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MARCH 2010, Vol. 28

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CRAO to Become a New eResearch Ancillary Committee!
Sign Up for Workshops and Q&A Sessions

The following announcement is made on behalf of Steve Kunkel, Ph.D., Senior Associate Dean for Research and Teri Grieb, Ph.D., Director, Office of Research:

The Clinical Research Calendar Review & Analysis Office (CRAO), which is a part of the Medical School Office of Research and was formerly known as the Clinical Research Billing Unit (CRBU), will now be included as an Ancillary Committee as part of Release 2.3 in eResearch on Friday, March 26, 2010.

Beginning with Release 2.3, PI/study teams will be required to submit the research billing calendar to CRAO prior to receiving IRBMED approval.

This new workflow will remove current bottlenecks and increase efficiency in the development of a research billing calendar and associated documents, such as the protocol and informed consent. The change in process will provide investigative teams with a single place to do their work, including uploading documents; eliminating multiple requests for the Principal Investigator/study team to respond to; and creating an environment where the CRAO and study teams can correspond similar to the current Core and Ancillary Committees. In addition, this change will enhance CRAO coordination with IRBMED. Importantly, this process is intended to make sure charges are appropriately allocated to study accounts, third-party payers, and/or subjects.

Q&A Sessions

In order to address questions from PI/study team members on this change in eResearch, we will hold a series of Q&A sessions in April conducted by Gina Vuocolo-Branch, Senior Manager, CRAO and Jan Hewett, Director, IRBMED.

"The Nuts & Bolts of Building a Research Billing Calendar" Workshop

We will also offer additional sessions of “The Nuts & Bolts of Building a Research Billing Calendar” workshop this month. This is a learning opportunity for those that are responsible for developing research billing calendars. Attendees of the workshop will learn why the billing calendar is required and valuable to the PI/study team, how to complete the calendar, and where to go for assistance in building a billing calendar. The workshop will also include information on the enrollment process as well as a brief discussion of the CRAO as an Ancillary Committee. Gina Vuocolo-Branch, Senior Manager of the CRAO, will present (45 min) and then answer questions (30 min).

Times / Locations / Registration

For times and locations – and to register for a Q&A session and/or workshop – please visit:

We thank you for your continued suggestions about your clinical research support needs. You can learn more about Clinical Research Billing on the CRAO website:

Contact Kathryn Ridner at ( or 734-763-4086 with any questions about the workshops or Q&A sessions.

Key Programming Decisions for the North Campus Research Complex

Ora Hirsch Pescovitz, M.D., Executive Vice President for Medical Affairs, made the following announcement on February 18, 2010 :

As a leading research university with incredible talent and intellect, we are positioned to create the future of scientific research. But simply being in such a fortunate position and having a vast pool of talent doesn’t guarantee success. As entrepreneur Ray Kroc once said "The two most important requirements for major success are: first, being in the right place at the right time, and second, doing something about it."

With our North Campus Research Complex (NCRC) as the catalyst, the University of Michigan is in the right place at the right time to spark ground-breaking research and discovery that can change the world. And it is up to all of us to take this extraordinary opportunity and do something about it.

Today, I’m excited to share the following decisions regarding plans for NCRC – plans that set the stage for a new era of collaboration and innovation at Michigan:

  1. Research Model: We will bring under one roof major scientific disciplines, economic sectors and others who play an important role in the discovery-to-delivery chain, turning scientific breakthroughs into real benefits to humanity. Learn more.

  2. Health Services Research: We will develop the nation’s premier institute for research in health care services, which is the study of effective ways to organize, manage, finance and deliver high quality care. Learn more.

  3. Technology: We have identified the first two technology anchors to develop at NCRC. The first is a world-class program in biointerfaces, which includes an interdisciplinary mix of nanotechnology, microfluidics and sensors, cell and tissue engineering, and biomaterials and drug delivery. The second is a cutting-edge collaboration in molecular, functional, and structural imaging. Learn more.

  4. Research Clusters – Call for Proposals: We are seeking grassroots faculty teams to form interdisciplinary research clusters at NCRC. These clusters will join our technology anchors as part of our revolutionary research model. If you would like to apply to have your multidisciplinary research program moved to NCRC, you can access application materials online.

I cannot wait to see your great ideas evolve as we work together to establish the University of Michigan as a national – even international – hub of research and innovation.

For the latest information on NCRC, as well as a photo gallery and short video, visit

Thank you,

Ora Hirsch Pescovitz, M.D.
Executive Vice President for Medical Affairs

Teri Grieb, Ph.D., Named MICHR Managing Director
Teri Grieb

The Michigan Institute for Clinical & Health Research (MICHR) is pleased to announce that Teri Grieb, Ph.D., has been named Managing Director. In a dual role reporting to Steven Kunkel, Ph.D. and Ken Pienta, M.D., Teri will also continue to lead the Office of Research in the Medical School as Senior Director of Research.

"We are thrilled to have Teri extend her research role to lead MICHR," said Ken Pienta, M.D., MICHR Faculty Director. "Her extensive research background and her familiarity with MICHR's efforts to enable and enhance clinical and translational research, and as an innovation engine for improving human health make her an excellent leader for this important role."

In her new role with MICHR, Teri’s top priorities will include representing both the Office of Research and MICHR, serving as lead administrative liaison and primary staff interface between MICHR and the institution, and representing MICHR to the NIH/CTSA consortium. She will also operationalize the faculty director’s vision through empowering managers and cascading deployment to front-line staff, ensuring coordination between working groups and between schools/colleges. "I look forward to advancing the mission of MICHR and fostering better collaboration of their research support programs and services with other research entities throughout the university," said Grieb.

Teri holds a Ph.D. from the Genetics program at George Washington University. After receiving her doctorate, she was Director of Tissue Biologics and lead scientist for an early-stage, life sciences start-up company. Later ,Teri joined MedImmune, Inc. where she oversaw commercial and university in-licensed technologies. Just prior to her current role at the university, Teri joined the Office of Research as the Industry Research Liaison, where she was responsible for planning and implementing research outreach activities to increase participation in technology transfer and foster entrepreneurship.


Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


Human Research

Revised IRBMED Standard Operating Procedures Now Available

The IRBMED would like to announce our revised Standard Operating Procedures (SOPs) are now available for review. The SOPs have been posted on the IRBMED website and can be accessed directly at ( or through the IRBMED Guidance Page at (

The format of the IRBMED SOPs had changed to reflect the Human Research Protection Program (HRPP) Operations Manual (OM). See (

Please contact the IRBMED at ( if you have any questions.

IRBMED Makes Asking Questions Easier

IRBMED continues to offer the Speak To A Regulatory Specialist (STARS) Program. STARS offers set times during the week when a Senior Associate Regulatory Analyst (SARA) will be available to speak immediately to callers whose inquiry relates to new or ongoing IRBMED business. STARS will be offered on:

  • Tuesdays from 10:00 AM - 12:00 PM
  • Wednesdays from 1:00 - 3:00 PM

This program supplements, rather than replaces, researchers’ access to IRBMED staff. We still welcome your questions at any time convenient to you, offer consults on new and ongoing research, and educational sessions geared specifically for your needs.

If you have any questions about this article, please contact Jan Hewett in the IRBMED office at 734-763-4768.


Animal Research

Inspections of Animal Facilities

Both the Public Health Service Policy (PHS Policy) and the Animal Welfare Regulations require semi-annual inspections of animal facilities. Every six months, the UCUCA inspects all animal housing and use rooms, facilities, and laboratories using the Guide for the Care and Use of Laboratory Animals as a basis for evaluation. Previously, this was conducted over a two-month period, twice a year. However, the inspections are now spread out over the entire six months and repeated twice each year. In addition, the UCUCA compliance staff inspects laboratory spaces that conduct rodent survival surgeries semi-annually on behalf of the UCUCA. The results of these inspections are reviewed by the UCUCA at a monthly meeting and sent in a report to the Vice President for Research twice each year.

Animal Concern Hotline

The UCUCA maintains an Animal Concern Hotline, operated through the UCUCA Office, to provide a mechanism for UM staff members and members of the public to report any matter of concern about the humane care and use of laboratory animals at the University. Reports are investigated on behalf of the UCUCA by the UCUCA Office staff and, if necessary, by a (ULAM) veterinary faculty member. Immediate steps are taken to ensure that animal care and use are appropriate and that animal welfare is sustained. The UCUCA is apprised of these investigations and their outcomes at their monthly meetings and makes further recommendations, if warranted. Reports and sources of information are maintained in confidence within University guidelines. To report an animal concern, please call 734-763-8028 or visit (

Animal Care Training

Animal care training is based on regulatory requirements (Public Health Service Policy and the Animal Welfare Act) and the commitment of the University of Michigan to ensure that animal research performed here is done in the most humane and effective manner. As the animal research program has grown over the years, it had become necessary to increase staff and develop new ways of providing support to animal users. In order to improve the utilization of training resources, increase the coordination of training activities and communications, and reduce redundancy in training, all of the training provided by ULAM and UCUCA has been combined into a centralized unit called the ULAM Training Core. By having trainers from each area work together, we have improved the consistency and availability of courses offered to all of our customers. The training core offices and wet laboratory are located in the Life Sciences Building (LSI). Training is coordinated through the Training Core instead of the UCUCA office.

