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JANUARY 2010, Vol. 28


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HEADLINES

New Steeper Clinical Research Discounts!

The Medical School and Hospitals & Health Centers are committed to supporting investigators conducting clinical trials research. Based on valuable feedback from investigators and study coordinators, we are pleased to announce a significant reduction in professional and hospital fees for clinical research. These new discounts will help achieve the Medical School objective of doubling clinical research by 2015 through improving researchers’ ability to successfully obtain funding from sponsors by offering more competitive pricing for clinical trials.

Effective January 1, 2010, the following discounts will apply to both federal and non-federal awards:

Professional Fee Discount
All charges will be discounted to the level of the Medicare fee schedule which is currently an overall average of a 71% discount rate.

Facility (Hospital/Technical) Fee Discount
All charges will be discounted by 80% except:

  • Inpatient room rates (routine, specialty beds and ICU) = 50% discount
  • Lab reference tests (tests not performed by UM labs, send-outs to reference laboratories) = No discount
  • Organ acquisition fees = No discount

These new discounts will be reflected in the Clinical Research Pricing Tool on January 1, and the Billing Office will apply the new discounts to research items and services. Investigators can use these rates now when creating budgets for upcoming clinical studies.

As a principal investigator, there is nothing you need to do immediately. However, given that your existing study budgets were created based on higher rates, you should review your award notices for any terms and conditions that may apply to re-purposing of funds, if applicable.

Details about this clinical research improvement, including a list of resources for any questions you may have, can be found in the FAQs about the new discounts. Please note that the FAQ document is available via U-M computers only and computers that are logged in via a VPN (Virtual Private Network).

Steve Kunkel, Ph.D.
Senior Associate Dean for Research

Dave Spahlinger, M.D.
Senior Associate Dean for Clinical Affairs

Dave Morlock
CFO, UM Health System

Workshop – "The Nuts & Bolts of Building a Research Billing Calendar"

The Clinical Research Calendar Review & Analysis Office (CR2AO) – formerly known as CRBU – cordially invites you to join us for a workshop where you can learn why the Billing Calendar is required and valuable to the PI / study team, how to complete the calendar, and where to go for assistance in building a completed Billing Calendar. Gina Vuocolo-Branch, Senior Manager of the CR2AO, will present (45 min) and then hold a Q&A session (30 min).

The same workshop will be offered three different times:

Thursday, February 18, 2010
2:00 - 3:15 PM
Ford Auditorium

Tuesday, February 23, 2010
10:00 - 11:15 AM
BSRB Auditorium

Wednesday, February 24, 2010
1:00 - 2:15 PM
BSRB Auditorium

The workshop will be videotaped – so if you’re unable to attend a live session, you can register to receive a link to the video when it’s available. (All those who attend a live session will automatically get the email alert.) To attend a live session – or to receive an email alert when the video is online – please register online.

This workshop is just one of several improvements being made by the CR2AO (which is a part of the Medical School Office of Research) to enhance our clinical research support services. The Health System just signed an agreement with eThority to provide a robust clinical trials software application, including budgeting, billing calendar, and patient enrollment capabilities. We expect to share more information very soon about how and when this application will be rolled out . Stay tuned!

Contact Kathryn Ridner at (kridner@umich.edu) or 734-763-4086 with any questions about the workshop.

Did You Miss It? – "Changes in the NIH Grant Game: Impact Trumps Details"
Speaker

This workshop, sponsored by the Medical School Office of Research, was held on December 17, 2009 in the BSRB Auditorium. The workshop focused on changes in the NIH peer review scoring system and the corresponding new format requirements. Chris Black from the Office of Research covered the changes as outlined on the NIH website. A panel of faculty members, who serve on NIH study sections, commented on their experience using the new review scale, and offered additional suggestions on addressing the evaluation criteria while complying with stricter page limits. The panel addressed R, K and P awards.

Watch the video and access the PowerPoint presentation and other information online.

* Please note that the website is available via U-M computers only and computers that are logged in via a VPN (Virtual Private Network).

Panelists included:

  • Thomas Carey, Ph.D., Departments of Otorhinolaryngology and Pharmacology
  • Deborah Gumucio, Ph.D., M.P.H., Department of Cell & Developmental Biology
  • John Li Puma, M.D., Department of Pediatrics & Communicable Diseases
  • Max Pietropaolo, M.D., Departments of Internal Medicine and Pediatrics & Communicable Diseases
  • Pavan Reddy, M.D., Department of Internal Medicine
  • Robert Silbergleit, M.D., Department of Emergency Medicine

Contact Kathryn Ridner (kridner@umich.edu or 734-763-4086) with any questions.

Panel

New! Reference List of Freelance Editors

In response to faculty interest in the availability of editing services, the Medical School Office of Research has developed a list of freelance editors, including their credentials. While we encourage faculty members to use internal resources (such as the MICHR Research Development Core or Chris Black in the Office of Research for grant proposals), we know that we may not have the capacity to meet the demand. The list of editors (along with CV/resumes and contact information) can be found at (http://www.med.umich.edu/medschool/research/support/editors).

The editors on this list have expertise in various types of writing (e.g., manuscripts, grant proposals, IRB protocol). If interested, please contact the editor to negotiate the work statement/pay arrangements.

Call for Submissions to Medicine at Michigan Magazine

Medicine at Michigan seeks news of books authored or edited by Medical School faculty – or guest editorship of a full journal issue – for the “In Print” section of the magazine’s spring 2010 issue.

Please send publication information, including title, co-authors/editors, publisher and publication date, to Robin Johnson (robinjo@umich.edu or 734-998-8828) by January 29, 2010 for inclusion in the spring issue. If possible, please also forward the book or journal to:

Office of Medical Development and Alumni Relations
301 E. Liberty, Suite 400
Ann Arbor, MI 48104-2251

The cover will be scanned to print specifications, and the image will likely appear with the publication announcement. The Dean’s Office would like to display your book or journal once the cover has been scanned. Please indicate if this is acceptable, or if you would like your items returned immediately after scanning.


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Animal Research

Adding Students to Protocols

Please remember that any new students should be added to your protocol if they will be working with animals. In order to add new personnel, please send an email to the UCUCA Office (ucuca.office@umich.edu) and provide the student’s name and contact information, the UCUCA approved protocol number, and the principal investigator’s name. Or log into eSirius and select “Submit an amendment to an approved protocol.”

Animal Concern Hotline

The UCUCA maintains an Animal Concern Hotline, operated through the UCUCA Office, to provide a mechanism for UM staff members and members of the public to report any matter of concern about the humane care and use of laboratory animals at the University. Reports are investigated on behalf of the UCUCA by the UCUCA Office staff and, if necessary, by a (ULAM) veterinary faculty member. Immediate steps are taken to ensure that animal care and use are appropriate and that animal welfare is sustained. The UCUCA is apprised of these investigations and their outcomes at their monthly meetings and makes further recommendations, if warranted. Reports and sources of information are maintained in confidence within University guidelines. To report an animal concern, please call 734-763-8028 or visit (http://www.ucuca.umich.edu/hotline.htm).

eResearch

Information Technology Services (ITS), the University Committee on Use and Care of Animals (UCUCA) office, and the Unit for Laboratory Animal Medicine (ULAM) are working together to design and develop the eResearch Animal Management (eRAM) system. This is a new web-based system being developed that accommodates the electronic management of UCUCA animal use research protocols and the associated ordering, census, and invoicing of animals for ULAM. The new system will replace eSirius and is expected to be available to the users in the fall of 2010 for the online application portion of the program. We are also soliciting input from our largest users – the research community! If you are interested in providing your feedback, you can sign up to be a volunteer to test the system by emailing (eram.contact@umich.edu). To keep up with our progress, please visit (http://eresearch.umich.edu/) and click on the section for “Animal Management.”


