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APRIL 2010, Vol. 28


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HEADLINES

Joel Swanson to Receive the Distinguished Faculty Lectureship Award in Biomedical Research

The Biomedical Research Council (BMRC) has the honor of selecting a faculty member for the Distinguished Faculty Lectureship Award in Biomedical Research each year. This award, which was initiated in 1979, continues to be the highest research honor bestowed by the Medical School upon a faculty member in the biomedical sciences. Each recipient has made outstanding contributions in the areas of research, teaching and institutional service.

The Dean’s 2010 Distinguished Faculty Lectureship in Biomedical Research has been awarded to Joel Swanson, Ph.D., Professor in the Department of Microbiology and Immunology. Dr. Swanson joined the faculty at the University of Michigan Medical School in 1996. His recent research focuses on the changes in the physiology of specific immune cells called macrophages following infection by bacterial cells or phagocytosis of foreign particles. His work is of critical importance because the physiological and chemical changes in macrophages are crucial in determining the outcome of an infection. He and his colleagues have developed a number of tools and methods to analyze physiological changes within single infected macrophages and in real time, allowing an understanding of the host response at an extraordinary fine level of detail. The work in Dr. Swanson’s lab has resulted in over 100 articles. Related to his research, Dr. Swanson has created and now directs the Center for Living-Cell Imaging. He is the director of the Biotechnology Intradepartmental Training Grant, has mentored numerous graduate students, and has taught both undergraduate and graduate level courses that require a thorough understanding of both biology and technology.

Dr. Swanson will receive this award and present a lecture later this year. The details for Dr. Swanson’s lecture, award presentation, and reception will be announced in a future issue of this newsletter.

New Record Set in NIH Funding: $366 Million

A message from Dean James Woolliscroft, M.D.

Dear Colleagues:

I am extremely proud to announce that U-M Medical School researchers have set a new record in NIH funding: $366 million.

These record-setting results reflect the extraordinary efforts of our physicians and scientists and cement our position among the top 10 medical schools in the nation in terms of NIH grants awarded.

Additional information is available in this press release.

Congratulations to all our faculty, staff, trainees and students whose creativity, expertise, and hard work are reflected in these results.

 

James Woolliscroft, M.D.

Dean
Lyle C. Roll Professor of Medicine

Workshop – “Considering All the Costs: Budgeting Proposals for Medical School Faculty”

Tuesday, May 4, 2010
1:00 - 2:30 PM
BSRB Auditorium

Even with a banner year of federal funding in FFY2009, Medical School PIs struggle to complete aggressive and innovative research programs within the funding received from external sponsors. A contributing factor may be understated budgets submitted at time of proposal. The purpose of this workshop is to review the conceptualization of the full costs required to perform research work plans, consider the sources of funds to complete the work, and discuss how peer reviewers perceive budget requests. Concepts presented and discussed will apply to all types of externally sponsored activities and sponsors. As part of the workshop, we will discuss NIH specifically as UMMS PIs receive less support on an average R01 than peers at other institutions – potentially affecting the PI’s ability to fund programs and the department’s long-term ability to provide sufficient support.

This workshop, offered by the Office of Research, is hosted by Heather Offhaus, Director of the Grant Review & Analysis Office. She will be joined by experienced peer reviewers from the Medical School faculty:

  • Steven Kunkel, Ph.D., Senior Associate Dean for Research, Endowed Professor in Pathology Research
  • David Pinsky, M.D., Professor of Molecular and Integrative Physiology and Director, Cardiovascular Center

There will be ample time for Q & A. This workshop is open to all, and we encourage faculty to attend along with their grant administrator. Please register at this website.

This presentation will also be videotaped and posted on the UMMS Office of Research website. Contact Kathryn Ridner (kridner@umich.edu or 734-763-4086) with any questions.


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Animal Research

World Week For Animals in Laboratories (April 17-24, 2010)

Each year, several animal activist groups observe World Week for Animals in Laboratories (WWAIL) or World Laboratory Animal Liberation Week (WLALW) to protest the use of animals in biomedical research. This year, these protests are scheduled to take place the week of April 17-24, 2010. A number of scheduled activities throughout the month of April are listed on the WWAIL (http://www.wwail.org) and WLALW websites (http://www.all-creatures.org/wlalw). The University of Michigan is not, at this time, a site scheduled for protests. Because of the potential for increased activity by animal activists, we should all be especially alert to maintaining additional security in the animal facilities during the month of April. Some animal activists are prepared to disrupt animal research operations, even if this means violating the law, risking arrest, and going to jail.

The Department of Public Safety recommends that the research community take the following precautions:

  • Keep laboratories and offices locked.
  • Monitor laboratories and offices for unauthorized persons.
  • Wear identification badges at all times.
  • Report suspicious persons, activity, or objects to DPS immediately (Call 911 or 734-763-1131 for emergency).
  • Report inquiries regarding building hours, locations of laboratories and offices, type of research being conducted, and location of animals to DPS (734-763-3434).

Please direct any inquiries regarding animal use or care to Margarita Bauza, University of Michigan Health System Public Relations and Marketing Communications, at 734-764-2220. Security concerns regarding the animals or animal facilities should be addressed to the Department of Public Safety and Security at 734-763-3434.

The University of Michigan maintains an exemplary animal care and use program of which all of us can be proud. Our animal care and use program maintains full compliance with federal and state regulations and policies, as well as nationally accepted professional standards. Because we are indebted to animals for their valuable contributions to our research and instructional endeavors, and because animal well-being is critical to good science, the University ensures that animals are used in a responsible, respectful, and humane manner.


OSEH UPDATE


Shipping Hazardous Materials – Heightened Awareness of FAA Regulations

In the past six months, there have been two incidents at U of M where principal investigators have shipped materials inappropriately and pulled the attention of the inspectors from the U.S. Department of Transportation, Federal Aviation Administration (FAA). In one case, a package was caught on inspection at the Detroit Metro Airport leaking water – from ice that was used inappropriately as a refrigerant. The researcher was untrained and unaware of the proper methods of purchasing and using refrigerative overpacks to protect their specimens in transit. In another case, a shipment of hazardous materials that was properly prepared for shipment was caught on random inspection and the investigation revealed that the shipper (U-M research employee) had not been properly trained as required by the regulations. In both cases, what could have been a citation and fine structure that starts in the $10,000 range was reduced to a warning, as U-M has very good awareness level outreach and certification training provided to the research community upon request.

In most cases, when these requirements are not followed, the package will not be accepted by the carrier picking them up; as they’ve been well-trained to carefully inspect packages and spot when things don’t seem quite right. Since the FAA inspectors may not be so kind the next time they visit our campus, please be aware that any research employee who intends to ship a hazardous material – including biological specimens – must be trained on the appropriate methods of preparing packages, labeling, marking, and manifesting. Online guidance can be reviewed at this website. Training on DOT shipping requirements can be provided by OSEH if you call 734-763-6973.


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains information on email alert groups, internal grant programs, upcoming limited submissions, and links to extramural funding search engines.


Internal Submissions

University of Michigan Center for Integrative Approaches to Health Disparities (CIAHD) Request for Pilot Grant Proposals
Deadline: May 7, 2010 (5:00 PM)

The Center for Integrative Approaches to Health Disparities is pleased to announce the third call for pilot proposals. The CIAHD will provide pilot funding for innovative research consistent with the general theme of the integration of social and biological factors in understanding minority health and health disparities. CIAHD will fund up to three competitive proposals for investigators interested in the area of minority health and health disparities. Applicants will be notified by June 11, 2010. For more information, please visit our website (http://www.sph.umich.edu/ciahd).

