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FEBRUARY 2010, Vol. 28


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HEADLINES

Workshop – "The Nuts & Bolts of Building a Research Billing Calendar"

The Clinical Research Calendar Review & Analysis Office (CR2AO) – formerly known as CRBU – cordially invites you to join us for a workshop where you can learn why the Billing Calendar is required and valuable to the PI / study team, how to complete the calendar, and where to go for assistance in building a completed Billing Calendar. Gina Vuocolo-Branch, Senior Manager of the CR2AO, will present (45 min) and then hold a Q&A session (30 min).

The same workshop will be offered three different times:

Thursday, February 18, 2010
2:00 - 3:15 PM
Ford Auditorium

Tuesday, February 23, 2010
10:00 - 11:15 AM
BSRB Auditorium

Wednesday, February 24, 2010
1:00 - 2:15 PM
BSRB Auditorium

The workshop will be videotaped – so if you’re unable to attend a live session, you can register to receive a link to the video when it’s available. (All those who attend a live session will automatically get the email alert.) To attend a live session – or to receive an email alert when the video is online – please register online.

This workshop is just one of several improvements being made by the CR2AO (which is a part of the Medical School Office of Research) to enhance our clinical research support services. The Health System just signed an agreement with eThority to provide a robust clinical trials software application, including budgeting, billing calendar, and patient enrollment capabilities. We expect to share more information very soon about how and when this application will be rolled out . Stay tuned!

Contact Kathryn Ridner at (kridner@umich.edu) or 734-763-4086 with any questions about the workshop.

Call for Pediatric Medical Device Ideas

The Medical Innovation Center can help you advance your pediatric medical device to commercialization by:

  • helping you find a collaborator (engineering, clinical, business)
  • designing a prototype
  • establishing the regulatory path
  • establishing the reimbursement path
  • assessing intellectual property
  • determining the most viable commercial path
  • finding funding for all of the above
  • project management for all of the above

Contact us at (UM-MIC@med.umich.edu) to start the process. Visit our website at (http://www.med.umich.edu/ummic).

MIC Logo
MICHR to Support Destination Programs /
Barnett Named Program Manager
Shari Barnett

The Michigan Institute for Clinical & Health Research (MICHR), led by Ken Pienta, M.D., will offer their programs, services, and overall research expertise in support the Destination Programs.

"Clinical and translational research is a key component of each destination program, and crucial to our ability to continue to offer unique, cutting-edge care," said Jim Montie, M.D., Destination Program Faculty Director. "MICHR can support the research needs of Destination Programs at a lower cost and higher quality than the programs could achieve working in isolation. MICHR's mission to 'enable and enhance clinical and translational research, and to make U-M a world leader in translating scientific discoveries into real health gains' is a perfect fit for helping make the Destination Programs successful developing system-wide improvements with scalability and efficiency." In support of this integrated model, the Faculty Group Practice Board recently approved $1.5M annually for three years for MICHR to extend its support to the DPs.

Additionally, Shari Barnett has been named to the new position of Assistant Managing Director, Destination Programs. Shari has been a program manager with MICHR for the past 10 years. Most recently, she served in the role of Assistant Managing Director for MICHR's Education, Career Development, and Mentoring program. Shari has a great deal of project management experience to help achieve the goals of developing an ideal patient care experience, improve our support of clinical research, and enhance the reputation of the University locally, nationally, and globally.


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Animal Research

AAALAC, One Year Away and Counting…

The Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) will be visiting the University of Michigan for the comprehensive tri-annual review in the first quarter of 2011. Every aspect of the University’s animal care and use program will be thoroughly examined to ensure compliance with University and Federal guidelines/laws. The AAALAC team of site visitors will also be focusing on some of the changes we have incorporated since the 2008 visit, including post-operative records and tumor monitoring records that now must be kept in the animal rooms. During the visit, the AAALAC site visitors will be visiting all animal use areas including laboratory spaces and animal facilities. Therefore, please ensure that your protocol is up to date with all applicable locations where your animals are used and procedures are performed. If any changes need to be made, please submit them as soon as possible. If you have any questions about the new procedures or policies, please feel free to contact the UCUCA Office at (UCUCA.Office@umich.edu) or 734-763-8028.

eResearch Animal Management (eRAM) System

Information Technology Services (ITS), the University Committee on Use and Care of Animals (UCUCA) office, and the Unit for Laboratory Animal Medicine (ULAM) are working together to design and develop the eResearch Animal Management (eRAM) system. This is a new web-based system being developed that accommodates the electronic management of UCUCA animal use research protocols and the associated ordering, census, and invoicing of animals for ULAM. The new system will replace eSirius and is expected to be available to users in the fall/winter of 2010 for the online application portion of the program. We are also soliciting input from our largest users, the research community! If you are interested in providing your feedback, you can sign up to be a volunteer to test the system by emailing (eram.contact@umich.edu). To keep up with our progress, please visit (http://eresearch.umich.edu) and click on the section for “Animal Management.”

New Resource Guide – Literature Searches for Alternatives

The literature search for alternatives is a component of applications for vertebrate animal use in research, teaching, or testing protocols submitted to the University Committee on Use and Care of Animals (UCUCA) for approval. The Health Sciences Library (HSL) has published a new resource guide to aid investigators in their alternatives literature searches. Available at (http://guides.lib.umich.edu/ucuca), the resource guide provides links to relevant bibliographic and scientific databases, sample PubMed terms and search strategies, and links to information about the Animal Welfare Act and the 3 Rs of humane experimental technique: Reduction, Refinement, and Replacement. The guide was created and is maintained by Marisa Conte, the Clinical and Translational Science Liaison at the HSL. For assistance with an alternatives literature search, contact Marisa at 734-615-8889 or (meese@umich.edu).


EDUCATIONAL OPPORTUNITIES


Using EndNote for Grant Writing

Thursday, February 25, 2010
10:00 - 11:30 AM

EndNote can help you in tackling the many hurdles of writing a grant. The program can help you in formatting references according to the grant instructions for the initial funding application, the annual progress reports, and the biosketches. Register online.

45th Graduate Summer Session in Epidemiology
Application Deadline: June 1, 2010

(Applications received by the deadline does not guarantee placement in a course. Enrollment is limited in a number of courses.)

The University of Michigan School of Public Health will offer one-week and three-week courses for all public health professionals and those interested in health research during their 45th Graduate Summer Session in Epidemiology to take place July 11-30, 2010. Topics include: Fundamentals of Biostatistics and Epidemiology, Intermediate Methods, Infectious Diseases, Applied Public Health Practice, Cancer Epidemiology, Clinical Trials, SAS, Logistic Model, Linear Regression, Survival Analysis, Behavioral Change, Social Epidemiology, Longitudinal Studies, Global Health, Pharmacoepidemiology, Surveillance, Multi-level Analysis in Public Health, Scientific Writing, Geographic Information Systems, Health Policy, Community-Based Research, Injury and Violence, Evolutionary Epidemiology.

  • Distance Learning Courses:
    • Fundamentals in Biostatistics
    • Fundamentals of Epidemiology
  • CME credit available

For application and information, visit (http://www.sph.umich.edu/epid/GSS). For questions, contact Jody Gray at 734-764-5454 or (umichgss@umich.edu).


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains a link to M-Quest (a database of opportunities for grants, honors, prizes and fellowships created and maintained by the Office of Research) as well as information on email alert groups.


Internal Submissions

UM Multidisciplinary Aortic Program (MAP) Fellowship
Deadline: March 1, 2010

The University of Michigan Cardiovascular Center is seeking qualified individuals to fill an open position beginning July 1, 2010 in its Aortic Research Fellowship Program. This one-year fellowship is intended to stimulate either basic science or clinical research in aortic disease.

The Multidisciplinary Aortic Program is a collaboration among the Departments of Surgery, Medicine and Radiology. It exemplifies the Cardiovascular Center and its goal of collaboration with physicians and nurse practitioners from multiple specialties seeing patients in a single visit to the University of Michigan. Each trainee will have a primary mentor and a secondary mentor. There is a wide range of expertise in the mentors and multiple departments are represented including Surgery, Internal Medicine, Radiology, Pathology, Human Genetics, Bioengineering, and the Unit for Laboratory Animal Medicine.

Candidates must hold an M.D. or Ph.D. degree and be citizens of the United States or foreign nationals with permanent residence. For application instructions, please visit the website (http://www.med.umich.edu/cvc/health_profs/map.htm). Contact Tom Draper (tdraper@umich.edu) with any questions about this program.

Life Sciences Institute Center for Chemical Genomics (CCG) Funding to Support Translational Research
Deadline: March 2, 2010

Through a partnership with the Michigan Institute for Clinical & Health Research (MICHR) and the Life Sciences Institute (LSI), funding is currently available to support high-throughput screening projects using the CCG's chemical, natural product extract collection and RNAi libraries. Of particular interest are projects that encompass novel or innovative targets, biomarkers or platforms that have the potential to increase our understanding of disease at the molecular and cellular levels. Applications related to metabolic disease are especially welcome. Funding is limited. For more information, download the Request for Proposals and other forms.

UM Henry Russel Lectureship
Deadline: March 29, 2010

Considered one of the University’s highest honors for a senior member of its active faculty, the Henry Russel Lectureship is awarded annually in recognition of exceptional achievements in research, scholarship and/or creative endeavors, and an outstanding record of teaching, mentoring and service. One award of $2,000 will be made annually. In addition, the recipient will be invited to deliver the Henry Russel Lecture.

Senior faculty with the rank of professor may be nominated for the Henry Russel Lectureship. Nominees must be active members of the faculty both at the time of nomination and at the time of delivering the Russel Lecture. (Departments nominating faculty who are close to retirement may wish to consider Distinguished Faculty Achievement Awards as an alternative way of seeking recognition for the faculty member's achievements and contributions.) Departments and programs are encouraged to nominate women, minorities, and members of other groups historically underrepresented in their disciplines. For full details, visit (http://www.rackham.umich.edu/faculty_staff/).

