
Project Dates and Amount of Award: 09/30/10-08/31/15; $1,512,120


UMMS RESEARCH PUBLICATIONS

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Books – Chapters or Volumes of Books – Contributions to Books

Neurology

Cheng, H.T.; Callaghan, B.; Dauch, J.R.; Feldman, E.L. Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy.  In: Nixon, R.A.; Yuan, A., editors. Cytoskeleton of the nervous system series: advances in neurobiology. 1st ed. Vol. 3. Ch. 27. Springer Publishers; 2010.

Pop-Busui, R.; Simmons, Z.; Feldman, E.L.  Treatment of diabetic neuropathy.  In:  Williams, R.; Herman, W.; Kinmonth, A.-L.; Wareham, N.J., editors. Evidence base for diabetes care. 2nd ed. Ch. 19. BMJ Publishing Group Ltd.; 2010. p. 317-40.

Vincent, A.M.; Feldman, E.L. Primary sensory and motor neuron cultures.  In: Doering, L.C., editor.  Protocols for neural cell culture.  4th ed. Humana Press; 2010. P. 161-74.

Otolaryngology

Garetz, Susan L., O'Brien, Louise M and Chervin,  Ronald D. Neurobehavioral Morbidity in Childhood Sleep Disorders. In:  Yaremchuk, Kathleen L. and  Wardrop,  Pell Ann,  editors. Sleep Medicine. San Diego: Plural publishing Inc: 2011. P 349-366

Psychiatry

Casher MI, Bess JD. Manual of inpatient psychiatry. Cambridge: Cambridge University Press; 2010.

Journal Articles

Anesthesiology

Hsu Michael C, Schubiner Howard, Lumley Mark A, Stracks John S, Clauw Daniel J, Williams David A. Sustained pain reduction through affective self-awareness in fibromyalgia: a randomized controlled trial. Journal of general internal medicine. 2010 Oct. 25(10): 1064-70. PMID# 20532650

Flint RaShonda R, Chang Theresa, Lydic Ralph, Baghdoyan Helen A. GABA(A) receptors in the pontine reticular formation of C57BL/6J mouse modulate neurochemical, electrographic, and behavioral phenotypes of wakefulness. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Sep 15. 30(37): 12301-9. PMID# 20844126

Biological Chemistry

Muaddi Hala, Majumder Mithu, Peidis Philippos, Papadakis Andreas I, Holcik Martin, Scheuner Donalyn, Kaufman Randal J, Hatzoglou Maria, Koromilas Antonis E. Phosphorylation of eIF2¿ at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Molecular biology of the cell. 2010 Sep 15. 21(18): 3220-31. PMID# 20660158

Cell & Developmental Biology

Raiker Stephen J, Lee Hakjoo, Baldwin Katherine T, Duan Yuntao, Shrager Peter, Giger Roman J. Oligodendrocyte-myelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Sep 15. 30(37): 12432-45. PMID# 20844138

Center for Computational Medicine and Bioinformatics

Ding Yousong, de Wet Jeffrey R, Cavalcoli James, Li Shengying, Greshock Thomas J, Miller Kenneth A, Finefield Jennifer M, Sunderhaus James D, McAfoos Timothy J, Tsukamoto Sachiko, Williams Robert M, Sherman David H. Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. Journal of the American Chemical Society. 2010 Sep 15. 132(36): 12733-40. PMID# 20722388

Dermatology

Orringer J S, Rittié L, Baker D, Voorhees J J, Fisher G. Molecular mechanisms of nonablative fractionated laser resurfacing. The British journal of dermatology. 2010 Oct. 163(4): 757-68. PMID# 20854401

Family Medicine

Klinkman Michael S, Bauroth Sabrina, Fedewa Stacey, Kerber Kevin, Kuebler Julie, Adman Tanya, Sen Ananda. Long-term clinical outcomes of care management for chronically depressed primary care patients: a report from the depression in primary care project. Annals of family medicine. 2010 Sep-Oct. 8(5): 387-96. PMID# 20843879

Internal Medicine – Allergy and Clinical Immunology

Mullen Douglas G, Borgmeier Emilee L, Desai Ankur M, van Dongen Mallory A, Barash Mark, Cheng Xue-min, Baker James R, Banaszak Holl Mark M. Isolation and characterization of dendrimers with precise numbers of functional groups. Chemistry (Weinheim an der Bergstrasse, Germany). 2010 Sep 17. 16(35): 10675-8. PMID# 20683917