Michigan Institute for Clinical and Health Research (MICHR) CTSA K – Mentored Clinical Scientists Career Development Program
Deadline: May 24, 2010

The Michigan Institute for Clinical and Health Research has released an RFA for the CTSA K Mentored Clinical Scientists Career Development Program. Awards will be for two years. Awardees will receive 75 percent (50 percent for surgery subspecialties) protected time. Awarded salary will be cost-shared (37.5 percent MICHR and 37.5 percent base department); additional awards will include $25,000 for research costs and $5,000 for tuition expenses annually. Applications will follow the K23 application format. They will require a proposal that facilitates clinical research, plans for training and career development, a strong mentoring arrangement and a budget and justification. Eligible applicants must hold an M.D. or Ph.D. degree with a clinical focus; U-M junior faculty and mid-career health care professionals interested in initiating careers in clinical research, are encouraged to apply. For more information, email Monica Stiddom at (mhealy@umich.edu), call 734-998-7348 or visit (http://www.michr.umich.edu/KL2/).

James T. Neubacher Award
Deadline: May 31, 2010

The University of Michigan's Council for Disability Concerns established the James T. Neubacher Award in October 1990 as a memorial to Jim Neubacher, an alumnus of the University who was a columnist for The Detroit Free Press and an advocate for equal rights and opportunities for people with disabilities.

This award, sponsored by the Office of Institutional Equity, the U-M Council for Disability Concerns and the Office of the President, recognizes individuals who are making significant contributions to improve awareness, access, acceptance and full participation in society for persons with disabilities. The award includes a stipend provided by the Office of the President and is presented annually in October during Investing in Ability Week, a series of programs and activities designed to increase awareness and understanding of people who have disabilities and disability-related issues.

Faculty, staff, students, and alumni of the University may be nominated. An award nominee need not be a person with a disability. Visit (http://www.hr.umich.edu/ability/neubacher.htm) for complete details.


External Open Submissions

Damon Runyon-Rachleff Innovation Award
Deadline: June 1, 2010 (Pre-Proposal)

Advances in cancer research often originate from innovative thinking and ingenious approaches. Securing funding for these truly out-of-the box ideas remains a challenge, especially to early career scientists. With this in mind, we are proud to announce the fourth application cycle for our newest award program, the Damon Runyon-Rachleff Innovation Award, and encourage any eligible applicants from University of Michigan Medical School to apply.

The Damon Runyon-Rachleff Innovation Award provides support for the next generation of exceptionally creative thinkers with "high risk/high reward" ideas that have the potential to significantly impact our understanding of and/or approaches to the prevention, diagnosis and treatment of cancer. This award is specifically designed to provide funding for extraordinary early career researchers who have an innovative, new idea but lack sufficient preliminary data to obtain traditional funding. The research supported by the award must be novel, exceptionally creative and, if successful, have the strong potential for high impact in the cancer field.

Eligible applicants (including non-U.S. citizens) must be conducting independent research at a U.S. institution. Institutional nominations are not required and there is no limit to the number of applications that can be received from a particular institution. Basic and translational/clinical projects will be considered and individuals with a background in multiple disciplines are especially encouraged to apply. The awards will provide $450,000 in direct costs during a three year award term. A complete award program description and application guidelines are available on the website.

We encourage you to work with Ann Verhey-Henke, Director, Foundation Relations in preparing this proposal. Ann can provide you more information about the Foundation, the types of proposals they historically fund, and provide pointers and feedback on writing specifically for a Foundation audience. You may contact her by phone (734-647-0282) or email (averhey@umich.edu).


UMMS AWARDED GRANTS

External Awarded Grants

Currently, due to limitations on data collection, we are unable to identify projects awarded with multiple PIs. As the eRPM system is used for proposals, we will be able to publish those awards accurately. We apologize for any misleading project information this causes.

Click here to view.

Anesthesiology

PI: Lydic, Ralph
Title: Foundation for Anesthesia Education and Research (FAER) 2010 Host Department Application Student Anesthesia Research Fellowship (MSARF)
Sponsor: Foundation for Anesthesia Education and Research
Project Dates and Amount of Award: 06/07/10-08/02/10; $6,400

Center for Computational Medicine and Bioinformatics

PI: Degiorgio, Michael
Title: Burrough Wellcome Fund 2010 Travel Grant - Michael DeGiorgio
Sponsor: Burroughs Wellcome Fund
Project Dates and Amount of Award: 07/03/10-07/09/10; $3,000

PI: Szpiech, Zachary
Title: Burroughs Wellcome Fund 2010 Travel Grant - Zachary Szpiech
Sponsor: Burroughs Wellcome Fund
Project Dates and Amount of Award: 07/03/10-07/09/10; $3,000

PI: Zhang, Yang
Title: Atomic-Level, Large-Scale Structure Prediction of G Protein-Coupled Receptors
Sponsor: NIH 7 R01 GM 084222 02
Project Dates and Amount of Award: 11/01/09-02/28/13; $1,223,111

Comprehensive Cancer Center

PI: Wicha, Max
Co-I: Beer, David (Thoracic Surgery Section) / Buckanovich, Ronald (Int Med-Hematology/Oncology) / Chinnaiyan, Arul (Pathology Department) / Cho, Kathleen (Pathology Department) / Fearon, Eric (Int Med-Molecular Med&Genetics) / Kumar, Chandan (Ctr fr Translational Pathology) / Larsen, Martha (Life Sciences Institute-Admin) / Palanisamy, Nallasivam (Ctr fr Translational Pathology) / Qin, Zhaohui (Biostatistics Department) / Simeone, Diane (General Surgery Section)
Title: National Functional Genomics Center--A Center for Genetic Origins of Cancer (CGOC) at the University of Michigan
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 04/05/10-05/04/11; $2,101,000

Dermatology

PI: Dlugosz, Andrzej
Co-I: Grachtchouk, Marina (Dermatology Department) / Pasca Di Magliano, Marina (General Surgery Section) / Verhaegen, Monique (Dermatology Department)
Title: MOLECULAR BASIS OF EPITHELIAL SKIN CANCER
Sponsor: NIH 2 R01 CA 087837 10
Project Dates and Amount of Award: 03/11/10-02/28/15; $1,603,190

Human Genetics

PI: Glover, Thomas
Title: THE MOLECULAR BASIS OF NONRECURRENT COPY NUMBER VARIANTS
Sponsor: March of Dimes Birth Defect Foundation
Project Dates and Amount of Award: 03/01/10-05/31/12; $207,109

Internal Medicine

PI: Baker, Laurence
Title: SOUTHWEST ONCOLOGY GROUP
Sponsor: NIH 2 U10 CA 027057 31
Project Dates and Amount of Award: 02/22/10-12/31/15; $2,835,589

PI: Bernal-Mizrachi, Ernesto
Title: AKT/MTOR Signaling and Regulation of Cell Cycle in Beta Cells
Sponsor: NIH 3 R01 DK 073716 05 S1
Project Dates and Amount of Award: 02/19/10-04/30/10; $56,537

PI: Bernal-Mizrachi, Ernesto
Co-I: Cras-Meneur, Corentin (Metabolism, Endo & Diabetes)
Title: AKT/MTOR SIGNALING AND REGULATION OF CELL CYCLE IN BETA CELLS
Sponsor: NIH 7 R01 DK 073716 05
Project Dates and Amount of Award: 11/01/09-05/31/11; $482,621

PI: Chan, Kevin
Title: A MULTICENTER, MULTINATIONAL, RANDOMIZED, DOUBLE BLIND,PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF AEROSOLISED ALN-RSV01 PLUS STANDARD OF CARE IN LUNG TRANSPLANT PATIENTS INFECTED WITH RESPIRATORY SYNCYTIAL VIRUS (RSV)
Sponsor: Alnylam Pharmaceuticals TO Medpace, Inc
Project Dates and Amount of Award: 02/01/10-05/31/13; $116,325