Training Core Offices:
Location: 1016 LSI (Life Sciences Building)
Phone: 734-763-8039


White House Releases FY11 Budget Proposal Details – Proposes a $1 Billion Increase for the NIH

On February 1, 2010 the Obama Administration released its Fiscal Year 2011 (FY11) Budget Request. Within this request, the National Institutes of Health (NIH) would receive $32.247 billion – a 3.2% increase over FY10. The Budget Request outlines five strategic priorities:

  • applying genomics and other high-throughput technologies;
  • translating basic science discoveries into new and better treatments and diagnostics;
  • using science to enable health care reform;
  • global health; and
  • reinvigorating and empowering the biomedical research community.

Priority areas include: cancer research; autism research; stem cell research; DNA sequencing; the Therapeutics for Rare and Neglected Disease program; Basic Behavioral Science Opportunity Network; Clinical and Translational Science Awards; Ruth L. Kirchstein National Research Service Awards; the National Nanotech Initiative; National Synchrotron Light Source-II; HIV/AIDS research; and computational biology. Specific funding allocations are as follows:

FY10 (enacted)

FY11 Budget Request

  NCI $5.1 billion $5.26 billion
  NHLBI $3.09 billion $3.19 billion
  NIDCR $413.07 million $423.51 million
  NIDDK $1.96 billion $2.01 billion
  NINDS $1.63 billion $1.68 billion
  NIAIDS $4.81 billion $4.98 billion
  NIGMS $2.05 billion $2.12 billion
  NICHS $1.33 billion $1.37 billion
  NEI $706.76 million $724.36 million
  NIEHS $689.56 million $707.34 million
  NIA $1.11 billion $1.14 billion
  NIAMS $538.85 million $555.71 million
  NIDCD $418.66 million $429.01 million
  NIMH $1.49 billion $1.54 billion
  NIDA $1.06 billion $1.09 billion
  NIAAA $462.17 million $474.65 million
  NINR $145.6 million $150.20 million
  NHGRI $515.88 million $533.96 million
  NIBIB $316.45 million $325.92 million
  NCRR $1.27 billion $1.31 billion
  NCCAM $128.79 million $132.00 million
  NCMHD $211.51 million $209.05 million
  FIC $70.00 million $73.03 million
  NLM $350.61 million $364.80 million
  Office of the Director

$1.18 billion $1.22 billion

With the details of the President’s Budget released, the House and Senate Appropriations Committees have begun writing legislation outlining the priorities of the two Chambers of Congress. In some cases, these priorities may significantly differ from the President’s proposal. Agreement between Congress and the White House on a final FY11 funding level will be reached near the end of the year. Working with members of the Michigan delegation, U-M will play an active role in the higher education research advocacy efforts on this important topic in the coming months.


Improving Children's Health Through Community-Engaged Research Workshop

Thursday, April 22, 2010
5:30 - 7:30 PM
Michigan League (Welcome Reception)

Friday, April 23, 2010
8:00 AM - 5:00 PM
Holiday Inn Ann Arbor (Workshop)

The Michigan Institute for Clinical and Health Research (MICHR) is offering an interactive workshop aimed at developing community engagement skills for researchers, increasing the knowledge and commitment to conduct rigorous cross-disciplinary research in order to improve health outcomes, and identifying effective strategies for project development, implementation, and dissemination in community-engaged research. The event is co-sponsored by the Association for Prevention Teaching and Research (APTR), City Connect Detroit, Community-Campus Partnerships for Health, and Washtenaw County Public Health.

Speakers will include:

  • Lawrence W. Green, D.R.P.H., Co-Leader; Society, Diversity, and Disparities Program; University of California, San Francisco
  • Michael Cabana, M.D., M.P.H., Director, Division of General Pediatrics, University of California, San Francisco
  • Sarah Flicker, Ph.D., M.P.H., Assistant Professor of Environmental Studies, York University

To register, visit ( For additional information, contact Nichole Washington at ( or 734-998-6797.

Nathan Shock Center Research Retreat on AGING and TOR SIGNALING

Thursday, May 6 - Friday, May 7, 2010
Biomedical Science Research Building

The 14th annual research retreat of the University of Michigan Nathan Shock Center for the Biology of Aging will focus on recent discoveries that have contributed to our current understanding of how aging and age-associated disease may be regulated by TOR signaling. Keynote lecturers include Mike Hall, Pankaj Kapahi, Reuben Shaw, Nahum Sonenberg, Randy Strong, and Dominic Withers. For more information, contact Jane Heibel at (

45th Graduate Summer Session in Epidemiology
Application Deadline: June 1, 2010

(Applications received by the deadline does not guarantee placement in a course. Enrollment is limited in a number of courses.)

The University of Michigan School of Public Health will offer one-week and three-week courses for all public health professionals and those interested in health research during their 45th Graduate Summer Session in Epidemiology to take place July 11-30, 2010. Topics include: Fundamentals of Biostatistics and Epidemiology, Intermediate Methods, Infectious Diseases, Applied Public Health Practice, Cancer Epidemiology, Clinical Trials, SAS, Logistic Model, Linear Regression, Survival Analysis, Behavioral Change, Social Epidemiology, Longitudinal Studies, Global Health, Pharmacoepidemiology, Surveillance, Multi-level Analysis in Public Health, Scientific Writing, Geographic Information Systems, Health Policy, Community-Based Research, Injury and Violence, Evolutionary Epidemiology.

  • Distance Learning Courses:
    • Fundamentals in Biostatistics
    • Fundamentals of Epidemiology
  • CME credit available

For application and information, visit ( For questions, contact Jody Gray at 734-764-5454 or (


Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains a link to M-Quest (a database of opportunities for grants, honors, prizes and fellowships created and maintained by the Office of Research) as well as information on email alert groups.

Internal Submissions

Michigan Gastrointestinal Peptide Research Center Pilot Feasibility Projects
Deadline: April 16, 2010

The Michigan Gastrointestinal Peptide Research Center invites applications for Pilot Feasibility Projects in the Area of Peptide Biology and Gastrointestinal Function.

First priority will be given to young investigators at the University of Michigan embarking on a research career, with the hope that the Pilot Feasibility Project will lead to the successful funding of an RO1 type application. At least three years of postdoctoral training is required prior to the start of the award. Postdocs meeting this requirement, instructors/lecturers and young faculty through Assistant Professors are encouraged to apply. More senior investigators will be considered only if the project represents a new direction in their research, and will be given lower priority.

Grants will be awarded for $10,000 to $25,000; the maximum request is for $25,000/year. A maximum of two years of funding will be provided. For complete information, visit (

External Limited Submissions

These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

William T. Grant Scholars Program
Deadline: July 6, 2010

The William T. Grant Scholars Program supports promising early career researchers from various disciplines. The award is intended to facilitate the professional development of early career scholars who have some demonstrated success in conducting high quality research and are seeking to further develop their skills and research program. Studies from these Scholars contribute to theory and policy/practice for improving the lives of young people.

The Foundation supports research to understand and improve the settings of youth ages 8 to 25 in the United States. Important settings include schools, youth-serving organizations, neighborhoods, families, and peer groups.

Candidates are nominated by a supporting institution*** and must submit five-year research plans that demonstrate creativity, intellectual rigor, and a commitment to continued professional development, are grounded in theory and sound scientific methods, and provide evidence for appropriate mentoring from senior investigators. Every year, four to six William T. Grant Scholars are selected and each receives $350,000 distributed over a five-year period.

The award is designed for early career researchers. Applicants must have received their terminal degree within seven years of submitting their application. The award may not be used as a postdoctoral fellowship. Visit the website for complete details.

*** Only one candidate may be nominated per major division of the university. For Medical School faculty, please contact Kathryn Ridner ( or 734-763-4086) at the Office of Research if you intend to apply so that the necessary internal selection process can be established.

External Open Submissions

Michigan’s University Research Corridor Funding to Support Research Symposia
Deadline: March 31, 2010

Michigan State University, the University of Michigan, and Wayne State University announce a funding opportunity of up to $60,000 to organize and host collaborative symposia focusing on major research topics. Topics can focus on life sciences, engineering, physical and/or social sciences with excellent potential for innovation and new research funding opportunities that span two or more URC institutions. For complete information including application instructions, visit (

Deadline Watch

Click here to view.