Internal Medicine – Cardiovascular Medicine

Jain Renuka, Nallamothu Brahmajee K, Chan Paul S. Body mass index and survival after in-hospital cardiac arrest. Circulation. Cardiovascular quality and outcomes. 2010 Sep 1. 3(5): 490-7. PMID# 20699443

Kommuri Naga V A, Johnson Monica L, Koelling Todd M. Six-minute walk distance predicts 30-day readmission in hospitalized heart failure patients. Archives of medical research. 2010 Jul. 41(5): 363-8. PMID# 20851294

Internal Medicine – Gastroenterology

Fontana Robert J, Dienstag Jules L, Bonkovsky Herbert L, Sterling Richard K, Naishadham Deepa, Goodman Zachary D, Lok Anna S F, Wright Elizabeth C, Su Grace L. Serum fibrosis markers are associated with liver disease progression in non-responder patients with chronic hepatitis C. Gut. 2010 Oct. 59(10): 1401-9. PMID# 20675691

Internal Medicine – General Medicine

Berry Scott R, Bell Chaim M, Ubel Peter A, Evans William K, Nadler Eric, Strevel Elizabeth L, Neumann Peter J. Continental Divide? The attitudes of US and Canadian oncologists on the costs, cost-effectiveness, and health policies associated with new cancer drugs. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010 Sep 20. 28(27): 4149-53. PMID# 20697077

Internal Medicine – Hematology and Oncology

Van Poznak Catherine. Predicting skeletal complications in metastatic breast cancer raises challenges. Breast cancer research and treatment. 2010 Oct. 123(3): 781-3. PMID# 20690039

Sikora M J, Rae J M, Johnson M D, Desta Z. Efavirenz directly modulates the oestrogen receptor and induces breast cancer cell growth. HIV medicine. 2010 Oct 1. 11(9): 603-7. PMID# 20408889

Internal Medicine – Infectious Diseases

Zhu Wenming, Murray Patrick R, Huskins W Charles, Jernigan John A, McDonald Lawrence C, Clark Nancye C, Anderson Karen F, McDougal Linda K, Hageman Jeff C, Olsen-Rasmussen Melissa, Frace Mike, Alangaden George J, Chenoweth Carol, Zervos Marcus J, Robinson Dissemination of an Enterococcus Inc18-Like vanA plasmid associated with vancomycin-resistant Staphylococcus aureus. Antimicrobial agents and chemotherapy. 2010 Oct. 54(10): 4314-20. PMID# 20660665

Internal Medicine – Metabolism, Endocrinology & Diabetes

Subauste Angela R, Elliott Brandon, Das Arun K, Burant Charles F. A role for 1-acylglycerol-3-phosphate-O-acyltransferase-1 in myoblast differentiation. Differentiation; research in biological diversity. 2010 Sep-Oct. 80(2-3): 140-6. PMID# 20561744

Internal Medicine – Molecular Medicine & Genetics

Mukherjee Bhramar, Ahn Jaeil, Gruber Stephen B, Ghosh Malay, Chatterjee Nilanjan. Case-control studies of gene-environment interaction: Bayesian design and analysis. Biometrics. 2010 Sep. 66(3): 934-48. PMID# 19930190

Internal Medicine – Rheumatology

Schoonen W Marieke, Thomas Sara L, Somers Emily C, Smeeth Liam, Kim Joseph, Evans Stephen, Hall Andrew J. Do selected drugs increase the risk of lupus? A matched case-control study. British journal of clinical pharmacology. 2010 Oct. 70(4): 588-96. PMID# 20840450

Medical Education

Funnell Martha M. Standards of care for diabetes: what's new? Nursing. 2010 Oct. 40(10): 54-6. PMID# 20844399

Albanese Mark A, Mejicano George, Anderson W Marshall, Gruppen Larry. Building a competency-based curriculum: the agony and the ecstasy. Advances in health sciences education : theory and practice. 2010 Aug. 15(3): 439-54. PMID# 18481188

Microbiology and Immunology

Rosario Christopher J, Janes Brian K, Bender Robert A. Genetic analysis of the nitrogen assimilation control protein from Klebsiella pneumoniae. Journal of bacteriology. 2010 Oct. 192(19): 4834-46. PMID# 20693327

Ding Yousong, de Wet Jeffrey R, Cavalcoli James, Li Shengying, Greshock Thomas J, Miller Kenneth A, Finefield Jennifer M, Sunderhaus James D, McAfoos Timothy J, Tsukamoto Sachiko, Williams Robert M, Sherman David H. Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. Journal of the American Chemical Society. 2010 Sep 15. 132(36): 12733-40. PMID# 20722388