UPDATE FROM WASHINGTON, DC


NIH Receives a 2.3 Percent Budget Increase for Fiscal Year 2010

On December 16, 2009 President Barack Obama signed legislation into law to fund the National Institutes of Health (NIH), as well as various other federal domestic agencies, for Fiscal Year 2010 (FY10). Within this law, the NIH will receive a 2.3 percent increase of $692 million over the regular FY09 budget (which does not include the additional $10.4 billion in additional Recovery Act funds) to a new funding level of $31.008 billion. As in past years, $300 million will be transferred to the Global HIV/AIDS Fund. Below are the allocations by institute for the FY10.

  • NCI = $5.1 billion – a 2.7% increase (FY09 = $4.97 billion)
  • NHLBI = $3.097 billion – a 2.7% increase (FY09 = $3.02 billion)
  • NIDR = $413.24 million – a 2.6% increase (FY09 = $403 billion)
  • NIDDK = $1.96 billion – a 2.4% increase (FY09 = $1.91 billion)
  • NINDS = $1.64 billion – a 2.7% increase (FY09 = $1.59 billion)
  • NIAIDS = $4.82 billion – a 2.5% increase (FY09 = $4.70 billion).
  • NIGMS = $2.052 billion – a 2.7% increase (FY09 = $1.99 billion)
  • Eugene Kennedy Shriver NICHS = $1.33 billion – a 2.7% increase (FY09 = $1.29 billion)
  • NEI = $707.04 million – a 2.7% increase (FY09 = $688 million)
  • NIEHS = $689.78 million – a 4.1 % increase (FY09 = $663 million)
  • NIA = $1.11 billion – a 2.7% increase (FY09 = $1.08 billion)
  • NIAMS = $539.08 million – a 2.7% increase (FY09 = $525 million)
  • NIDCD = $418.83 million – a 2.8% increase (FY09 = $407 million)
  • NIMH = $1.49 billion – a 2.7% increase (FY09 = $1.45 billion)
  • NIDA = $1.06 billion – a 2.6% increase (FY = $1.03 billion)
  • NIAAA = $462.35 million – a 2.7% increase (FY09 = $450 million)
  • NINR = $145.6 million – a 2.7% increase (FY09 = $142 million)
  • NHGRI = $516.03 million – a 2.7% increase (FY09 = $502 million)
  • NIBIB = $316.58 million – a 2.7% increase (FY09 = $308 million)
  • NCRR = $1.27 billion – a 3.5% increase (FY09 = $1.26 billion)
  • NCCAM = $128.84 million – a 2.7% increase (FY09 = $125 million)
  • NCMHD = $211.57 million – a 2.7% increase (FY09 = $206 million)
  • FIC = $70.05 million – a 2% increase (FY09 = $69 million)
  • NLM = $339.71 million – a 2.7% increase (FY09 = $331 million)
    • $4 million will go to improved information systems.
  • Office of the Director = $1.18 billion – a 5.6% cut (FY09 = $1.25 billion).
    • $193.88 million would go to the National Children's Study.
    • $544.11 million is allocated to the Common Fund.


EDUCATIONAL OPPORTUNITIES


What is My NCBI?

Thursday, February 11, 2010
10:00 - 11:30 AM

Are you aware of this tool provided via PubMed that makes keeping up with current published research and clinical practice easier? This class will show you the many options available in My NCBI, such as saving a search strategy that can be updated when new records are added to PubMed, getting email alerts, setting up an RSS Feed. The class will also explore using the Collections and Bibliography tools. Register online.

Using EndNote for Grant Writing

Thursday, February 25, 2010
10:00 - 11:30 AM

EndNote can help you in tackling the many hurdles of writing a grant. The program can help you in formatting references according to the grant instructions for the initial funding application, the annual progress reports, and the biosketches. Register online.


FYI CORNER


Center for Organogenesis Associate Director Search

The Center for Organogenesis is seeking a Ph.D. faculty member to serve as Associate Director. Associate and Full Professor level faculty will be considered. Applicants should have a strong and successful research history in basic sciences and also have a history of service to the Center for Organogenesis (participation in training grant, graduate courses, symposia, seminars, journal clubs, Bio-Artography). The Associate Director will assist the Director in planning and implementing program activities, including but not limited to, education initiatives, enhancing campus-wide communication and information sharing, and supporting the development of new programs to further the translational research mission of the Center. The Associate Director will also assist the Director in recruiting new faculty whose work aligns with the mission of the Center.

Interested individuals should submit a letter of interest and a curriculum vitae to Rebecca Pintar (rpintar@umich.edu) by February 19, 2010.


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains a link to M-Quest (a database of opportunities for grants, honors, prizes and fellowships created and maintained by the Office of Research) as well as information on email alert groups.


External Limited Submissions


These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

David and Lucile Packard Foundation Fellowships for Science and Engineering
Internal Deadline: February 12, 2010
(Nominees identified to Foundation by March 15, 2010)
Foundation Deadline: April 20, 2010

The intent of the Fellowship Program is to provide support for unusually creative researchers early in their careers and to emphasize support for innovative individual research that involves the Fellows, their students, and junior colleagues, rather than extensions or components of large-scale, ongoing research programs.

Eligible candidates: Faculty members engaged in research in the natural and physical sciences or engineering. Candidates must be faculty members in the first three years of their faculty career, that is, whose initial faculty appointments began no earlier than May 31, 2007, and no later than May 31, 2010.

Disciplines that will be considered include physics, chemistry, mathematics, biology, astronomy, computer science, earth science, ocean science, and all branches of engineering. Candidates engaged in research in the social sciences will not be considered. The awards provide individual grants of $875,000 distributed over five years.

The University of Michigan has been invited to nominate up to two faculty members to apply. For consideration as an institutional nominee, submit the following electronically in a single PDF document to (OVPRlimitedsubmissions@umich.edu) by February 12, 2010:

  1. Nomination letter from dean or department chair
  2. 1-2 page research statement responsive to the RFP, describing why the research is important and outlining the general goals for the next five years
  3. NIH formatted biosketch
  4. Names only of three external references, with at least one a person who has had no supervisory or collaborative contact with the nominee.

The University's nominees will be notified promptly of their selection and must then prepare and submit their completed applications to the Packard Foundation by Tuesday, April 20, 2010. Additional information and guidelines for preparation are posted on the Foundation website.

Please contact Jane Ritter (ritterj@umich.edu or 734-763-1290) with questions regarding this fellowship program. Further information on this and other current funding opportunities may be found online.


External Open Submissions

Dr. Paul Janssen Award for Biomedical Research
Deadline: February 15, 2010

Nominate your most talented scientists for The Dr. Paul Janssen Award for Biomedical Research. The Award salutes individuals whose efforts have made significant transformational contributions towards the improvement of human health. Candidates will be evaluated by an independent selection committee of top researchers from around the world. Past winners include Craig Mello, Axel Ullrich, Marc Feldmann and Sir Ravinder Maini. Nomination forms are available online at (http://pauljanssenaward.com/). The winner will receive a $100,000 cash prize and broad international recognition for his or her achievements.