UM Henry Russel Lectureship
Deadline: March 29, 2010


UM Postdoctoral Translational Scholars Program
Deadline: April 9, 2010



External Awarded Grants

Currently, due to limitations on data collection, we are unable to identify projects awarded with multiple PIs. As the eRPM system is used for proposals, we will be able to publish those awards accurately. We apologize for any misleading project information this causes.

Click here to view.

Comprehensive Cancer Center

PI: Smith, David
Title: An Open-Label, Dose Escalation, Phase 1 Study of TAK-901 in Adult Patients with Advanced Solid Tumors or Lymphoma
Sponsor: Millennium Pharm, Inc.
Project Dates and Amount of Award: 02/10/10-07/31/12; $1,199,424

PI: Wicha, Max
Title: University of Michigan Comprehensive Cancer Center Community Outreach Program Women and Cancer Series
Sponsor: Knight, James A. and Faith, Foundation
Project Dates and Amount of Award: 12/17/09-12/31/10; $3,700

Family Medicine

PI: Gold, Katherine
Sponsor: NIH 1 K23 MH 085882 01 A1
Project Dates and Amount of Award: 12/28/09-11/30/13; $711,557

Internal Medicine

PI: Bitzer, Markus
Title: TGF-b and microRNAs in Renal Disease
Sponsor: American Society Of Nephrology
Project Dates and Amount of Award: 09/01/09-08/31/10; $121,163

PI: Jakubowiak, Andrzej
Title: UMCC 2009.112 Elotuzumab HuLuc63-1703
Sponsor: Facet Biotech Corporation TO Quintiles, Inc
Project Dates and Amount of Award: 02/17/10-02/28/13; $481,288

PI: Jakubowiak, Andrzej
Title: Proteomic and Gene Expression Profiling of Patients with Newly DiagnosedMultiple Myeloma Treated with Lenalidomide (Revlimid), Bortezomib (Velcade), Liposomal Doxorubicin (Doxil) and Dexamethasone (RVDD)
Sponsor: Multiple Myeloma Research Consortium
Project Dates and Amount of Award: 03/03/10-03/02/11; $75,000

PI: Jakubowiak, Andrzej
Co-I: Griffith, Kent (Univ of Mich Cancer Center)
Title: MMRC Clinical Trials Core Grant Agreement
Sponsor: Multiple Myeloma Research Foundation
Project Dates and Amount of Award: 01/01/10-12/31/10; $40,000

PI: Jakubowiak, Andrzej
Title: MMRC Site Management Support
Sponsor: Multiple Myeloma Research Foundation
Project Dates and Amount of Award: 11/01/09-10/31/13; $50,000

PI: Oral, Elif
Co-I: Avram, Anca (Radiology Department) / Gadegbeku, Crystal (Int Med-Nephrology)
Title: An Exploratory Phase 2 Study to Assess the Effect of Dapagliflozin on Glomerular filtration Rate (GFR) in Subjects with Type 2 Diabetes who have Inadequate Glycemic and Blood Pressure (BP) Control
Sponsor: Bristol-Myers Squibb
Project Dates and Amount of Award: 02/12/10-02/11/11; $99,410

PI: Pietropaolo, Massimo
Title: Study to Investigate the Impact of Diamyd on the Progression of Diabetes in Patients Newly Diagnosed with Type 1 Diabetes Mellitus
Sponsor: TKL Research, Inc. TO Diamyd, Inc.
Project Dates and Amount of Award: 02/01/10-01/31/12; $72,604

PI: Samaniego, Milagros
Co-I: Sung, Randall (General Surgery Section)
Sponsor: NIH - Subcontracts TO Mount Sinai Medical Center, The U01 A1 070107
Project Dates and Amount of Award: 08/01/09-07/31/10; $222,661

PI: Schiopu, Elena
Title: Glomerular Filtration Rate in Scleroderma Associated with: Protocol TDE-DU-201: DISTOL-1 Digital Ischemic Lesions in Scleroderma Treated with Oral Treprostinil Diethanolamine: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study
Sponsor: United Therapeutics Corp
Project Dates and Amount of Award: 02/22/10-01/31/12; $46,188

PI: Smith, David
Title: Exelixis Consulting Agreement
Sponsor: Exelixis
Project Dates and Amount of Award: 10/22/09-09/25/11; $15,000

PI: Volk, Michael
Sponsor: NIH 1 K23 DK 085204 01
Project Dates and Amount of Award: 02/10/10-12/31/14; $900,918

Microbiology and Immunology

PI: King, Philip
Sponsor: NIH - Subcontracts TO University of Texas CA 128919
Project Dates and Amount of Award: 08/01/09-07/31/10; $28,311


PI: Barbas, Nancy
Title: A Phase 3 Extension, Multicenter, Double-Blind, Long Term Safety and Tolerability Treatment Trial of Bapineuzumab (AAB-001, ELN115727 in Subjects with Alzheimer's Disease who Participated in Study ELN115727-301 or in Study ELN115727-302
Sponsor: Janssen Alzheimer Immunotherapy
Project Dates and Amount of Award: 02/08/10-12/31/12; $362,918

PI: Parent, Jack
Co-I: Liu, Yu (Neurology Department) / Mata, Marina (Neurology Department) / Zhang, Huailin (Neurology Department) / Zhou, Zhigang (Neurology Department)
Sponsor: NIH 1 R01 NS 065450 01 A1
Project Dates and Amount of Award: 02/01/10-01/31/15; $1,653,578

PI: Paulson, Henry
Co-I: Rodriguez, Edgardo (Neurology Department)
Sponsor: NIH 1 R21 NS 067111 01
Project Dates and Amount of Award: 03/01/10-02/29/12; $414,793

PI: Paulson, Henry
Co-I: Elenitoba-Johnson, Kojo (Pathology Department) / Shakkottai, Vikram (Neurology Department) / Todi, Sokol (Neurology Department)
Sponsor: NIH 2 R01 NS 038712 12
Project Dates and Amount of Award: 02/15/10-01/31/15; $2,637,017

PI: Paulson, Henry
Co-I: Rodriguez, Edgardo (Neurology Department)
Sponsor: Shire Human Genetic Therapies
Project Dates and Amount of Award: 01/01/10-01/01/11; $188,243


PI: Elrick, Matthew
Sponsor: NIH 1 F30 NS 065662 01 A1
Project Dates and Amount of Award: 07/01/10-06/30/13; $106,836

PI: Hogaboam, Cory
Title: Pathogen and Danger Signal-Mediated Exacerbation of Pulmonary Fibrosis in a Novel SCID Model of Human IPF
Sponsor: MedImmune, Inc.
Project Dates and Amount of Award: 02/11/10-12/31/10; $151,205

Pediatrics & Communicable Diseases

PI: Hildebrandt, Friedhelm
Co-I: Zhou, Weibin (Pediatrics-Nephrology)
Title: Center for Advanced Renal Microscopic Analysis
Sponsor: NIH - Subcontracts TO Indiana University 5 P30 DK 079312 03
Project Dates and Amount of Award: 06/01/09-05/31/10; $45,000

PI: Layman, Wanda
Sponsor: NIH 1 F31 DC 010955 01
Project Dates and Amount of Award: 06/01/10-05/31/13; $97,068

PI: LiPuma, John
Title: CFF Burkholderia Cepacia Research Laboratory and Repository
Sponsor: Cystic Fibrosis Foundation
Project Dates and Amount of Award: 03/01/10-02/28/11; $369,958


PI: Maybaum, Jonathan
Co-I: Canman, Christine (Pharmacology Department) / Morgan, Meredith (Radiation Oncology - Ann Arbor) / Normolle, Daniel (Radiation Oncology - Ann Arbor) / Parsels, Leslie (Pharmacology Department) / Zalupski, Mark (Int Med-Hematology/Oncology)
Sponsor: NIH 1 R01 CA 138723 01 A1
Project Dates and Amount of Award: 04/01/10-01/31/15; $2,310,647


PI: Bolling, Steven
Co-I: Kirakosyan, Ara (Cardiac Surgery Section) / Seymour, E (Cardiac Surgery Section)
Sponsor: Cherry Marketing Institute
Project Dates and Amount of Award: 10/01/09-09/30/10; $86,965

PI: Pagani, Francis
Title: Heartmate II Destination Therapy Post Approval Study
Sponsor: Thoratec Corporation
Project Dates and Amount of Award: 01/25/10-01/24/15; $50,000

PI: Pelletier, Shawn
Co-I: Volk, Michael (Int Med-Gastroenterology)
Sponsor: HRSA 1 R38 OT 15492 01
Project Dates and Amount of Award: 09/01/09-08/31/12; $570,531

Unit for Laboratory Animal Medicine

PI: Dirita, Victor
Sponsor: NIH 2 R01 AI 045125 11 A1
Project Dates and Amount of Award: 03/01/10-02/28/15; $1,646,485

PI: Eaton, Kathryn
Sponsor: Various Sponsors
Project Dates and Amount of Award: 12/01/09-12/31/11; $2,379


Click here to view.

