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MAY 2010, Vol. 28

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Resource Profiles – A New Tool on the Web from the Office of Research!

The Office of Research has developed a new, online document called “UMMS Resource Profiles.” The document contains descriptions of units and resources at UMHS and elsewhere on campus. These boilerplate descriptions are meant to be adapted by the user to fit his or her needs, e.g., marketing, recruiting, writing grant proposal resource sections.

You may access the beta version at ( During this rollout phase, we ask that you read pertinent sections and give us additions, revisions, or feedback. Please send suggestions to ( Once UMMS personnel have reviewed the document, we will make a public link available (July 2010). You may start using this document immediately. We will be constantly editing and updating to make this document as useful as possible.

Protein Structure Facility – UM’s One-stop Shop for Proteomics and Peptide Synthesis Services
PSF Logo

The Protein Structure Facility, a part of the Biomedical Research Core Facilities (BRCF), is the only core laboratory providing both proteomics and peptide synthesis services to the entire research community at UM.


The BRCF Protein Structure Facility expanded its capabilities to offer a comprehensive suite of proteomics services including:

  • Protein identification
  • Analysis of posttranslational modifications (e.g. phosphorylation site mapping)
  • Protein quantification (protein expression, relative and absolute quantification)
  • Analysis of protein cleavage sites (N-terminal sequencing)
  • Characterization of intact proteins (e.g. accurate mass measurements)
  • Biomarker services  (discovery, assay development and testing)

Project consultation, protocols for sample preparation as well as data reporting, interpretation, and discussion provide additional value to the investigator.

Peptide Synthesis

The peptide synthesis laboratory provides an extensive repertoire of routine and sophisticated synthesis options including (fluorophore) labeled and cyclic peptides. Heavy isotope labeled peptides are manufactured at competitive prices to meet the demand for reference standards in quantitative proteomics research.  Additional small-scale synthesis options will be available later this summer.

Contact Us for a Free Consultation

The Protein Structure Facility provides quality solutions to fit the investigator’s project scope and budget. Contact Dr. Henriette Remmer ( or 734-763-6285) to schedule a consultation. For more information, please visit the Protein Structure Facility website at (  Click here to add your name to our mailing list for upcoming news and announcements.

UMMS Dean’s Faculty Research Awards
Deadline: June 30, 2010

Basic Science Research Award

The Medical School Dean’s Office is soliciting nominations for the Basic Science Research Award. This award recognizes a scientist or group of scientists identified as having made outstanding contributions to the Medical School in basic biomedical science research. The award carries a $5,000 discretionary academic support prize, which will be given to the faculty member or group.

There is a two-stage selection process. Nominations are reviewed by the Biomedical Research Council, and a list of potential awardees is given to the Dean of the Medical School. The Dean makes the final selection.

Nominees must be in the rank of Assistant or Associate Professor, or Assistant or Associate Research Professor of the University of Michigan Medical School. See the website for complete instructions for submission.

Clinical & Health Services Research Award

This award recognizes a faculty member or group of faculty members who are identified as having made outstanding contributions to the Medical School in clinical or health services research. This award carries a $5,000 discretionary academic support prize, which will be given to the faculty member or group.

There is a two-stage selection process. Nominations submitted to the selection committee will be reviewed and a list of potential awardees given to the Dean of the Medical School. The Dean makes the final selection.

Nominees must be University of Michigan Medical School faculty at the level of Assistant or Associate Professor, Professor, or Assistant or Associate Research Professor, or Research Professor. See the website for complete instructions for submission.

Annual Outside Interests, Activities, or Relationships Reports Required Using M-Inform
Reporting Begins: July 1, 2010 – Deadline: July 31, 2010

As in previous years, UMHS Policy 01-04-003 requires that all Medical School faculty members (instructional, clinical and research tracks) and House Officers report outside interests, activities, or relationships related to their work or position at UMHS that have the real or perceived potential to result in benefit to them or their spouses, domestic partners, or dependents.

  • “Related” means an interest, activity, or relationship that relies upon or has the potential to influence Faculty and House Officers’ clinical, research, teaching, or other expertise that the University considers part of their work at UMHS.
  • Examples include an equity interest or owning stock in a company; licensed intellectual property for which one could receive royalties; unpaid or paid consulting with a drug company. For more examples see the COI Guidance Page.
  • Note: Gifts, salary, and other support from an outside entity (e.g., NIH, Pfizer) that are administered by DRDA or a University development office do not constitute an outside interest.

To comply with this UMHS Conflict of Interest policy, certain executives and management staff must also disclose their outside interests, activities, or relationships for themselves and their family members.

Key Points Include:

  1. The Outside Interest Reporting Form (M-Inform) must be completed between July 1 and July 31.
  2. Reporting forms will be reviewed between August 1 and August 31, with follow-up as needed.
  3. Upon signing and submitting the form, MLearning will track one’s completion.
  4. Reports and any additional information gathered shall be treated as sensitive data, and access to this information granted only to those University or UMHS personnel requiring such information to perform their duties.
  5. The UMHS Conflict of Interest and Outside Interest Disclosures website ( is available to provide additional information on this process.

Access to M-Inform is at ( This electronic format provides an easy mechanism for submitting reports and allows participants to copy activities disclosed in 2009 or previous years into their 2010 record as needed. Additional information can be found at (, and additional support is available by contacting (

UM Gets $63 Million NIH Grant for SWOG Cancer Trials Network

Noting that the organization's research "has touched the lives of virtually every adult cancer patient in this nation," the National Cancer Institute (NCI) has renewed the UM based Southwest Oncology Group's operating grants for six years, with a total funding package over that period expected to exceed $120 million.

The principal grant, more than $63 million, will be administered by the University of Michigan, and is the largest single research award ever to the UM Medical School. Most of the remainder of the NCI package will be distributed directly to the Group's member institutions.

Additional information is available in this press release.

First Medical Technology Spinoff Company for Medical Innovation Center

The first class of Innovation Fellows from the Medical Innovation Center finalized the licensing of their technology with the Office of Technology Transfer.  The technology they prototyped during their fellowship program was licensed to the company they created in 2009, Tangent Medical Technologies Inc.  The University of Michigan holds an equity position in the new company. The fellowship class developed a new design for the ubiquitous IV catheter and attracted an angel investor who now serves as their CEO.  For the background story on the fellows and their invention, visit (

Medical Innovation Center Extends Its Reach to Virginia

The FDA awarded additional funding of over $300,000 to the Medical Innovation Center to assist with the launch of a pediatric device consortium in Roanoke, Virginia.  The new consortium will be led by PMDI (Pediatric Medical Device Institute), a not-for-profit organization that was created to assist a network of 12 children's hospitals commercialize pediatric device ideas.  This funding is incremental to the original $2M awarded to launch MPED, the University of Michigan's own Pediatric Device Consortium.  For more information about the Consortia, visit   (

CRAO Is a New eResearch Ancillary Committee!
You Are Invited and Encouraged to Attend a Q&A Session

The following announcement is made on behalf of Steve Kunkel, Ph.D., Senior Associate Dean for Research and Teri Grieb, Ph.D., Senior Director for Research, Office of Research:

The Clinical Research Calendar Review & Analysis Office (CRAO), which is a part of the Medical School Office of Research and was formerly known as the Clinical Research Billing Unit (CRBU), was included as an Ancillary Committee as part of Release 2.3 in eResearch on Friday, March 26, 2010.

Beginning with Release 2.3, PI/study teams are now required to submit the research billing calendar to CRAO prior to receiving IRBMED approval.

This new workflow will remove current bottlenecks and increase efficiency in the development of a research billing calendar and associated documents, such as the protocol and informed consent.  The change in process will provide investigative teams with a single place to do their work, including uploading documents; eliminating multiple requests for the Principal Investigator/study team to respond to; and creating an environment where the CRAO and study teams can correspond similar to the current Core and Ancillary Committees.  In addition, this change will enhance CRAO coordination with IRBMED.  Importantly, this process is intended to make sure charges are appropriately allocated to study accounts, third-party payers, and/or subjects.

Q&A Sessions

In order to address questions from PI/study team members on this change in eResearch, we are holding a series of Q&A sessions conducted by Gina Vuocolo-Branch, Senior Manager, CRAO and Jan Hewett, Director, IRBMED.