UMMS AWARDED GRANTS

External Awarded Grants

Currently, due to limitations on data collection, we are unable to identify projects awarded with multiple PIs. As the eRPM system is used for proposals in 2009, we will be able to publish those awards accurately. We apologize for any misleading project information this causes.

Click here to view.

Anesthesiology

PI: Ramachandran, Satya Krishna
Title: ACOUSTICAL RESPIRATORY RATE MONITORING CLINICAL RESEARCH PLAN
Sponsor: Masimo Corporation
Project Dates and Amount of Award: 12/05/09-02/28/10; $30,035

PI: Tremper, Kevin
Title: CONTINUOUS NON-INVASIVE HEMOGLOBIN (SPHB) DATA COLLECTION VIA PULSE CO-OXIMETRY
Sponsor: Masimo Corporation
Project Dates and Amount of Award: 01/05/10-05/01/11; $21,476

PI: Wasserman, Ronald
Co-I: Brummett, Chad (Anesthesiology Department)
Title: INTERICTAL, ICTAL AND POST-TREATMENT ADIPOCYTOKINE LEVELS IN MIGRAINE
Sponsor: Glaxosmithkline TO Pennsylvania Headache Center, P.C.
Project Dates and Amount of Award: 11/17/09-08/31/10; $110,650

Biological Chemistry

PI: Chiku, Taurai
Title: THE MECHANISM AND REGULATION OF HS2 BIOGENESIS BY CYSTATHIONINE GAMMA-LYASE
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 01/01/10-12/31/11; $95,224

PI: Malhotra, Jyoti
Title: CELLULAR STRESS RESPONSES ASSOCIATED WITH COAGULATION FACTOR VIII EXPRESSION
Sponsor: American Heart Assoc, Inc.
Project Dates and Amount of Award: 01/01/10-12/31/13; $308,000

Center for Computational Medicine and Bioinformatics

PI: Zhang, Yang
Title: Alfred P. Sloan Foundation Research Fellowship for Yang Zhang BR-4852
Sponsor: Sloan, Alfred P., Foundation
Project Dates and Amount of Award: 09/16/09-09/15/11; $29,726

Comprehensive Cancer Center

PI: Talpaz, Moshe
Title: ALXN6000 IN PATIENTS WITH RELAPSING OR REFRACTORY B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA (A PHASE I/II OPEN LABEL STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS OF)
Sponsor: Alexion Pharm Incorporated
Project Dates and Amount of Award: 04/29/09-04/28/10; $1,319,836

PI: Talpaz, Moshe
Title: DCC-2036 IN SUBJECTS WITH PHILADELPHIA CHROMOSOME POSITIVE LEUKEMIAS (A MULTICENTER PHASE 1 CLINICAL AND PHARMACOKINETIC STUDY OF)
Sponsor: Deciphera Pharmaceuticals, LLC
Project Dates and Amount of Award: 01/01/09-12/31/10; $404,106

Family Medicine

PI: Green, Lee
Co-I: Nease Jr, Donald (Department of Family Medicine)
Title: IT IMPLEMENTATION BY COGNITIVE ENGINEERING OF ORGANIZATIONAL ROUTINES
Sponsor: AHRQ 1 R18 HS 018170 01
Project Dates and Amount of Award: 09/30/09-07/31/12; $1,199,137

Human Genetics

PI: Robins, Diane
Title: VAV3 ONCOGENE POTENTIATION OF ANDROGEN RECEPTOR SIGNALING IN PROSTATE CANCER
Sponsor: NIH - Subcontracts TO University of Miami, Florida R01 CA 132200
Project Dates and Amount of Award: 07/01/09-04/30/10; $7,513

Internal Medicine

PI: Burgio, Louis
Title: North Carolina REACH II Translation Project: Resources for Enhancing Alzheimer's Caregiver Health
Sponsor: Health and Human Services, Department of-Administration on Aging-Subcontracts TO North Carolina, State of
Project Dates and Amount of Award: 10/01/09-09/30/10; $25,000

PI: Fries, Brant
Title: MENTAL HEALTH ASSESSMENT PROJECT
Sponsor: MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $198,000

PI: Hammer, Gary
Co-I: Giordano, Thomas (Pathology Department)
Title: WNT-RESPONSIVE ADRENOCORTICAL CELLS IN ORGAN MAINTENANCE AND CANCER
Sponsor: NIH 1 R01 CA 134606 01 A2
Project Dates and Amount of Award: 12/01/09-11/30/14; $1,511,081

PI: Hammer, Gary
Title: A Multi-Institutional Phase II Study of IMC-A12, A Recombinant Human IgG1/Lamda Monoclonal Antibody Directed at the Type I Insulin-Line Growth Factor Receptor (IFG-rR), in Adrenocortical Cancer: A Randomized Trial Comparing the Activity of IMC-A12 with Mitotane Versus Mitotane Alone
Sponsor: NIH - Subcontracts TO SAIC
Project Dates and Amount of Award: 11/19/09-09/25/10; $21,214

PI: Herman, William
Title: REPRODUCTIVE HEALTH INTERVENTION FOR TEEN GIRLS WITH DM
Sponsor: NIH TO University of Pittsburgh R01 HD 044097
Project Dates and Amount of Award: 06/01/09-05/31/10; $19,115

PI: Herman, William
Title: DIABETES PREVENTION PROGRAM OUTCOMES STUDY (DPPOS) - PHASE 2
Sponsor: NIH - Subcontracts TO George Washington University U01 DK 048489
Project Dates and Amount of Award: 04/01/09-01/31/10; $36,587

PI: Kaminski, Mark
Title: PHASE 1 STUDY OF RADIOSENSITIZATION USING BORTEZOMIB IN PATIENTS WITH RELAPSED MANTLE CELL OR AGGRESSIVE LYMPHOMA RECEIVING
Sponsor: Glaxosmithkline TO Cornell University
Project Dates and Amount of Award: 11/20/09-12/14/10; $55,700

PI: Koch, Alisa
Co-I: Ruth, Jeffrey (Int Med-Rheumatology)
Title: USE OF CTLA4-LG (ABSTRACT) IN AN IN VITRO MODEL OF ANGIOGENESIS
Sponsor: Bristol-Myers Squibb
Project Dates and Amount of Award: 12/04/09-12/03/10; $79,950

PI: Koch, Alisa
Co-I: Amin, Mohammad (Int Med-Rheumatology)
Title: ROLE OF PROINFLAMMATORY MEDIATORS IN MSU INDUCED GOUT
Sponsor: Takeda Pharmaceuticals
Project Dates and Amount of Award: 12/17/09-06/17/11; $109,382

PI: Monrad, Seetha
Title: METHODOLOGY FOR TEACHING MEDICAL STUDENTS REHEUMATOLOGY
Sponsor: American College of Radiology
Project Dates and Amount of Award: 07/01/10-06/30/13; $180,000

PI: Peters-Golden, Marc
Title: CONTRACT TO EVALUATE E PROSTANOID 2 AGONISTS
Sponsor: Nycomed Amersham plc
Project Dates and Amount of Award: 12/01/09-11/30/11; $250,000