UM Postdoctoral Translational Scholars Program
Deadline: April 9, 2010

The Michigan Institute for Clinical & Health Research (MICHR) announces recruitment for the fourth cohort of the Postdoctoral Translational Scholars Program (PTSP). The PTSP is a multidisciplinary career development program designed to prepare individuals with a Ph.D. in a biomedical science or social science discipline for independent careers in translational research. Individuals with Ph.D. degrees who are interested in obtaining additional training in translational sciences are encouraged to apply for this unique funding opportunity, which will provide trainees with a $100,000 career development award that can be utilized over two to three years. Candidates must be a U.S. citizen or permanent resident. Postdoctoral Translational Scholars will be expected to commit 50 to 75 percent of full time effort to the program. For more information and an application, visit (http://www.michr.umich.edu/ptsp). Questions may be directed to Monica Stiddom (mhealy@umich.edu) or Shari Barnett (shbailey@umich.edu).


External Limited Submissions


These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

Edward Mallinckrodt, Jr. Foundation Grant Program Internal
Internal Deadline: March 11, 2010

The basic aim of the Edward Mallinckrodt, Jr. Foundation is to advance knowledge in the various fields of medical and health research. It is further the general aims to (1) confine contributions to those worthy projects that are in need of initial start-up funding to move the projects forward to the point of other independent support or (2) support highly promising young investigators (e.g. have not been a PI on an R01) at the time when start-up funds are limited and initial progress is dependent on additional funding. The Foundation is most interested in basic research with upstream potential for impacting disease. The applicant must have an appointment in the Medical School. Clinical instructors are not eligible.

It is not the intent to support projects that are already under way and are already receiving significant grant support to provide long-range funding beyond an initial three-year period of support. The Foundation will not fund overhead, and grants will be made and restricted to domestic institutions.

Grants are made in the amount of $50,000 - $75,000 per year for a period of one to three years and are contingent upon a yearly progress report by the applicant. The Foundation reviews applications three times a year. The next Foundation deadline is May 1, 2010. The University of Michigan may submit a maximum of three proposals.

For consideration as an institutional nominee, submit the following electronically in a single PDF document – in the order listed – by March 11, 2010 to (limitedsubmissions@umich.edu): a nominating letter from the department chair, a 2- to 4-page research plan (double-spaced), and a NIH formatted biosketch. We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions. The complete Foundation guidelines are available online.


External Open Submissions

Center for Technology and Aging Remote Patient Monitoring Diffusion Grants Program
Deadline: March 12, 2010 (Letter of Intent)

The Center for Technology and Aging (the Center) is soliciting letters of intent from organizations that are interested in expanding use of remote patient monitoring technologies that help improve the health and safety of older adults. The Center is interested in funding projects that aim to further disseminate proven remote patient monitoring technologies. The three areas of remote patient monitoring that will be addressed in this program are chronic disease monitoring, post-acute care monitoring, and safety monitoring. Health care problems in these three areas are important, widespread, and potentially addressable by beneficial technologies. Grants will be awarded up to $100,000 per grant for a period of 12-months. Up to six grants will be awarded. Funded projects are expected to commence in July 2010. For complete details, visit (http://www.techandaging.org/grants_home.html).


UMMS AWARDED GRANTS

External Awarded Grants

Currently, due to limitations on data collection, we are unable to identify projects awarded with multiple PIs. As the eRPM system is used for proposals, we will be able to publish those awards accurately. We apologize for any misleading project information this causes.

Click here to view.

Anesthesiology

PI: Clauw, Daniel
Title: PAIN AND MUSCULOSKELETAL DISORDERS: TRANSLATING SCIENTIFIC ADVANCES INTO PRACTICE
Sponsor: NIH 1 U13 AR 058069 01
Project Dates and Amount of Award: 12/01/09-11/30/10; $76,000

PI: Malviya, Shobha
Title: A Phase III, Randomized, Double-Blind, Dose-Controlled, Multicenter, Study Evaluating the Safety and Efficacy of Dexmedetomidine in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit Subjects
Sponsor: Hospira, Inc TO Pharmaceutical Research Associates, Inc.
Project Dates and Amount of Award: 02/01/10-01/31/12; $74,944

Biological Chemistry

PI: Banerjee, Ruma
Title: A RADICAL ENZYME AND ITS ESCORTS
Sponsor: NIH 3 R01 DK 045776 18 S1
Project Dates and Amount of Award: 01/01/10-03/31/10; $48,500

Cell & Developmental Biology

PI: Barolo, Scott
Title: Structure and Function of a Signal-Regulated Development Enhancer
Sponsor: NIH 3 R01 GM 076509 03 S1
Project Dates and Amount of Award: 12/20/09-11/30/10; $49,944

PI: Fingar, Diane
Title: IDENTITY, REGULATION AND FUNCTION OF MTOR PHOSPHORYLATION SITES
Sponsor: NIH 3 R01 DK 078135 03 S1
Project Dates and Amount of Award: 02/01/10-04/30/10; $70,683

PI: Giger, Roman
Title: ELECTROPHYSIOLOGICAL ASSESSMENT OF NGR TRIPLE KOS
Sponsor: Wyeth Pharmaceuticals, Inc.
Project Dates and Amount of Award: 02/01/10-01/31/11; $20,000

PI: Tsai, Billy
Title: MECHANISM OF CHOLERA TOXIN RETRO-TRANSLOCATION
Sponsor: NIH 1 R01 A1 083252 01 A1
Project Dates and Amount of Award: 02/01/10-01/31/15; $1,515,025

Comprehensive Cancer Center

PI: Smith, David
Title: A Study to Evaluate the Relationship Between Ramucirumab (IMC-1121B) Therapy and Corrected QT (QTc) Interval Changes in Patients with Advanced Cancer
Sponsor: ImClone Systems Inc.
Project Dates and Amount of Award: 01/14/10-11/08/11; $394,940

Dermatology

PI: Helfrich, Yolanda
Title: EFFICACY AND SAFETY OF ALITRETINOIN IN THE TREATMENT OF SEVERE CHRONIC HAND ECZEMA REFRACTORY
Sponsor: Basilea Pharmaceutica, Ltd TO Covance Inc.
Project Dates and Amount of Award: 12/18/09-08/17/12; $153,849

PI: Helfrich, Yolanda
Title: A Phase 2A, Open-Label, Multiple-Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Teplizumab in Adults with Moderate or More Severe Psoriasis
Sponsor: MacroGenics, Inc
Project Dates and Amount of Award: 01/18/10-04/30/11; $218,403

Emergency Medicine

PI: Barsan, William
Co-I: Morgenstern, Lewis (Neurology Department) / Wang, Michael (Neurology Department) / Zahuranec, Darin (Neurology Department)
Title: THE PLATELET-ORIENTED INHIBITION IN NEW TIA (POINT) TRIAL
Sponsor: NIH - Subcontracts TO University of California - San Francisco
Project Dates and Amount of Award: 09/30/09-08/31/10; $692,472

Family Medicine

PI: Fetters, Michael
Title: MEDICAL MARVELS INTERACTIVE TRANSLATIONAL RESEARCH EXPERIENCE
Sponsor: NIH 3 R03 LM 010052 01 S1
Project Dates and Amount of Award: 09/30/09-09/29/10; $19,282

Human Genetics

PI: Sing, Charles
Co-I: Dyson, Gregory (Human Genetics Department)
Title: GENE-ENVIRONMENT INTERACTIONS IN HUMAN PARTURITION
Sponsor: NIH - Subcontracts TO University of California - Irvine P01 HD 047609
Project Dates and Amount of Award: 09/30/09-09/29/10; $67,597

PI: Sing, Charles
Title: BUILDING ON GWAS FOR NHLBI-DISEASES: THE CHARGE CONSORTIUM
Sponsor: NIH - Subcontracts TO University of Texas RC2 HL 102419
Project Dates and Amount of Award: 09/30/09-07/31/10; $280,229

Internal Medicine

PI: Arenberg, Douglas
Title: Validation of a Multi-Gene Test for Lung Cancer Risk
Sponsor: NIH - Subcontracts TO University of Toledo
Project Dates and Amount of Award: 09/30/09-08/31/11; $250,000

PI: Arvan, Peter
Title: THYROCYTE PROTEIN TRANSPORT TO THE CELL SURFACE
Sponsor: NIH 3 R01 DK 040344 22 A1S1
Project Dates and Amount of Award: 12/23/09-03/31/10; $77,422

PI: Arvan, Peter
Title: PEPTIDE HORMONE SORTING TO THE SECRETARY/STORAGE GRANULE
Sponsor: NIH 3 R01 DK 048280 16 S1
Project Dates and Amount of Award: 12/23/09-03/31/10; $22,500

PI: Burant, Charles
Title: USING SYSTEMS BIOLOGY TO UNDERSTAND ISLET ADAPTATION AND FAILURE DIABETES
Sponsor: NIH 3 R01 DK 079084 03 S1
Project Dates and Amount of Award: 12/03/09-02/28/10; $77,001

PI: Chan, Kevin
Title: GILEAD IPF
Sponsor: Gilead Sciences, Inc.
Project Dates and Amount of Award: 12/16/09-07/31/11; $156,624

PI: Chun, Tae-Hwa
Title: 3-DIMENSIONAL PROTEOLYTIC REGULATION OF ADIPOSE TISSUE DEVELOPMENT AND FUNCTION
Sponsor: NIH 3 K08 DK 078801 01 S1
Project Dates and Amount of Award: 12/14/09-02/28/10; $21,648

PI: Erba, Harry
Title: A Phase I, Dose Escalation Study of Plerixafor in Combination with Cytarabine and Daunorubicin in Patients with De Novo Acute Myeloid Leukemia
Sponsor: Genzyme Corporation
Project Dates and Amount of Award: 12/08/09-11/04/12; $312,878

PI: Erba, Harry
Title: 2009.018: The OPAL Study: A Phase II Study to Evaluate the Efficacy, Safety and Tolerability of Tosedostat (CHR-2797) in Elderly Subjects with Treatment Refractory or Relapsed Acute Myeloid Leukemia
Sponsor: Quintiles, Inc TO Chroma Therapeutics, Ltd
Project Dates and Amount of Award: 01/29/10-01/31/11; $288,465

PI: Farmer, Jocelyn
Title: THE ROLE OF NEURONAL MATURATION ON ANTIVIRAL TYPE I INTERFERON PATHWAY ACTIVITY
Sponsor: NIH 1 F30 NS 065566 01 A1
Project Dates and Amount of Award: 02/01/10-01/31/12; $64,712