Wednesday, May 12, 2010
10:30 - 11:30 AM
M3330 Med Sci I

Wednesday, May 26, 2010
11:00 AM - 12:00 PM
M3330 Med Sci I

"The Nuts & Bolts of Building a Research Billing Calendar" Workshop

In February and March 2010, the CRAO held several sessions of “The Nuts & Bolts of Building a Research Billing Calendar” workshop. This was a learning opportunity for those that are responsible for developing research billing calendars.  Attendees of the workshop learned why the billing calendar is required and valuable to the PI/study team, how to complete the calendar, and where to go for assistance in building a billing calendar. The workshop also included information on the enrollment process as well as a brief discussion of the CRAO as an Ancillary Committee. Gina Vuocolo-Branch, Senior Manager of the CRAO, presented (45 min) and then answered questions (30 min). If you were not able to attend a workshop, you may watch the video and access the PowerPoint presentation online.

* Please note that the above webpage is available only via U-M computers and computers that are logged in via a VPN (Virtual Private Network).

We thank you for your continued suggestions about your clinical research support needs. You can learn more about Clinical Research Billing on the CRAO website:

Contact Kathryn Ridner at ( or 734-763-4086 with any questions about the workshop or Q&A sessions.


Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


Animal Research

A Reminder About Procedures and Training for New Staff in Labs

As summer is quickly approaching, many laboratories may be bringing in students or temporary staff for summer research projects. The UCUCA would like to remind you that any individual working with animals in research must be listed on an approved UCUCA protocol. Additionally, the UCUCA does require a number of training courses for animal users. Because summer projects can be time sensitive, it would helpful to begin the process of adding students to your protocol and arranging for attendance to training courses as soon as possible to expedite these processes. Please contact the UCUCA office to have students added to your animal care and use protocols.

Once you have notified the UCUCA, please arrange for students to take UCUCA required courses as soon as possible. The following courses should be considered (schedules can be found at

  • Orientation to Animal Care and Use at the University of Michigan (Lecture)
  • Introduction to Species – Required for any species an individual will be working with (e.g. Introduction to Laboratory Mice and Rats, Introduction to the Laboratory Dog, etc.) (Lecture)
  • Rodent Survival Surgery – Only required for individuals that will be doing survival surgery on mice and rats. (Lecture)
  • Workshops for Mice and Rats – Handling and procedural wet-labs for users of mice and rats. Enrollment is limited to individuals on approved UCUCA protocols.
  • ULAM Hazard Containment – Only required for individuals working with hazardous materials in animals. (Lecture)

If you have a large number of students or staff joining your laboratory at one time, you can arrange for a trainer to come to your laboratory and provide courses directly for your group. Please contact the ULAM Training Core at (

For additional questions regarding UCUCA protocols, please contact the UCUCA office at 734-936-8028 or (

For additional questions regarding required courses please contact the ULAM Training Core at 734-763-8039 or (


Shipping Specimens with Dry Ice

OSEH is receiving indications that researchers are undertaking shipments of specimens with dry ice refrigerant, but who lack training and experience in properly packaging and shipping with that hazardous material (yes, dry ice is considered a HazMat by the U.S. Department of Transportation – Federal Aviation Administration).  This type of activity is highly regulated by the government and requires specific training/certification in order to successfully and legally ship hazardous materials, including dry ice.  For more information, please review the OSEH Guideline on shipping specimens with dry ice refrigerant.

Anesthetic Gas Use in Animal Surgery

OSEH is receiving indications that researchers who use anesthetic machines to treat animals prior to surgery may be using improper flow-rates, and thus are exposing themselves to high levels of waste anesthetic gases (WAG).  Some of this activity may result from under-training, lack of awareness of the risks, or rushed methods.  In conjunction with OSEH, the Unit for Laboratory Animal Medicine (ULAM) will be undertaking outreach education on the proper set-up of these devices and flow-rates for safe use of anesthetic gases with research animals.  If there are any questions on this workplace risk, please contact our office at 734-763-6973.


The National Institutes of Public Health Public Access Policy

Do you still have questions about the NIH Public Access Policy? This presentation will clear up any confusion and answer any questions that you have about the Policy. It will clearly explain the Policy, when compliance is required, who is responsible for compliance, how to comply, and its impact on the NIH grant process. Sponsored by the Health Sciences Libraries, Taubman Medical Library.

Register for this class.

Friday, June 18, 2010
10:00 - 11:30 AM
3330 Medical Science I

Inserting Graphics into NIH Grant Applications

Recent changes in the NIH grant application reduce the number of pages available for the research plan, making proper placement of images, charts and graphics critical. This session will cover basic features in Microsoft Word to help with grant application preparation, including image placement, captioning and wordwrap. Following a brief presentation, instructors will assist you with specific issues you’re encountering in formatting your grant application – please feel free to bring sample documents! This workshop was developed in response to feedback from faculty members to both the Medical School Office of Research and the Health Sciences Libraries. Note: this session will be conducted using Word 2007 (docx). Documents created in the class can be saved in Word 2003 format (doc). Sponsored by the Health Sciences Libraries, Taubman Medical Library.  There are two sessions scheduled:

Wednesday, June 30, 2010
2:00 - 3:00 PM
Taubman Learning Center, 2802 Medical Sciences Building II
Register for this session.

Thursday, August 5, 2010
10:00 - 11:00 AM
Taubman Learning Center, 2802 Medical Sciences Building II
Register for this session.


Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains information on email alert groups, internal grant programs, upcoming limited submissions, and links to extramural funding search engines.

External Limited Submissions

These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

Edward Mallinckrodt, Jr. Foundation Grant Program
Internal Deadline: June 8, 2010

The basic aim of the Edward Mallinckrodt, Jr. Foundation is to advance knowledge in the various fields of medical and health research. It is further the general aims to (1) confine contributions to those worthy projects that are in need of initial start-up funding to move the projects forward to the point of other independent support or (2) support highly promising young investigators (e.g. have not been a PI on an R01) at the time when start-up funds are limited and initial progress is dependent on additional funding. The Foundation is most interested in basic research with upstream potential for impacting disease.

The applicant must have a tenure-track appointment in the Medical School. Those with titles of Clinical Lecturer or Clinical Instructor would not qualify for this funding program, as these are not tenure-track appointments. Research Investigators are eligible for this award.

It is not the intent to support projects that are already under way and are already receiving significant grant support to provide long-range funding beyond an initial three-year period of support. The Foundation will not fund overhead, and grants will be made and restricted to domestic institutions.

Grants are made in the amount of $50,000 - $75,000 per year for a period of one to three years and are contingent upon a yearly progress report by the applicant. The Foundation reviews applications three times a year. The next Foundation deadline is August 1, 2010. The University of Michigan may submit a maximum of three proposals.

For consideration as an institutional nominee, submit the following electronically in a single PDF document – in the order listed – by June 8, 2010 to (

  • Cover sheet (downloaded from the website below)
  • Nominating letter from the department chair
  • 2- to 4-page research plan (double-spaced)
  • NIH formatted biosketch

We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or ( with any questions. Please visit this website to download the cover sheet and view complete Foundation guidelines.

V Foundation for Cancer Research V Scholar Grant
Internal Deadline: June 14, 2010

The V Foundation, founded in 1993 by award-winning coach and commentator Jim Valvano, seeks to find a cure for cancer.  Funding is available for laboratory based fundamental and translational research through the V Scholar Grant.  Each grant will total $200,000, and is given in two yearly installments.  This grant has a zero indirect cost policy.

The UM Comprehensive Cancer Center may nominate one individual. To be eligible, the candidate must meet the following criteria:

  • Demonstrated expertise and promise in the designated areas of research
  • Completed at least two years of fellowship training
  • Currently hold a tenured track faculty position
  • No more than five years since joining the faculty as Instructor or Assistant Professor
  • No more than 10 years since terminal degree (M.D. or Ph.D.) – Exceptions must be approved prior to submission.
  • Not been promoted to Associate Professor

Researchers who have secured their own R01 funding are not eligible for this award.  Applicants with institutional or K08 awards are eligible.

Deadline for submission of a proposal to the Foundation is August 6, 2010.  Grants will be awarded in September 2010 and first payment will be made October 2010.