Biological Chemistry

Akey DL, Razelun JR, Tehranisa J, Sherman DH, Gerwick WH, Smith JL. Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure. 2010 Jan 13; 18(1): 94-105.

Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J Biol Chem. 2009 Dec 18; 284(51): 35769-80.

Bulfer SL, Scott EM, Pillus L, Trievel RC. Structural basis for L-lysine feedback inhibition of homocitrate synthase. J Biol Chem. 2010 Jan 19. (Epub ahead of print)

Carson WF 4th, Cavassani KA, Ito T, Schaller M, Ishii M, Dou Y, Kunkel SL. Impaired CD4+ T cell proliferation and effector function correlates with repressive histone methylation events in a mouse model of severe sepsis. Eur JImmunol. 2010 Feb 1. (Epub ahead of print)

Cavassani KA, Carson W 4th, Moreira AP, Wen H, Schaller MA, Ishii M, Lindell DM, Dou Y, Lukacs NN, Keshamouni VG, Hogaboam CM, Kunkel SL. The post sepsis-induced expansion and enhanced function of regulatory T cells creates an environment to potentiate tumor growth. Blood. 2010 Feb 3. (Epub ahead of print)

Galbán CJ, Bhojani MS, Lee KC, Meyer CR, Van Dort ME, Kuszpit KK, Koeppe RA, Ranga R, Moffat BA, Johnson TD, Chenevert TL, Rehemtulla A, Ross BD. Evaluation of Treatment-Associated Inflammatory Response on Diffusion-Weighted Magnetic Resonance Imaging and 2-[18F]-Fluoro-2-Deoxy-D-Glucose-Positron Emission Tomography Imaging Biomarkers. Clin Cancer Res. 2010 Feb 16. (Epub ahead of print)

Geng J, Klionsky DJ. Determining Atg protein stoichiometry at the phagophore assembly site by fluorescence microscopy. Autophagy. 2010 Jan; 6(1): 144-7.

Hurst TK, Wang D, Thompson RB, Fierke CA. Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives. Biochim Biophys Acta. 2010 Feb; 1804(2): 393-403.

Klionsky DJ. J. Fred "Paulo" Dice: In memoriam. Autophagy. 2010 Apr 18; 6(3).

Klionsky DJ, Lane JD. Alternative macroautophagy. Autophagy. 2010 Feb 7; 6(2).

Koutmou KS, Casiano-Negroni A, Getz MM, Pazicni S, Andrews AJ, Penner-Hahn JE, Al-Hashimi HM, Fierke CA. NMR and XAS reveal an inner-sphere metal binding site in the P4 helix of the metallo-ribozyme ribonuclease P. Proc Natl Acad Sci U S A. 2010 Feb 9; 107(6): 2479-84.

Lynch-Day MA, Klionsky DJ. The Cvt pathway as a model for selective autophagy. FEBS Lett. 2010 Feb 8. (Epub ahead of print)

Kwee TC, Galbán CJ, Tsien C, Junck L, Sundgren PC, Ivancevic MK, Johnson TD, Meyer CR, Rehemtulla A, Ross BD, Chenevert TL. Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas. J Magn Reson Imaging. 2010 Feb 25; 31(3): 531-537. (Epub ahead of print)

Marvin MC, Engelke DR. Broadening the mission of an RNA enzyme. J Cell Biochem. 2009 Dec 15; 108(6): 1244-51.

Nair U, Cao Y, Xie Z, Klionsky DJ. The roles of the lipid-binding motifs of Atg18 and Atg21 in the cytoplasm to vacuole targeting pathway and autophagy. J Biol Chem. 2010 Feb 12. (Epub ahead of print)

Ninfa AJ. Use of two-component signal transduction systems in the construction of synthetic genetic networks. Curr Opin Microbiol. 2010 Feb 8. (Epub ahead of print)

Pai DA, Engelke DR. Spatial organization of genes as a component of regulated expression. Chromosoma. 2010 Feb; 119(1): 13-25.

Ramacciotti E, Hawley AE, Wrobleski SK, Myers DD Jr, Strahler JR, Andrews PC, Guire KE, Henke PK, Wakefield TW. Proteomics of microparticles after deep venous thrombosis. Thromb Res. 2010 Feb 13. (Epub ahead of print)

Robida AM, Kerppola TK. Bimolecular fluorescence complementation analysis of inducible protein interactions: effects of factors affecting protein folding on fluorescent protein fragment association. J Mol Biol. 2009 Dec 4; 394(3): 391-409.

Stelzer AC, Frazee RW, Van Huis C, Cleary J, Opipari AW Jr, Glick GD, Al-Hashimi HM. NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase. Biopolymers. 2010 Jan; 93(1): 85-92.

Strunk BS, Karbstein K. Powering through ribosome assembly. RNA. 2009 Dec; 15(12): 2083-104.

Vitvitsky V, Witcher M, Banerjee R, Thoene J. The redox status of cystinotic fibroblasts. Mol Genet Metab. 2009 Dec 21. (Epub ahead of print)

Yan Z, Banerjee R. Redox remodeling as an immunoregulatory strategy. Biochemistry. 2010 Feb 16; 49(6): 1059-66.

Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol. 2009 Dec 22. (Epub ahead of print)

Yates JA, Menon T, Thompson BA, Bochar DA. Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8. FEBS Lett. 2010 Feb 19; 584(4): 689-93.

Yen WL, Shintani T, Nair U, Cao Y, Richardson BC, Li Z, Hughson FM, Baba M, Klionsky DJ. The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy. J Cell Biol. 2010 Jan 11; 188(1): 101-14.

Zeng Z, Wang W, Yang Y, Chen Y, Yang X, Diehl JA, Liu X, Lei M. Structural Basis of Selective Ubiquitination of TRF1 by SCF(Fbx4). Dev Cell. 2010 Feb 16; 18(2): 214-225.

Zhang Y, Deng X, Scheller EL, Kwon TG, Lahann J, Franceschi RT, Krebsbach PH. The effects of Runx2 immobilization on poly (varepsilon-caprolactone) on osteoblast differentiation of bone marrow stromal cells in vitro. Biomaterials. 2010 Apr; 31(12): 3231-6.

Cell & Developmental Biology

Dumas KJ, Guo C, Wang X, Burkhart KB, Adams EJ, Alam H, Hu PJ. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Dev Biol. 2010 Feb 20. (Epub ahead of print)

Duan Y, Giger RJ. A New Role for RPTP{sigma} in Spinal Cord Injury: Signaling Chondroitin Sulfate Proteoglycan Inhibition. Sci Signal. 2010 Feb 23; 3(110): pe6.

Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J Biol Chem. 2010 Jan 1; 285(1): 80-94.

Hammond JW, Huang CF, Kaech S, Jacobson C, Banker G, Verhey KJ. Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons. Mol Biol Cell. 2010 Feb; 21(4): 572-83.

Maillard I, Hess JL. The role of menin in hematopoiesis. Adv Exp Med Biol. 2009; 668: 51-7.

Moore P, Bernardi KM, Tsai B. The Ero1{alpha}-PDI Redox Cycle Regulates Retro-Translocation of Cholera Toxin. Mol Biol Cell. 2010 Feb 3. (Epub ahead of print)

Yamashita YM. A tale of mother and daughter. Mol Biol Cell. 2010 Jan; 21(1): 7-8.

Yamashita YM. A new member of the spindle orientation club: mammalian intestinal stem cells. Cell Stem Cell. 2010 Feb 5; 6(2): 91-2.

Yamashita YM, Yuan H, Cheng J, Hunt AJ. Polarity in stem cell division: asymmetric stem cell division in tissue homeostasis. Cold Spring Harb Protoc. 2010 Jan; 2(1): a001313.

Human Genetics

Brewer GJ. Risks of Copper and Iron Toxicity during Aging in Humans. Chem Res Toxicol. 2010 Feb 15; 23(2): 319-26.

Chernin G, Heeringa SF, Vega-Warner V, Schoeb DS, Nürnberg P, Hildebrandt F. Adequate use of allele frequencies in Hispanics--a problem elucidated in nephrotic syndrome. Pediatr Nephrol. 2010 Feb; 25(2): 261-6.

Gao J, Tarcea VG, Karnovsky A, Mirel BR, Weymouth TE, Beecher CW, Cavalcoli JD, Athey BD, Omenn GS, Burant CF, Jagadish HV. Metscape: a Cytoscape plug-in for visualizing and interpreting metabolomic data in the context of human metabolic networks. Bioinformatics. 2010 Feb 7. (Epub ahead of print).