PI: Flanders, Scott
Co-I: Gandhi, Tejal (Int Med-Infectious Diseases) / Washer, Laraine (Int Med-Infectious Diseases)
Title: Targeting Hospitalist to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections
Sponsor: Merck and Company, Inc. TO National Foundation for the Centers for Disease Control & Prevention Inc.(CDC Foundation)
Project Dates and Amount of Award: 12/01/09-11/30/12; $158,978

PI: Garg, Puneet
Title: REGULATION OF PODOCYTE ACTIN CYTOSKELETON
Sponsor: NIH 3 K08 DK 081403 02 S1
Project Dates and Amount of Award: 01/16/10-12/31/10; $54,000

PI: Hawley, Sarah
Co-I: Fagerlin, Angela (Int Med-General Medicine)
Title: A TARGETED DECISION AID TO IMPROVE MINORITY PARTICIPATION IN CLINICAL TRIALS
Sponsor: NIH - Subcontracts TO University of Miami, Florida RC2
Project Dates and Amount of Award: 09/28/09-06/30/10; $169,751

PI: Herman, William
Title: DIABETES RESEARCH AND TRAINING CENTER ADMINISTRATIVE SUPPLEMENT
Sponsor: NIH 3 P60 DK 020572 32 S3
Project Dates and Amount of Award: 12/04/09-11/30/10; $309,000

PI: Herman, William
Co-I: Brown, Michael (Biostatistics Department) / Ye, Wen (Biostatistics Department)
Title: SUPPLEMENTARY ECONOMIC ANALYSES OF THE DIABETES PREVENTION PROGRAM (DPP)
Sponsor: NIH - Subcontracts TO George Washington University U01 DK 048489
Project Dates and Amount of Award: 10/01/09-08/31/11; $400,000

PI: Higgins, Peter
Co-I: Sen, Ananda (Ctr Statistical Consul & Res)
Title: ULCERATIVE COLITIS PRO DEVELOPMENT PROTOCOL
Sponsor: Genentech, Inc.
Project Dates and Amount of Award: 12/01/09-07/31/10; $375,000

PI: Hoogerwerf, Willemijntje
Title: ROLE OF CLOCK GENES IN COLONIC MOTILITY
Sponsor: NIH 3 R21 DK 074477 02 S1
Project Dates and Amount of Award: 02/01/10-01/31/11; $69,512

PI: Iwashyna, Theodore
Title: THE CONTRIBUTION OF FUNCTIONAL DECLINE IN LONG-TERM COSTS OF SEVERE SEPSIS
Sponsor: Soc of Critical Care Medicine
Project Dates and Amount of Award: 01/01/10-12/31/11; $50,000

PI: Jackson, Elizabeth
Title: YOUNG WOMEN WITH ACUTE MYOCARDIAL INFARCTION, VIRGO
Sponsor: NIH - Subcontracts TO Yale University R01 HL 081153
Project Dates and Amount of Award: 04/01/08-05/31/11; $20,000

PI: Jakubowiak, Andrzej
Co-I: Maillard, Ivan (Life Sciences Institute-Admin)
Title: IDENTIFICATION AND TARGETED THERAPY OF MULTIPLE MYELOMA CELLS
Sponsor: Multiple Myeloma Research Foundation
Project Dates and Amount of Award: 08/01/09-07/31/10; $100,000

PI: Kaplan, Mark
Title: A SEARCH FOR A VITAL CAUSE OF AIDS LYMPHOMA
Sponsor: Concerned Parents for AIDS Research
Project Dates and Amount of Award: 11/01/09-10/31/10; $60,000

PI: Kaul, Daniel
Title: A multicenter, randomized, double-blind, placebo-controlled dose-escalation study of the safety, tolerability and ability of CMX001 to prevent or control CMV infection in R+ hematopoietic stem cell transplant recipients
Sponsor: Chimerix, Inc TO Clinimtrics Research Associates
Project Dates and Amount of Award: 02/01/10-01/31/11; $59,160

PI: Koelling, Todd
Title: PhosphodiesteRasE-5 Inhibition to Improve CLinical Status And EXercise Capacity in Diastolic Heart Failure Study acronym: RELAX
Sponsor: NIH - Subcontracts TO Duke University
Project Dates and Amount of Award: 10/01/09-02/28/11; $150,267

PI: Kretzler, Matthias
Title: MOLECULAR PREDICTORS OF PROGRESSIVE RENAL FAILURE IN THE CHRONIC RENAL INSUFFICENCY COHORT
Sponsor: NIH 3 R01 DK 079912 02 S1
Project Dates and Amount of Award: 12/08/09-11/30/10; $105,792

PI: Kretzler, Matthias
Title: IDENTIFICATION OF BIOMARKERS FOR PROGRESSIVE DIABETIC NEPHROPATHY
Sponsor: NIH 3 R21 DK 079441 02 S3
Project Dates and Amount of Award: 12/15/09-11/30/10; $93,142

PI: Lok, Anna
Title: BMS-790052 and BMS-650032 in Combination in Null Responders with Chronic HCV Genotype 1
Sponsor: Bristol-Myers Squibb
Project Dates and Amount of Award: 01/29/10-01/18/13; $116,457

PI: Marks, Rory
Title: ACR/REF RHEUMATOLOGY FELLOWSHIP TRAINING AWARD
Sponsor: Amer College of Rheumatology
Project Dates and Amount of Award: 07/01/10-06/30/11; $25,000

PI: Marrero, Jorge
Title: A Randomized, Double-blind, Multi-center Phase III Study of Brivanib plus Best Supportive Care (BSC) versus Placebo plus BSC in Subjects with Advanced Hepatocellular Carcinoma (HCC) who have Failed or are Intolerant to Sorafenib: The BRISK PS Study CA182-034-098
Sponsor: Bristol-Myers Squibb
Project Dates and Amount of Award: 12/01/09-11/30/12; $375,519

PI: Martinez, Fernando
Title: LUNG GENOMICS RESEARCH CONSORTIUM
Sponsor: NIH - Subcontracts TO National Jewish Medical Center
Project Dates and Amount of Award: 09/30/09-08/31/10; $19,054

PI: McCune, William
Co-I: Cagnoli, Patricia (Int Med-Rheumatology) / Somers, Emily (Int Med-Rheumatology)
Title: A PROSPECTIVE REGISTRY TO STUDY PRESENTATION, CLINICAL COURSE, TREATMENT PATTERNS, AND OUTCOMES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Sponsor: Lupus Clinical Trials Consortium
Project Dates and Amount of Award: 07/01/09-06/30/14; $548,750

PI: Miller, Richard
Title: Glenn Award for Research in Biological Mechanisms of Aging
Sponsor: Glenn Foundation for Medical Research
Project Dates and Amount of Award: 12/02/09-11/30/11; $60,000

PI: Myers Jr, Martin
Title: MOLECULAR MECHANISMS OF LEPTIN RECEPTOR/JAK2 ACTION
Sponsor: NIH 3 R37 DK 056731 11 S1
Project Dates and Amount of Award: 12/21/09-02/28/10; $84,639

PI: Redman, Bruce
Co-I: Lao, Christopher (Int Med-Hematology/Oncology)
Title: A Phase 2, Multicenter, Open-Label Study of YM155 Plus Docetaxel in Subjects with Stage 3 (Unresectable) or Stage 4 Melanoma
Sponsor: Astellas Pharma US, Inc.
Project Dates and Amount of Award: 12/17/09-12/17/12; $1,086,688

PI: Redman, Bruce
Title: 2009.060 - A Phase 1/2, Multicenter, Open-Label, Dose-Escalation Study to Evaluate the Safety and Efficacy of Lenalidomide in Combination with Sunitinib in Subjects with Advanced or Metastatic Renal Cell Carcinoma
Sponsor: Celgene Corporation
Project Dates and Amount of Award: 01/15/10-01/14/11; $330,353

PI: Roessler, Blake
Co-I: Holmes, Crystal (Metabolism, Endo & Diabetes) / Morris, Michael (LSA Chemistry)
Title: TRANSCUTANEOUS RAMAN SPECTROSCOPY FOR DIAGNOSIS OF DIABETIC OSTEOMYELITIS
Sponsor: NIH 1 R21 EB 010126 01
Project Dates and Amount of Award: 02/01/10-01/31/12; $386,250

PI: Shayman, James
Title: LYSOSOMAL PHOSPHOLIPASE A2 IN AUTOIMMUNE DISEASE
Sponsor: NIH 1 R01 AR 056991 01 A1
Project Dates and Amount of Award: 02/01/10-11/30/14; $1,697,305

PI: Smith, David
Title: 2009.076 A Randomized Discontinuation Study of XL184 in Subjects with Advanced Solid Tumors
Sponsor: Exelixis
Project Dates and Amount of Award: 01/13/10-01/12/13; $1,212,209

PI: Weinberg, Joel
Title: CELLULAR PATHOPHYSIOLOGY OF ACUTE RENAL FAILURE
Sponsor: NIH 3 R01 DK 034275 22 S1
Project Dates and Amount of Award: 12/07/09-12/06/10; $85,238

PI: Weitzel III, William
Title: NOVEL METHODS FOR HEMODIALYSIS ACCESS EVALUATION
Sponsor: NIH 3 K08 DK 062848 05 S1
Project Dates and Amount of Award: 12/17/09-11/30/10; $53,200

PI: Wellik, Deneen
Title: MOLECULAR GENETICS OF HOX GENES AND KIDNEY DEVELOPMENT
Sponsor: NIH 3 R01 DK 071929 04 S1
Project Dates and Amount of Award: 12/21/09-11/30/10; $80,340

PI: Wicha, Max
Title: AN INTEGRATED APPROACH TO TARGETING MOLECULAR BREAST CANCER SUBTYPES
Sponsor: Amer Assoc for Cancer Research TO Univ Of California Los Angeles
Project Dates and Amount of Award: 10/01/09-09/30/10; $409,255

PI: Wiggins, Roger
Title: PODOCYTE STRESS, HYPERTENSION, AND DEPLETION
Sponsor: NIH 3 R01 DK 046073 15 S1
Project Dates and Amount of Award: 12/17/09-12/16/10; $70,379