For consideration as the institutional nominee, submit the following electronically in a single PDF document – in the order listed – by June 14, 2010 to (

We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or ( with any questions. The V Foundation’s website is (

Deadline Watch

Click here to view.

Michigan Institute for Clinical and Health Research (MICHR) CTSA K – Mentored Clinical Scientists Career Development Program
Deadline: May 24, 2010


James T. Neubacher Award
Deadline: May 31, 2010

Damon Runyon-Rachleff Innovation Award
Deadline: June 1, 2010 (Pre-Proposal)


External Awarded Grants

Click here to view.


PI: Clauw, Daniel
Co-I: Glass, Jennifer (Psychiatry Department) / Harte, Steven (Anesthesiology Department) / Williams, David (Anesthesiology Department)
Title: "A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study to Evaluate the Effects of Milnacipran on Pain Processing and Functional Magnetic Resonance Imaging Activation Patterns in Patients with Fibromyalgia."
Sponsor: Forest Research Institute, Inc
Project Dates and Amount of Award: 02/01/10-06/30/11; $578,658

Biological Chemistry

PI: Andrews, Philip
Co-I: Nesvizhskii, Alexey (Pathology Department)
Sponsor: NIH  1 T32 CA 140044 01 A1
Project Dates and Amount of Award: 05/01/10-04/30/15; $1,035,791

PI: Kaufman, Randal
Sponsor: NIH  3 R37 DK 042394 11 S1
Project Dates and Amount of Award: 12/20/09-11/30/10; $99,000

PI: Vojtek, Anne
Sponsor: NIH  1 R21 AG 034264 01 A1
Project Dates and Amount of Award: 04/15/10-03/31/12; $344,704

Cell & Developmental Biology

PI: Giger, Roman
Sponsor: NIH  2 R56 NS 047333 06 A1
Project Dates and Amount of Award: 05/01/10-04/30/11; $424,722

Center for Computational Medicine and Bioinformatics

PI: Zhang, Yang
Title: I-TASSER Based Atomic-Level Protein Structure Prediction
Sponsor: NIH  7 R01 GM 083107 03
Project Dates and Amount of Award: 09/07/09-03/31/13; $997,892


PI: Maier, Lisa
Title: Investigation of the Topical Retinoid, Atralin gel 0.05% for the Treatment of Erythematotelangiectatic Rosacea
Sponsor: Valeant Pharmaceuticals
Project Dates and Amount of Award: 03/04/10-12/31/11; $384,231

Emergency Medicine

PI: Scott, Phillip
Sponsor: CDC-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $11,520

Family Medicine

PI: Fetters, Michael
Co-I: Skye, Eric (Family Medicine)
Title: Shizuoka-University of Michigan Advanced Residency Training, Education and Research in Family Medicine (SMARTER Family Medicine)
Sponsor: Shizuoka Prefectural Government
Project Dates and Amount of Award: 04/01/10-03/31/14; $1,408,626

Human Genetics

PI: Antonellis, Anthony
Sponsor: Muscular Dystrophy Assoc. TO Thomas Jefferson University
Project Dates and Amount of Award: 01/01/10-12/31/10; $32,531

Internal Medicine

PI: Baker, Laurence
Co-I: Erba, Harry (Int Med-Hematology/Oncology) / Hayes, Daniel (Int Med-Hematology/Oncology) / Hoban, Carolyn (Int Med-Hematology/Oncology) / Pienta, Kenneth (Int Med-Hematology/Oncology) / Redman, Bruce (Int Med-Hematology/Oncology) / Schott, Anne (Int Med-Hematology/Oncology)
Sponsor: NIH  2 U10 CA 032102 31
Project Dates and Amount of Award: 03/23/10-12/31/15; $63,452,004

PI: Bixby, Dale
Sponsor: Leukemia and Lymphoma Society
Project Dates and Amount of Award: 07/01/09-06/30/12; $195,000

PI: Chan, Kevin
Title: ARTEMIS-PH: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel-Group Study to Evaluate the Efficacy and Safety of Ambrisentan in Subjects with Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension
Sponsor: Gilead Sciences, Inc. TO PPD, Inc.
Project Dates and Amount of Award: 12/28/09-09/30/11; $116,526

PI: Chang, Robert
Sponsor: Blue Cross Blue Shield of Michigan Foundation
Project Dates and Amount of Award: 04/12/10-04/11/11; $10,000

PI: Chugh, Aman
Co-I: Corbett, James (Radiology Department) / Koeppe, Robert (Radiology Department)
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 04/12/10-04/11/11; $173,850

PI: Hussain, Maha
Title: A Pilot Study Combining ABT-888, an Oral PARP Inhibitor, with Temozolomide in Patients with Metastatic Castration Resistant Prostate Cancer Who Have Failed Up to Two Non-Hormonal Systemic Therapies
Sponsor: Abbott Laboratories
Project Dates and Amount of Award: 04/26/10-04/30/13; $154,489

PI: Kaminski, Mark
Title: An Open-Label, Single-Arm, Phase 2 Study of Inotuzumab Ozogamicin Plus Rituximab in Subjects with Relapsed/Refractory CD22-Positive Diffuse Large B-Cell Lymphoma, Eligible for Autologous Stem Cell Transplantation:  2009.099
Sponsor: Wyeth Pharmaceuticals, Inc.
Project Dates and Amount of Award: 03/22/10-03/21/13; $186,794

PI: Luan, Fu-Lung
Title: RAD US92
Sponsor: Novartis
Project Dates and Amount of Award: 04/13/10-05/11/13; $396,885

PI: Marotte, Hubert
Sponsor: Arthritis Foundation, The
Project Dates and Amount of Award: 07/01/10-06/30/12; $100,000

PI: Owyang, Chung
Co-I: Andrews, Philip (Biological Chemistry Dept) / Grabauskas, Gintautas (Int Med-Gastroenterology)
Sponsor: NIH  1 R01 DK 084039 01 A1
Project Dates and Amount of Award: 05/01/10-04/30/15; $1,676,556

PI: Patel, Dipak
Sponsor: Arthritis Foundation, The
Project Dates and Amount of Award: 07/01/10-06/30/12; $100,000

PI: Reddy, Pavan
Sponsor: Leukemia and Lymphoma Society
Project Dates and Amount of Award: 07/01/10-06/30/15; $550,000

PI: Roychowdhury, Sameek
Title: Transcriptome Sequencing of Myeloproliferative Neoplasms
Sponsor: Amer Assoc for Cancer Research
Project Dates and Amount of Award: 07/01/10-06/30/11; $45,000

PI: Simon, Richard
Title: Cystic Fibrosis Foundation Data Safety Monitoring Board
Sponsor: Cystic Fibrosis Foundation
Project Dates and Amount of Award: 07/01/10-06/30/11; $26,568

PI: Smith, David
Title: An Open -Label, Single-Arm, Phase II Trial of Intravenous BI 6727 in Patients with Locally Advanced, Metastatic or Recurrent Urothelial Cancer of the Bladder, Renal Pelvis, or Ureters after Failure of Prior Chemotherapy
Sponsor: Boehringer Ingelheim, Ltd.
Project Dates and Amount of Award: 04/27/10-04/26/12; $396,118

PI: Witteman, Holly
Co-I: Chua, Hannah Faye (Hlth Behavior & Hlth Ed Dept)
Title: Development and Evaluation of Interactive Interfaces for Values Exploration and Clarification
Sponsor: Foundation for Informed Medical Decision Making
Project Dates and Amount of Award: 04/15/10-05/15/11; $25,000

PI: Worden, Francis
Title: A Double-Blind, Randomized Phase III Study Evaluating the Efficacy and Safety of Sorafenib Compared to Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid Cancer
Sponsor: Bayer Corporation
Project Dates and Amount of Award: 04/22/10-04/21/13; $354,800

PI: Zhang, Yi
Co-I: Kuick, Rork (Univ of Mich Cancer Center)
Sponsor: American Cancer Society
Project Dates and Amount of Award: 07/01/10-06/30/14; $720,000

Molecular & Integrative Physiology

PI: MacDougald, Ormond
Sponsor: NIH  3 R01 DK 051563 13 S1
Project Dates and Amount of Award: 03/01/10-05/31/10; $92,377