PI: Eagle, Kim
Title: University of Michigan Health System Patient Education Clearinghouse
Sponsor: NIH - Subcontracts TO University of Illinois
Project Dates and Amount of Award: 01/01/10-06/30/10; $1,935

PI: Galecki, Andrzej
Title: NATURAL HISTORY OF MICROALBUMINURIA IN TYPE 1 DIABETES
Sponsor: NIH - Subcontracts TO Joslin Diabetes Center
Project Dates and Amount of Award: 09/01/09-03/31/10; $26,392

PI: Guan, Jun-Lin
Title: MOLECULAR ANALYSIS OF SIGNAL TRANSDUCTION IN CANCER DEVELOPMENT AND PROGRESSION
Sponsor: NIH 2 R01 GM 048050 18
Project Dates and Amount of Award: 03/01/10-12/31/14; $1,456,535

PI: Hodish, Israel
Title: A NOVEL TOOL TO UNDERSTAND INSULIN PRODUCTION AND FAILURE IN PANCREATIC BETA-CELLS
Sponsor: NIH 3 R00 DK 077441 03 S1
Project Dates and Amount of Award: 12/20/09-03/31/10; $99,945

PI: Hussain, Maha
Title: A Phase 2 Multicenter Open-Label Study Evaluating the Safety and Efficacy of TAK-700 in Patients with Nonmetastatic Castration-resistant Prostate Cancer (CRPC) and a Rising Prostate-specific Antigen (PSA)
Sponsor: Millennium Pharm, Inc.
Project Dates and Amount of Award: 04/01/10-03/31/15; $261,062

PI: Marrero, Jorge
Title: Brivanib vs sorafenib as first-line treatment in patients with advance HC 033 study
Sponsor: Bristol-Myers Squibb
Project Dates and Amount of Award: 02/05/10-02/07/13; $399,144

PI: Miller, Richard
Co-I: Alexander, Neil (Institute of Gerontology) / Ashton-Miller, James (Mechanical Engineering) / Burke, David (Human Genetics Department) / Cartee, Gregory (Molec & Integrative Physiology) / Faulkner, John (Molec & Integrative Physiology) / Gafni, Ari (Biological Chemistry Dept) / Gestwicki, Jason (LSA Chemistry) / Gestwicki, Jason (Pathology Department) / Goldstein, Steven (Orthopaedic Surgery) / Herzog, Susan (Molec & Integrative Physiology) / Hsu, Ao-Lin (Int Med-Geriatric Medicine) / Jakob, Ursula (LSA Molec./Cell./Develop. Bio) / Keller, Evan (Urology Surgery) / Larkin, Lisa (Molec & Integrative Physiology) / Morrison, Sean (Cell and Developmental Biology) / Paulson, Henry (Neurology Department) / Pletcher, Scott (Molec & Integrative Physiology) / Richardson, Bruce (Int Med-Rheumatology) / Schacht, Jochen (Otorhinolaryngology Department) / Seidler, Rachael (School of Kinesiology) / Yung, Raymond (Int Med-Geriatric Medicine)
Title: RESEARCH TRAINING IN BIOGERONTOLOGY
Sponsor: NIH 2 T32 AG 000114 26
Project Dates and Amount of Award: 05/01/10-04/30/15; $1,990,175

PI: Norman, Silas
Title: STX-002 PHASE II STROMEDIX
Sponsor: CTI Clinical Trial and Consulting Services TO Stromedix
Project Dates and Amount of Award: 02/17/10-07/31/10; $10,300

PI: Oral, Elif
Co-I: Gianchandani, Roma (Metabolism, Endo & Diabetes) / Tan, Meng (Metabolism, Endo & Diabetes)
Title: BEGIN TM: EASY PM (NN1250-3718)
Sponsor: NOVO Nordisk A/S
Project Dates and Amount of Award: 03/29/10-07/31/11; $141,340

PI: Padela, Aasim
Title: Where Religion, Policy, and Bioethics Meet: An Interdisciplinary Conference on Islamic Bioethics and End-of-Life Care.
Sponsor: Greenwall Foundation
Project Dates and Amount of Award: 03/01/11-06/30/11; $8,000

PI: Riddell IV, James
Title: NP303 ADVENT Crofelemer in HIV
Sponsor: Salix Pharmaceuticals, Inc
Project Dates and Amount of Award: 04/01/10-02/29/12; $106,218

PI: Schiopu, Elena
Co-I: Phillips, Kristine (Int Med-Rheumatology)
Title: A Phase 1, Randomized, Double-blind, Placebo-controlled Study of the Safety and Tolerability of MEDI-551 in Scleroderma
Sponsor: MedImmune, Inc.
Project Dates and Amount of Award: 03/22/10-01/31/12; $146,506

PI: Standiford, Theodore
Co-I: Baker Jr, James (Int Med-Allergy) / Duckett, Colin (Pathology Department) / Keshamouni, Venkateshwar (Int Med-Pulm./Critical Care) / Moore, Bethany (Int Med-Pulm./Critical Care) / Nunez, Gabriel (Pathology Department) / O'Riordan, Mary (Microbiology and Immunology)
Title: FLAGELLIN STIMULATES LUNG INNATE MUCOSAL IMMUNITY
Sponsor: NIH 1 R01 HL 097564 01 A1
Project Dates and Amount of Award: 04/01/10-02/28/14; $1,700,689

PI: Urba, Susan
Title: 2008.048: PALONOSETRON FOR THE TREATMENT OF NAUSEA AND VOMITING IN TERMINALLY ILL PATIENTS
Sponsor: Eisai Co., Ltd.
Project Dates and Amount of Award: 03/23/10-03/22/12; $92,719

PI: Wang, Thomas
Co-I: Kurabayashi, Katsuo (Mechanical Engineering) / Luker, Gary (Radiology Department)
Title: TARGETED MULTI-SPECTRAL DUAL AXES CONFOCAL IMAGING OF IN VIVO MOLECULAR EXPRESSION
Sponsor: NIH 1 R01 CA 142750 01
Project Dates and Amount of Award: 02/25/10-12/31/14; $2,661,016

PI: Weitzel III, William
Title: NOVEL DEVICE WITH HEMOSTATIC INJECTION SYSTEM TO CONTROL POST BIOPSY BLEEDING
Sponsor: NIH - Subcontracts TO MC3, Inc.
Project Dates and Amount of Award: 03/03/10-08/31/10; $18,185

PI: White, Eric
Co-I: Bruce, Allen (Dermatology Department)
Title: A PHASE 2, MULTICENTER, RANDOMIZED, DOUBLE BLIND, PARALLEL GROUP, PLACEBO-CONTROLLED STUDY EVALUATING THE SAFETY AND EFFICACY OF TREATMENT WITH USTEKINUMAB OR GOLIMUMAB IN SUBJECTS WITH CHRONIC SARCOIDOSIS
Sponsor: Johnson & Johnson TO Centocor, Inc.
Project Dates and Amount of Award: 11/10/09-11/21/11; $105,200

PI: Zimmermann, Ellen
Title: GI Fellows Educational Support
Sponsor: Abbott Laboratories
Project Dates and Amount of Award: 05/01/10-12/31/10; $4,830

PI: Zimmermann, Ellen
Title: GI Fellows Educational Support
Sponsor: Centocor Ortho Biotech Services, LLC
Project Dates and Amount of Award: 04/01/10-03/31/11; $4,500