PI: Pienta, Kenneth
Title: 2009.052: An Open-Label, Multicenter, Phase 2 Study of Single-agent CNTO 888 for Treatment of Subjects with Metastatic Castrate-Resistant Prostate Cancer
Sponsor: Centocor, Inc.
Project Dates and Amount of Award: 12/02/09-06/07/12; $607,495

PI: Riddell IV, James
Title: A PHASE 2B/3 OPEN-LABEL ROLLOVER STUDY FOR SUBJECTS DISCONTINUING FROM THE UK-453,061 PROTOCOLS FOR THE TREATMENT OF HIV-1 INFECTED SIBJECTS
Sponsor: Pfizer Incorporated TO ICON Clinical Research, Inc.
Project Dates and Amount of Award: 10/23/09-10/22/12; $4,988

PI: Riddell IV, James
Title: TRIAL OF UK-453,061 VERSUS ETRAVIRINE IN COMBINATION WITH DARUNAVIR/RITONAVIR AND A NUCLEOTIDE/NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR FOR THE TREATMENT OF ANTIRETROVIRAL EXPERIENCED HIV-1 INFECTED SUBJECTS WITH EVIDENCE OF NNRT1 RESISTANT HIV-1
Sponsor: Pfizer Incorporated TO ICON Clinical Research, Inc.
Project Dates and Amount of Award: 10/23/09-10/22/12; $40,506

PI: Rosen, Allison
Co-I: Bambauer, Kara (Psychiatry Department) / Langa, Kenneth (Int Med-General Medicine) / Norman, Joseph (Int Med-General Medicine) / Raghunathan, Trivellore (Biostatistics Department) / Valenstein, Marcia (Psychiatry Department) / Vijan, Sandeep (Int Med-General Medicine)
Title: EXPANDING THE NATIONAL HEALTH ACCOUNTS
Sponsor: NIH - Subcontracts TO National Bureau of Economic Research P01 AG 031098
Project Dates and Amount of Award: 04/01/09-01/31/10; $998,128

PI: Samaniego, Milagros
Title: treatement of recurrent thrombolic miroangiopathy (TMA) due to antiphospholipid antibody syndrome (APS) in the renal transplant causing worsening kidney function, in a patient who has not responded to conventional treatment for this condition.
Sponsor: Alexion Pharm Incorporated
Project Dates and Amount of Award: 10/21/09-10/21/10; $50,065

PI: Sato, Priscila
Title: HETEROCELLULAR INTERACTIONS IN ARRHYTHMOGENIC RIGHT VENTRICULAR CARIOMYOPATHY
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 01/01/10-12/31/11; $52,000

PI: Schuetze, Scott
Title: A Randomized, Double-Blinded, Placebo-Controlled, Multi-Institutional, Phase II.5 Study of AZD0530, a Selective Src Kinase Inhibitor, In Patients with Recurrent Osteosarcoma Localized to the Lung
Sponsor: SARC
Project Dates and Amount of Award: 12/17/09-11/04/14; $38,968

PI: Shahinian, Vahakn
Title: INFLUENCE OF REIMBURSEMENT ON ANDROGEN DEPRIVATION USE FOR PROSTATE CANCER
Sponsor: American Cancer Society
Project Dates and Amount of Award: 01/01/10-12/31/12; $534,000

PI: Smerage, Jeffrey
Title: UMCC 2007.056: DETERMINATION OF HER2 TUMOR STATUS BY CIRCULATING TUMOR CELL ANALYSIS
Sponsor: Genentech, Inc. TO University of Texas
Project Dates and Amount of Award: 11/20/09-10/31/11; $73,760

PI: Uhlmann, Wendy
Title: Presenting Diagnostic results from Large-Scale Clinical Mutation Testing
Sponsor: Cleveland Clinic Lerner College of Medicine TO NIH - Subcontracts R01 HG 004500
Project Dates and Amount of Award: 05/01/09-04/30/10; $11,588

PI: Wang, Shaomeng
Title: DESIGN OF ORALLY BIOAVAILABLE IAP ANTAGONISTS FOR CANCER TREATMENT
Sponsor: NIH 2 R01 CA 109025 05
Project Dates and Amount of Award: 12/18/09-11/30/14; $1,381,998

PI: Wicha, Max
Title: EPIGENETIC CHANGES AND THEIR IMPACTS ON BREAST CANCER PROGRESSION AND INITIAL SUSCEPTIBILITY
Sponsor: NIH - Subcontracts TO Cold Spring Harbor Lab
Project Dates and Amount of Award: 09/30/09-08/31/10; $218,652

PI: Zimmermann, Ellen
Title: EFFECT OF ADALIMUMAB ON INTESTINAL FIBROSIS IN AN ANIMAL MODEL OF CROHN'S DISEASE
Sponsor: Abbott Laboratories
Project Dates and Amount of Award: 12/07/09-12/06/10; $61,368

Medical School Administration Enabling Technologies

PI: Hanss, Theodore
Co-I: Engleberg, N (Int Med-Infectious Diseases)
Title: 2010-2011 AFRICAN HEALTH OER NETWORK
Sponsor: Hewlett, William and Flora, Foundation, The
Project Dates and Amount of Award: 11/16/09-11/16/11; $624,401

Molecular & Behavioral Neuroscience Institute

PI: Akil, Huda
Title: MOLECULES AND CIRCUITS OF POSITIVE EMOTIONS: A NEW APPROACH TO UNDERSTANDING AND COMBATING DEPRESSION
Sponsor: Hope For Depression Research Foundation
Project Dates and Amount of Award: 01/01/10-12/31/11; $110,000

PI: Zubieta, Jon
Title: FUNCTIONAL CHARACTERIZATION OF OPRM1 A118G IN ND
Sponsor: NIH - Subcontracts TO University of Pennsylvania R21
Project Dates and Amount of Award: 09/30/09-08/31/10; $21,361

Neurology

PI: Shakkottai, Vikram
Title: UNDERSTANDING THE ROLE OF ALTERED PHYSIOLOGY IN THE PATHOGENESIS OF SCA3
Sponsor: National Ataxia Foundation
Project Dates and Amount of Award: 01/01/10-12/31/10; $35,000

Obstetrics & Gynecology

PI: Johnson, Mark
Co-I: Saunders, Thomas (Int Med-Molecular Med&Genetics)
Title: INVESTIGATING THE BIOLOGICAL CONSEQUENCES OF ANEUPLOIDY ON EARLY EMBRYOGENESIS
Sponsor: NIH - Subcontracts TO The Jackson Laboratory 2 P40 RR 01183
Project Dates and Amount of Award: 09/25/09-04/30/10; $342,070

PI: Salari, Kataneh
Title: THE EFFECT OF DHA ON GLOBAL GENE EXPRESSION IN THE IMMATURE RAT BRAIN AFTER HYPOXIA-ISCHEMIA
Sponsor: American College of Obstetricians and Gynecologists
Project Dates and Amount of Award: 08/01/09-07/31/10; $5,000

Ophthalmology & Visual Sciences

PI: Demb, Jonathan
Title: NEURAL CIRCUITS AND SYNAPSES FOR EARLY VISUAL PROCESSING
Sponsor: NIH 2 R01 EY 014454 06
Project Dates and Amount of Award: 12/01/09-11/30/13; $1,401,808

PI: Smith, Terry
Title: 2009 RPB PHYSICIAN-SCIENTIST AWARD
Sponsor: Research To Prevent Blindness
Project Dates and Amount of Award: 12/01/09-11/30/10; $60,000