PI: MacDougald, Ormond
Sponsor: NIH - Subcontracts TO Maine Medical Center 1 R24   01
Project Dates and Amount of Award: 04/28/10-11/30/10; $114,513


PI: Dauer, William
Title: The FADD/CASPASE-8 Pathway as a Mediator of LRRK2 Neurotoxicity
Sponsor: NIH - Subcontracts TO Columbia University
Project Dates and Amount of Award: 08/01/09-07/31/10; $282,771

PI: Leventhal, Daniel
Title: In Vivo Striatal Fast Spiking Interneuron Suppression using Optogenetic Techniques
Sponsor: Tourette Syndrome Assoc
Project Dates and Amount of Award: 07/01/10-06/30/11; $40,000

PI: Segal, Benjamin
Title: Multiple Sclerosis: A Heterogeneous Syndrome
Sponsor: Teva Neuroscience
Project Dates and Amount of Award: 04/01/10-03/31/11; $50,000

Ophthalmology & Visual Sciences

PI: Comer, Grant
Sponsor: Centocor, Inc. TO Ocuscience
Project Dates and Amount of Award: 02/19/10-06/30/10; $24,000

PI: Gillespie, Erin
Title: Fibrocytes as a Potential Biomarker for Thyroid Associated Ophthalmopathy
Sponsor: Howard Hughes Medical Institute
Project Dates and Amount of Award: 06/01/10-05/31/11; $38,000

PI: Zacks, David
Title: Preventing Photoreceptor Cell Death in Age-related Macular Degeneration
Sponsor: The Lincy Foundation
Project Dates and Amount of Award: 05/01/10-04/30/11; $100,000


PI: Dou, Yali
Sponsor: American Cancer Society
Project Dates and Amount of Award: 07/01/10-06/30/14; $720,000

PI: Ferguson, David
Title: Roles of Mre11 in Lymphocyte Development and DNA Repair
Sponsor: NIH  2 R01 HL 079118 06 A1
Project Dates and Amount of Award: 05/01/10-04/30/14; $1,466,520

PI: Maher, Christopher
Title: Characterization of Prostate Cancer Transcriptomes using Next Generation Sequencing
Sponsor: Prostate Cancer Foundation
Project Dates and Amount of Award: 04/19/10-04/18/13; $225,000

PI: Nikolovska-Coleska, Zaneta
Co-I: Stuckey, Jeanne (Biological Chemistry Dept) / Sun, Haiying (Int Med-Hematology/Oncology)
Sponsor: NIH  1 R01 CA 149442 01
Project Dates and Amount of Award: 04/01/10-01/31/15; $1,612,641

PI: Wilson, Thomas
Co-I: Yu, Xiaochun (Int Med-Molecular Med&Genetics)
Sponsor: NIH  2 R01 CA 102563 06 A1
Project Dates and Amount of Award: 08/01/10-07/31/15; $1,278,616

Pediatrics & Communicable Diseases

PI: Christner, Jennifer
Title: Schwartz Center Grant - Jenny Christner
Sponsor: Schwartz, Kenneth B., Center
Project Dates and Amount of Award: 05/01/10-04/30/11; $2,000

PI: Gaffney, Diane
Sponsor: AGA Medical Corporation
Project Dates and Amount of Award: 04/12/10-04/11/12; $59,214

PI: Hildebrandt, Friedhelm
Sponsor: NIH  2 R01 DK 068306 06
Project Dates and Amount of Award: 05/01/10-04/30/15; $1,612,094

PI: Shanley, Thomas
Title: CPCCRN Core Data Project (CCDP) / Parent: Colloborative Pediatric  Critical Care Research Network (CPCCRN)
Sponsor: NIH - Subcontracts TO University of Utah  U01 HD 049934
Project Dates and Amount of Award: 03/29/10-11/30/10; $30,900

PI: Shanley, Thomas
Title: Clinical Pertussis- Sub of Collaborative Pediatric Critical Care Network (CPCCRN)
Sponsor: NIH - Subcontracts TO University of Utah  U01 HD 049934
Project Dates and Amount of Award: 03/29/10-11/30/10; $46,350

PI: Shanley, Thomas
Co-I: Moler, Frank (Pediatrics-Intensive Care)
Title: Critical Asthma Mortality and Morbidity Planning Study(CAMMPS)
Sponsor: NIH - Subcontracts TO University of Utah  U01 HD 049934
Project Dates and Amount of Award: 12/01/09-11/30/10; $145,862


PI: Beg, Asim
Title: Activity-dependent Remodeling of the Corticospinal Motor System
Sponsor: The Hartwell Foundation
Project Dates and Amount of Award: 04/01/10-03/31/13; $300,000

PI: Isom, Lori
Sponsor: NIH  1 R01 NS 064245 01 A2
Project Dates and Amount of Award: 05/01/10-03/31/15; $1,463,380


PI: Swain, James
Title: Effects of Postpartum Depression on Mothers
Sponsor: NARSAD
Project Dates and Amount of Award: 07/01/09-06/30/10; $38,551

Radiation Oncology

PI: Feng, Felix
Sponsor: ASCO
Project Dates and Amount of Award: 07/01/10-06/30/11; $50,000

PI: Hamstra, Daniel
Title: Evaluation of the PI3K/Akt/mTOR axis for Radiation Sensitization
Sponsor: Prostate Cancer Foundation
Project Dates and Amount of Award: 06/01/10-05/31/13; $225,000

PI: Ljungman, Mats
Co-I: Simeone, Diane (General Surgery Section)
Sponsor: NIH  1 R21 CA 150100 01
Project Dates and Amount of Award: 04/13/10-03/31/12; $363,777


PI: Kilbourn, Michael
Title: GE Tech Transfer
Sponsor: GE Healthcare
Project Dates and Amount of Award: 02/18/10-12/31/10; $98,100

PI: Liu, Peter
Co-I: Francis, Isaac (Radiology Department) / Hoff, Carrie (UMH H.O. Core Radiology) / Liu, Peter (Radiology Department) / Morani, Ajaykumar (Radiology Department)
Sponsor: Bayer Corporation
Project Dates and Amount of Award: 11/19/09-03/18/12; $75,300

PI: Luker, Gary
Sponsor: NIH  1 S10 RR 028819 01
Project Dates and Amount of Award: 04/15/10-04/14/11; $939,608


PI: Dewyer, Nicholas
Title: Characterization of the Sterile Inflammatory Response in Deep Vein Thrombosis Resolution: The Interaction of Toll-Like Receptor and Notch Signaling Pathways
Sponsor: Howard Hughes Medical Institute
Project Dates and Amount of Award: 06/01/10-05/31/11; $38,000

PI: Magee, John
Co-I: Resnicow, Kenneth (Hlth Behavior & Hlth Ed Dept)
Sponsor: HRSA TO National Kidney Fdn. Of Mi.
Project Dates and Amount of Award: 09/01/09-08/31/12; $169,625

PI: Mychaliska, George
Sponsor: NIH  1 R03 HD 062713 01
Project Dates and Amount of Award: 04/01/10-03/31/12; $149,405

PI: Pagani, Francis
Title: The Relationship of Sleep Pattern Disturbance, Depression, Cognitive Function, and Self-Care in Adults with Long-Term Left Ventricular Assist Devices (LVADs)
Sponsor: Johnson, Robert Wood, Fdn. TO Wayne State University
Project Dates and Amount of Award: 09/01/09-08/31/10; $8,707

PI: Teitelbaum, Daniel
Co-I: Brei, Diann (Mechanical Engineering) / Luntz, Jonathan (Mechanical Engineering)
Sponsor: NIH - Subcontracts TO MC3, Inc.
Project Dates and Amount of Award: 04/01/10-03/31/11; $35,000


PI: Roberts, William
Sponsor: NIH  3 K08 DK 081656 02 S1
Project Dates and Amount of Award: 03/19/10-02/28/11; $53,309


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Biological Chemistry

Cremers CM, Reichmann D, Hausmann J, Ilbert M, Jakob U. Unfolding of metastable linker region is at the core of Hsp33 activation as a redox-regulated  chaperone. J Biol Chem. 2010 Apr 9;285(15):11243-51. Epub 2010 Feb 5.