Khan AP, Poisson LM, Bhat VB, Fermin D, Zhao R, Kalyana-Sundaram S, Michailidis G, Nesvizhskii AI, Omenn GS, Chinnaiyan AM, Sreekumar A. Quantitative proteomic profiling of prostate cancer reveals a role for miR-128 in prostate cancer. Mol Cell Proteomics. 2010 Feb; 9(2): 298-312.

Louie CM, Caridi G, Lopes VS, Brancati F, Kispert A, Lancaster MA, Schlossman AM, Otto EA, Leitges M, Gröne HJ, Lopez I, Gudiseva HV, O'Toole JF, Vallespin E, Ayyagari R, Ayuso C, Cremers FP, den Hollander AI, Koenekoop RK, Dallapiccola B, Ghiggeri GM, Hildebrandt F, Valente EM, Williams DS, Gleeson JG. AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis. Nat Genet. 2010 Feb; 42(2): 175-80.

Sartor MA, Mahavisno V, Keshamouni VG, Cavalcoli J, Wright Z, Karnovsky A, Kuick R, Jagadish HV, Mirel B, Weymouth T, Athey B, Omenn GS. ConceptGen: a gene set enrichment and gene set relation mapping tool. Bioinformatics. 2010 Feb 15; 26(4): 456-63.

Schoeb DS, Chernin G, Heeringa SF, Matejas V, Held S, Vega-Warner V, Bockenhauer D, Vlangos CN, Moorani KN, Neuhaus TJ, Kari JA, Macdonald J, Saisawat P, Ashraf S, Ovunc B, Zenker M, Hildebrandt F; Members of the Gesselschaft für Paediatrische Nephrologie (GPN) Study Group. Nineteen novel NPHS1 mutations in a worldwide cohort of patients with congenital nephrotic syndrome (CNS). Nephrol Dial Transplant. 2010 Feb 18. (Epub ahead of print).

Stengård JH, Dyson G, Frikke-Schmidt R, Tybjærg-Hansen A, Nordestgaard BG, Sing CF. Context-Dependent Associations Between Variation in Risk of Ischemic Heart Disease and Variation in the 5' Promoter Region of the Apolipoprotein E Gene in Danish Women. Circ Cardiovasc Genet. 2010 Feb 1; 3(1): 22-30.

Van Hout CV, Levin AM, Rampersaud E, Shen H, O'Connell JR, Mitchell BD, Shuldiner AR, Douglas JA. Extent and distribution of linkage disequilibrium in the Old Order Amish. Genet Epidemiol. 2010 Feb; 34(2): 146-50.

Vilar E, Gruber SB. Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010 Feb 9. (Epub ahead of print).

Zaucke F, Boehnlein JM, Steffens S, Polishchuk RS, Rampoldi L, Fischer A, Pasch A, Boehm CW, Baasner A, Attanasio M, Hoppe B, Hopfer H, Beck BB, Sayer JA, Hildebrandt F, Wolf MT. Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary Uromodulin expression. Hum Mol Genet. 2010 Feb 18. (Epub ahead of print).

Internal Medicine

Infectious Diseases:
Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings SE, Rice JC, Saint S, Schaeffer AJ, Tambayh PA, Tenke P, Nicolle LE. Diagnosis, Prevention, and Treatment of Catheter-Associated Urinary Tract Infection in Adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis, 2010; 50(5): 625-663,.

Kaul DR, Taranto S, Alexander C, Covington S, Marvin M, Nowicki M, Orlowski J, Pancoska C, Pruett TL, Ison MG. HTLV Donor Screening Advisory Grp. Donor Screening for Human T-cell Lymphotrophic Virus 1/2: Changing Paradigms for Changing Testing Capacity. Am J Transplant. 2010; 10(2): 207-213.

Microbiology and Immunology

Antonoff MB, Swanson JA, Acton RD, Chipman JG, Maddaus MA, Schmitz CC, D'Cunha J. Improving Surgical Intern Confidence through the Implementation of Expanded Orientation Sessions. J Surg Res. 2010 Feb; 158(2): 248-9.

Carlson PE Jr, Dixon SD, Janes BK, Carr KA, Nusca TD, Anderson EC, Keene SE, Sherman DH, Hanna PC. Genetic analysis of petrobactin transport in Bacillus anthracis. Mol Microbiol. 2010 Jan 5. (Epub ahead of print)

Chang AT, Platt JL. The role of antibodies in transplantation. Transplant Rev (Orlando). 2009 Oct; 23(4): 191-8.

Chang KC, Lo CW, Fan TC, Chang MD, Shu CW, Chang CH, Chung CT, Fang SL, Chao CC, Tsai JJ, Lai YK. TNF-alpha Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells. BMC Cell Biol. 2010 Jan 20; 11(1): 6.

Chen F, He Y. Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus. PLoS One. 2009 Aug 28; 4(8): e6830.

Chukkapalli V, Oh SJ, Ono A. Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain. Proc Natl Acad Sci USA. 2010 Jan 4. (Epub ahead of print)

Franz DR, Ehrlich SA, Casadevall A, Imperiale MJ, Keim PS. The "nuclearization" of biology is a threat to health and security. Biosecur Bioterror. 2009 Sep; 7(3): 243-4.

Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, Håkansson K, Smith JL, Sherman DH. Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc. 2009 Nov 11; 131(44): 16033-5.

Luker KE, Gupta M, Steele JM, Foerster BR, Luker GD. Imaging ligand-dependent activation of CXCR7. Neoplasia. 2009 Oct; 11(10): 1022-35.

Luker KE, Luker GD. Real-time bioluminescence imaging of viral pathogenesis. Methods Mol Biol. 2009; 574: 125-35.

Meyer-Morse N, Robbins JR, Rae CS, Mochegova SN, Swanson MS, Zhao Z, Virgin HW, Portnoy D. Listeriolysin O is necessary and sufficient to induce autophagy during Listeria monocytogenes infection. PLoS One. 2010 Jan 6; 5(1): e8610.

Platt JL, Cascalho M, West L. Lessons from cardiac transplantation in infancy. Pediatr Transplant. 2009 Nov; 13(7): 814-9.

Raghavan M. TAP-inhibitors from old world primate 1-herpesviruses and their use: WO2009008713. Expert Opin Ther Pat. 2010 Feb; 20(2): 277-82.

Rizvi SM, Raghavan M. Mechanisms of Function of Tapasin, a Critical Major Histocompatibility Complex Class I Assembly Factor. Traffic. 2009 Dec 3. (Epub ahead of print)

Sivick KE, Schaller MA, Smith SN, Mobley HL. The Innate Immune Response to Uropathogenic Escherichia coli Involves IL-17A in a Murine Model of Urinary Tract Infection. J Immunol. 2010 Jan 18. (Epub ahead of print)

Sofi MH, Liu Z, Zhu L, Yu Q, Kaplan MH, Chang CH. Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol Immunol. 2010 Jan 15. (Epub ahead of print)

Swanson JA, Antonoff MB, D'Cunha J, Maddaus MA, Schmitz CC. Developing surgical leaders: assessing the personal and professional development needs of surgical residents. J Surg Res. 2010 Feb; 158(2): 247.

Weeks SA, Shield WP, Sahi C, Craig EA, Rospert S, Miller DJ. A targeted analysis of cellular chaperones reveals contrasting roles for heat shock protein 70 in flock house virus RNA replication. J Virol. 2010 Jan; 84(1): 330-9.

Whitfield NN, Byrne BG, Swanson MS. Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis. Infect Immun. 2010 Jan; 78(1): 423-32.


Kron MM, Zhang H, Parent JM. The developmental stage of dentate granule cells dictates their contribution to seizure-induced plasticity. J Neurosci. 2010 Feb 10; 30(6): 2051-9.

Van Deerlin VM, Sleiman PMA, Martinez-Lage M, Chen-Plotkin A, Wang L-S, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DMA, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Randall L, Woltjer RL, Bigio EH, Mesulam M, al-Sarraj S, Troakes C, Rosenberg RN, White III CL, Ferrer I, Lladó A , Neumann M , Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, Lopez de Munain A, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IRA, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J , Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JPG, Troncoso JC , Kril JJ, Kwok JBK, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SM, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Thomas G. Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Caballero Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Virginia M.-Y. Lee VM-Y. Common genetic variants at 7p21 show strong association with frontotemporal lobar degeneration with TDP-43 inclusions. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet. 2010 Mar; 42(3): 234-9.


Al-Holou WN, Maher CO, Muraszko KM, Garton HJ. The natural history of pineal cysts in children and young adults. J Neurosurg Pediatr. 2010 Feb; 5(2): 162-6.