Otolaryngology

PI: Duncan, Robert
Title: MOLECULAR MECHANISMS OF AUDITORY NACHR SYNAPSE ASSEMBLY
Sponsor: NIH - Subcontracts TO Tufts University R01 DC 008802
Project Dates and Amount of Award: 09/19/09-08/31/10; $94,200

PI: Raphael, Yehoash
Title: STUDIES OF COCHLEAR TOXICITY OF NOVEL SXP AMINOGLYCOSIDES IN A GUINEA PIG MODEL
Sponsor: SelectX Pharmaceuticals, Inc
Project Dates and Amount of Award: 01/01/10-12/31/10; $144,993

Pathology

PI: Beecher, Christopher
Title: Metabolomic Analysis - GSK
Sponsor: Glaxosmithkline
Project Dates and Amount of Award: 12/15/09-11/11/10; $132,030

PI: Beecher, Christopher
Co-I: Mosberg, Henry (PHARMACY Medicinal Chemistry)
Title: Human Blood Plasma Consortium
Sponsor: Various Sponsors
Project Dates and Amount of Award: 11/12/09-11/11/11; $1,000,000

PI: Hogaboam, Cory
Title: Effects of Novel Pharmacological Inhibitors or Activators on Primary Human Fibroblast Synthetic Properties.
Sponsor: MedImmune, Inc.
Project Dates and Amount of Award: 12/01/09-11/30/10; $58,424

PI: Newton, Duane
Title: EARLY EVALUATION OF THE NEW COBAS 4800 SYSTEM
Sponsor: Roche Laboratories
Project Dates and Amount of Award: 12/07/09-02/07/10; $13,326

Pediatrics & Communicable Diseases

PI: Brownlee, Joshua
Title: Genetic determinates of Arboviral Neurovirulence
Sponsor: The Hartwell Foundation
Project Dates and Amount of Award: 01/01/10-12/31/11; $100,000

PI: Dempsey, Peter
Title: AUTOCRINE ERBB SIGNALING IN BETA-CELL FUNCTION AND SURVIVAL
Sponsor: American Diabetes Assoc, Inc.
Project Dates and Amount of Award: 01/01/10-12/31/12; $315,669

PI: Mody, Rajen
Title: Children's Oncology Group Phase I/Pilot Consortium - 2009-2010 - Subcontract 19246
Sponsor: NIH - Subcontracts TO National Childhood Cancer Foundation 3 U01 CA 097452 07 S2
Project Dates and Amount of Award: 06/01/09-05/31/11; $22,465

PI: Pipe, Steven
Title: PRO-PACT: RETROSPECTIVE PROPHYLAXIS PATIENT CASE COLLECTION (PROTOCOL ID: F7HAEM-3695)
Sponsor: NOVO Nordisk A/S
Project Dates and Amount of Award: 12/10/09-12/31/10; $6,350

PI: Prosser, Lisa
Title: HRQOL IMPACTS OF ILLNESS ON FAMILY AND CAREGIVERS
Sponsor: NIH - Subcontracts TO Brandeis University 1 R01 NR 011880 01
Project Dates and Amount of Award: 09/29/09-07/31/10; $185,400

PI: Shanley, Thomas
Co-I: Han, Yong (Pediatrics-Intensive Care)
Title: COLLABORATIVE PEDIATRIC CRITICAL CARE RESEARCH NETWORK
Sponsor: NIH 1 U10 HD 063106 01
Project Dates and Amount of Award: 12/24/09-11/30/14; $1,339,763

Pharmacology

PI: Brackenbury, William
Title: REGULATION OF MIGRATION BY THE VOLTAGE-GATED SODIUM CHANNEL BETA 1 SUBUNIT
Sponsor: Epilepsy Foundation of America
Project Dates and Amount of Award: 01/01/10-12/31/10; $45,000

Psychiatry

PI: McInnis, Melvin
Title: BIPOLAR SCHIZOPHRENIA NETWORK ON INTERMEDIATE PHENOTYPES (B-SNIP)
Sponsor: NIH - Subcontracts TO Beth Israel Hospital R01 MH 078113
Project Dates and Amount of Award: 06/01/09-05/31/10; $42,691

PI: Neal, David
Co-I: Barry, Kristen (Psychiatry Department) / Blow, Frederic (Psychiatry Department) / Eisenberg, Daniel (Health Management and Policy) / Ewell Foster, Cynthia (Psychiatry Department) / Gibbons, Patrick (Psychiatry Department) / Ilgen, Mark (Psychiatry Department) / Kilbourne, Amy (Psychiatry Department) / Lumeng, Julie (Child Behavioral Health) / Marcus, Sheila (Psychiatry Department) / Mcdonough, Susan (Center for Human Growth & Dev) / Milner, Karen (Psychiatry Department) / Mohammed, Layla (Pediatrics-Ambulatory Care Pgm) / Mozurkewich, Ellen (Obstetrics and Gynecology Dept) / Muzik, Maria (Psychiatry Department) / Rosenblum, Katherine (Psychiatry Department) / Sabnis, Deepika (Psychiatry Department) / Treadwell, Marjorie (Obstetrics and Gynecology Dept) / Williams, Brent (Int Med-General Medicine)
Title: INTEGRATED CARE FOR MEDICAID WITH BEHAVIORAL HEALTH CARE NEEDS
Sponsor: Health and Human Services, Department of-Office of the Secretary-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $741,975

Radiology

PI: Corbett, James
Co-I: Chetcuti, Stanley (Int Med-Cardiology) / Ficaro, Edward (Radiology Department) / Frey, Kirk (Radiology Department) / Hubers, David (Radiology-Nuclear Medicine) / Koeppe, Robert (Radiology-Nuclear Medicine)
Title: LANTHEUS BMS747158-201 PET MPI
Sponsor: Lantheus Medical Imaging
Project Dates and Amount of Award: 11/18/09-08/31/10; $167,062

PI: Williams, David
Co-I: Dasika, Narasimham (Radiology Department) / Deeb, G (Cardiac Surgery Section) / Patel, Himanshu (Cardiac Surgery Section) / Upchurch Jr, Gilbert (Vascular Surgery Section)
Title: EVALUATION OF THE GORE CONFORMABLE TAG THORACIC ENDOPROSTHESIS FOR TREATMENT OF ACUTE COMPLICATED TYPE B AORTIC DISSECTION (GORE TAG 08-01)
Sponsor: Gore, W. L. & Associates, Inc.
Project Dates and Amount of Award: 12/16/09-09/30/14; $65,088

PI: Williams, David
Co-I: Dasika, Narasimham (Radiology Department) / Deeb, G (Cardiac Surgery Section) / Patel, Himanshu (Cardiac Surgery Section) / Upchurch Jr, Gilbert (Vascular Surgery Section)
Title: GORE TAG 08-02
Sponsor: Gore, W. L. & Associates, Inc.
Project Dates and Amount of Award: 12/02/09-09/30/14; $65,088

Surgery

PI: Mychaliska, George
Title: Artificial Placenta Program
Sponsor: Helen L. Kay Charitable Private Foundation
Project Dates and Amount of Award: 07/01/09-06/30/11; $20,000