PI: Wiggins, Roger
Title: PREVENTION OF PODOCYTE DEPLETION BY ALISKERIN
Sponsor: Novartis
Project Dates and Amount of Award: 01/01/10-01/01/11; $202,834

Medical Education

PI: De Vries, Raymond
Title: A STUDY OF THE FACTORS INFLUENCING WOMEN'S DECISION ABOUT CHILDBIRTH
Sponsor: NIH - Subcontracts TO Minnesota State University
Project Dates and Amount of Award: 09/18/09-08/31/10; $45,766

Medical School Administration

PI: Pienta, Kenneth
Title: SENTINEL NETWORK FOR COMMUNITY BASED PARTICIPATORY RESEARCH
Sponsor: NIH - Subcontracts TO Washington University 3 UL1 RR 023422 03 S3
Project Dates and Amount of Award: 08/28/09-08/27/10; $50,440

Microbiology and Immunology

PI: Schloss, Patrick
Title: THE HORTON PROJECT: DEVELOPING BIOINFORMATICS RECIPES FOR MICROBIAL ECOLOGY IN R
Sponsor: NSF
Project Dates and Amount of Award: 09/01/09-01/31/11; $206,367

Molecular & Behavioral Neuroscience Institute

PI: Clinton, Sarah
Title: NEURODEVELOPMENTAL UNDERPINNINGS OF RODENT ANXIETY AND DEPRESSIVE BEHAVIOR
Sponsor: NIH 1 K99 MH 085859 01 A1
Project Dates and Amount of Award: 01/01/10-12/31/11; $169,693

Molecular & Integrative Physiology

PI: Carter-Su, Christin
Title: GROWTH HORMONE REGULATION OF SH2-B
Sponsor: NIH 3 R01 DK 054222 10 S1
Project Dates and Amount of Award: 12/28/09-02/28/10; $66,500

PI: Carter-Su, Christin
Title: GROWTH HORMONE RECEPTORS AND ACTIONS
Sponsor: NIH 3 R37 DK 034171 25 S1
Project Dates and Amount of Award: 12/28/09-02/28/10; $66,500

PI: Low, Malcolm
Title: NEUROCHEMISTRY/PHYSIOLOGY OF PROOPIOMELANOCORTIN NEURONS
Sponsor: NIH 3 R01 DK 066604 05 A1S1
Project Dates and Amount of Award: 01/03/10-03/31/10; $95,634

PI: Rui, Liangyou
Title: SH2-B REGULATION OF BODY WEIGHT AND ENERGY - ADMIN SUPP
Sponsor: NIH 3 R01 DK 073601 04 S1
Project Dates and Amount of Award: 12/21/09-02/28/10; $100,000

PI: Schwartz, Jessica
Title: GROWTH HORMONE SIGNALING TO THE NUCLEUS
Sponsor: NIH 3 R01 DK 046072 12 S2
Project Dates and Amount of Award: 01/01/10-03/31/10; $45,600

PI: Stuenkel, Edward
Title: MECHANISMS OF RAB27 REGULATION OF INSULIN SECRETION - ADMIN SUPPLEMENT
Sponsor: NIH 3 R01 DK 077050 01 A2S2
Project Dates and Amount of Award: 01/20/10-04/03/10; $71,491

Neurology

PI: Dauer, William
Title: The Mechanism of LRRK2-mediated Neurodegeneration in Parkinson's disease
Sponsor: NIH 7 R01 NS 061098 03
Project Dates and Amount of Award: 12/01/09-07/31/11; $569,159

PI: Dayalu, Praveen
Title: Teva MSA-RAS-202
Sponsor: Teva Pharmaceuticals, USA
Project Dates and Amount of Award: 01/14/10-12/31/10; $48,894

PI: Feldman, Eva
Title: TRAINING IN CLINICAL AND BASIC NEUROSCIENCE
Sponsor: NIH 3 T32 NS 007222 28 S2
Project Dates and Amount of Award: 07/01/09-06/30/12; $897,007

PI: Junck, Larry
Title: UMCC 2007.094 AVASTIN AND TEMOZOLOMIDE FOLLOWING RADIATION AND CHEMOTHERAPY FOR NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME: A PHASE II STUDY
Sponsor: Genentech, Inc. TO University of Chicago
Project Dates and Amount of Award: 02/01/09-02/28/12; $17,598

PI: Morgenstern, Lewis
Title: FAMILIAL INTRACRANIAL ANEURYSM STUDY
Sponsor: NIH - Subcontracts TO University of Cincinnati
Project Dates and Amount of Award: 09/15/09-08/31/10; $20,022

PI: Parent, Jack
Co-I: Glynn, Simon (Neurology Department)
Title: The Epilepsy Phenome/Genome Project (EPGP)
Sponsor: NIH - Subcontracts TO University of California - San Francisco U01 NS 053998
Project Dates and Amount of Award: 09/30/09-08/31/11; $123,290

PI: Segal, Benjamin
Title: THE REGULATION OF MYELOID CELL DEVELOPMENT AND MOBILIZATION DURING AUTOIMMUNE DEMYELINATING DISEASE
Sponsor: NIH 1 R01 NS 057670 01 A1
Project Dates and Amount of Award: 01/15/10-12/31/14; $1,304,749

Neurosurgery

PI: Park, Paul
Co-I: La Marca, Frank (Neurosurgery) / Sullivan, Stephen (Neurosurgery)
Title: TRINITY EVOLUTION MATRIX CERVICAL FUSION CTF
Sponsor: Blackstone Medical, Inc
Project Dates and Amount of Award: 01/20/10-01/19/11; $59,779

Ophthalmology & Visual Sciences

PI: Demb, Jonathan
Title: FUNCTIONAL CIRCUITRY OF VISUAL ADAPTION
Sponsor: NIH 3 R01 EY 014454 05 S1
Project Dates and Amount of Award: 02/01/10-01/31/11; $104,383

PI: Richards, Julia
Title: GENOTYPE PHENOTYPE STUDIES OF OPEN-ANGLE GLAUCOMA
Sponsor: Research To Prevent Blindness
Project Dates and Amount of Award: 12/01/09-11/30/10; $75,000

PI: Smith, Terry
Title: IMMUNOGLOBULIN ACTIVATION OF FIBROBLASTS
Sponsor: NIH 7 R01 DK 063121 05
Project Dates and Amount of Award: 09/01/09-08/31/10; $421,632

Pathology

PI: Chinnaiyan, Arul
Co-I: Rhodes, Daniel (Ctr fr Translational Pathology)
Title: AN INTEGRATED APPROACH TO TARGETING BREAST CANCER MOLECULAR SUBTYPES AND THEIR "RESISTANCE" PHENOTYPES
Sponsor: Amer Assoc for Cancer Research TO Univ Of California Los Angeles
Project Dates and Amount of Award: 10/01/09-09/30/10; $388,580

PI: Lim, Megan
Co-I: Basrur, Venkatesha (Pathology Department)
Title: Proteomic Biomarkers of ALK Activation in Neuroblastoma
Sponsor: Emily's Power for a Cure Foundation
Project Dates and Amount of Award: 01/01/10-12/31/12; $150,000

PI: Lim, Megan
Co-I: Elenitoba-Johnson, Kojo (Pathology Department)
Title: PROTEOMIC BIOMARKERS OF ALK+ LYMPHOMA
Sponsor: NIH 1 R01 CA 140806 01 A1
Project Dates and Amount of Award: 12/03/09-11/30/13; $1,282,352

Pediatrics & Communicable Diseases

PI: Dombkowski, Kevin
Co-I: Clark, Sarah (Pediatrics-Ambulatory Care Pgm)
Title: Increasing Influenza Vaccination Rates among Michigan Children
Sponsor: Center for Healthcare Research & Transformation
Project Dates and Amount of Award: 10/01/09-09/30/11; $90,000

PI: Goldberg, Caren
Co-I: Smith, Cynthia (Pediatrics-Cardiology)
Title: PCQLI-QUALITY OF LIFE ASSESSMENT IN THE PEDIATRIC CARDIAC POPULATION: TESTING THE PEDIATRIC CARDIAC QUALITY OF LIFE INVENTORY
Sponsor: Cincinnati Children's Hospital Medical Center
Project Dates and Amount of Award: 06/01/09-05/31/12; $10,300

PI: Lewis, Toby
Co-I: Batterman, Stuart (Environmental Health Sciences) / Chernyak, Sergey (Environmental Health Sciences) / Hershenson, Marc (Pediatrics-Pulmonary Medicine) / Mukherjee, Bhramar (Biostatistics Department) / Parker, Edith (Hlth Behavior & Hlth Ed Dept) / Robins, Thomas (Environmental Health Sciences)
Title: INTERACTIONS OF DIESEL EXHAUST AND RESPIRATORY VIRUSES IN ASTHMATIC CHILDREN
Sponsor: NIH 1 R01 ES 016769 01 A1
Project Dates and Amount of Award: 01/13/10-11/30/14; $3,241,782

PI: LiPuma, John
Title: BcRLR analytical services
Sponsor: Gilead Sciences, Inc.
Project Dates and Amount of Award: 11/01/09-12/31/11; $296,370

PI: Lumeng, Carey
Title: ADIPOSE TISSUE MACROPHAGE POLARIZATION AND ITS INFLUENCE ON ADIPOCYTE FUNCTION
Sponsor: NIH 3 K08 DK 078851 03 S1
Project Dates and Amount of Award: 12/14/09-02/28/10; $38,058

PI: Menon, Ram
Title: FETAL/POSTNATAL REGULATION OF EXPRESSION OF THE GH RECEPTOR
Sponsor: NIH 3 R01 DK 049845 13 S1
Project Dates and Amount of Award: 12/15/09-11/30/10; $58,688

PI: Nasr, Samya
Title: Therapeutics Development Network 2010
Sponsor: Cystic Fibrosis Foundation Therapeutics, Inc.
Project Dates and Amount of Award: 01/01/10-12/31/10; $108,000

PI: Nasr, Samya
Title: A Randomized, Double Blind, Parallel Group, Placebo Controlled 28 Day Study to Investigate the Safety, Tolerability and Pharmacodynamics of SB-656933 in Patients with Cystic Fibsosis
Sponsor: Glaxosmithkline TO Seattle Children's Hospital
Project Dates and Amount of Award: 10/23/09-10/31/10; $75,988