Al-Holou WN, Park P, Wang AC, Than KD, Marentette LJ. Modified trans-oral approach with an inferiorly based flap. J Clin Neurosci. 2010 Feb 16. (Epub ahead of print)

Bowerson M, Nelson VS, Yang LJ. Diaphragmatic paralysis associated with neonatal brachial plexus palsy. Pediatr Neurol. 2010 Mar; 42(3): 234-236.

Obstetrics & Gynecology

Burke LM, Kalpakjian CZ, Smith YR, Quint EH. Gynecologic Issues of Adolescents with Down Syndrome, Autism, and Cerebral Palsy. J Pediatr Adolesc Gynecol. 2010 Feb; 23(1): 11-15.

Liang J, Quiñones AR, Bennett JM, Ye W, Xu X, Shaw BA, Ofstedal MB. Evolving Self-Rated Health in Middle and Old Age: How Does It Differ Across Black, Hispanic, and White Americans? J Aging Health 2010; 22(1): 3-26.

McCarthy JD, Erickson KM, Smith YR, Quint EH. Premenarchal Ovarian Torsion and Elevated CA-125. J Pediatr Adolesc Gynecol. 2010 Feb; 23(1): e47-e50.

Mozurkewich E, Berman DR, Chilimigras J. Role of omega-3 fatty acids in maternal, fetal, infant and child wellbeing. Expert Review Obstet Gynecol, 2010; 5(1): 125-138.

Oakes MB, Beck S, Smith YR, Quint EH, Park JM. Augmentation Vaginoplasty of Colonic Neovagina Stricture Using Oral Mucosa Graft. J Pediatr Adolesc Gynecol. 2010 Feb; 23(1): e39-e42.

Oakes MB, Hussain HK, Smith YR, Quint EH. Concomitant resorptive defects of the reproductive tract: a uterocervicovaginal septum and imperforate hymen. Fertil Steril. 2010 Jan; 93(1): 268.e3-5.

Xu X, Ivy JS, Patel DA, Patel SN, Smith DG, Ransom SB, Fenner D, DeLancey JOL. Pelvic Floor Consequences of Cesarean Delivery on Maternal Request in Women with a Single Birth: A Cost-Effectiveness Analysis. J Women’s Health 2010; 19(1): 147-160.

Ophthalmology & Visual Sciences

Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA. AP-2{alpha} Knockout Mice Exhibit Optic Cup Patterning Defects and Failure of Optic Stalk Morphogenesis. Hum Mol Genet 2010 (Epub ahead of print).

Cornblath WT. Pearls: visual loss. Semin Neurol 2010; 30(1): 44-50.

Garton HJ, Gebarski SS, Ahmad O, Trobe JD. Clival epidural hematoma in traumatic sixth cranial nerve palsies combined with cervical injuries. J Neuroophthalmol 2010; 30(1): 18-25.

Jayasundera T, Rhoades W, Branham K, Niziol LM, Musch DC, Heckenlively JR. Peripapillary Dark Choroid Ring as a Helpful Diagnostic Sign in Advanced Stargardt Disease. Am J Ophthalmol 2010 (Epub ahead of print).

Johnson MW. Posterior Vitreous Detachment: Evolution and Complications of Its Early Stages. Am J Ophthalmol 2010; 149(3): 371-82 e1.

Murga-Zamalloa CA, Swaroop A, Khanna H. RPGR-containing protein complexes in syndromic and non-syndromic retinal degeneration due to ciliary dysfunction. J Genet 2009; 88(4): 399-407.

O'Toole JF, Liu Y, Davis EE, Westlake CJ, Attanasio M, Otto EA, Seelow D, Nurnberg G, Becker C, Nuutinen M, Karppa M, Ignatius J, Uusimaa J, Pakanen S, Jaakkola E, van den Heuvel LP, Fehrenbach H, Wiggins R, Goyal M, Zhou W, Wolf MT, Wise E, Helou J, Allen SJ, Murga-Zamalloa CA, Ashraf S, Chaki M, Heeringa S, Chernin G, Hoskins BE, Chaib H, Gleeson J, Kusakabe T, Suzuki T, Isaac RE, Quarmby LM, Tennant B, Fujioka H, Tuominen H, Hassinen I, Lohi H, van Houten JL, Rotig A, Sayer JA, Rolinski B, Freisinger P, Madhavan SM, Herzer M, Madignier F, Prokisch H, Nurnberg P, Jackson P, Khanna H, Katsanis N, Hildebrandt F. Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest 2010 (Epub ahead of print).

Parmar H, Trobe JD. A "First Cut" at Interpreting Brain MRI Signal Intensities: What's White, What's Black, and What's Gray. J Neuroophthalmol 2010; 30(1): 91-3.

Stein JD, Newman-Casey PA, Niziol LM, Gillespie BW, Lichter PR, Musch DC. Association between the use of glaucoma medications and mortality. Arch Ophthalmol 2010; 128(2): 235-40.

Trobe JD. The evaluation of horner syndrome. J Neuroophthalmol 2010; 30(1): 1-2.

Trobe JD. The Way We've Been: The Journal of Neuro-Ophthalmology, 2001-2010. J Neuroophthalmol 2010; 30(1): 3-4.

Zacks DN. Gene transcription profile of the detached retina (An AOS Thesis). Trans Am Ophthalmol Soc 2009; 107: 343-82.

Orthopaedic Surgery

Aslam MN, Kreider JM, Paruchuri T, Bhagavathula N, Dasilva M, Zernicke RF, Goldstein SA, Varani J. A Mineral-Rich Extract from the Red Marine Algae Lithothamnion calcareum Preserves Bone Structure and Function in Female Mice on a Western-Style Diet. Calcif Tissue Int. 2010 Feb 24. (Epub ahead of print)

Chang PC, Seol YJ, Cirelli JA, Pellegrini G, Jin Q, Franco LM, Goldstein SA, Chandler LA, Sosnowski B, Giannobile WV. PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration. Gene Ther. 2010 Jan; 17(1): 95-104.

Daley E, Streeten EA, Sorkin JD, Kuznetsova N, Shapses SA, Carleton SM, Shuldiner AR, Marini JC, Phillips CL, Goldstein SA, Leikin S, McBride D: Variable bone fragility associated with an Amish COLIA2 variant and a knock-in mouse model. J Bone Miner Res. 2010 25(2): 247-261.

Vander Have KL, Ganley TJ, Kocher MS, Price CT, Herrera-Soto JA. Arthrofibrosis after Surgical Fixation of Tibial Eminence Fractures in Children and Adolescents. Am J Sports Med. 2010; 38(2): 298-301.

Pediatrics & Communicable Diseases

Attar MA, Dechert RE Becker MA, Donn SM. Variability in the Response to Dexamethasone Treatment in Term Neonates with Respiratory Failure. Archives of Medical Science, 2009, 5: 427-433.

Barks JD, Liu YQ, Shangguan Y, Silverstein FS. Phenobarbital Augments Hypothermic Neuroprotection. Pediatr Res. 2010 Jan 21 (Epub ahead of print)

Birkhead GS, Almquist JR, Clover RD, Dekker C, Feinberg M, Fergie J, Gordon LK, Humiston SG, Jackson LA, Lovell C Jr, Mason JO, McCormick M, Nevin-Woods C, Parnell T, Pavia A, Riley LE, Birkhead GS, Abramson JS, Almquist JR, Coleman MS, Edwards B, Feinberg M, Freed GL, Gellin B, Gordon LK, Greenbaum E, Haddix AC, Hinman AR, Johnson CB, Kelman J, Klein JO, Lindley MC, Orenstein WA, Pauly M, Pisani AA, Rodewald LE, Rosenberg A, Salesa J, Shen AK, Wallace G, Wilson JJ, Wisniewski AC. (National Vaccine Advisory Committee) Financing Vaccination of Children and Adolescents: National Vaccine Advisory Committee Recommendations. Pediatrics. 2009 Dec; 124 Suppl 5: S558-62.

Choi SW, Levine JE, Ferrara JL. Pathogenesis and Management of Graft-Versus-Host-Disease. Immunol Allergy Clin North Am. 2010 Feb; 30(1): 75-101.

Davis MM, Butchart AT, Coleman MS, Singer DC, Wheeler JR, Pok A, Freed GL. The Expanding Vaccine Development Pipeline, 1995-2008. Vaccine. 2010 Feb 3; 28(5): 1353-6.