Hamstra DA, Eisbruch A, Naidu MU, Ramana GV, Sunkara P, Campbell KC, Ross BD,  Rehemtulla A. Pharmacokinetic Analysis and Phase 1 Study of MRX-1024 in Patients  Treated with Radiation Therapy with or without Cisplatinum for Head and Neck Cancer. Clin Cancer Res. 2010 Apr 13. [Epub ahead of print]

Hedglin M, O'Brien PJ. Hopping enables a DNA repair glycosylase to search both strands and bypass a bound protein. ACS Chem Biol. 2010 Apr 16;5(4):427-36.

Hein ND, Stuckey JA, Rainier SR, Fink JK, Richardson RJ. Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties. Toxicol Lett. 2010 Apr 9. [Epub ahead of print]

Huang HS, Kubish GM, Redmond TM, Turner DL, Thompson RC, Murphy GG, Uhler MD.  Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation. Mol Cell Neurosci. 2010 Apr 9. [Epub ahead of print]

Karbstein K. Chaperoning ribosome assembly. J Cell Biol. 2010 Apr 5;189(1):11-2.

Lynch-Day MA, Bhandari D, Menon S, Huang J, Cai H, Bartholomew CR, Brumell JH, Ferro-Novick S, Klionsky DJ. Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy. Proc Natl Acad Sci U S A. 2010 Apr 7. [Epub ahead of print]

Schauerte JA, Wong PT, Wisser KC, Ding H, Steel DG, Gafni A. Simultaneous single-molecule fluorescence and conductivity studies reveal distinct classes of  abeta species on lipid bilayers. Biochemistry. 2010 Apr 13;49(14):3031-9.

Srinivasan A, Galbán CJ, Johnson TD, Chenevert TL, Ross BD, Mukherji SK. Utility of the k-means clustering algorithm in differentiating apparent diffusion coefficient values of benign and malignant neck pathologies. AJNR Am J Neuroradiol. 2010 Apr;31(4):736-40. Epub 2009 Dec 10.

Tsien C, Galbán CJ, Chenevert TL, Johnson TD, Hamstra DA, Sundgren PC, Junck L, Meyer CR, Rehemtulla A, Lawrence T, Ross BD. Parametric Response Map As an Imaging Biomarker to Distinguish Progression From Pseudoprogression in High-Grade Glioma. J Clin Oncol. 2010 Apr 5. [Epub ahead of print]

Cell & Developmental Biology

McCullough AR, Hellstrom WG, Wang R, Lepor H, Wagner KR, Engel JD. Recovery of Erectile Function After Nerve Sparing Radical Prostatectomy and Penile Rehabilitation With Nightly Intraurethral Alprostadil Versus Sildenafil Citrate. J Urol. 2010 Apr 17. [Epub ahead of print]

Rao A, States DJ, Hero AO 3rd, Engel JD. Understanding distal transcriptional regulation from sequence, expression and interactome perspectives. J Bioinform Comput Biol. 2010 Apr;8(2):219-46.

Foster KG, Fingar DC. mTOR: Conducting the cellular signaling symphony. J Biol Chem. 2010 Mar 15. [Epub ahead of print]

Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC. mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J Biol Chem. 2010 Mar 12;285(11):7866-79.

Tsai B, Qian M. Cellular Entry of Polyoma viruses. Curr Top Microbiol Immunol. 2010 Apr 1. [Epub ahead of print]

Swanson CI, Evans NC, Barolo S. Structural rules and complex regulatory circuitry constrain expression of a Notch- and EGFR-regulated eye enhancer. Dev Cell. 2010 Mar 16;18(3):359-70.

Maillard I, Hess JL. The role of menin in hematopoiesis. Adv Exp Med Biol. 2009;668:51-7.

Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010 Apr 16;141(2):331-43.  

Guan JL. Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life. 2010 Apr;62(4):268-76.

Human Genetics

Askari F, Innis D, Dick RB, Hou G, Marrero J, Greenson J, Brewer GJ. Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial. Transl Res. 2010 Mar;155(3):123-30.

Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Guéranger Q, Glover TW, Canman CE. Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol. 2010 Mar;30(5):1217-30.

O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson P, Khanna H, Katsanis N, Hildebrandt F. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest. 2010 Mar 1;120(3):791-802.

Osorio N, Cathala L, Meisler MH, Crest M, Magistretti J, Delmas P. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells. J Physiol. 2010 Feb 15;588(Pt 4):651-70.

Rozek LS, Herron CM, Greenson JK, Moreno V, Capella G, Rennert G, Gruber SB. Smoking, Gender, and Ethnicity Predict Somatic BRAF Mutations in Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):838-43.

Vilar E, Gruber SB. Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010 Mar;7(3):153-62.

Zentner GE, Layman WS, Martin DM, Scacheri PC. Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome. Am J Med Genet A. 2010 Mar;152A(3):674-86.

Internal Medicine

Infectious Diseases:
Carter CC, Onafuwa-Nuga A, McNamara LA, Riddell J, Bixby D, Savona MR, Collins KL. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nature Med 16 (4): 446-U127, 2010.

Chick DA, Friedman HP, Young VB, Solomon D. Relationship Between COMLEX and USMLE Scores Among Osteopathic Medical Students who Take Both Examinations. Teach Learn Med  22 (1): 3-7, 2010.

Kontoyiannis DP, Marr KA, Park BJ, Alexander BD, Anaissie EJ, Walsh TJ, Ito J, Andes DR, Baddley JW, Brown JM, Brumble LM, Freifeld AG, Hadley S, Herwaldt LA, Kauffman CA, Knapp K, Lyon GM, Morrison VA, Papanicolaou G, Patterson TF, Perl TM, Schuster MG, Walker R, Wannemuehler KA, Wingard JR, Chiller TM, Pappas PG. Prospective Surveillance for Invasive Fungal Infections in Hematopoietic Stem Cell Transplant Recipients, 2001-2006: Overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database. Clin Infect Dis 50 (8): 1091-1100, 2010.

Pappas PG, Alexander BD, Andes DR, Hadley S, Kauffman CA, Freifeld A, Anaissie EJ, Brumble LM, Herwaldt L, Ito J, Kontoyiannis DP, Lyon GM, Marr KA, Morrison VA, Park BJ, Patterson TF, Perl TM, Oster RA, Schuster MG, Walker R, Walsh TJ, Wannemuehler KA, Chiller TM. Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis 50 (8): 1101-1111, 2010.

Shuman EK. Global Climate Change and Infectious Diseases. New Engl J Med 362 (12): 1061-1063, 2010.

Shuman EK, Washer LL, Arndt JL, Zalewski CA, Hyzy RC, Napolitano LM, Chenoweth CE. Analysis of Central Line-Associated Bloodstream Infections in the Intensive Care Unit after Implementation of Central Line Bundles. Infect Contr Hosp Epidemiol 31 (5): 551-553, 2010.

Southwick F, Katona P, Kauffman C, Monroe S, Pirofski LA, del Rio C, Gallis H, Dismukes W. Commentary: IDSA Guidelines for Improving the Teaching of Preclinical Medical Microbiology and Infectious Diseases. Academic Med 85 (1): 19-22, 2010.

Microbiology and Immunology

Castorena KM, Stapleford KA, Miller DJ. Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication. BMC Genomics. 2010 Mar 17;11:183. PubMed Central PMCID: PMC2847973.

Chukkapalli V, Oh SJ, Ono A. Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1600-5. PubMed Central PMCID: PMC2824378.

Dalebroux ZD, Yagi BF, Sahr T, Buchrieser C, Swanson MS. Distinct roles of ppGpp and DksA in Legionella pneumophila differentiation. Mol Microbiol. 2010 Feb 28. [Epub ahead of print].

Eaton KA. Health Informatics: What's in a Name? Prim Dent Care. 2010 Apr;17(2):51-2.

Edwards RL, Jules M, Sahr T, Buchrieser C, Swanson MS. The Legionella pneumophila LetA/LetS two-component system exhibits rheostat-like behavior. Infect Immun. 2010 Mar 29. [Epub ahead of print]

Felek S, Muszyński A, Carlson RW, Tsang TM, Hinnebusch BJ, Krukonis ES. Phosphoglucomutase of Yersinia pestis is required for autoaggregation and polymyxin B resistance. Infect Immun. 2010 Mar;78(3):1163-75. PubMed Central PMCID: PMC2825912.