PI: Zimmermann, Ellen
Title: INFORM: Investigating Natalizumab through Further Observational Research and Monitoring
Sponsor: Elan Pharmaceutical Research Corporation TO United BioSource Corporation
Project Dates and Amount of Award: 03/12/10-04/30/15; $77,066

PI: Zimmermann, Ellen
Title: GI Fellows Educational Support
Sponsor: Shire Pharmaceutical
Project Dates and Amount of Award: 05/01/10-12/31/10; $4,830

Microbiology and Immunology

PI: Martens, Eric
Title: Complex Glycan Utilization by Human Gut Bacteroides
Sponsor: NIH 7 K01 DK 084214 02
Project Dates and Amount of Award: 09/01/09-03/31/14; $598,664

Molecular & Behavioral Neuroscience Institute

PI: Goldman, Daniel
Title: Muller glia-dependent regeneration of retinal ganglion cells
Sponsor: American Health Assistance Fdn
Project Dates and Amount of Award: 04/01/10-03/31/12; $100,000

PI: Sutton, Michael
Title: LOCAL HOMEOSTATIC CONTROL OF SYNAPSE FUNCTION
Sponsor: NIH 1 R01 MH 085798 01 A1
Project Dates and Amount of Award: 04/01/10-01/31/15; $1,881,290

Neurology

PI: Barbas, Nancy
Title: ELN115727 Protocol 3133K1-3001
Sponsor: Wyeth Pharmaceuticals, Inc.
Project Dates and Amount of Award: 02/25/10-09/30/12; $380,592

PI: Chou, Kelvin
Co-I: Persad, Carol (Psychiatry Department)
Title: Validating the MoCA for MCI in PD
Sponsor: Fox, Michael J., Foundation for Parkinson's Research TO University of Toronto
Project Dates and Amount of Award: 03/08/10-08/31/12; $84,656

PI: Hao, Shuanglin
Co-I: Mata, Marina (Neurology Department)
Title: HIV AND NRTI'S-INDUCED PAINFUL PATHOGENIC MECHANISMS AND GENE THERAPY
Sponsor: NIH 1 R01 NS 066792 01 A1
Project Dates and Amount of Award: 04/01/10-03/31/15; $1,834,690

PI: Leventhal, Daniel
Title: Optogenetic Manipulation of Striatal Fast Spiking Interneurons In Vivo
Sponsor: Dystonia Medical Research Fdn
Project Dates and Amount of Award: 04/15/10-04/14/11; $48,121

PI: Segal, Benjamin
Title: MS Current Research Review
Sponsor: Teva Neuroscience
Project Dates and Amount of Award: 04/01/10-03/31/11; $13,300

Obstetrics & Gynecology

PI: Johnson, Timothy
Co-I: Smith, Yolanda (Obstetrics and Gynecology Dept)
Title: UNIVERSITY OF MICHIGAN WRHR CAREER DEVELOPMENT PROGRAM
Sponsor: NIH 1 K12 HD 065257 01
Project Dates and Amount of Award: 04/01/10-03/31/15; $2,375,575

Ophthalmology & Visual Sciences

PI: Kasprick, Daniel
Title: Development and Regeneration of Extraocular Muscles in Zebrafish
Sponsor: Sigma Xi Society
Project Dates and Amount of Award: 03/01/10-02/28/11; $2,500

PI: Wong, Kwoon
Title: CROSS-TALK BETWEEN GANGLION-CELL PHOTORECPTORS AND OTHER NEURONS IN THE RETINA
Sponsor: NIH 7 R00 EY 018863 03
Project Dates and Amount of Award: 04/01/10-03/31/13; $746,999

Otolaryngology

PI: Pfingst, Bryan
Co-I: Zwolan, Teresa (Otorhinolaryngology Department)
Title: ACROSS-SITE PATTERNS OF PERCEPTION WITH COCHLEAR IMPLANTS
Sponsor: NIH 1 R01 DC 010786 01
Project Dates and Amount of Award: 04/05/10-03/31/15; $1,641,565

PI: Raphael, Yehoash
Co-I: Altschuler, Richard (Otorhinolaryngology Department)
Title: FUNCTIONAL IMPLICATIONS OF REINNERVATION OF AUDITORY NERVE PERIPHERAL PROCESSES IN THE IMPLANTED COCHLEA
Sponsor: MED-EL Corporation
Project Dates and Amount of Award: 03/01/10-08/31/11; $150,000

PI: Sha, Suhua
Title: MOLECULAR MECHANISMS IN NOISE-INDUCED HEARING LOSS
Sponsor: NIH 1 R01 DC 009222 01 A2
Project Dates and Amount of Award: 04/01/10-03/31/15; $1,906,775

Pathology

PI: Elenitoba-Johnson, Kojo
Co-I: Basrur, Venkatesha (Pathology Department)
Title: RECHARGE: Protein ID by LTQ-ETD and Protein ID by LTQ-Orbitrap XL
Sponsor: NIH - Subcontracts TO Howard Hughes Medical Institute
Project Dates and Amount of Award: 01/05/10-01/04/11; $7,929

PI: Kruger, Heather
Title: UNDERSTANDING THE FUNCTION OF EZH2 AS A DETERMINANT OF BREAST CANCER INVASION AND METASTASIS
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 03/15/10-04/14/13; $129,600

PI: Palanisamy, Nallasivam
Co-I: Han, Bo (Ctr fr Translational Pathology) / Mehra, Rohit (Ctr fr Translational Pathology) / Subramaniam, Manish (Ctr fr Translational Pathology)
Title: MOLECULAR PROFILING OF ETS GENE REARRANGEMENT IN PROSTATE CANCER PATIENTS REGISTERED IN THE REDEEM AND REDUCE CLINICAL TRIAL
Sponsor: Glaxosmithkline
Project Dates and Amount of Award: 03/12/10-08/31/10; $191,205

PI: Palanisamy, Nallasivam
Title: VALIDATION STUDIES IN SUPPORT OF THE DEVELOPMENT OF MULTI-PROBE FISH ASSAYS IN PROSTATE CANCER PARTNERS
Sponsor: Ventana Medical Systems
Project Dates and Amount of Award: 01/01/10-03/31/10; $75,042

Pediatrics & Communicable Diseases

PI: Adams, Barbara
Title: CARRA Enhanced Drug Safety Surveillance Project in JRA/JIA
Sponsor: Pfizer Incorporated TO Seattle Children's Hospital
Project Dates and Amount of Award: 12/01/09-01/31/11; $3,800

PI: Cornell, Timothy
Title: MKP-2 AS AN ENDOGENOUS REGULATOR OF THE PRO-INFLAMMATORY RESPONSE IN SEPSIS
Sponsor: NIH 1 K08 HD 062142 01 A1
Project Dates and Amount of Award: 04/01/10-03/31/14; $505,332

PI: Gipson, Debbie
Title: PROMIS Pediatrics: Longitudinal Validation & Linking Pediatric & Adult Item Banks
Sponsor: NIH - Subcontracts TO University Of North Carolina Chapel Hill U01 AR 052181
Project Dates and Amount of Award: 09/30/09-07/31/10; $36,121

PI: Lawlor, Elizabeth
Title: Modeling Ewing Tumor Initiation in Human Neural Crest Stem Cells
Sponsor: Amer Assoc for Cancer Research
Project Dates and Amount of Award: 02/01/10-01/31/13; $750,000

PI: Lumeng, Carey
Title: ROLE OF MONOCYTE/MACROPHAGE LECTIN RECEPTORS IN OBESITY-INDUCED INFLAMMATION
Sponsor: NIH 1 R03 DK 087999 01
Project Dates and Amount of Award: 04/05/10-03/31/12; $151,460