PI: Napolitano, Lena
Co-I: Park, Pauline (General Surgery Section) / Pelletier, Shawn (General Surgery Section)
Title: VTI-206 Efficacy and Safety of the Extracorporeal Liver Assist Device (ELAD) in Subjects with Acute on Chronic Hepatitis (AOCH)
Sponsor: Vital Therapies, Inc (VTI)
Project Dates and Amount of Award: 11/19/09-09/30/11; $195,418

PI: Patel, Himanshu
Co-I: Upchurch Jr, Gilbert (Vascular Surgery Section) / Williams, David (Radiology Department)
Title: AN EVALUATION OF GORE CONFORMABLE TAG THORACIC ENDOPROSTHESIS FOR THE PRIMARY TREATMENT OF ANEURYSM OF THE DESCENDING THORACIC AORTIC
Sponsor: Gore, W. L. & Associates, Inc.
Project Dates and Amount of Award: 11/20/09-09/30/16; $111,024

PI: Sung, Randall
Title: GENOMICS FOR KIDNEY TRANSPLANTATION
Sponsor: NIH - Subcontracts TO Scripps Research Institute U19 A1 063603
Project Dates and Amount of Award: 09/01/09-12/31/10; $27,000

Urology

PI: Miller, David
Title: QUALITY COLLABORATIVES TI IMPROVE PROSTATE CANCER CARE IN THE STATE OF MICHIGAN: A PILOT AND FEASIBILITY STUDY
Sponsor: Blue Cross Blue Shield of Michigan Foundation
Project Dates and Amount of Award: 07/01/10-06/30/11; $10,000

PI: Wei, John
Co-I: Brown, Morton (Biostatistics Department) / Little, Roderick (Biostatistics Department) / Spino, Catherine (Biostatistics Department)
Title: BENIGN PROSTATIC HYPERPLASIA REGISTRY DATA GENERATION AND COMMUNICATIONS
Sponsor: Sanofi-Aventis Pharmaceuticals
Project Dates and Amount of Award: 11/30/09-12/31/10; $427,494

PI: Wei, John
Title: A PROSPECTIVE, MULTI-CENTER PROSTATE CANCER INDIVIDUAL SIGNATURE EVALUATION (PRECISE) TRIAL IN PATIENTS UNDERGOING SCHEDULED PROSTATE BIOPSY
Sponsor: Source MDx
Project Dates and Amount of Award: 11/23/09-08/31/10; $84,859


UMMS RESEARCH PUBLICATIONS


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Biological Chemistry

Banerjee R, Gherasim C, Padovani D. The tinker, tailor, soldier in intracellular B12 trafficking. Curr Opin Chem Biol. 2009 Oct;13(4):477-84. Epub 2009 Aug 7.

Chenevert TL, Ross BD. Diffusion imaging for therapy response assessment of brain tumor. Neuroimaging Clin N Am. 2009 Nov;19(4):559-71.

Di Bella N, Taetle R, Kolibaba K, Boyd T, Raju R, Barrera D, Cochran EW Jr, Dien PY, Lyons R, Schlegel PJ, Vukelja SJ, Boston J, Boehm KA, Wang Y, Asmar L. Results of a phase II study of bortezomib in patients with relapsed or refractory indolent lymphoma. Blood. 2009 Nov 19. [Epub ahead of print]

Goldstein IJ. My Favorite Enzyme: For love of lectins. IUBMB Life. 2009 Nov 24. [Epub ahead of print].

Hopper AK, Pai DA, Engelke DR. Cellular dynamics of tRNAs and their genes. FEBS Lett. 2009 Nov 21. [Epub ahead of print] PubMed PMID: 199315321: Koutmou KS, Zahler NH, Kurz JC, Campbell FE, Harris ME, Fierke CA. Protein-Precursor tRNA Contact Leads to Sequence-Specific Recognition of 5' Leaders by Bacterial Ribonuclease P. J Mol Biol. 2009 Nov 27. .

Martinov MV, Vitvitsky VM, Banerjee R, Ataullakhanov FI. The logic of the hepatic methionine metabolic cycle. Biochim Biophys Acta. 2010 Jan;1804(1):89-96. Epub 2009 Oct 13.

Padovani D, Banerjee R. A G-protein editor gates coenzyme B12 loading and is corrupted in methylmalonic aciduria. Proc Natl Acad Sci U S A. 2009 Dec 2. [Epub ahead of print]

Palfey BA, McDonald CA. Control of catalysis in flavin-dependent monooxygenases. Arch Biochem Biophys. 2009 Nov 26. [Epub ahead of print]

Rimon G, Sidhu RS, Lauver DA, Lee JY, Sharma NP, Yuan C, Frieler RA, Trievel RC, Lucchesi BR, Smith WL. Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1. Proc Natl Acad Sci U S A. 2009 Dec 1. [Epub ahead of print]

Song T, Wei C, Zheng Z, Xu Y, Cheng X, Yuan Y, Guan K, Zhang Y, Ma Q, Shi W, Zhong H. c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response. FEBS Lett. 2009 Nov 13. [Epub ahead of print]

Zhao B, Lei Q, Guan KL. Mst out and HCC in. Cancer Cell. 2009 Nov 6;16(5):363-4. PubMed

Cell & Developmental Biology

Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim KC, Engel JD. GATA-3 is required for early T lineage progenitor development. J Exp Med. 2009 Nov 23. [Epub ahead of print]

Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, Koh C, Zhang J, Li YM, Maciaczyk J, Nikkhah G, Dimeco F, Piccirillo S, Vescovi AL, Eberhart CG. Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts. Stem Cells. 2009 Nov 10. [Epub ahead of print].

Cheng J, Waite AL, Tkaczyk ER, Ke K, Richards N, Hunt AJ, Gumucio DL. Kinetic properties of ASC protein aggregation in epithelial cells. J Cell Physiol. 2009 Dec 17. [Epub ahead of print]

Li X, Udager AM, Hu C, Qiao XT, Richards N, Gumucio DL. Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal life. Dev Dyn. 2009 Dec;238(12):3205-17.

Verhey KJ, Hammond JW. Traffic control: regulation of kinesin motors. Nat Rev Mol Cell Biol. 2009 Nov;10(11):765-77. Review.

Liang CC, Wang C, Peng X, Gan B, Guan JL. Neural specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem. 2009 Nov 24. [Epub ahead of print]

Li S, Lin JD. Molecular control of circadian metabolic rhythms. J Appl Physiol. 2009 Dec;107(6):1959-64..

Sandy AR, Maillard I. Notch signaling in the hematopoietic system. Expert Opin Biol Ther. 2009 Nov;9(11):1383-98.

Dauer WT, Worman HJ. The nuclear envelope as a signaling node in development and disease. Dev Cell. 2009 Nov;17(5):626-38. Review.

Yallowitz AR, Gong KQ, Swinehart IT, Nelson LT, Wellik DM. Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo. Dev Biol. 2009 Nov 1;335(1):156-65. Epub 2009 Aug 28.

Wellik DM. Hox genes and vertebrate axial pattern. Curr Top Dev Biol. 2009;88:257-78. Review..

Nelson LT, Rakshit S, Sun H, Wellik DM. Generation and expression of a Hoxa11eGFP targeted allele in mice. Dev Dyn. 2008 Nov;237(11):3410-6.

Calinescu AA, Raymond PA, Hitchcock PF. Midkine expression is regulated by the circadian clock in the retina of the zebrafish. Vis Neurosci. 2009 Oct 28:1-7. [Epub ahead of print]

Gage PJ, Zacharias AL. Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye. Dev Dyn. 2009 Sep;238(9):2149-62. Review.