Goldman DL, Huffnagle GB. Potential contribution of fungal infection and colonization to the development of allergy. Med Mycol. 2009;47(5):445-56. Review.

Hodges AP, Dai D, Xiang Z, Woolf P, Xi C, He Y. Bayesian network expansion identifies new ROS and biofilm regulators. PLoS One. 2010 Mar 3;5(3):e9513. PubMed Central PMCID: PMC2831072.

Kao JY, Zhang M, Miller MJ, Mills JC, Wang B, Liu M, Eaton KA, Zou W, Berndt BE, Cole TS, Takeuchi T, Owyang SY, Luther J. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology. 2010 Mar;138(3):1046-54. PubMed Central PMCID: PMC2831148.

Katpally U, Voss NR, Cavazza T, Taube S, Rubin JR, Young VL, Stuckey J, Ward VK, Virgin HW 4th, Wobus CE, Smith TJ. High-resolution cryo-electron microscopy structures of MNV-1 and RHDV reveals marked flexibility in the receptor binding domains. J Virol. 2010 Mar 24. [Epub ahead of print]

McNamara LA, He Y, Yang Z. Using epitope predictions to evaluate efficacy and population coverage of the Mtb72f vaccine for tuberculosis. BMC Immunol. 2010 Mar 30;11(1):18.

Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW, Toews GB, Huffnagle GB, Olszewski MA. CD11c+ cells are required to prevent progression from local acute lung injury to multiple organ failure and death. Am J Pathol. 2010 Jan;176(1):218-26. PubMed Central PMCID: PMC2797884.

Ono A. Relationships between plasma membrane microdomains and HIV-1 assembly. Biol Cell. 2010 Mar 25;102(6):335-50.

Shetron-Rama LM, Herring-Palmer AC, Huffnagle GB, Hanna P. Transport of Bacillus anthracis from the lungs to the draining lymph nodes is a rapid process facilitated by CD11c+ cells. Microb Pathog. 2010 Feb 25.

Sivick KE, Schaller MA, Smith SN, Mobley HL. The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection. J Immunol. 2010 Feb 15;184(4):2065-75. PubMed Central PMCID: PMC2821792.

Sivick KE, Mobley HL. Waging war against uropathogenic Escherichia coli: Winning back the urinary tract. Infect Immun. 2010 Feb;78(2):568-85. PubMed Central PMCID: PMC2812207.

Sofi MH, Liu Z, Zhu L, Yu Q, Kaplan MH, Chang CH. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol Immunol. 2010 Mar;47(6):1262-8.  PubMed Central PMCID: PMC2830291.

Swanson JA, Schmitz D, Chung KC. How to Practice Evidence-Based Medicine. Plast Reconstr Surg. 2010 Mar 9.

Taube S, Rubin JR, Katpally U, Smith TJ, Kendall A, Stuckey JA, Wobus CE. High Resolution X-Ray Structure and Functional Analysis of the Murine Norovirus (MNV)-1 Capsid Protein Protruding (P) Domain. J Virol. 2010 Mar 24.

Torisawa YS, Mosadegh B, Luker GD, Morell M, O'Shea KS, Takayama S. Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids. Integr Biol (Camb). 2009 Dec;1(11-12):649-54. PubMed Central PMCID: PMC2825702.

Xu L, Shen X, Bryan A, Banga S, Swanson MS, Luo ZQ. Inhibition of host vacuolar H+-ATPase activity by a Legionella pneumophila effector. PLoS Pathog. 2010 Mar 19;6(3):e1000822.  PubMed Central PMCID:PMC2841630.

Waghray M, Zavros Y, Saqui-Salces M, El-Zaatari M, Alamelumangapuram CB, Todisco A, Eaton KA, Merchant JL. Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology. 2010 Feb;138(2):562-72, 572.e1-2.


Todd PK, Paulson HL. RNA-mediated neurodegeneration in repeat expansion disorders. Ann Neurol. 2010 Mar;67(3):291-300.

Telfer WR, Busta AS, Bonnemann CG, Feldman EL, Dowling JJ. Zebrafish models of collagen VI-related myopathies. Hum Mol Genet. 2010 Apr 9. [Epub ahead of print]

Irani DN, Prow NA.  Acute viral encephalitis: Role of the immune system in viral clearance from the CNS and in the generation of pathology.  In: Inflammatory Diseases of the Central Nervous System, T Kilpatrick, R Ransohoff, S Wesselingh, Eds.  2010, Cambridge: Cambridge University Press, pp. 125-136.

Albin RL, Koeppe RA, Burke JF, Giordani B, Kilbourn MR, Gilman S, Frey KA. Comparing fludeoxyglucose F18-PET assessment of regional cerebral glucose metabolism and [11C]dihydrotetrabenazine-PET in evaluation of early dementia and mild cognitive impairment. Arch Neurol 2010;67(4):440-446.


He J, Liu Y, Xie X, Zhu T, Soules M, Dimeco F, Vescovi AL, Fan X, Lubman DM. Identification of Cell Surface Glycoprotein Markers for Glioblastoma-Derived Stem-Like Cells Using a Lectin Microarray and LC-MS/MS Approach. J Proteome Res.  2010 Apr 6. [Epub ahead of print]

Orringer DA, Chen T, Huang DL, Armstead WM, Hoff BA, Koo YE, Keep RF, Philbert MA, Kopelman R, Sagher O. The brain tumor window model: a combined cranial window and implanted glioma model for evaluating intraoperative contrast agents. Neurosurgery. 2010 Apr;66(4):736-43.

Wang L, Park P, Zhang H, La Marca F, Lin CY. Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. Int J Cancer. 2010 Mar 22. [Epub ahead of print]

Obstetrics & Gynecology

Ansbacher R: Letter to the Editor. Rectal Exam: A Necessary Part of the Physical Exam.    Michigan Medicine 2010, 109, Number 2: 3, March/April, 2010

Domino SE, Reynolds RK: Implementation and Evaluation of an Academic Career Development Curriculum for Obstetrics and Gynecology Fellows.  2010 J Grad Med Ed 2(1):133-135. 

Ephgrave K, Margo KL, White C, Hammoud M, Brodkey A, Painter T, Juel VC, Shaw D, Ferguson K. Acad Med 2010, 85(4):710-5.

Lebovic DI, Mwenda JM, Chai DC, Santi A, Xu X, D’Hooghe T. Peroxisome proliferator-activated receptor-(gamma) receptor ligand partially prevents the development of endometrial explants in baboons: a prospective, randomized, placebo-controlled study. Endocrinology 2010;151(4):1846-1852.

Shah DK, Menon KMJ, Cabrera LM, Vahratian A, Kavoussi SK, Lebovic DI.  Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro. Fertility and Sterility 2010; 93:2042-2047.

Wang L, Gulappa, T, Menon KM. Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries. Biochim Biophys Acta.  2010 May; 1803(5): 596-597. Epub 2010 Feb 16

Ophthalmology & Visual Sciences

Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Corton M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A 107 (16):7401-6.

Elfline M, Clark A, Petty HR, Romero R. Bi-Directional Calcium Signaling Between Adjacent Leukocytes and Trophoblast-Like Cells. Am J Reprod Immunol [Epub ahead of print].

Naik VM, Naik MN, Goldberg RA, Smith TJ, Douglas RS. Immunopathogenesis of thyroid eye disease: emerging paradigms. Surv Ophthalmol 55 (3):215-26.

Sitrin RG, Sassanella TM, Petty HR. An Obligate Role for Membrane-associated Neutral Sphingomyelinase Activity in Orienting Chemotactic Migration of Human Neutrophils. Am J Respir Cell Mol Biol [Epub ahead of print].

Smith TJ. Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases? Pharmacol Rev [Epub ahead of print].

Zhu A, Romero R, Petty HR. Amplex UltraRed enhances the sensitivity of fluorimetric pyruvate detection. Anal Biochem [Epub ahead of print].