Dillman JR, Dorfman AL, Attili AK, Agarwal PP, Bell A, Mueller GC, Hernandez RJ. Cardiovascular Magnetic Resonance Imaging of Hypoplastic Left Heart Syndrome in Children. Pediatr Radiol. 2010 Jan 27 (Epub ahead of print)

Freed GL, Dunham KM; the Research Advisory Committee of the American Board of Pediatrics. All Primary Care Trainees are not the Same: The Role of Economic Factors and Career Choice. Pediatrics. 2010 Feb 1 (Epub ahead of print)

Freed GL, Dunham KM, Clark SJ, Davis MM. Perspectives and preferences among the general public regarding physician selection and board certification. J Pediatr. 2010 Feb 4 (Epub ahead of print)

Freed GL, Dunham KM, Lamarand KE; Permanent Pediatric Diplomate Awareness of and Perspectives on Maintenance of Certification. J Pediatr. 2009 Dec; 155(6): 919-923.e1.

Hashish M, Raghavan S, Somara S, Gilmont RR, Miyasaka E, Bitar KN, Teitelbaum DH. Surgical Implantation of a Bioengineered Internal Anal Sphincter. J Pediatr Surg. 2010 Jan; 45(1): 52-8.

Houle CR, Caldwell CH, Conrad FG, Joiner TA, Parker EA, Clark NM. Blowing the Whistle: What do African American Adolescents With Asthma and Their Caregivers Understand by “Wheeze”? J Asthma. 2010 Feb; 47(1): 26-32.

Kato K, Cui S, Kuick R, Mineishi S, Hexner E, Ferrara JL, Emerson SG, Zhang Y. Identification of Stem Cell Transcriptional Programs Normally Expressed in Embryonic and Neural Stem Cells in Alloreactive CD8 (+) T Cells Mediating Graft-Versus-Host-Disease. Biol Blood Marrow Transplant 2010 Jan 27 (Epub ahead of print)

Knepp MD, Rocchini AP, Lloyd TR, Aiyagari RM. Long-Term Follow up of Secundum Atrial Septal Defect Closure with the Amplatzer Septal Occluder. Congenit Heart Dis. 2010 Jan; 5(1): 32-7.

Lancaster CA, Flynn HA, Johnson TR, Marcus SM, Davis MM. Peripartum Length of Stay for Women With Depressive Symptoms During Pregnancy. J Women’s Health (Larchmt). 2010 Jan; 19(1): 31-7.

Lancaster CA, Gold KJ, Flynn HA, Yoo H, Marcus SM, Davis MM. Risk Factors for Depressive Symptoms During Pregnancy: A Systematic Review. Am J Obstet Gynecol. 2010 Jan; 202(1): 5-14.

Prosser LA, Kong CY, Rusinak D, Waisbren SL. Projected Costs, Risks and Benefits of Expanded Newborn Screening for MCADD. Pediatrics. 2010 Feb; 125(2): e286-94.

Schilling PL, Campbell DA Jr, Englesbe MJ, Davis MM. A Comparison of In-Hospital Mortality Risk Conferred by High Hospital Occupancy, Differences in Nurse Staffing Levels, Weekend Admission and Seasonal Influenza. Med Care 2010 Feb 17 (Epub ahead of print)

Schwan WR, Dunek C, Gebhardt M, Engelbrecht K, Klett T, Monte A, Toce J, Rott M, Volk TJ, LiPuma JJ, Liu XT, McKelvey R. Screening Mushroom Extract Library for Activity Against Acinetobacter Baumannii and Burkholderia Cepacia and the Identification of a Compound With anti-Burkholderia Activity. Ann Clin Microbiol Antimicrob 2010 Jan 21; 9(1): 4 (Epub ahead of print)

Silva IA, Olkiewicz K, Askew D, Fisher JM, Chaudhary MN, Vannella KM, Deurloo DT, Choi SW, Pierce E, Clouthier SG, Liu C, Cooke KR. Secondary Lymphoid Organs Contribute to, but are not Required for the Induction of Graft-Versus-Host Responses Following Allogenic Bone Marrow Transplantation: A Shifting Paradigm for T-cell Allo-Activation. Biol Blood Marrow Transplant 2010 Jan 28 (Epub ahead of print)

Singer K, Rosenthal A, Kasa-Vubu JZ. Elevated Testosterone and Hypergonadotropism in Active Adolescents of Normal Weight With Oligomenorrhea. J pediatr Adolesc Gynecol 2009 Oct; 22(5): 323-7.


Abelson JL, Khan S, Young EA, Liberzon I. Cognitive modulation of endocrine responses to CRH stimulation in healthy subjects. Psychoneuroendocrinology. 2010 Apr; 35(3): 451-459.

Arnold PD, Hanna GL, Rosenberg DR. Imaging the amygdala: changing the face of gene discovery in child psychiatry (editorial). J Am Acad Child Adolesc Psychiatry 49: 7-10, 2010.

Brower KJ, Perron BE. Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances. Med Hypotheses. 2009 Nov 10. (Epub ahead of print)

Cruz M, Pincus HA, Welsh DE, Greenwald D, Lasky E, Kilbourne AM. The relationship between religious involvement and clinical status of patients with bipolar disorder. Bipolar Disord. 2010 Feb; 12(1): 68-76.

Cunningham RM, Walton MA, Goldstein A, Chermack ST, Shope JT, Bingham CR, Zimmerman MA, Blow FC. Three-month follow-up of brief computerized and therapist interventions for alcohol and violence among teens. Acad Emerg Med. 2009 Nov; 16(11): 1193-207.

Duffy SA, Scholten RL, Karvonen-Gutierrez CA. The relation of tobacco use during hospitalization to post-discharge smoking cessation among US veterans. Prev Med. 2010 Feb 1. (Epub ahead of print)

Goldman B, Dixon LB, Adler DA, Berlant J, Dulit RA, Hackman A, Oslin DW, Siris SG, Valenstein M. Rational protection of subjects in research and quality improvement activities. Psychiatr Serv. 2010 Feb; 61(2): 180-3.

Kilbourne AM, Fullerton C, Dausey D, Pincus HA, Hermann RC. A framework for measuring quality and promoting accountability across silos: the case of mental disorders and co-occurring conditions. Qual Saf Health Care. 2010 Feb 8. (Epub ahead of print)

Lin JC, Karno MP, Tang L, Barry KL, Blow FC, Davis JW, Ramirez KD, Welgreen S, Hoffing M, Moore AA. Do Health Educator Telephone Calls Reduce At-risk Drinking Among Older Adults in Primary Care? J Gen Intern Med. 2010 Jan 26. (Epub ahead of print)

Loh K, Walton MA, Harrison SR, Zimmerman M, Stanley R, Chermack ST, Cunningham RM. Prevalence and correlates of handgun access among adolescents seeking care in an urban emergency department. Accid Anal Prev. 2010 Mar; 42(2): 347-353.

Dhawan N, Kunik ME, Oldham J, Coverdale J. Prevalence and treatment of narcissistic personality disorder in the community: a systematic review. In Press Corrected Proof , Available online 21 December 2009. Comprehensive Psychiatry. DOI: 10.1016/j.comppsych.2009.09.003.

Pfeiffer PN, Szymanski B, Dhawan N, Difranco D, Valenstein M, Zivin K. Is there an "unhealthy volunteer effect" in mental health outpatient research? Psychiatry Res. 2010 Jan 30. (Epub ahead of print)

Stearns SC, Nesse RM, Govindaraju DR et al. Evolutionary perspectives on health and medicine. Proceedings of the National Academy of Sciences 2010; 107 (suppl 1): 1691-5.

Stearns SC, Nesse RM, Govindaraju DR et al., editors. Evolutionary perspectives on health and medicine; Proceedings of the National Academy of Sciences 2010; 107 (suppl 1): 1691-1808.

Villafuerte SM, Vallabhaneni K, Sliwerska E, McMahon FJ, Young EA, Burmeister M. SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. Psychiatr Genet. 2009 Dec; 19(6): 281-91.

Wojnar J, Brower KJ, Dopp R, Wojnar M, Emslie G, Rintelmann J, Hoffmann RF, Armitage R. Sleep and body mass index in depressed children and healthy controls. Sleep Med. 2010 Feb 4. (Epub ahead of print)

Zivin K, Madden JM, Graves AJ, Zhang F, Soumerai SB. Cost-related medication nonadherence among beneficiaries with depression following Medicare Part D. Am J Geriatr Psychiatry. 2009 Dec; 17(12): 1068-76.

Radiation Oncology

Azu M, Abrahamse P, Katz SJ, Jagsi R, Morrow M. What is an adequate margin for breast-conserving surgery? Surgeon attitudes and correlates. Ann Surg Oncol. 2010 Feb; 17(2): 558-63.