PI: Pipe, Steven
Title: TRANSGENIC MICE STUDY
Sponsor: University of Nebraska
Project Dates and Amount of Award: 03/18/10-03/31/10; $32,758

PI: Thoene, Jess
Title: CHARACTERIZATION OF MATERIAL DERIVED FROM CTNS-TRANSFECTED SF9 CELLS THAT CAUSES CRISTINE DEPLETION IN CYSTINOTIC FIBROBLASTS AS A GLYCOSYLATED PROTEIN
Sponsor: Shire Human Genetic Therapies
Project Dates and Amount of Award: 03/01/10-03/31/11; $73,042

PI: Yanik, Gregory
Title: NANT YR10 AMENDMENT #11B
Sponsor: Children's Hospital of Los Angeles TO Genentech, Inc.
Project Dates and Amount of Award: 06/01/09-05/31/10; $35,100

Pharmacology

PI: Brim, Remy
Title: TOWARDS THE TREATMENT OF COCAINE ABUSE WITH A MUTANT BACTERIAL COCAINE ESTERASE
Sponsor: NIH 1 F31 01
Project Dates and Amount of Award: 03/05/10-03/04/12; $64,568

PI: Martens, Jeffrey
Co-I: Larsen, Scott (PHARMACY Medicinal Chemistry) / Westfall, Margaret (PHARMACY Medicinal Chemistry)
Title: TRAFFICKING AND REGULATION OF CARDIOVASCULAR K+CHANNELS
Sponsor: NIH 2 R01 HL 070973 06 A2
Project Dates and Amount of Award: 04/01/10-03/31/14; $1,557,017

PI: Merrins, Matthew
Title: METABOLIC OSCILATIONS IN PANCREATIC BETA-CELLS
Sponsor: NIH 1 F32 DK 085960 01 A1
Project Dates and Amount of Award: 03/01/10-02/28/13; $150,234

PI: Traynor, John
Title: DISCOVERY OF NEW TREATMENTS FOR DRUG ABUSE
Sponsor: NIH - Subcontracts TO University Of Bath
Project Dates and Amount of Award: 09/15/09-07/31/10; $180,835

Psychiatry

PI: Ewell Foster, Cynthia
Title: TRANSFORMING YOUTH SUICIDE PREVENTION IN MICHIGAN
Sponsor: SAMHSA - Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $35,473

Radiology

PI: Frey, Kirk
Co-I: Gilman, Sid (Neurology Department)
Title: A Principal Open-Label Study to Assess the Prognostic Usefulness of Flutemetamol (18F) Injection for Identifying Subjects with Amnestic Mild Cognitive Impairment who will Convert to Probable Alzheimer's Disease
Sponsor: General Electric Company
Project Dates and Amount of Award: 04/01/10-03/31/12; $373,438

PI: Williams, David
Title: CORAL: Cardiovascular Outcomes in Renal Artheroscierotic Lesions
Sponsor: NIH - Subcontracts TO University of Toledo
Project Dates and Amount of Award: 02/01/10-01/31/15; $31,869

Surgery

PI: Birkmeyer, Nancy
Co-I: Banerjee, Mousumi (Biostatistics Department) / Baser, Onur (Surgery Department) / Birkmeyer, John (General Surgery Section)
Title: OPTIMIZING PROPHYLAXIS AGAINST VENOUS THROMBOEMBOLISM IN BARIATRIC SURGERY
Sponsor: AHRQ 1 R01 HS 018050 01 A1
Project Dates and Amount of Award: 04/01/10-01/31/13; $676,146

PI: Birkmeyer, Nancy
Co-I: Banerjee, Mousumi (Biostatistics Department) / Baser, Onur (Surgery Department) / Birkmeyer, John (General Surgery Section)
Title: RETURN ON INVESTMENT FOR QUALITY IMPROVEMENT COLLABORATIVES IN SURGERY
Sponsor: AHRQ 1 R01 HS 018728 01
Project Dates and Amount of Award: 04/01/10-01/31/13; $879,535

PI: Haft, Jonathan
Co-I: Bartlett, Robert (General Surgery Section)
Title: Arterial Cannula with Permissive Distal Perfusion
Sponsor: NIH - Subcontracts TO MC3, Inc.
Project Dates and Amount of Award: 01/01/10-06/30/10; $20,000

PI: Haft, Jonathan
Title: A SIMPLE VENTRICULAR ASSIST DEVICE FOR SHORT TERM CARDIAC SUPPORT
Sponsor: NIH - Subcontracts TO MC3, Inc. HL 096168
Project Dates and Amount of Award: 03/01/10-02/28/11; $45,672

PI: Lubman, David
Co-I: Buckanovich, Ronald (Int Med-Hematology/Oncology) / Shedden, Kerby (LSA Statistics)
Title: MARKERS OF OVARIAN CANCER USING A GLYCOPROTEIN/ANTIBODY ARRAY
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 04/15/10-05/14/13; $579,375

PI: Raghavendran, Krishnan
Co-I: Hogaboam, Cory (Pathology Department) / Moore, Bethany (Pathology Department)
Title: MECHANISMS OF MCP-1 ACTIVITY IN LUNG CONTUSION WITH AND WITHOUT GASTRIC ASPIRATION
Sponsor: NIH 1 R01 HL 102013 01
Project Dates and Amount of Award: 04/01/10-02/28/14; $1,545,000

PI: Zou, Weiping
Title: HUMAN TREGS IN OVARIAN CANCER
Sponsor: NIH 2 R01 CA 099985 04
Project Dates and Amount of Award: 04/01/10-01/31/15; $1,118,395

Unit for Laboratory Animal Medicine

PI: Ellermeier, Jeremy
Title: REGULATION OF THE CTS TYPE II SECRETION SYSTEM AND ITS ROLE IN GENETIC VARIATION OF CAMPYLOBACTOR JEJUNI
Sponsor: US Agriculture, Department of
Project Dates and Amount of Award: 02/01/10-01/31/12; $125,000

Urology

PI: Keller, Evan
Title: RKIP REGULATION AS A POTENTIAL FOR TUMOR SUPPRESSION
Sponsor: NIH - Subcontracts TO University of Toledo
Project Dates and Amount of Award: 07/17/09-06/30/11; $100,757


UMMS RESEARCH PUBLICATIONS


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Biological Chemistry

Argetsinger LS, Stuckey JA, Robertson SA, Koleva RI, Cline JM, Marto JA, Myers MG Jr, Carter-Su C. Tyrosines 868, 966, and 972 in the Kinase Domain of JAK2 Are Autophosphorylated and Required for Maximal JAK2 Kinase Activity. Mol Endocrinol. 2010 Mar 19. [Epub ahead of print]

Brenner JC, Graham MP, Kumar B, Saunders LM, Kupfer R, Lyons RH, Bradford CR, Carey TE. Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010 Apr;32(4):417-26.

Crippen GM, Rousaki A, Revington M, Zhang Y, Zuiderweg ER. SAGA: rapid automatic mainchain NMR assignment for large proteins. J Biomol NMR. 2010 Apr;46(4):281-98. Epub 2010 Mar 16.

Evans CG, Chang L, Gestwicki JE. Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target. J Med Chem. 2010 Mar 24. [Epub ahead of print]

Hernick M, Gattis SG, Penner-Hahn JE, Fierke CA. Activation of Escherichia coli UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase by Fe2+ yields a more efficient enzyme with altered ligand affinity. Biochemistry. 2010 Mar 16;49(10):2246-55.