Orthopaedic Surgery

Bovid KM, Salata MJ, Vander Have KL, Sekiya JK. Arthroscopic posterior cruciate ligament reconstruction in a skeletally immature patient: A new technique with case report. Arthroscopy 2010 26:563-570.

Pediatrics & Communicable Diseases

Attar MA, Lieberman K, Hieber S, Donn SM. Do Beractant Dosing Intervals Make a Difference? Journal of Neonatal and Perinatal Medicine. 2010,3:21-25

Cornell TT, Rodenhouse P, Cai Q, Sun L, Shanley TP. Mitogen Activated Protein Kinase Phosphatase 2, MKP-2, Regulates the Inflammatory Response in Sepsis.  Infect Immun. 2010 Mar 29 [Epub ahead of print]

Davis MM. Medicaid, Underinsurance, and the Dawn of an era for Children’s Coverage.  Pediatrics. 2010 Apr;125(4):817-9

Goldstein BH, Connor CE, Gooding L, Rocchini AP. Relation of Systemic Venous Return, Pulmonary Vascular Resistance, and Diastolic Dysfunction to Exercise Capacity in Patients With Single Ventricle Receiving Fontan Palliation. Am J Cardiol. 2010 Apr 15;105(8):1169-75.

Hildebrandt F. Genetic Kidney Diseases. Lancet. 2010 Apr 10;375(9722):1287-95.

LiPuma JJ. The Changing Microbiol Epidemiology in Cystic Fibrosis. Clin Microbiol Rev. 2010 Apr;23(2):299-323.

Markel H. Grasping at Straws:  Eugene O’Neill, Tuberculosis and Transformation. JAMA. 2010 Apr 7;303(13):1316-7

Niedner M. B-Type Natriuretic Peptide:  Perioperative Patterns in Congenital Heart Disease. Congenital Heart Disease 2010 May/June;5(3) [Epub ahead of print]

Paczesny S, Braun TM, Levine JE, Hogan J, Crawford J, Coffing B, Olsen S, Choi SW, Wang H, Faca V, Pitteri S, Zhang Q, Chin A, Kitko C, Mineishi S, Yanik G, Peres E, Hanauer D, Wang Y, Reddy P, Hanash S, Ferrara JL. Elafin is a Biomarker of Graft-Versus-Host Disease of the Skin. Sci Transl Med. 2010 Jan 6;2(13):13ra2

Patton SR, Williams LB, Eder SJ, Crawford MJ, Dolan L, Powers SW. Use of Continuous Glucose Monitoring in Young Children With Type 1 Diabetes: Implications for Behavioral Research. Pediatr Diabetes. 2010 Mar 10 [Epub ahead of print]

Rocchini AP, Yang JQ, Smith MJ, Supiano MA. Serial Changes in Norepinephrine Kinetics Associated With Feeding Dogs a High-Fat Diet. J Clin Hypertens (Greenwich). 2010 Feb 1; 12(2):117-24.

Rosen DS. Living With Eating Disorders. Eat Disord. 2010 Mar;18(2):178-9

Sarkar S, Barks JD. Systemic Complications and Hypothermia. Semin Fetal Neonatal Med. 2010 Mar 11[Epub ahead of print]

Schneider D, Ganesan S, Comstock AT, Meldrum CA, Mahidhara R, Goldsmith AM, Curtis JL, Martinez FJ, Hershenson MB, Sajjan U. Increased Cytokine Response of Rhinovirus-Infected Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease.  Am J Respir Crit Care Med. 2010 Apr 15. [Epub ahead of print]


Allen KS and JR Bostwick.  Role of Hyperparathyroidism in the Management of Depression and Anxiety.  J Am Psychiatr Nurses Assoc 2010; 16; 101.

Brower KJ, Perron BE.  Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances. Med Hypotheses. 2010;74:928-33.

Cunningham RM, Resko SM, Harrison SR, Zimmerman M, Stanley R, Chermack ST, Walton MA.  Screening adolescents in the emergency department for weapon carriage. Acad Emerg Med. 2010 Feb;17(2):168-76.

Goodrich DE, Lai Z, Lasky E, Burghardt AR, Kilbourne AM.  Access to weight loss counseling services among patients with bipolar disorder. J Affect Disord. 2010 Apr 7. [Epub ahead of print]

Hunt J, Eisenberg D, Kilbourne AM.  Consequences of receipt of a psychiatric diagnosis for completion of college. Psychiatr Serv. 2010 Apr;61(4):399-404.

Nesse RM.  Social selection and the origins of culture.  In Schaller M, Heine SJ, Norenzayan A, Yamagishi T, & Kameda T, editors. Evolution, culture, and the human mind. Philadelphia, PA: Lawrence Erlbaum Associates, 2010. p 137-150.

Prossin AR, McInnis MG, Anand A, Heitzeg MM, Zubieta JK.  Tackling the Kraepelinian Dichotomy: A Neuroimaging Review.  Psychiatr Ann. 2010 Mar 1;40(3):162-167.

Serras A, Saules KK, Cranford JA, Eisenberg D.  Self-injury, substance use, and associated risk factors in a multi-campus probability sample of college students.  Psychol Addict Behav. 2010 Mar;24(1):119-28. PubMed PMID: 20307119.

Wojnar J, Brower KJ, Dopp R, Wojnar M, Emslie G, Rintelmann J, et al.  Sleep and body mass index in depressed children and healthy controls. Sleep Med. 2010;11:295-301.

Hussong AM, Huang W, Curran PJ, Chassin L and Zucker RA.  Parent alcoholism impacts the severity and timing of children’s externalizing symptoms.  J Abnorm Child Psychol. 2010 Apr; 38(3):367-80. PubMed PMID: 20084453.

Wong MM, Brower KJ, Nigg JT and Zucker RA.  Childhood sleep problems, response inhibition, and alcohol and drug outcomes in adolescence and young adulthood. (Highlighted article for issue). Alcohol Clin Exp Res. 2010 Apr 5.PubMed PMID: 20374209

Zucker RA.  Addiction research centres and the nurturing of creativity: University of Michigan Addiction Research Center (UMARC)-development, evolution, and direction. Addiction. 2010 Mar 10.  PubMed PMID: 20331547

Radiation Oncology

Ahsan A, Hiniker SM, Ramanand SG, Nyati S, Hegde A, Helman A, Menawat R, Bhojani MS, Lawrence TS, Nyati MK. Role of epidermal growth factor receptor degradation in cisplatin-induced cytotoxicity in head and neck cancer. Cancer Res. 2010 Apr 1;70(7):2862-9. Epub 2010 Mar 9.

Alderman AK, Jagsi R. Discussion: immediate post-mastectomy breast reconstruction followed by radiotherapy: risk factors for complications. Breast Cancer Res Treat. 2010 Apr 8. [Epub ahead of print]

Amro H, Wilderman SJ, Dewaraja YK, Roberson PL. Methodology to incorporate biologically effective dose and equivalent uniform dose in patient-specific 3-dimensional dosimetry for non-Hodgkin lymphoma patients targeted with 131I-tositumomab therapy. J Nucl Med. 2010 Apr;51(4):654-9. Epub 2010 Mar 17.

Bentzen SM, Constine LS, Deasy JO, Eisbruch A, Jackson A, Marks LB, Ten Haken RK, Yorke ED. Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S3-9.

Bhandare N, Jackson A, Eisbruch A, Pan CC, Flickinger JC, Antonelli P, Mendenhall WM. Radiation therapy and hearing loss. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S50-7. Review.

Cai XW, Xu LY, Wang L, Hayman JA, Chang AC, Pickens A, Cease KB, Orringer MB, Kong FM. Comparative survival in patients with postresection recurrent versus newly diagnosed non-small-cell lung cancer treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):1100-5. Epub 2009 Jun 18.

Cao Y, Li D, Shen Z, Normolle D. Sensitivity of quantitative metrics derived from DCE MRI and a pharmacokinetic model to image quality and acquisition parameters. Acad Radiol. 2010 Apr;17(4):468-78.

Cimprich B, Reuter-Lorenz P, Nelson J, Clark PM, Therrien B, Normolle D, Berman MG, Hayes DF, Noll DC, Peltier S, Welsh RC. Prechemotherapy alterations in brain function in women with breast cancer. J Clin Exp Neuropsychol. 2010 Mar;32(3):324-31. Epub 2009 Jul 29.