Beroukhim R, Mermel CH, Porter D, Wei G, Raychaudhuri S, Donovan J, Barretina J, Boehm JS, Dobson J, Urashima M, Mc Henry KT, Pinchback RM, Ligon AH, Cho YJ, Haery L, Greulich H, Reich M, Winckler W, Lawrence MS, Weir BA, Tanaka KE, Chiang DY, Bass AJ, Loo A, Hoffman C, Prensner J, Liefeld T, Gao Q, Yecies D, Signoretti S, Maher E, Kaye FJ, Sasaki H, Tepper JE, Fletcher JA, Tabernero J, Baselga J, Tsao MS, Demichelis F, Rubin MA, Janne PA, Daly MJ, Nucera C, Levine RL, Ebert BL, Gabriel S, Rustgi AK, Antonescu CR, Ladanyi M, Letai A, Garraway LA, Loda M, Beer DG, True LD, Okamoto A, Pomeroy SL, Singer S, Golub TR, Lander ES, Getz G, Sellers WR, Meyerson M. The landscape of somatic copy-number alteration across human cancers. Nature. 2010 Feb 18; 463(7283): 899-905.

Bodenreider C, Beer D, Keller TH, Sonntag S, Wen D, Yap L, Yau YH, Shochat SG, Huang D, Zhou T, Caflisch A, Su XC, Ozawa K, Otting G, Vasudevan SG, Lescar J, Lim SP. A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease. Anal Biochem. 2009 Dec 15; 395(2): 195-204.

Boonstra JJ, van Marion R, Beer DG, Lin L, Chaves P, Ribeiro C, Pereira AD, Roque L, Darnton SJ, Altorki NK, Schrump DS, Klimstra DS, Tang LH, Eshleman JR, Alvarez H, Shimada Y, van Dekken H, Tilanus HW, Dinjens WN. Verification and unmasking of widely used human esophageal adenocarcinoma cell lines. J Natl Cancer Inst. 2010 Feb 24; 102(4): 271-4.

Desai S, Ben-Josef E, Griffith KA, Simeone D, Greenson JK, Francis IR, Hampton J, Colletti L, Chang AE, Lawrence TS, Zalupski MM. Gemcitabine-based combination chemotherapy followed by radiation with capecitabine as adjuvant therapy for resected pancreas cancer. Int J Radiat Oncol Biol Phys. 2009 Dec 1; 75(5): 1450-5.

DeSano JT, Xu L. MicroRNA regulation of cancer stem cells and therapeutic implications. AAPS J. 2009 Dec; 11(4): 682-92.

Dijkema T, Raaijmakers CP, Ten Haken RK, Roesink JM, Braam PM, Houweling AC, Moerland MA, Eisbruch A, Terhaard CH. Parotid Gland Function After Radiotherapy: The Combined Michigan and Utrecht Experience. Int J Radiat Oncol Biol Phys. 2010 Jan 5. (Epub ahead of print)

Divi V, Worden FP, Prince ME, Eisbruch A, Lee JS, Bradford CR, Chepeha DB, Teknos TN, Hogikyan ND, Moyer JS, Tsien CI, Urba SG, Wolf GT. Chemotherapy alone for organ preservation in advanced laryngeal cancer. Head Neck. 2009 Dec 1. (Epub ahead of print)

Fairchild A, Barnes E, Ghosh S, Ben-Josef E, Roos D, Hartsell W, Holt T, Wu J, Janjan N, Chow E. International patterns of practice in palliative radiotherapy for painful bone metastases: evidence-based practice? Int J Radiat Oncol Biol Phys. 2009 Dec 1; 75(5): 1501-10.

Galbán CJ, Bhojani MS, Lee KC, Meyer CR, Van Dort ME, Kuszpit KK, Koeppe RA, Ranga R, Moffat BA, Johnson TD, Chenevert TL, Rehemtulla A, Ross BD. Evaluation of Treatment-Associated Inflammatory Response on Diffusion-Weighted Magnetic Resonance Imaging and 2-[18F]-Fluoro-2-Deoxy-D-Glucose-Positron Emission Tomography Imaging Biomarkers. Clin Cancer Res. 2010 Feb 16. (Epub ahead of print)

Gong Z, Holly EA, Wang F, Chan JM, Bracci PM. Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area. Int J Cancer. 2010 Jan 26. (Epub ahead of print)

Herawi M, Drew PA, Pan CC, Epstein JI. Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma. Hum Pathol.2010 Jan 6. (Epub ahead of print)

Houweling AC, Philippens ME, Dijkema T, Roesink JM, Terhaard CH, Schilstra C, Ten Haken RK, Eisbruch A, Raaijmakers CP. A Comparison of Dose-response Models for the Parotid Gland in a Large Group of Head-and-neck Cancer Patients. Int J Radiat Oncol Biol Phys. . (Epub ahead of print)

Jabbari S, Weinberg VK, Shinohara K, Speight JL, Gottschalk AR, Hsu IC, Pickett B, McLaughlin PW, Sandler HM, Roach M 3rd. Equivalent biochemical control and improved prostate-specific antigen nadir after permanent prostate seed implant brachytherapy versus high-dose three-dimensional conformal radiotherapy and high-dose conformal proton beam radiotherapy boost. Int J Radiat Oncol Biol Phys. 2010 Jan 1; 76(1): 36-42.

Jagsi R, Ben-David MA, Moran JM, Marsh RB, Griffith KA, Hayman JA, Pierce LJ. Unacceptable cosmesis in a protocol investigating intensity-modulated radiotherapy with active breathing control for accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys. 2010 Jan 1; 76(1): 71-8.

Jagsi R, Motomura AR, Griffith KA, Rangarajan S, Ubel PA. Sex differences in attainment of independent funding by career development awardees. Ann Intern Med. 2009 Dec 1; 151(11): 804-11.

Katz MS, Carroll PR, Cowan JE, Chan JM, D'Amico AV. Association of statin and nonsteroidal anti-inflammatory drug use with prostate cancer outcomes: results from CaPSURE. BJU Int. 2010 Feb 11. (Epub ahead of print)

Katz SJ, Hawley ST, Morrow M, Griggs JJ, Jagsi R, Hamilton AS, Graff JJ, Friese CR, Hofer TP. Coordinating cancer care: patient and practice management processes among surgeons who treat breast cancer. Med Care. 2010 Jan; 48(1): 45-51.

King AN, Beer DG, Christensen PJ, Simpson RU, Ramnath N. The Vitamin D/CYP24A1 Story in Cancer. Anticancer Agents Med Chem. 2010 Feb 25. (Epub ahead of print)

King JC, Lawrence TS, Murphy SB, Davidson NE, Mayer RJ. The American Society of Clinical Oncology Cancer Foundation Grants Program: A 25-Year Report and a Look Toward the Future. J Clin Oncol. 2010 Feb 22. (Epub ahead of print)

Kwee TC, Galbán CJ, Tsien C, Junck L, Sundgren PC, Ivancevic MK, Johnson TD, Meyer CR, Rehemtulla A, Ross BD, Chenevert TL. Comparison of apparent diffusion coefficients and distributed diffusion coefficients in high-grade gliomas. J Magn Reson Imaging. 2010 Feb 25; 31(3): 531-537. (Epub ahead of print)

Kwee TC, Galbán CJ, Tsien C, Junck L, Sundgren PC, Ivancevic MK, Johnson TD, Meyer CR, Rehemtulla A, Ross BD, Chenevert TL. Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas. NMR Biomed. 2010 Feb; 23(2): 179-87.

Maxwell JH, Kumar B, Feng FY, Worden FP, Lee JS, Eisbruch A, Wolf GT, Prince ME, Moyer JS, Teknos TN, Chepeha DB, McHugh JB, Urba SG, Stoerker J, Walline HM, Kurnit DM, Cordell KG, Davis SJ, Ward PD, Bradford CR, Carey TE. Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res. 2010 Feb 15; 16(4): 1226-35.

McLaughlin PW, Evans C, Feng M, Narayana V. Radiographic and anatomic basis for prostate contouring errors and methods to improve prostate contouring accuracy. Int J Radiat Oncol Biol Phys. 2010 Feb 1; 76(2): 369-78.

Popovtzer A, Cao Y, Feng FY, Eisbruch A. Anatomical changes in the pharyngeal constrictors after chemo-irradiation of head and neck cancer and their dose-effect relationships: MRI-based study. Radiother Oncol. 2009 Dec; 93(3): 510-5.

Rehemtulla A. The War on Cancer rages on. Neoplasia. 2009 Dec; 11(12): 1252-63.

Richman EL, Stampfer MJ, Paciorek A, Broering JM, Carroll PR, Chan JM. Intakes of meat, fish, poultry, and eggs and risk of prostate cancer progression1,2. Am J Clin Nutr. 2010 Mar; 91(3): 712-21.

Shih CM, Huang CT, Chi CH, Lin JW, Pan CC. CA125-producing Clear Cell Adenocarcinoma Arising From the Upper Ureter and Renal Pelvis. J Chin Med Assoc. 2010 Jan; 73(1): 40-3.