PI: Nasr, Samya
Title: I Change Adherence & Change Expectations (iCARE)
Sponsor: Novartis TO University of Miami, Florida
Project Dates and Amount of Award: 02/01/10-01/25/11; $25,050

PI: Shanley, Thomas
Title: Pediatric Sepsis Biomarker Risk Model (PERSEVERE)
Sponsor: NIH - Subcontracts TO Cincinnati Children's Hospital Medical Center RC1 HL 100474
Project Dates and Amount of Award: 09/30/09-08/30/10; $1,800

Pharmacology

PI: Beg, Asim
Title: MOLECULAR AND ACTIVITY-DEPENDENT PLASTICITY IN THE DEVELOPING CORTICOSPINAL MOTOR SYSTEM
Sponsor: March of Dimes Birth Defect Foundation
Project Dates and Amount of Award: 02/01/10-01/31/12; $150,000

Psychiatry

PI: Kim, Scott
Title: THE BLURRING OF TREATMENT AND RESEARCH IN CLINICAL TRIALS: TWO PROBLEMS
Sponsor: NIH - Subcontracts TO University of Massachusetts 1 RC1 NR 011612 01
Project Dates and Amount of Award: 09/28/09-07/31/10; $54,725

PI: Swain, Jason
Co-I: Liberzon, Israel (Psychiatry Department)
Title: CHILDHOOD POVERTY AND BRAIN DEVELOPMENT: THE ROLE OF CHRONIC STRESS AND PARENTING
Sponsor: NIH - Subcontracts TO Cornell University RC2 MD 004767
Project Dates and Amount of Award: 09/28/09-07/31/10; $399,440

Radiation Oncology

PI: Morgan, Meredith
Co-I: Lawrence, Theodore (Radiation Oncology - Ann Arbor) / Maybaum, Jonathan (Radiation Oncology - Ann Arbor) / Parsels, Leslie (Radiation Oncology - Ann Arbor)
Title: The effect of AZD7762 on pancreatic cancer stem cells in response to gemcitabine and radiation therapies
Sponsor: AstraZeneca plc
Project Dates and Amount of Award: 01/13/10-01/12/12; $208,000

Radiology

PI: Bapuraj, Jayapalli
Co-I: Maher, Cormac (Neurosurgery) / Muraszko, Karin (Neurosurgery)
Title: Dynamic MRI and Quantitative CSF Flow Studies in Chiari I Malformations
Sponsor: C and S Patient Education Foundation
Project Dates and Amount of Award: 01/01/10-12/31/10; $50,000

PI: Koeppe, Robert
Title: AMYLOID IMAGING, VMCI AND ANALYSIS FOR ADNI
Sponsor: NIH - Subcontracts TO University of California - San Francisco
Project Dates and Amount of Award: 09/30/09-08/31/10; $281,963

Surgery

PI: Englesbe, Michael
Title: TOWARDS PAY FOR PERFORMANCE IN KIDNEY TRANSPLANTATION
Sponsor: NIH 3 K08 DK 082758 01 S1
Project Dates and Amount of Award: 01/01/10-12/31/10; $52,599

PI: Magee, John
Title: BILIARY ATRESIA CONSORTIUM: DATA COORDINATING CENTER
Sponsor: NIH 3 U01 DK 062456 08 S1
Project Dates and Amount of Award: 02/01/10-01/31/11; $150,417

PI: Teitelbaum, Daniel
Co-I: Dempsey, Peter (Pediatrics-Gastroenterology) / Feng, Yong (Pediatric Surgery Section)
Title: TPN INDUCED CHANGES IN INTRAEPITHELIAL LYMPHOCYTES
Sponsor: NIH 2 R01 AI 044076 11 A1
Project Dates and Amount of Award: 02/01/10-01/31/15; $1,736,058

Urology

PI: Keller, Evan
Title: IN VIVO NON-INVASIVE 3D QUANTITATIVE MOLECULAR IMAGING SYSTEM
Sponsor: NIH 1 S10 RR 025078 01
Project Dates and Amount of Award: 02/01/10-01/31/11; $359,897

PI: Sarma, Aruna
Title: UROEDIC II: RISK AND PROGRESSION OF UROLOGIC COMPLICATIONS IN TYPE 1 DIABETES
Sponsor: NIH - Subcontracts TO University of Washington R01 DK
Project Dates and Amount of Award: 08/01/09-07/31/10; $223,188

PI: Wood Jr, David
Title: EFFECTIVENESS OF ROBOTIC COMPARED TO STANDARD PROSTATECTOMY FOR PROSTATE CANCER
Sponsor: NIH - Subcontracts TO Beth Israel Deaconess Medical Center RC1 EB 01100
Project Dates and Amount of Award: 09/30/09-08/31/10; $19,535


UMMS RESEARCH PUBLICATIONS


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Biological Chemistry

Bhattacharya A, Revington M, Zuiderweg ER. Measurement and interpretation of (15)N-(1)H residual dipolar couplings in larger proteins. J Magn Reson. 2009 Nov 26. (Epub ahead of print).

Chakraborty S, Ortiz-Maldonado M, Entsch B, Ballou DP. Studies on the mechanism of p-hydroxyphenylacetate 3-hydroxylase from Pseudomonas aeruginosa: a system composed of a small flavin reductase and a large flavin-dependent oxygenase. Biochemistry. 2010 Jan 19; 49(2): 372-85.

Chang DE, Leung S, Atkinson MR, Reifler A, Forger D, Ninfa AJ. Building biological memory by linking positive feedback loops. Proc Natl Acad Sci USA. 2010 Jan 5; 107(1): 175-180.

Chen X, Sans MD, Strahler JR, Karnovsky A, Ernst SA, Michailidis G, Andrews PC, Williams JA. Quantitative Organellar Proteomics Analysis of Rough Endoplasmic Reticulum from Normal and Acute Pancreatitis Rat Pancreas. J Proteome Res. 2009 Dec 23. (Epub ahead of print).

Chen X, Simon ES, Xiang Y, Kachman M, Andrews PC, Wang Y. Quantitative proteomics analysis of cell cycle regulated Golgi disassembly and reassembly. J Biol Chem. 2010 Jan 7. (Epub ahead of print).

Davis SW, Castinetti F, Carvalho LR, Ellsworth BS, Potok MA, Lyons RH, Brinkmeier ML, Raetzman LT, Carninci P, Mortensen AH, Hayashizaki Y, Arnhold IJ, Mendonca BB, Brue T, Camper SA. Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol. 2009 Dec 16. (Epub ahead of print).

Foit L, Morgan GJ, Kern MJ, Steimer LR, von Hacht AA, Titchmarsh J, Warriner SL, Radford SE, Bardwell JC. Optimizing protein stability in vivo. Mol Cell. 2009 Dec 11; 36(5): 861-71.

Gantt SL, Joseph CG, Fierke CA. Activation and inhibition of histone deacetylase 8 by monovalent cations. J Biol Chem. 2009 Dec 22. (Epub ahead of print).

Gestwicki JE. Special series: Molecular chaperones in protein folding and disease. Biopolymers. 2010 Mar; 93(3): 209-10.

Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME, Fierke CA. Protein-Precursor tRNA Contact Leads to Sequence-Specific Recognition of 5' Leaders by Bacterial Ribonuclease P. J Mol Biol. 2009 Nov 28. (Epub ahead of print).

Sun J, Yu EY, Yang Y, Confer LA, Sun SH, Wan K, Lue NF, Lei M. Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev. 2009 Dec 15; 23(24): 2900-14.

Srinivasan A, Galbán CJ, Johnson TD, Chenevert TL, Ross BD, Mukherji SK. Utility of the K-Means Clustering Algorithm in Differentiating Apparent Diffusion Coefficient Values of Benign and Malignant Neck Pathologies. AJNR Am J Neuroradiol. 2010 (Epub ahead of print).

Swanson MD, Winter HC, Goldstein IJ, Markovitz DM. A lectin isolated from bananas is a potent inhibitor of HIV replication. J Biol Chem. 2010 Jan 15. (Epub ahead of print).

Tapley TL, Franzmann TM, Chakraborty S, Jakob U, Bardwell JC. Protein refolding by pH-triggered chaperone binding and release. Proc Natl Acad Sci USA. 2010 Jan 7. (Epub ahead of print).

Cell & Developmental Biology

Bernardi KM, Williams JM, Kikkert M, van Voorden S, Wiertz EJ, Ye Y, Tsai B. The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation. Mol Biol Cell. 2010 Jan; 21(1): 140-51.

Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J Biol Chem. 2010 Jan 1; 285(1): 80-94.

Hammond JW, Huang CF, Kaech S, Jacobson C, Banker G, Verhey KJ. Posttranslational Modifications of Tubulin and the Polarized Transport of Kinesin-1 in Neurons. Mol Biol Cell. 2009 Dec 23. (Epub ahead of print).

Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim KC, Engel JD. GATA-3 is required for early T lineage progenitor development. J Exp Med. 2009 Dec 21; 206(13): 2987-3000.

Li X, Udager AM, Hu C, Qiao XT, Richards N, Gumucio DL. Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal life. Dev Dyn. 2009 Dec; 238(12): 3205-17.

Ma TC, Campana A, Lange PS, Lee HH, Banerjee K, Bryson JB, Mahishi L, Alam S, Giger RJ, Barnes S, Morris SM Jr, Willis DE, Twiss JL, Filbin MT, Ratan RR. A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. J Neurosci. 2010 Jan 13; 30(2): 739-48.

Okamura E, Matsuzaki H, Campbell AD, Engel JD, Fukamizu A, Tanimoto K. All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice. FASEB J. 2009 Dec; 23(12): 4335-43.

Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC. mTOR S2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J Biol Chem. 2009 Dec 18. (Epub ahead of print).

Torisawa YS, Mosadegh B, Luker GD, Morell M, O'Shea KS, Takayama S. Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids. Integr Biol (Camb). 2009 Dec; 1(11-12): 649-54.

Yamashita YM. A tale of mother and daughter. Mol Biol Cell. 2010 Jan; 21(1): 7-8.

Family Medicine

Gold KJ, Leon I, Chames MC. National survey of obstetrician attitudes about timing the subsequent pregnancy after perinatal death. Am J Obstet Gynecol. 2010 Jan 13 (Epub ahead of print).