Family Medicine

Wagner JA, Perkins DW, Piette JD, Lipton B, Aikens JE. Racial differences in the discussion and treatment of depressive symptoms accompanying type 2 diabetes. Diabetes Res Clin Pract. 2009 Nov;86(2):111-6.

Gant L, Benn R, Gioia D, Seabury B.  Incorporating integrative health services in Social Work education. Journal of Social Work Education. 2009, 45(3), 407-425.

Benn  R, Maizes V, Guerrera M, Sierpina V, Cook, P, Lebensohn P. Integrative Medicine in Residency: Success and challenges in developing and implementing a comprehensive research driven curriculum in residency education. Fam Med. 2009, 41(10), 708-14. 

Kitamura K, Fetters MD, Sano K, Sato J, Ban N. Lifestyle changes of Japanesepeople on overseas assignment in Michigan, USA. Asia Pac Fam Med. 2009 Jul16;8(1):7. PubMed Central PMCID: PMC2722578.

Jimbo M, Barrie WE, Dorsch MP, Harrison RV, Jamerson KA. Essential Hypertension. Ann Arbor, MI:  Office of Clinical Affairs, University of Michigan Health System, 2009. [Available from the Agency for Healthcare Research and Quality at www.guideline.gov and from UMHS at www.med.umich.edu/1info/fhp/practiceguides ] [practice guideline]

Bryan C, Songer T, Brooks MM, Thase ME, Gaynes B, Klinkman M, Balasubramani GK, Rush AJ, Trivedi MH, Fava M, Wisniewski SR. Do Depressed Patients With Diabetes Experience More Side Effects When Treated With CitalopramThan Their Counterparts Without Diabetes? A STAR*D Study. Prim Care Companion J Clin Psychiatry. 2009;11(5):186-196; PubMed Central PMCID: PMC2781029.

Nease DE Jr. Depression in Post-MI Patients: An Opportunity for Primary Care. Am Fam Physician. 2009 Nov 1;80(9):917.

Human Genetics

Brewer GJ. Risks of Copper and Iron Toxicity during Aging in Humans. Chem Res Toxicol. 2009 Dec 7. [Epub ahead of print].

Brewer GJ. Drug development for orphan diseases in the context of personalized medicine. Transl Res. 2009 Dec;154(6):314-22.

Ferguson CJ, Lenk GM, Meisler MH. Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. Hum Mol Genet. 2009 Dec 15;18(24):4868-78.

Kopelman NM, Stone L, Wang C, Gefel D, Feldman MW, Hillel J, Rosenberg NA. Genomic microsatellites identify shared Jewish ancestry intermediate between Middle Eastern and European populations. BMC Genet. 2009 Dec 8;10(1):80.

McCarroll SA, Bradner JE, Turpeinen H, Volin L, Martin PJ, Chilewski SD, Antin JH, Lee SJ, Ruutu T, Storer B, Warren EH, Zhang B, Zhao LP, Ginsburg D, Soiffer RJ, Partanen J, Hansen JA, Ritz J, Palotie A, Altshuler D. Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease. Nat Genet. 2009 Dec;41(12):1341-4.

Moran JV, Malik HS. Diamonds and rust: how transposable elements influence mammalian genomes. Conference on Mobile Elements in Mammalian Genomes. EMBO Rep. 2009 Dec;10(12):1306-10.

Omenn GS. Evolution and public health. Proc Natl Acad Sci U S A. 2009 Dec 4. [Epub ahead of print]

Internal Medicine

Infectious Diseases:

Agarwal PP, Cinti S, Kazerooni EA. Chest Radiographic and CT Findings in Novel Swine-Origin Influenza A (H1N1) Virus (S-OIV) Infection. Am J Roentgenol 193 (6): 1488-1493, 2009.

Aronoff DM, Ballard JD. Clostridium sordellii toxic shock syndrome. Lancet Infect Dis 9 (12): 725-726, 2009.

Bae IG, Federspiel JJ, Miro JM, Woods CW, Park L, Rybak MJ, Rude TH, Bradley S, Bukovski S, de la Maria CG, Kanj SS, Korman TM, Marco F, Murdoch DR, Plesiat P, Rodriguez-Creixems M, Reinbott P, Steed L, Tattevin P, Tripodi MF, Newton KL, Corey GR, Fowler VG.  Int Collaboration Endocarditis-Mic; Int Collaboration Endocarditis-Mic. Heterogeneous Vancomycin-Intermediate Susceptibility Phenotype in Bloodstream Methicillin-Resistant Staphylococcus aureus Isolates from an International Cohort of Patients with Infective Endocarditis: Prevalence, Genotype, and Clinical Significance. J Infect Dis 200 (9): 1355-1366, 2009.

Freifeld, AG, Wheat, LJ, Kaul, DR. Histoplasmosis in solid organ transplant recipients: early diagnosis and treatment. Curr Opin Organ Transplant 14 (6): 601-605, 2009.

Luan FL, Stuckey LJ, Park JM, Kaul D, Cibrik D, Ojo A. Six-Month Prophylaxis Is Cost Effective in Transplant Patients at High Risk for Cytomegalovirus Infection. J Am Soc Nephrol 20 (11): 2449-2458, 2009.

Sagana RL, Yan M, Cornett AM, Tsui JL, Stephenson DA, Huang SK, Moore BB, Ballinger MN, Melonakos J, Kontos CD, Aronoff DM, Peters-Golden M, White ES. Phosphatase and Tensin Homologue on Chromosome 10 (PTEN) Directs Prostaglandin E-2-mediated Fibroblast Responses via Regulation of E Prostanoid 2 Receptor Expression. J Biol Chem 284 (47): 32264-32271, 2009.

Shanahan, A, Malani, PN, Kaul, DR. Relapsing cytomegalovirus infection in solid organ transplant recipients. Transpl Infect Dis 11 (6): 513-518, 2009.

Weeks SA, Shield WP, Sahi C, Craig EA, Rospert S, Miller DJ. A Targeted Analysis of Cellular Chaperones Reveals Contrasting Roles for Heat Shock Protein 70 in Flock House Virus RNA Replication. J Virol 84 (1): 330-339, 2010.

Wang, Q, Nagarkar, DR, Bowman, ER, Schneider, D, Gosangi, B, Lei, J, Zhao, Y, McHenry, CL, Burgens, RV, Miller, DJ, Sajjan, U, Hershenson, MB. Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses. J Immunol 183 (11): 6989-6997, 2009.