Kirschner Denise E, Young Douglas, Flynn JoAnne L. Tuberculosis: global approaches to a global disease. Current opinion in biotechnology. 2010 Aug. 21(4): 524-31. PMID# 20637596

Molecular & Behavioral Neuroscience Institute

Fisher Stephen K, Heacock Anne M, Keep Richard F, Foster Daniel J. Receptor regulation of osmolyte homeostasis in neural cells. The Journal of physiology. 2010 Sep 15. 588(Pt 18): 3355-64. PMID# 20498228

Molecular & Integrative Physiology

Cheng Jie, Shah Yatrik M, Ma Xiaochao, Pang Xiaoyan, Tanaka Toshiya, Kodama Tatsuhiko, Krausz Kristopher W, Gonzalez Frank J. Therapeutic role of rifaximin in inflammatory bowel disease: clinical implication of human pregnane X receptor activation. The Journal of pharmacology and experimental therapeutics. 2010 Oct. 335(1): 32-41. PMID# 20627999

Neurology

Kroenke Mark A, Chensue Stephen W, Segal Benjamin M. EAE mediated by a non-IFN-¿/non-IL-17 pathway. European journal of immunology. 2010 Aug. 40(8): 2340-8. PMID# 20540117

Neurosurgery

Fisher Stephen K, Heacock Anne M, Keep Richard F, Foster Daniel J. Receptor regulation of osmolyte homeostasis in neural cells. The Journal of physiology. 2010 Sep 15. 588(Pt 18): 3355-64. PMID# 20498228

Obstetrics & Gynecology

Morris Mark S, Domino Edward F, Domino Steven E. Opioid modulation of oxytocin release. Journal of clinical pharmacology. 2010 Oct. 50(10): 1112-7. PMID# 20350953

Orthopaedic Surgery

Bedi Asheesh, Fox Alice J S, Harris Paul E, Deng Xiang-Hua, Ying Liang, Warren Russell F, Rodeo Scott A. Diabetes mellitus impairs tendon-bone healing after rotator cuff repair. Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.]. 2010 Oct. 19(7): 978-88. PMID# 20303293

Ben-Dor Itsik, Pichard Augusto D, Gonzalez Manuel A, Weissman Gaby, Li Yanlin, Goldstein Steven A, Okubagzi Petros, Syed Asmir I, Maluenda Gabriel, Collins Sara D, Delhaye Cedric, Wakabayashi Kohei, Gaglia Michael A, Torguson Rebecca, Xue Zhenyi, Satler L Correlates and causes of death in patients with severe symptomatic aortic stenosis who are not eligible to participate in a clinical trial of transcatheter aortic valve implantation. Circulation. 2010 Sep 14. 122(11 Suppl): S37-42. PMID# 20837923

Otolaryngology

Aranha Andreza M F, Zhang Zhaocheng, Neiva Kathleen G, Costa Carlos A S, Hebling Josimeri, Nör Jacques E. Hypoxia enhances the angiogenic potential of human dental pulp cells. Journal of endodontics. 2010 Oct. 36(10): 1633-7. PMID# 20850667

Baker Shan R. Retrospective review of transconjunctival sub-orbicularis oculi pad lift blepharoplasty. Archives of facial plastic surgery : official publication for the American Academy of Facial Plastic and Reconstructive Surgery, Inc. and the International Federation of Facial Plastic Surgery Societies. 2010 Sep-Oct. 12(5): 349-51. PMID# 20855779

Pathology

Kroenke Mark A, Chensue Stephen W, Segal Benjamin M. EAE mediated by a non-IFN-¿/non-IL-17 pathway. European journal of immunology. 2010 Aug. 40(8): 2340-8. PMID# 20540117

Pediatrics & Communicable Diseases

Fredericks Emily M, Dore-Stites Dawn. Adherence to immunosuppressants: how can it be improved in adolescent organ transplant recipients? Current opinion in organ transplantation. 2010 Oct. 15(5): 614-20. PMID# 20651598

Pharmacology

Neubig Richard R. Mind your salts: when the inactive constituent isn't. Molecular pharmacology. 2010 Oct. 78(4): 558-9. PMID# 20651116

Sjögren Benita, Neubig Richard R. Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling. Molecular pharmacology. 2010 Oct. 78(4): 550-7. PMID# 20664002

Houamed Khaled M, Sweet Ian R, Satin Leslie S. BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic ¿-cells. The Journal of physiology. 2010 Sep 15. 588(Pt 18): 3511-23. PMID# 20643769