Li X, Dou Y. New perspectives for the regulation of acetyltransferase MOF. Epigenetics. 2010 Apr 31;5(3). [Epub ahead of print]

Menon T, Yates JA, Bochar DA. Regulation of Androgen-Responsive Transcription by the Chromatin Remodeling Factor CHD8. Mol Endocrinol. 2010 Mar 22. [Epub ahead of print]

Sharma NP, Dong L, Yuan C, Noon KR, Smith WL. Asymmetric Acetylation of the Cyclooxygenase-2 Homodimer by Aspirin and Its Effects on the Oxygenation of Arachidonic, Eicosapentaenoic and Docosahexaenoic Acids. Mol Pharmacol. 2010 Mar 1. [Epub ahead of print]

Taube S, Rubin JR, Katpally U, Smith TJ, Kendall A, Stuckey JA, Wobus CE. High Resolution X-Ray Structure and Functional Analysis of the Murine Norovirus (MNV)-1 Capsid Protein Protruding (P) Domain. J Virol. 2010 Mar 24. [Epub ahead of print]

Veldman MB, Bemben MA, Goldman D. Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish. Mol Cell Neurosci. 2010 Apr;43(4):370-83. Epub 2010 Feb 1.

Family Medicine

Acheson LS, Wang C, Zyzanski SJ, Lynn A, Ruffin MT 4th, Gramling R, Rubinstein WS, Oʼneill SM, Nease DE Jr; for the Family HealthwareTM Impact Trial (FHITr) Group. Family history and perceptions about risk and prevention for chronic diseases in primary care: a report from the Family HealthwareTM Impact Trial. Genet Med. 2010 Mar 3. [Epub ahead of print]

Dalton VK, Harris LH, Gold KJ, Kane-Low L, Schulkin J, Guire K, Fendrick AM. Provider knowledge, attitudes, and treatment preferences for early pregnancy failure.Am J Obstet Gynecol. 2010 Mar 12. [Epub ahead of print]

Djuric Z, Ellsworth JS, Ren J, Sen A, Ruffin MT 4th. A randomized feasibility trial of brief telephone counseling to increase fruit and vegetable intakes. Prev Med. 2010 Mar 10. [Epub ahead of print] PubMed PMID: 20226809.

Human Genetics

Askari F, Innis D, Dick RB, Hou G, Marrero J, Greenson J, Brewer GJ. Treatment of primary biliary cirrhosis with tetrathiomolybdate: results of a double-blind trial. Transl Res. 2010 Mar;155(3):123-30.

Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Guéranger Q, Glover TW, Canman CE. Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol. 2010 Mar;30(5):1217-30.

O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Kärppä M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson P, Khanna H, Katsanis N, Hildebrandt F. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest. 2010 Mar
1;120(3):791-802.

Osorio N, Cathala L, Meisler MH, Crest M, Magistretti J, Delmas P. Persistent Nav1.6 current at axon initial segments tunes spike timing of cerebellar granule cells. J Physiol. 2010 Feb 15;588(Pt 4):651-70.

Rozek LS, Herron CM, Greenson JK, Moreno V, Capella G, Rennert G, Gruber SB. Smoking, Gender, and Ethnicity Predict Somatic BRAF Mutations in Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):838-43. Epub 2010 Mar 3.

Vilar E, Gruber SB. Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010 Mar;7(3):153-62.

Zentner GE, Layman WS, Martin DM, Scacheri PC. Molecular and phenotypic aspects of CHD7 mutation in CHARGE syndrome. Am J Med Genet A. 2010 Mar;152A(3):674-86.

Internal Medicine

Infectious Diseases:
Cooke DT, Pagani FD, Kaul DR, Cooke KR, Lau CL, Riddell J. Successful treatment of pulmonary zygomycosis in two transplant recipients with liposomal amphotericin B and partial surgical resection followed by posaconazole. Mycoses 53 (2): 163-167, 2010.

McDowell KL, Begley LA, Mor-Vaknin N, Markovitz DM, Macoska JA. Leukocytic Promotion of Prostate Cellular Proliferation. Prostate 70 (4): 377-389, 2010.

Phipps JC, Aronoff DM, Curtis JL, Goel D, O'Brien E, Mancuso P. Cigarette Smoke Exposure Impairs Pulmonary Bacterial Clearance and Alveolar Macrophage Complement-Mediated Phagocytosis of Streptococcus pneumoniae. Infection Immunity 78 (3): 1214-1220, 2010.

Swanson MD, Winter HC, Goldstein IJ, Markovitz DM. A Lectin Isolated from Bananas Is a Potent Inhibitor of HIV Replication. J Biol Chem 285 (12): 8646-8655, 2010.

Neurology

Blunden S, Chervin RD. Sleep, performance and behaviour in Australian indigenous and non-indigenous children: An exploratory comparison. J Paediatr Child Health. 2009 Nov 23.

Segal BM. Th17 cells in autoimmune demyelinating disease. Semin Immunopathol. 2010 Mar;32(1):71-7. Epub 2010 Feb 27.

Neurosurgery

Coffey MJ, Chou KL, Patil PG. Catatonia during deep brain stimulator implantation complicated by intracranial hemorrhage. Mov Disord. 2010 Mar 10. [Epub ahead of print]

Etame AB, Wang AC, Than KD, La Marca F, Park P. Outcomes after surgery for cervical spine deformity: review of the literature. Neurosurg Focus. 2010 Mar;28(3):E14.

Garton HJ, Gebarski SS, Ahmad O, Trobe JD. Clival epidural hematoma in traumatic sixth cranial nerve palsies combined with cervical injuries. J Neuroophthalmol. 2010 Mar;30(1):18-25.

Hervey-Jumper SL, Ghori AK, Quint DJ, Marentette LJ, Maher CO. Cerebrospinal fluid leak with recurrent meningitis following tonsillectomy. J Neurosurg Pediatr. 2010 Mar;5(3):302-5.

Ibrahim M, Parmar H, Yang L. Horner syndrome associated with contusion of the longus colli muscle simulating a tumor. J Neuroophthalmol. 2010 Mar;30(1):70-2.

Lien SC, Maher CO, Garton HJ, Kasten SJ, Muraszko KM, Buchman SR. Local and regional flap closure in myelomeningocele repair: a 15-year review. Childs Nerv Syst. 2010 Mar 2. [Epub ahead of print]

Obstetrics & Gynecology

Quint EH, McCarthy JD, Smith YR. Vaginal surgery for congenital anomalies. Clin Obstet Gynecol 2010 Mar;53(1):115-124. (PMID: 20142648).

Sauber-Schatz EK, Markovic N. Weiss HB, Bodnar LM, Wilson JW, Pearlman MD. Descriptive epidemiology of birth trauma in the United States in 2003. Paediatric Perinatal Epidemiol 2010 Feb 24:116-124.

Ophthalmology & Visual Sciences

Cho RI, Choe CH, Elner VM. Ultrasonic bone removal versus high-speed burring for lateral orbital decompression: comparison of surgical outcomes for the treatment of thyroid eye disease. Ophthal Plast Reconstr Surg 26 (2):83-7.

Daiger SP, Sullivan LS, Bowne SJ, Birch DG, Heckenlively JR, Pierce EA, Weinstock GM. Targeted high-throughput DNA sequencing for gene discovery in retinitis pigmentosa. Adv Exp Med Biol 664:325-31.

Demirci H, Frueh BR, Nelson CC. Marcus Gunn Jaw-Winking Synkinesis Clinical Features and Management. Ophthalmology. [Epub ahead of print]

Feuerman JM, Flint A, Elner VM. Cystic solitary fibrous tumor of the orbit. Arch Ophthalmol 128 (3):385-7.

Kothary PC, Badhwar J, Weng C, Del Monte MA. Impaired Intracellular Signaling May Allow Up-Regulation of CTGF-Synthesis and Secondary Peri-Retinal Fibrosis in Human Retinal Pigment Epithelial Cells from Patients with Age-Related Macular Degeneration. Adv Exp Med Biol 664:419-28.