Darby SC, Cutter DJ, Boerma M, Constine LS, Fajardo LF, Kodama K, Mabuchi K, Marks LB, Mettler FA, Pierce LJ, Trott KR, Yeh ET, Shore RE. Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):656-65. Review.

Dawson LA, Kavanagh BD, Paulino AC, Das SK, Miften M, Li XA, Pan C, Ten Haken RK, Schultheiss TE. Radiation-associated kidney injury. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S108-15. Review.

Deasy JO, Moiseenko V, Marks L, Chao KS, Nam J, Eisbruch A. Radiotherapy dose-volume effects on salivary gland function. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S58-63. Review.

Deasy JO, Bentzen SM, Jackson A, Ten Haken RK, Yorke ED, Constine LS, Sharma A, Marks LB. Improving normal tissue complication probability models: the need to adopt a "data-pooling" culture. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S151-4.

Eisbruch A, Harris J, Garden AS, Chao CK, Straube W, Harari PM, Sanguineti G, Jones CU, Bosch WR, Ang KK. Multi-institutional trial of accelerated hypofractionated intensity-modulated radiation therapy for early-stage oropharyngeal cancer (RTOG 00-22). Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1333-8. Epub 2009 Jun 18.

Galbán CJ, Bhojani MS, Lee KC, Meyer CR, Van Dort ME, Kuszpit KK, Koeppe RA, Ranga R, Moffat BA, Johnson TD, Chenevert TL, Rehemtulla A, Ross BD. Evaluation of treatment-associated inflammatory response on diffusion-weighted magnetic resonance imaging and 2-[18F]-fluoro-2-deoxy-D-glucose-positron emission tomography imaging biomarkers. Clin Cancer Res. 2010 Mar 1;16(5):1542-52. Epub 2010 Feb 16.

Hamstra DA, Eisbruch A, Naidu MU, Ramana GV, Sunkara P, Campbell KC, Ross BD, Rehemtulla A. Pharmacokinetic Analysis and Phase 1 Study of MRX-1024 in Patients Treated with Radiation Therapy with or without Cisplatinum for Head and Neck Cancer. Clin Cancer Res. 2010 Apr 13. [Epub ahead of p rint]

Hartojo W, Silvers AL, Thomas DG, Seder CW, Lin L, Rao H, Wang Z, Greenson JK, Giordano TJ, Orringer MB, Rehemtulla A, Bhojani MS, Beer DG, Chang AC. Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma. Transl Oncol. 2010 Apr;3(2):99-108.

Houweling AC, Philippens ME, Dijkema T, Roesink JM, Terhaard CH, Schilstra C, Ten Haken RK, Eisbruch A, Raaijmakers CP. A comparison of dose-response models for the parotid gland in a large group of head-and-neck cancer patients. Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):1259-65. Epub 2009 Dec 16.

Jackson A, Marks LB, Bentzen SM, Eisbruch A, Yorke ED, Ten Haken RK, Constine LS, Deasy JO. The lessons of QUANTEC: recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S155-60.

Jagsi R, Abrahamse P, Morrow M, Hawley ST, Griggs JJ, Graff JJ, Hamilton AS,  Katz SJ. Patterns and Correlates of Adjuvant Radiotherapy Receipt After Lumpectomy and After Mastectomy for Breast Cancer. J Clin Oncol. 2010 Mar 29. [Epub ahead of print]

Jeraj R, Cao Y, Ten Haken RK, Hahn C, Marks L. Imaging for assessment of radiation-induced normal tissue effects. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S140-4. Review.

Ji Q, Karnak D, Hao P, Wang R, Xu L. No small matter: microRNAs - key regulators of cancer stem cells. Int J Clin Exp Med. 2010 Mar 12;3(1):84-7.

Jin JY, Kong FM, Chetty IJ, Ajlouni M, Ryu S, Ten Haken R, Movsas B. Impact of fraction size on lung radiation toxicity: hypofractionation may be beneficial  in dose escalation of radiotherapy for lung cancers. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):782-8. Epub 2009 Jul 4.

Kausar T, Ahsan A, Hasan MR, Lin L, Beer DG, Ralhan R. Sperm protein 17 is a  novel marker for predicting cisplatin response in esophageal squamous cancer cell lines. Int J Cancer. 2010 Mar 15;126(6):1494-503.

Kavanagh BD, Pan CC, Dawson LA, Das SK, Li XA, Ten Haken RK, Miften M. Radiation dose-volume effects in the stomach and small bowel. Int J Radiat Oncol  Biol Phys. 2010 Mar 1;76(3 Suppl):S101-7. Review.

Khanna D, Hamilton CA, Bhojani MS, Lee KC, Dlugosz A, Ross BD, Rehemtulla A.  A Transgenic Mouse for Imaging Caspase-Dependent Apoptosis within the Skin. J Invest Dermatol. 2010 Apr 1. [Epub ahead of print]

King AN, Beer DG, Christensen PJ, Simpson RU, Ramnath N. The vitamin D/CYP24A1 story in cancer. Anticancer Agents Med Chem. 2010 Mar;10(3):213-24.

King JC, Lawrence TS, Murphy SB, Davidson NE, Mayer RJ. The American Society  of Clinical Oncology Cancer Foundation Grants Program: a 25-year report and a look toward the future. J Clin Oncol. 2010 Mar 20;28(9):1616-21. Epub 2010 Feb 22.

Kwee TC, Galbán CJ, Tsien C, Junck L, Sundgren PC, Ivancevic MK, Johnson TD,  Meyer CR, Rehemtulla A, Ross BD, Chenevert TL. Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas. J Magn Reson Imaging. 2010 Mar;31(3):531-7.

Marks LB, Yorke ED, Jackson A, Ten Haken RK, Constine LS, Eisbruch A, Bentzen SM, Nam J, Deasy JO. Use of normal tissue complication probability models in the  clinic. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S10-9.

Marks LB, Ten Haken RK, Martel MK. Guest editor's introduction to QUANTEC: a  users guide. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S1-2.

Pan CC, Kavanagh BD, Dawson LA, Li XA, Das SK, Miften M, Ten Haken RK. Radiation-associated liver injury. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3  Suppl):S94-100. Review.

Pierce LJ, Phillips KA, Griffith KA, Buys S, Gaffney DK, Moran MS, Haffty BG, Ben-David M, Kaufman B, Garber JE, Merajver SD, Balmaña J, Meirovitz A, Domchek SM. Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: comparison of breast conservation and mastectomy. Breast Cancer Res Treat. 2010 Apr 22. [Epub ahead of print]

R ancati T, Schwarz M, Allen AM, Feng F, Popovtzer A, Mittal B, Eisbruch A. Radiation dose-volume effects in the larynx and pharynx. Int J Radiat Oncol Biol  Phys. 2010 Mar 1;76(3 Suppl):S64-9. Review.

Rasch CR, Steenbakkers RJ, Fitton I, Duppen JC, Nowak PJ, Pameijer FA, Eisbruch A, Kaanders JH, Paulsen F, van Herk M. Decreased 3D observer variation with matched CT-MRI, for target delineation in Nasopharynx cancer. Radiat Oncol.  2010 Mar 15;5:21.

Tsien C, Galbán CJ, Chenevert TL, Johnson TD, Hamstra DA, Sundgren PC, Junck  L, Meyer CR, Rehemtulla A, Lawrence T, Ross BD. Parametric Response Map As an Imaging Biomarker to Distinguish Progression From Pseudoprogression in High-Grade Glioma. J Clin Oncol. 2010 Apr 5. [Epub ahead of print]

Yao H, Veine DM, Fay KS, Staszewski ED, Zeng ZZ, Livant DL. The PHSCN dendrimer as a more potent inhibitor of human breast cancer cell invasion, extravasation, and lung colony formation. Breast Cancer Res Treat. 2010 Mar 19. [Epub ahead of print]

Yao H, Veine DM, Zeng ZZ, Fay KS, Staszewski ED, Livant DL. Increased potency of the PHSCN dendrimer as an inhibitor of human prostate cancer cell invasion, extravasation, and lung colony formation. Clin Exp Metastasis. 2010 Mar;27(3):173-84. Epub 2010 Mar 26.