Psychiatry

Kim Hyungjin Myra, Eisenberg Daniel, Ganoczy Dara, Hoggatt Katherine, Austin Karen L, Downing Karen, McCarthy John F, Ilgen Mark, Valenstein Marcia. Examining the relationship between clinical monitoring and suicide risk among patients with depression: matched case-control study and instrumental variable approaches. Health services research. 2010 Oct. 45(5 Pt 1): 1205-26. PMID# 20609017

Cranford James A, Zucker Robert A, Jester Jennifer M, Puttler Leon I, Fitzgerald Hiram E. Parental alcohol involvement and adolescent alcohol expectancies predict alcohol involvement in male adolescents. Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors. 2010 Sep. 24(3): 386-96. PMID# 20853923

Klinkman Michael S, Bauroth Sabrina, Fedewa Stacey, Kerber Kevin, Kuebler Julie, Adman Tanya, Sen Ananda. Long-term clinical outcomes of care management for chronically depressed primary care patients: a report from the depression in primary care project. Annals of family medicine. 2010 Sep-Oct. 8(5): 387-96. PMID# 20843879

Radiology

Holly Thomas A, Abbott Brian G, Al-Mallah Mouaz, Calnon Dennis A, Cohen Mylan C, DiFilippo Frank P, Ficaro Edward P, Freeman Michael R, Hendel Robert C, Jain Diwakar, Leonard Scott M, Nichols Kenneth J, Polk Donna M, Soman Prem. Single photon-emission computed tomography. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2010 Oct. 17(5): 941-73. PMID# 20552312

Zhang M, Fabiilli M L, Haworth K J, Fowlkes J B, Kripfgans O D, Roberts W W, Ives K A, Carson P L. Initial investigation of acoustic droplet vaporization for occlusion in canine kidney. Ultrasound in medicine&biology. 2010 Oct. 36(10): 1691-703. PMID# 20800939

Sanchez Ramon, Ladino-Torres Maria F, Bernat John A, Joe Annette, DiPietro Michael A. Breast fibroadenomas in the pediatric population: common and uncommon sonographic findings. Pediatric radiology. 2010 Oct. 40(10): 1681-9. PMID# 20449731

Wong KK, Frey KA, Koral KF, Sisson JC, Avram AM. Staging of Differentiated Thyroid Carcinoma Using Diagnostic 131-I SPECT-CT. AJR Am J Roentgenol. 2010 Sep;195(3):730-6.

Surgery – General Surgery

Henke Peter K, Kubus Jim, Englesbe Michael J, Harbaugh Calista, Campbell Darrell A. A statewide consortium of surgical care: a longitudinal investigation of vascular operative procedures at 16 hospitals. Surgery. 2010 Oct. 148(4): 883-89; discussion 889-92. PMID# 20719350

Sonnenday Christopher J, Birkmeyer John D. A tale of two provinces: regionalization of pancreatic surgery in Ontario and Quebec. Annals of surgical oncology. 2010 Oct. 17(10): 2535-6. PMID# 20499281

Surgery – Pediatric Surgery

Miyasaka Eiichi A, Okawada Manabu, Utter Brent, Mustafa-Maria Haytham, Luntz Jonathan, Brei Diann, Teitelbaum Daniel H. Application of distractive forces to the small intestine: defining safe limits. The Journal of surgical research. 2010 Oct. 163(2): 169-75. PMID# 20605600

Sukhotnik Igor, Shany Annette, Bashenko Yulia, Hayari Lili, Chemodanov Elena, Mogilner Jorge, Coran Arnold G, Shaoul Ron. Parenteral but not enteral omega-3 fatty acids (Omegaven) modulate intestinal regrowth after massive small bowel resection in rats. JPEN. Journal of parenteral and enteral nutrition. 2010 Sep-Oct. 34(5): 503-12. PMID# 20852178

Surgery – Plastic Surgery

Inyang Alero F, Schwarz Daniel A, Jamali Ameen M, Buchman Steven R. Quantitative histomorphometric assessment of regenerate cellularity and bone quality in mandibular distraction osteogenesis after radiation therapy. The Journal of craniofacial surgery. 2010 Sep. 21(5): 1438-42. PMID# 20818254

Urology

Zhang M, Fabiilli M L, Haworth K J, Fowlkes J B, Kripfgans O D, Roberts W W, Ives K A, Carson P L. Initial investigation of acoustic droplet vaporization for occlusion in canine kidney. Ultrasound in medicine&biology. 2010 Oct. 36(10): 1691-703. PMID# 20800939

 


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