Lee S, Taban M, Mancini R, Chong K, Goldberg RA, Douglas RS. Endoscopic removal of nasoglabellar dermoid cysts. Ophthal Plast Reconstr Surg 26 (2):136-9.

Murga-Zamalloa C, Swaroop A, Khanna H. Multiprotein Complexes of Retinitis Pigmentosa GTPase Regulator (RPGR), a Ciliary Protein Mutated in X-Linked Retinitis Pigmentosa (XLRP). Adv Exp Med Biol 664:105-14.

Orthopaedic Surgery

Farley FA, Kay RM. Management of the Multiply Injured Child. Rockwood and Wilkins’ Fractures in Children, Beaty JH, Kasser JR, 7th Edition, Lippincott Williams and Wilkins, Philadelphia, 2010.

Manske S.L, Boyd SK, Zernicke RF. Muscle and bone follow similar temporal patterns of recovery from muscle-induced disuse due to Botulinum toxin injection. Bone 2010 46: 24-31.

Pediatrics & Communicable Diseases

Aiello AE, Coulborn RM, Aragon TJ, Baker MG, Burrus BB, Cowling BJ, Duncan A, Enanoria W, Fabian MP, Ferng YH, Larson EL, Leung GM, Markel H, Milton DK, Monto AS, Morse SS, Navarro JA, Park SY, Priest P, Stebbins S, Stern AM, Uddin M, Wetterhall SF, Vukotich CJ Jr. Research findings
from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the research. Am J Infect Control. 2010 Mar 11 [Epub ahead of print]

Carlos R, Resnicow K, Dempsey A, Patel D, Ruffin M, Dalton V. Maternal Cultural Barriers Correlate With Adolescent HPV Vaccine Use. Cancer Epidemiol Biomarkers Prev. 2010 Mar;19(3):895.

Carlos RC, Dempsey AF, Patel DA, Dalton VK. Cervical cancer prevention through human papillomavirus vaccinations: using the “teachable moment” for educational interventions. Obstet Gynecol. 2010 Apr;115(4):834-8

Carter CC, Onafuwa-Nuga A, McNamara LA, Riddell J 4th, Bixby D, Savona MR, Collins KL. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nat Med. 2010 Mar 7[Epub ahead of print]

Deng H, Hershenson MB, Lei J, Anyanwu AC, Pinsky DJ, Bentley JK. Pulmonary artery smooth muscle hypertrophy: Roles of glycogen synthase kinase-3{beta} and p70 ribosomal S6 kinase. Am J Physiol Lung Cell Mol Physiol. 2010 Feb 26 [Epub ahead of print]

Freed GL, Dunham KM, Gebremariam A, Wheeler JR; The Research Advisory Committee of the American Board of Pediatrics. Which Pediatricians are Providing Care to America’s Children? J Pediatr. 2010 Mar 12. [Epub ahead of print]

Freed GL, Clark SJ, Butchart AT, Singer DC, Davis MM. Parental Vaccine Safety Concerns in 2009. Pediatrics 2010 Mar 1 [Epub ahead of print]

Freed GL, Dunham KM, Clark SJ, Davis MM. Perspectives and preferences among the general public regarding physician selection and board certification. J Pediatr. 2010 Feb 4 [Epub ahead of print]

Hirsch JC, Charpie JR, Ohye RG, Gurney JG. Near Infrared Spectroscopy (NIRS) Should not be Standard of Care for Postoperative Management. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2010;13(1):51-54

Hoban TF. Sleep disorders in children. Ann N Y Acad Sci. 2010 Jan;1184:1-14.

Kato K, Cui S, Kuick R, Mineishi S, Hexner E, Ferrara JL, Emerson SG, Zhang Y. Identification of Stem Cell Transcriptional Programs Normally Expressed in Embryonic and Neural Stem Cells in Alloreactive CD8 (+) T Cells Mediating Graft-Versus-Host-Disease. Biol Blood Marrow Transplant 2010 Jan 27 [Epub ahead of print]

Knepp MD, Rocchini AP, Lloyd TR, Aiyagari RM. Long-Term Follow up of Secundum Atrial Septal Defect Closure with the Amplatzer Septal Occluder. Congenit Heart Dis. 2010 Jan;5(1):32-7

Lee JM, Kaciroti N, Appugliese D, Corwyn RF, Bradley RH, Lumeng JC. Body mass index and timing of pubertal initiation in boys. Arch Pediatr Adolesc Med. 2010 Feb:164(2):139-44.

Lu C, Kumar PA, Fan Y, Sperling MA, Menon RK. A Novel Effect of Growth Hormone on Macrophage Modulates Macrophage-Dependent Adipocyte Differentiation. Endocrinology. 2010 Feb 25 [Epub ahead of print]

Magenau JM, Qin X, Tawara I, Rogers CE, Kitko CL, Schlough M, Bickley D, Braun TM, Jang PS, Lowler KP, Jones DM, Choi SW, Reddy P, Mineishi S, Levine JE, Ferrara JL, Paczesny S. Frequency of CD4(+)CD25(hi)FOXP3(+) Regulatory T Cells has Diagnostic and Prognostic Value as a Biomarker for Acute Graft-Versus-Host-Disease. Biol Blood Marrow Transplant. 2010 Mar 16 [Epub ahead of print]

Markel H. Abraham Flexner and his remarkable report on medical education: a century later. JAMA.2010 Mar 3;303(9):888-90.

Markel H. King Tutankhamun, modern medical science, and the expanding boundaries of historical inquiry. JAMA 2010 Feb 17;303(7):667-8

Odetola FO, Mann NC, Hansen KW, Patrick S, Bratton SL. Source of admission and outcomes for critically injured children in the mountain states. Arch Pediatr Adolesc Med. 2010 Mar;164(3):277-82

O’Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Karppa M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H. Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houton JL, Rotig A, Syaer JA, Rolinski B, Freisinger P, Madhaven SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson P, Khanna H, Katsanis N, Hildebrandt F. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest. 2010 Mar 1; 120 (3): 791-802. doi: 10.1172/JCI40076.

Perrin JM, Knapp AA, Browning MF, Comeau AM, Green NS, Lipstein EA, Metterville DR, Prosser L, Queally D, Kemper AR. An evidence development process for newborn screening. Genet Med. 2010 Feb 11 [Epub ahead of print]

Popova AP, Bozyk PD, Goldsmith AM, Linn MJ, Lei J, Bentley JK, Hershenson MB. Autocrine production of TGF-{beta}1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells. Am J Physiol Lung Cell Mol Physiol. 2010 Feb 26 [Epub ahead of print]

Wong HR, Freishtat RJ, Monaco M, Odoms K, Shanley TP. Leukocyte subset-derived genomewide expression profiles in pediatric septic shock. Pediatr Crit Care Med. [Epub ahead of print]

Psychiatry

Cranford JA, Tennen H, Zucker RA. Feasibility of using interactive voice response to monitor daily drinking, moods, and relationship processes on a daily basis in alcoholic couples. Alcohol Clin Exp Res. 2010 Mar;34(3):499-508. PubMed PMID: 20028351.

Jarman CN, Perron BE, Kilbourne AM, Teh CF. Perceived treatment effectiveness, medication compliance, and complementary and alternative medicine use among veterans with bipolar disorder. J Altern Complement Med. 2010 Mar;16(3):251-5.

Kales HC. Comorbidity of cognitive and mood disorders: furthering the understanding of heterogeneity. Am J Geriatr Psychiatry. 2010 Apr;18(4):277-80.