Human Genetics

Bai Y, Zhang X, Katona I, Saporta MA, Shy ME, O'Malley HA, Isom LL, Suter U, Li J. Conduction block in PMP22 deficiency. J Neurosci. 2010 Jan 13; 30(2): 600-8.

Bommer GT, Feng Y, Iura A, Giordano TJ, Kuick R, Kadikoy H, Sikorski D, Wu R, Cho KR, Fearon ER. IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype. J Biol Chem. 2010 Jan 15; 285(3): 1928-38.

Brewer GJ. Copper toxicity in the general population. Clin Neurophysiol. 2010 Jan 11. (Epub ahead of print).

Burt RW, Barthel JS, Dunn KB, David DS, Drelichman E, Ford JM, Giardiello FM, Gruber SB, Halverson AL, Hamilton SR, Ismail MK, Jasperson K, Lazenby AJ, Lynch PM, Martin EW Jr, Mayer RJ, Ness RM, Provenzale D, Rao MS, Shike M, Steinbach G, Terdiman JP, Weinberg D. NCCN Clinical Practice Guidelines in Oncology: Colorectal Cancer Screening. J Natl Compr Canc Netw. 2010 Jan; 8(1): 8-61.

Goto M, Mitra RS, Liu M, Lee J, Henson BS, Carey T, Bradford C, Prince M, Wang CY, Fearon ER, D'Silva NJ. Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2010 Jan 1; 16(1): 65-76.

Mosher JT, Pemberton TJ, Harter K, Wang C, Buzbas EO, Dvorak P, Simón C, Morrison SJ, Rosenberg NA. Lack of population diversity in commonly used human embryonic stem-cell lines. N Engl J Med. 2010 Jan 14; 362(2): 183-5.

Rosenberg NA, Degnan JH. Coalescent histories for discordant gene trees and species trees. Theor Popul Biol. 2010 Jan 8. (Epub ahead of print).

Rosenfeld JA, Ballif BC, Martin DM, Aylsworth AS, Bejjani BA, Torchia BS, Shaffer LG. Clinical characterization of individuals with deletions of genes in holoprosencephaly pathways by aCGH refines the phenotypic spectrum of HPE. Hum Genet. 2010 Jan 12. (Epub ahead of print).

Internal Medicine

Infectious Diseases:
Flinn DR, Diehl KM, Seyfried LS, Malani PN. Better Sleep in the ICU for Preventing Postoperative Delirium Reply. J Am College Surgeons. 2009; 209(6): 793-793.

Kim CS, Pile JC, Lozon MM, Wilkerson WM, Wright CM, Cinti S. Role of Hospitalists in an Offsite Alternate Care Center (ACC) for Pandemic Flu. J Hosp Med. 2009; 4(9): 546-549.

Thammavongsa V, Schaefer M, Filzen T, Collins KL, Carrington M, Bangia N, Raghavan M. Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503. Immunogenetics. 2009; 61(11-12): 703-716.

Microbiology and Immunology

Alteri CJ, Hagan EC, Sivick KE, Smith SN, Mobley HL. Mucosal immunization with iron receptor antigens protects against urinary tract infection. PLoS Pathog. 2009 Sep; 5(9): e1000586.

Carlson JC, Li S, Burr DA, Sherman DH. Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp. J Nat Prod. 2009 Nov; 72(11): 2076-9.

Chang J, Kunkel SL, Chang CH. Negative regulation of MyD88-dependent signaling by IL-10 in dendritic cells. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43): 18327-32.

Dunnick WA, Collins JT, Shi J, Westfield G, Fontaine C, Hakimpour P, Papavasiliou FN. Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region. J Exp Med. 2009 Nov 23; 206(12): 2613-23.

Faust SM, Lu G, Marini BL, Zou W, Gordon D, Iwakura Y, Laouar Y, Bishop DK. Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection. J Immunol. 2009 Dec 1; 183(11): 7297-306.

Garcia EL, Onafuwa-Nuga A, Sim S, King SR, Wolin SL, Telesnitsky A. Packaging of host mY RNAs by murine leukemia virus may occur early in Y RNA biogenesis. J Virol. 2009 Dec; 83(23): 12526-34.

Jain AV, Zhang Y, Fields WB, McNamara DA, Choe MY, Chen GH, Erb-Downward J, Osterholzer JJ, Toews GB, Huffnagle GB, Olszewski MA. Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection. Infect Immun. 2009 Dec; 77(12): 5389-99.

Kim BG, Lee MJ, Seo J, Hwang YB, Lee MY, Han K, Sherman DH, Kim ES. Identification of functionally clustered nystatin-like biosynthetic genes in a rare actinomycetes, Pseudonocardia autotrophica. J Ind Microbiol Biotechnol. 2009 Nov; 36(11): 1425-34.

Li S, Chaulagain MR, Knauff AR, Podust LM, Montgomery J, Sherman DH. Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase. Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44): 18463-8.

Lloyd AL, Smith SN, Eaton KA, Mobley HL. Uropathogenic Escherichia coli Suppresses the host inflammatory response via pathogenicity island genes sisA and sisB. Infect Immun. 2009 Dec; 77(12): 5322-33.

Lynch RJ, Platt JL. Escaping from rejection. Transplantation. 2009 Dec 15; 88(11): 1233-6. Review.

Onafuwa-Nuga A, Telesnitsky A. The remarkable frequency of human immunodeficiency virus type 1 genetic recombination. Microbiol Mol Biol Rev. 2009 Sep; 73(3): 451-80, Table of Contents. Review.

Sherman DH. Biochemistry: Enzyme's black box cracked open. Nature. 2009 Oct 22; 461(7267): 1068-9.

Sivick KE, Mobley HL. An "omics" approach to uropathogenic Escherichia coli vaccinology. Trends Microbiol. 2009 Oct; 17(10): 431-2.

Torisawa YS, Mosadegh B, Luker GD, Morell M, O'Shea KS, Takayama S. Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids. Integr Biol (Camb). 2009 Dec; 1(11-12): 649-54.

Wang Q, Nagarkar DR, Bowman ER, Schneider D, Gosangi B, Lei J, Zhao Y, McHenry CL, Burgens RV, Miller DJ, Sajjan U, Hershenson MB. Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol. 2009 Dec 1; 183(11): 6989-97.

Yoshida S, Hoppe AD, Araki N, Swanson JA. Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages. J Cell Sci. 2009 Sep 15; 122(Pt 18): 3250-61.

Neurology

Eckner JT, Kutcher JS. Concussion symptom scales and sideline assessment tools: a critical literature update. Curr Sports Med Rep. 2010 Jan-Feb; 9(1): 8-15.

Kutcher JS, Eckner JT. At-risk populations in sports-related concussion. Curr Sports Med Rep. 2010 Jan-Feb; 9(1): 16-20.

Neurosurgery

Ansari SF, Maher CO, Tubbs RS, Terry CL, Cohen-Gadol AA. Surgery for extratemporal nonlesional epilepsy in children: a meta-analysis. Childs Nerv Syst. 2009 Dec 15. (Epub ahead of print).

Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, Koh C, Zhang J, Li YM, Maciaczyk J, Nikkhah G, Dimeco F, Piccirillo S, Vescovi AL, Eberhart CG. NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. Stem Cells. 2010 Jan; 28(1): 5-16.

Nakamura T, Kuroda Y, Hosomi N, Okabe N, Kawai N, Tamiya T, Xi G, Keep RF, Itano T. Serine protease inhibitor attenuates intracerebral hemorrhage-induced brain injury and edema formation in rat. Acta Neurochir Suppl. 2010; 106: 307-10.

Okauchi M, Hua Y, Keep RF, Morgenstern LB, Schallert T, Xi G. Deferoxamine Treatment for Intracerebral Hemorrhage in Aged Rats. Therapeutic Time Window and Optimal Duration. Stroke. 2009 Dec 31. (Epub ahead of print).

Oweis Y, Gemmete JJ, Chaudhary N, Pandey A, Ansari S. Delayed Development of Brain Abscesses Following Stent-Graft Placement in a Head and Neck Cancer Patient Presenting with Carotid Blowout Syndrome. Cardiovasc Intervent Radiol. 2009 Dec 24. (Epub ahead of print).

Park P, Leveque JC, Marca FL, Sullivan SE. Dural Closure Using the U-clip in Minimally Invasive Spinal Tumor Resection. J Spinal Disord Tech. 2010 Jan 11. (Epub ahead of print).

Plane JM, Andjelkovic AV, Keep RF, Parent JM. Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cells. Neurobiol Dis. 2010 Jan; 37(1): 218-27.

Thawani JP, Wang AC, Than KD, Lin CY, Marca FL, Park P. Bone Morphogenetic Proteins and Cancer: Review of the Literature. Neurosurgery. 2009 Dec 29. (Epub ahead of print).

Obstetrics & Gynecology

Kim C, Vahratian A. Self-rated health and health care use among women with histories of gestational diabetes mellitus. Diabetes Care 2010; 33: 41-42.

Lancaster C, Gold K, Flynn H, Marcus S, Davis M. Risk Factors for Depressive Symptoms during Pregnancy: A Systematic Review. Am J Obstet Gynecol 2010 Jan; 202(1): 5-14.

Smith RD. Contemporary hysteroscopic methods for female sterilization. Int J Gynaecol Obstet. 2010 Jan; 108(1): 79-84.

Ophthalmology & Visual Sciences

Besirli CG, Johnson MW. Proliferative diabetic retinopathy. Mayo Clin Proc 2009; 84(12): 1054.

Clark AJ, Petty HR. A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils. Cell Immunol 2009 (Epub ahead of print).

Craig SE, Thummel R, Ahmed H, Vasta GR, Hyde D, Hitchcock PF. The zebrafish galectin Drgal1-L2 is expressed by proliferating Muller glia and photoreceptor progenitors and regulates the regeneration of rod photoreceptors. Invest Ophthalmol Vis Sci 2010 (Epub ahead of print).

Douglas RS, Afifiyan NF, Hwang CJ, Chong K, Haider U, Richards P, Gianoukakis AG, Smith TJ. Increased generation of fibrocytes in thyroid-associated ophthalmopathy. J Clin Endocrinol Metab 2010; 95(1): 430-8.