Mezuk B, Morden NE, Ganoczy D, Post EP, Kilbourne AM. Anticonvulsant use, bipolar disorder, and risk of fracture among older adults in the veterans health administration. Am J Geriatr Psychiatry. 2010 Mar;18(3):245-55.

Muzik M., Marcus SM, Flynn HA, Rosenblum KL. Depression in pregnancy: detection, comorbidity and treatment. Asia-Pacific Psychiatry 2010 (2):7-18.

Silk KR. Introduction to the special issue on National Institute for Health and Clinical Excellence guidelines. Personality and Mental Health, 2010 (4): 1-2.

Sen S, Kranzler HK, Chan G, Speller H, Krystal JH, Gelernter J, Guille C. A Prospective Cohort Study Investigating Factors Associated with Depression during Medical Internship. Archives of General Psychiatry. 2010; 67(6). Available online 4/5/2010.

Sirey JA, Bruce ML, Kales HC. Improving Antidepressant Adherence and Depression Outcomes in Primary Care: The Treatment Initiation and Participation (TIP) Program. Am J Geriatr Psychiatry. 2010 Mar 10. [Epub ahead of print]

Surgery

General Surgery:
Mathur AK, Ghaferi AA, Osborne NH, Pawlik TM, Campbell DA Jr, Englesbe MJ, Welling TH. Body Mass Index and Adverse Perioperative Outcomes Following Hepatic Resection. Submitted to The Journal of GI Surgery 3/10.

Schilling PL, Campbell DA, Jr., Englesbe MJ, Davis MM. A comparison of in-hospital mortality risk conferred by high hospital occupancy, differences in nurse staffing levels, weekend admission, and seasonal influenza. Medical Care. 2010; Mar;48(3):224-232.

Pediatric Surgery:
Nose, K, Yang, H, Sun X, Nose, S, Koga, H, Feng, Y, Miyasaka, E, Teitelbaum, DH: Glutamine Prevents Total Parenteral Nutrition -Associated Changes to Intraepithelial Lymphocyte Phenotype and Function: A Potential Mechanism for the Preservation of Epithelial Barrier Function. J Interferon and Cytokine Res 2010, 30(2): 67-80. PMID 20028208

Hashish, M, Dawoud, HH, Hirschl, RB, Bruch, SW, El Bartarny, AM, Mychaliska, GB, Drongowski, R, Ehrlich, PF, Hassaballa, SZ, El-Dosuky, NI, Teitelbaum, DH: Long term functional outcome and quality of life in patients with high imperforate anus. J Pediatr Surg 2010, 45(1) 224-30.

Hashish, M, Raghavan, S, Somara, S, Gilmont, R, Miyasaka, E, Bitar, KN, Teitelbaum, DH: Development and implantation of a bioartificial anal sphincter. J Pediatr Surg 2010, 45(1) 52-8.

Flum, AS, Golladay, ES, Teitelbaum, DH: Recurrent Rectal Prolapse Following Primary Surgical Treatment. Ped Surg Intern 2010, 26(4):427-31.

 Feng, Y, McDunn, JE, Teitelbaum, DH: Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: A potential mechanism for the development of intestinal mucosal atrophy. Am J Physiol Gastrointest Liver Physiol, 2010, Mar 18 [Epub ahead of print] PMID 20299605

Plastic Surgery:
Cederna PS. Review of Plastic Surgery Emergencies: Principles and Techniques. Plastic and Reconstructive Surgery 123:5, 1628-1629, 2009.

 Frost CM Urbanchek MG, Egeland BM, Larkin LM, Abidian MR, Daneshvar DE, Miriani RM, Kuzon WM Jr, Kipke DR, Cederna PS. Development of a Biosynthetic “Living Interface” with Severed Peripheral Nerve. Plastic and Reconstructive Surgery 123:6S, 12, 2009.

 Egeland BM, Urbanchek MG, Abidian MR, Kuzon WM Jr, Cederna PS. A Tissue-Based Bioelectrical Interface has Reduced Impedance Compared to Copper Wire and Nerve. Plastic and Reconstructive Surgery 123:6S, 26, 2009.

 Schroeder KA, Urbanchek MG, Egeland BM, Ewing KA, Abidian MR, Daneshvar DE, Miriani RM, Kuzon WM Jr, Kipke DR, Cederna PS. Sensory Protection Recovery Follows Nerve Regeneration Through an Electrically Conducting Nerve Graft. Plastic and Reconstructive Surgery 123:6S, 40, 2009.

 Egeland BM, Urbanchek MG, Richardson-Burns SM, Kuzon WM Jr, Kipke DR, Martin DC, Cederna PS. In Vivo Electrophysiologic Properties of poly(3,4-ethylenedioxythiophene) PEDOT in Peripheral Motor Nerves. Plastic and Reconstructive Surgery 123:6S, 89, 2009.

 Jadcherla Y, Urbanchek MG, Abidian MR, Egeland BM, Miriani RM, Schroeder KM, Daneshvar DE, Ewing KA, Kuzon WM Jr, Kipke DR, Cederna PS. Nerve Regeneration Through an Electrically Conducting Polymer Nerve Graft. Plastic and Reconstructive Surgery 123:6S, 90, 2009.

 Levi B, Brown, DL, Cederna PS. Outcomes of Tissue Expander Reconstruction of the Burned and Congenital Breast Using Endoscopic and Open Expander Placement. Plastic and Reconstructive Surgery 123:6S, 102, 2009.

 Egeland BM, Urbanchek M, Martin DC, Kipke DR, Kuzon WM, Cederna PS. Engineering and Development of a Stable, Low Impedance, Biolelectrical Peripheral Nerve Interface. Journal of the American College of Surgeons 209:3, S76, 2009.

 Oakes MB, Quint EH, Smith YR, Cederna PS. Early Staged Reconstruction In Young Women With Severe Breast Asymmetry. Journal of Pediatric and Adolescent Gynecology 22(4): 223-228, 2009.

 Levi B, Brown DL, Cederna PS. A Comparative Analysis of Tissue Expander Reconstruction of Burned and Unburned Chest and Breasts Using Endoscopic and Open Techniques. Plastic and Reconstructive Surgery 125:2, 547-556, 2010.

 Gauger PG, Hauge LS, Andreatte PB, Hamstra SJ, Hillard ML, Arble EP, Kasten SJ, Mullan PB, Cederna PS, Minter RM. Laparoscopic Simulation Training of With Proficiency Targets Improves Practice and Performance of Novice Surgeons. American Journal of Surgery (In Press).

 Cederna PS. Invited Discussion: Human and Mouse Osteoprogenitor Cells Exhibit Distinct Patterns of Osteogenesis in Three-Dimnesional Engineering Scaffolds. Plastic and Reconstructive Surgery (In Press).

Thoracic Surgery:
Chang AC and Lee JS. Resection for esophageal cancer in the elderly. Thoracic Surgical Clinics, 19:333-343, 2009.

Hartojo W, Silvers AL, Thomas DG, Seder CW, Lin L, Rao H, Wang Z, Greenson JK, Giordano TJ, Orringer MB, Rehemtulla A, Bhojani MS, Beer DG and Chang AC. Curcumin promotes apoptosis, increases chemosensitivity and inhibits NF-kB in esophageal adenocarcinoma. Transl Oncol, 2010;3:99-108.

Chang AC, Lee JS, Sawicki KT, Pickens A and Orringer MB. Outcomes following esophagectomy in patients with prior antireflux or hiatal hernia surgery. Ann Thorac Surg, in press, 2010.

Surgery:
Greenfield LJ. National Health Care Expenditures: Addressing the Cost of Health Care in the United States. Ann Surg, 2010; 251(2):203-204