Heckenlively JR, Ferreyra HA, Janasundera T. Controversies of diagnosing autoimmune retinopathy. Arch Ophthalmol 2010; 128(1): 147-8; author reply 8-9.

Lass JH, Sugar A, Benetz BA, Beck RW, Dontchev M, Gal RL, Kollman C, Gross R, Heck E, Holland EJ, Mannis MJ, Raber I, Stark W, Stulting RD. Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty. Arch Ophthalmol 2010; 128(1): 63-9.

Lelli GJ, Jr., Musch DC, Frueh BR, Nelson CC. Outcomes in silicone rod frontalis suspension surgery for high-risk noncongenital blepharoptosis. Ophthal Plast Reconstr Surg 2009; 25(5): 361-5.

Lu Y, Jia L, He S, Hurley MC, Leys MJ, Jayasundera T, Heckenlively JR. Melanoma-associated retinopathy: a paraneoplastic autoimmune complication. Arch Ophthalmol 2009; 127(12): 1572-80.

Mian SI, Li AY, Dutta S, Musch DC, Shtein RM. Dry eyes and corneal sensation after laser in situ keratomileusis with femtosecond laser flap creation Effect of hinge position, hinge angle, and flap thickness. J Cataract Refract Surg 2009; 35(12): 2092-8.

Mian SI, Malta JB. Moraxella keratitis: risk factors, presentation, and management. Acta Ophthalmol 2009 (Epub ahead of print).

Paul E, Kielbasinski M, Sedivy JM, Murga-Zamalloa C, Khanna H, Klysik JE. Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse. Transgenic Res 2009 (Epub ahead of print).

Pribila JT, Cornblath WT, Ramocki JM, Marentette LJ, Flint A, Elner VM. Glomus cell tumor of the orbit. Arch Ophthalmol 2010; 128(1): 144-6.

Schneider E, Mian SI. Recommended practices for femtosecond laser in refractive surgery. Insight 2009; 34(4): 8-12.

Sitrin RG, Sassanella TM, Landers JJ, Petty HR. Migrating Human Neutrophils Exhibit Dynamic Spatiotemporal Variation in Membrane Lipid Organization. Am J Respir Cell Mol Biol 2009 (Epub ahead of print).

Stein JD, Zacks DN, Grossman D, Grabe H, Johnson MW, Sloan FA. Adverse events after pars plana vitrectomy among medicare beneficiaries. Arch Ophthalmol 2009; 127(12): 1656-63.

Trobe JD. Robert B. Daroff, MD pioneer of ocular motor research. J Neuroophthalmol 2009; 29(4): 342-53.

Warden KF, Parmar H, Trobe JD. Perineural spread of cancer along the three trigeminal divisions. J Neuroophthalmol 2009; 29(4): 300-7.

Orthopaedic Surgery

Bernas GA, Ruberte Thiele RA, Kinnaman KA, Hughes RE, Miller BS, Carpenter JE. Defining safe rehabilitation for ulnar collateral ligament reconstruction of the elbow: A biomechanical study. American Journal of Sports Medicine 2009; 37(12): 2392-2400.

Blaha JD, Mancinelli C, Overgaard K. Failure of Sex to Predict the Size and Shape of thee Knee. J Bone Joint Surg 2009; 91: 19-22.

Blaha JD, Overgaard BS. Difference Between the Sexes in the Anatomy of the Anterior Condyle of the Knee. By Ferring et al. Dec 2009; 91: 2335-41.

Chang C-Y, Rupp JD, Reed MP, Hughes RE, Schneider LW. Predicting the effects of muscle activation on knee, thigh, and hip injuries in frontal crashes using finite-element model with muscle forces from subject testing and musculoskeletal modeling. Stapp Car Crash Journal 2009; 53: 291-328.

Gatti CJ, Hughes RE. Optimization of muscle wrapping objects using simulated annealing. Annals of Biomedical Engineering 2009; 37:1342-1347.

Manske SL, Boyd SK, Zernicke RF. Muscle and bone follow similar temporal patterns of recovery from muscle-induced disuse due to Botulinum toxin injection. Bone 2010; 46: 24-31.

Otolaryngology

Kang SY, Colesa DJ, Swiderski DL, Su GL, Raphael Y, Pfingst BE. Effects of Hearing Preservation on Psychophysical Responses to Cochlear Implant Stimulation. J Assoc Res Otolaryngol. 2009 Nov 10 (Epub ahead of print).

Pediatrics & Communicable Diseases

Chattoraj SS, Murthy R, Ganesan S, Goldberg JB, Zhao Y, Hershenson MB, Sajjan US. Pseudomonas aeruginosa alginate promotes Burkholderia cenocepacia persistence in CFTR knockout mice. Infect Immun. 2010 Jan 4 (Epub ahead of print).

Dempsey AF, Freed GL. Health care utilization by adolescents on Medicaid: implications for delivering vaccines. Pediatrics. 2010 Jan; 125(1): 43-9.

Dillman JR, Mueller GC, Attili AK, Dorfman AL, Ensing GJ, Gordon D. Case 153: atypical tumefactive hypertrophic cardiomyopathy. Radiology. 2010 Jan; 254(1): 310-3.

Freed GL, Cowan AE, Clark SJ. Primary care physician perspectives on reimbursement for childhood immunizations. Pediatrics. 2009 Dec; 124 Suppl 5: S466-71.

Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Gueranger Q, Glover TW, Canman CE. Differential roles for DNA polymerases eta, zeta and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. Mol Cell Biol. 2009 Dec 22 (Epub ahead of print).

Major TC, Brant DO, Reynolds MM, Bartlett RH, Meyerhoff ME, Handa H, Annich GM. The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer. Biomaterials. 2009 Dec 28 (Epub ahead of print).

McCrea KW, Wang ML, Xie J, Sandstedt SA, Davis GS, Lee JH, Marrs CF, Gilsdorf JR. Prevalence of the sodC genei in nontypeable Haemophilus influenzae and Haemophilus haemolyticus by microarray-based hybridization. J Clin Microbiol. 2009 Dec 30 (Epub ahead of print).

Padmanabhan V, Sarma HN, Savabieasfahani M, Steckler TL, Veiga-Lopez A. Developmental reprogramming of reproductive and metabolic dysfunction in sheep: native steroids vs. environmental steroid receptors modulators. Int J Androl. 2010 Jan 12 (Epub ahead of print).

Raeker MO, Bieniek AN, Ryan AS, Tsai HJ, Zahn KM, Russell MW. Targeted deletion of the zebrafish obscurin A RhoGEF domain affects heart, skeletal muscle and brain development. Dev Biol 2010. (Epub ahead of print).

Westcott DJ, Delproposto JB, Geletka LM, Wang T, Singer K, Saltiel AR, Lumeng CN. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med. 2009 Dec 21; 206(13): 3143-56.

Zebrack BJ, Donohue JE, Gurney JG, Chesler MA, Bhatia S, Landier W. Psychometric evaluation of the impact of cancer (IOC-CS) scale for young adult survivors of childhood cancer. Qual Life Res. 2010 Jan 8 (Epub ahead of print).

Psychiatry

Bedi G, Phan KL, Angstadt M, de Wit H. Effects of MDMA on sociability and neural response to social threat and social reward. Psychopharmacology (Berl). 2009 Nov; 207(1): 73-83.

Bohnert AS, German D, Knowlton AR, Latkin CA. Friendship networks of inner-city adults: A latent class analysis and multi-level regression of supporter types and the association of supporter latent class membership with supporter and recipient drug use. Drug Alcohol Depend. 2009 Nov 23. (Epub ahead of print).

Bohnert AS, Latkin CA. HIV testing and conspiracy beliefs regarding the origins of HIV among African Americans. AIDS Patient Care STDS. 2009 Sep; 23(9): 759-63.

Duffy SA, Karvonen-Gutierrez CA, Ewing LA, Smith PM, and Veterans Integrated Service Network (VISN) 11 Tobacco Tactics Team. Implementation of the Tobacco Tactics Program in the Department of Veterans Affairs. J Gen Intern Med 2009, 25(Suppl 1): 3–10.

Guyer, M.J. & Levy, R. Introduction to the Legal System. In: Textbook of Principles and Practice of Child and Adolescent Forensic Mental Health. (Eds. Benedek, E., Ash, P. & Scott) Am Psychiatric Assoc. Press, Inc. Wash. D.C. 2009.

Kilbourne AM, Greenwald DE, Hermann RC, Charns MP, McCarthy JF, Yano EM. Financial incentives and accountability for integrated medical care in Department of Veterans Affairs mental health programs. Psychiatr Serv. 2010 Jan; 61(1): 38-44.

King A, McNamara P, Angstadt M, Phan KL. Neural Substrates of Alcohol-Induced Smoking Urge in Heavy Drinking Nondaily Smokers. Neuropsychopharmacology. 2009 Nov 11. (Epub ahead of print).

Leung S, Croft RJ, Guille V, Scholes K, O'Neill BV, Phan KL, Nathan PJ. Acute dopamine and/or serotonin depletion does not modulate mismatch negativity (MMN) in healthy human participants. Psychopharmacology (Berl). (Epub ahead of print).

Lin JC, Karno MP, Barry KL, Blow FC, Davis JW, Tang L, Moore AA. Determinants of Early Reductions in Drinking in Older At-Risk Drinkers Participating in the Intervention Arm of a Trial to Reduce At-Risk Drinking in Primary Care. J Am Geriatr Soc. 2010 Jan 8. (Epub ahead of print).

Perron BE, Fries LE, Kilbourne AM, Vaughn MG, Bauer MS. Racial/Ethnic group differences in bipolar symptomatology in a community sample of persons with bipolar I disorder. J Nerv Ment Dis. 2010 Jan; 198(1): 16-21.

Post EP, Kilbourne AM, Bremer RW, Solano FX Jr, Pincus HA, Reynolds CF 3rd. Organizational factors and depression management in community-based primary care settings. Implement Sci. 2009 Dec 31; 4(1): 84.

Raue PJ, Morales KH, Post EP, Bogner HR, Ten Have T, Bruce ML. The Wish to Die and 5-Year Mortality in Elderly Primary Care Patients. Am J Geriatr Psychiatry. 2009 Nov 10. (Epub ahead of print).

Rohsenow DJ, Howland J, Arnedt JT, Almeida AB, Greece J, Minsky S, Kempler CS, Sales S. Intoxication With Bourbon Versus Vodka: Effects on Hangover, Sleep, and Next-Day Neurocognitive Performance in Young Adults. Alcohol Clin Exp Res. 2009 Dec 17. (Epub ahead of print).

Silk KR: The quality of depression in borderline personality disorder and the diagnostic process. J Personal Disord, 2010; 24: 25-37.

Silk KR, Jibson MD: Personality disorders. In Rothchild, A. (Ed). The Evidence-Based Guide to Antipsychotic Medication. Washington, DC: American Psychiatric Publishing, Inc, 2010: pp 101-124.

Tso IF, Grove TB, Taylor SF. Emotional experience predicts social adjustment independent of neurocognition and social cognition in schizophrenia. Schizophr Res. 2010 Jan 3. (Epub ahead of print).

Zivin K, Ratliff S, Heisler MM, Langa KM, Piette JD. Factors Influencing Cost-Related Nonadherence to Medication in Older Adults: A Conceptually Based Approach. Value Health. 2010 Jan 8. (Epub ahead of print).

Radiation Oncology

Boonstra JJ, van Marion R, Beer DG, Lin L, Chaves P, Ribeiro C, Pereira AD, Roque L, Darnton SJ, Altorki NK, Schrump DS, Klimstra DS, Tang LH, Eshleman JR, Alvarez H, Shimada Y, van Dekken H, Tilanus HW, Dinjens WN. Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines. J Natl Cancer Inst. 2010 Jan 14. (Epub ahead of print).

Desai S, Ben-Josef E, Griffith KA, Simeone D, Greenson JK, Francis IR, Hampton J, Colletti L, Chang AE, Lawrence TS, Zalupski MM. Gemcitabine-based combination chemotherapy followed by radiation with capecitabine as adjuvant therapy for resected pancreas cancer. Int J Radiat Oncol Biol Phys. 2009 Dec 1; 75(5): 1450-5.

Dijkema T, Raaijmakers CP, Ten Haken RK, Roesink JM, Braam PM, Houweling AC, Moerland MA, Eisbruch A, Terhaard CH. Parotid Gland Function After Radiotherapy: The Combined Michigan and Utrecht Experience. Int J Radiat Oncol Biol Phys. 2010 Jan 5. (Epub ahead of print).

Divi V, Worden FP, Prince ME, Eisbruch A, Lee JS, Bradford CR, Chepeha DB, Teknos TN, Hogikyan ND, Moyer JS, Tsien CI, Urba SG, Wolf GT. Chemotherapy alone for organ preservation in advanced laryngeal cancer. Head Neck. 2009 Dec 1. (Epub ahead of print).

Fairchild A, Barnes E, Ghosh S, Ben-Josef E, Roos D, Hartsell W, Holt T, Wu J, Janjan N, Chow E. International patterns of practice in palliative radiotherapy for painful bone metastases: evidence-based practice? Int J Radiat Oncol Biol Phys. 2009 Dec 1; 75(5): 1501-10.

Herawi M, Drew PA, Pan CC, Epstein JI. Clear cell adenocarcinoma of the bladder and urethra: cases diffusely mimicking nephrogenic adenoma. Hum Pathol. 2010 Jan 6. (Epub ahead of print).

Houweling AC, Philippens ME, Dijkema T, Roesink JM, Terhaard CH, Schilstra C, Ten Haken RK, Eisbruch A, Raaijmakers CP. A Comparison of Dose-response Models for the Parotid Gland in a Large Group of Head-and-neck Cancer Patients. Int J Radiat Oncol Biol Phys. (Epub ahead of print).

Jabbari S, Weinberg VK, Shinohara K, Speight JL, Gottschalk AR, Hsu IC, Pickett B, McLaughlin PW, Sandler HM, Roach M 3rd. Equivalent biochemical control and improved prostate-specific antigen nadir after permanent prostate seed implant brachytherapy versus high-dose three-dimensional conformal radiotherapy and high-dose conformal proton beam radiotherapy boost. Int J Radiat Oncol Biol Phys. 2010 Jan 1; 76(1): 36-42.

Jagsi R, Ben-David MA, Moran JM, Marsh RB, Griffith KA, Hayman JA, Pierce LJ. Unacceptable cosmesis in a protocol investigating intensity-modulated radiotherapy with active breathing control for accelerated partial-breast irradiation. Int J Radiat Oncol Biol Phys. 2010 Jan 1; 76(1): 71-8.

Jagsi R, Motomura AR, Griffith KA, Rangarajan S, Ubel PA. Sex differences in attainment of independent funding by career development awardees. Ann Intern Med. 2009 Dec 1; 151(11): 804-11.

Katz SJ, Hawley ST, Morrow M, Griggs JJ, Jagsi R, Hamilton AS, Graff JJ, Friese CR, Hofer TP. Coordinating cancer care: patient and practice management processes among surgeons who treat breast cancer. Med Care. 2010 Jan; 48(1): 45-51.

Mani RS, Tomlins SA, Callahan K, Ghosh A, Nyati MK, Varambally S, Palanisamy N, Chinnaiyan AM. Induced chromosomal proximity and gene fusions in prostate cancer. Science. 2009 Nov 27; 326(5957): 1230.

Moffat BA, Galbán CJ, Rehemtulla A. Advanced MRI: translation from animal to human in brain tumor research. Neuroimaging Clin N Am. 2009 Nov; 19(4): 517-26.

Popovtzer A, Cao Y, Feng FY, Eisbruch A. Anatomical changes in the pharyngea constrictors after chemo-irradiation of head and neck cancer and their dose-effect relationships: MRI-based study. Radiother Oncol. 2009 Dec; 93(3): 510-5.

Rehemtulla A. The War on Cancer rages on. Neoplasia. 2009 Dec;11(12):1252-63.Sundgren PC, Cao Y. Brain irradiation: effects on normal brain parenchyma and radiation injury. Neuroimaging Clin N Am. 2009 Nov; 19(4): 657-68.

Radiology

Miller DL, Dou C, Wiggins RC, In vivo gas body efficacy for glomerular capillary hemorrhage induced by diagnostic ultrasound in rats. IEEE Trans BioMed Eng, 2010; 57: 167-174,.

Surgery

General Surgery:
Cheng J, Zhou W, Warner GM, Knudsen BE, Garovic VD, Gray CE, Lerman LO, Platt JL, Romero JC, Textor SC, Nath KA, Grande JP. Temporal Analysis of Signaling Pathways Activated in a 2 Murine Model of 2-Kidney, 1-Clip Hypertension. American Journal of Physiology - Renal Physiology. 297(4): 1055-1068, 2009.

Gauger PG, Hauge LS, Andreatta PB, Hamstra SJ, Hillard ML, Arble EP, Kasten SJ, Mullan PB, Cederna PS, Minter RM: Simulation training of laparoscopic skills with proficiency targets improves practice and performance of novice surgeons. American Journal of Surgery 199: 72-80, 2010.

Lynch RJ, Platt JL. Escaping from Rejection. Transplantation, 88(11): 1233-1266, 2009.

Napolitano LM: Clinical Practice Guideline: Red Bllod Cell Transfusion in Adult Trauma and Critical Care. J Trauma. 2009 Dec; 67(6): 1439-42.

Platt JL. Xenotransplantation of the kidney. In: UpToDate. Brennan DC, ed. Waltham, MA. UpToDate, 2009.

Tseng-Rogenski S, Gee J, Ignatoski KW, Kunju LP. Bucheit A, Kintner HJ, Morris D, Tallman C, Evron J, Wood CG, Grossman HB, Lee CT, Liebert M. Loss of 15-Hydroxyprostaglandin Dehydrogenase Expression Contributes to Bladder Cancer Progression. The American Journal of Pathology, Vol. 176, No. 3, March 2010. (Accepted).

Urschel S, Meyer SR, Larsen IM, Derkatz K, Coe JY, Tinckam K, Nuebel J, Birnbaum J, Netz H, Kauke T, Platt JL, Campbell PM, West LJ. Absence of donor-specific anti-HLA antibodies after ABO-incompatible heart transplantation in infancy - altered immunity or age? American Journal of Transplantation 10: 149-156, 2010.

Wahl WL, Arbabi S, Zalewski C, Wang SC, Hemmila MR. Intensive Care Unit Core Measures Improve Infectious Complications in Burn Patients. J Burn Care Res. 2010 Jan-Feb; 31(1): 190-5.

Pediatric Surgery:
Brown JK, Campbell BT, Drongowski RA, Alderman AK, Geiger JD, Teitelbaum DH, Quinn J, Coran AG, Hirschl RB: A prospective, randomized comparison of skin adhesive and subcuticular suture for closure of pediatric hernia incisions: cost and cosmetic considerations. J Pediatr Surg 2009; 44(7): 1418-1422.

Hashish, M, Dawoud, HH, Hirschl, RB, Bruch, SW, El Bartarny, AM, Mychaliska, GB, Drongowski, R, Ehrlich, PF, Hassaballa, SZ, El-Dosuky, NI, Teitelbaum, DH: Long term functional outcome and quality of life in patients with high imperforate anus. J Pediatr Surg 2010, 45(1): 224-30.

Hashish, M, Raghavan, S, Somara, S, Gilmont, R, Miyasaka, E, Bitar, KN, Teitelbaum, DH: Development and implantation of a bioartificial anal sphincter. J Pediatr Surg 2010; 45(1): 52-8.

Nose, K, Yang, H, Sun X, Nose, S, Koga, H, Feng, Y, Miyasaka, E, Teitelbaum, DH: Glutamine Prevents Total Parenteral Nutrition -Associated Changes to Intraepithelial Lymphocyte Phenotype and Function: A Potential Mechanism for the Preservation of Epithelial Barrier Function. J Interferon and Cytokine Res 2010; 30(2): 13-24.

Seetharamaiah, R, West, BT, Ignash, SJ, Pakarinen, MP, Koivusalo, A, Rintala, RJ, Liu, DC, Spencer, AU, Skipton, K, Geiger, JD, Hirschl, RB, Coran, AG, Teitelbaum, DH: Outcomes in pediatric patients undergoing straight versus J-pouch ileoanal anastomosis: A multi-center analysis. J Pediatr Surg 2009; 44(7): 1410-1417.