Microbiology and Immunology

Abend JR, Low JA, Imperiale MJ. Global effects of BKV infection on gene expression in human primary kidney epithelial cells. Virology. 2009 Nov 27. [Epub ahead of print]

Agakishiev G, Balanda A, Bassini R, Belver D, Belyaev AV, Blanco A, Böhmer M, Boyard JL, Braun-Munzinger P, Cabanelas P, Castro E, Chernenko S, Christ T, Destefanis M, Díaz J, Dohrmann F, Dybczak A, Eberl T, Fabbietti L, Fateev OV, Finocchiaro P, Fonte P, Friese J, Fröhlich I, Galatyuk T, Garzón JA, Gernhäuser R, Gil A, Gilardi C, Golubeva M, González-Díaz D, Guber F, Hennino T, Holzmann R, Iori I, Ivashkin A, Jurkovic M, Kämpfer B, Kanaki K, Karavicheva T, Kirschner D, Koenig I, Koenig W, Kolb BW, Kotte R, Krizek F, Krücken R, Kühn W, Kugler A, Kurepin A, Lang S, Lange JS, Lapidus K, Liu T, Lopes L, Lorenz M, Maier L, Mangiarotti A, Markert J, Metag V, Michalska B, Michel J, Mishra D, Morinière E, Mousa J, Müntz C, Naumann L, Otwinowski J, Pachmayer YC, Palka M, Parpottas Y, Pechenov V, Pechenova O, Pietraszko J, Przygoda W, Ramstein B, Reshetin A, Roy-Stephan M, Rustamov A, Sadovsky A, Sailer B, Salabura P, Schmah A, Sobolev YG, Spataro S, Spruck B, Ströbele H, Stroth J, Sturm C, Sudol M, Tarantola A, Teilab K, Tlusty P, Traxler M, Trebacz R, Tsertos H, Wagner V, Weber M, Wisniowski M, Wojcik T, Wüstenfeld J, Yurevich S, Zanevsky YV, Zhou P, Zumbruch P; HADES Collaboration. Deep subthreshold Xi;{-} production in Ar + KCl reactions at 1.76A GeV. Phys Rev Lett. 2009 Sep 25;103(13):132301.

Beemiller P, Zhang Y, Mohan S, Levinsohn E, Gaeta I, Hoppe AD, Swanson JA. A Cdc42 Activation Cycle Coordinated by PI 3-kinase during Fc Receptor-mediated Phagocytosis. Mol Biol Cell. 2009 Dec 2.

Ben Gaied N, Zhao Z, Gerrard SR, Fox KR, Brown T. Potent triple helix stabilization by 5',3'-modified triplex-forming oligonucleotides. Chembiochem. 2009 Jul 20;10(11):1839-51.

Carlson JC, Li S, Burr DA, Sherman DH. Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp. J Nat Prod. 2009 Nov;72(11):2076-9.

Carr KA, Lybarger SR, Anderson EC, Janes BK, Hanna PC. The Role of Bacillus anthracis Germinant Receptors in Germination and Virulence. Mol Microbiol. 2009 Nov 25. [Epub ahead of print].

Del Cid N, Jeffery E, Rizvi SM, Stamper E, Peters LR, Brown WC, Provoda C, Raghavan M. Modes of calreticulin recruitment to the major histocompatibility complex (MHC) class I assembly pathway. J Biol Chem. 2009 Dec 3. [Epub ahead of print]

Dunnick WA, Collins JT, Shi J, Westfield G, Fontaine C, Hakimpour P, Papavasiliou FN. Switch recombination and somatic hypermutation are controlled by the heavy chain 3' enhancer region. J Exp Med. 2009 Nov 23;206(12):2613-23.

Dyson MC, Eaton KA, Chang C. Helicobacter spp. in wild mice (Peromyscus leucopus) found in laboratory animal facilities. J Am Assoc Lab Anim Sci. 2009 Nov;48(6):754-6. PubMed Central PMCID: PMC2786929.

Faust SM, Lu G, Marini BL, Zou W, Gordon D, Iwakura Y, Laouar Y, Bishop DK. Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection. J Immunol. 2009 Dec 1;183(11):7297-306.

Flannery EL, Mody L, Mobley HL. Identification of a modular pathogenicity island that is widespread among urease-producing uropathogens and shares features with a diverse group of mobile elements. Infect Immun. 2009 Nov;77(11):4887-94. PubMed Central PMCID: PMC2772549.

Kao JY, Zhang M, Miller MJ, Mills JC, Wang B, Liu M, Eaton KA, Zou W, Berndt BE, Cole TS, Takeuchi T, Owyang SY, Luther J. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology. 2009 Nov 17. [Epub ahead of print].

Lapinski PE, Oliver JA, Bodie JN, Marti F, King PD. The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B. Immunol Rev. 2009 Nov;232(1):240-54.

Larson ET, Parussini F, Huynh MH, Giebel JD, Kelley AM, Zhang L, Bogyo M, Merritt EA, Carruthers VB. Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl. J Biol Chem. 2009 Sep 25;284(39):26839-50.

Milam JE, Erb-Downward JR, Chen GH, Osuchowski MF, McDonald R, Chensue SW, Toews GB, Huffnagle GB, Olszewski MA. CD11c+ Cells Are Required to Prevent Progression from Local Acute Lung Injury to Multiple Organ Failure and Death. Am J Pathol. 2009 Nov 30. [Epub ahead of print]

Miyazaki Y, Garcia EL, King SR, Iyalla K, Loeliger K, Starck P, Syed S, Telesnitsky A, Summers MF. An RNA Structural Switch Regulates Diploid Genome Packaging by Moloney Murine Leukemia Virus. J Mol Biol. 2009 Nov 17. [Epub ahead of print].

Osterholzer JJ, Chen GH, Olszewski MA, Curtis JL, Huffnagle GB, Toews GB. Accumulation of CD11b+ Lung Dendritic Cells in Response to Fungal Infection Results from the CCR2-Mediated Recruitment and Differentiation of Ly-6Chigh Monocytes. J Immunol. 2009 Nov 23. [Epub ahead of print]

Rossi EA, Goldenberg DM, Cardillo TM, Stein R, Chang CH. CD20-targeted tetrameric interferon-alpha, a novel and potent immunocytokine for the therapy of B-cell lymphomas. Blood. 2009 Oct 29;114(18):3864-71. Epub 2009 Aug 26.

Sivick KE, Mobley HL. Waging War against Uropathogenic Escherichia coli: Winning Back the Urinary Tract. Infect Immun. 2009 Nov 16. [Epub ahead of print].

Song JW, Cavnar SP, Walker AC, Luker KE, Gupta M, Tung YC, Luker GD, Takayama S. Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS One. 2009 Jun 1;4(6):e5756. PubMed Central PMCID:PMC2684591.

Tseng-Rogenski SS, Arredouani MS, Escara-Wilke JF, Neeley YC, Imperiale MJ, Sanda MG. A safety-modified SV40 Tag developed for human cancer immunotherapy. Drug Des Devel Ther. 2009 Feb 6;2:17-24. PubMed Central PMCID: PMC2761181.

Waghray M, Zavros Y, Saqui-Salces M, El-Zaatari M, Alamelumangapuram CB, Todisco A, Eaton KA, Merchant JL. Interleukin-1beta Promotes Gastric Atrophy Through Suppression of Sonic Hedgehog. Gastroenterology. 2009 Oct 30. [Epub ahead of print]

Wang Q, Nagarkar DR, Bowman ER, Schneider D, Gosangi B, Lei J, Zhao Y, McHenry CL, Burgens RV, Miller DJ, Sajjan U, Hershenson MB. Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol. 2009 Dec 1;183(11):6989-97.

Zhang Y, Wang F, Tompkins KC, McNamara A, Jain AV, Moore BB, Toews GB, Huffnagle GB, Olszewski MA. Robust Th1 and Th17 Immunity Supports Pulmonary Clearance but Cannot Prevent Systemic Dissemination of Highly Virulent Cryptococcus neoformans H99. Am J Pathol. 2009 Nov 5. [Epub ahead of print].

Neurology

Salloway S, Sperling R, Gilman S, Fox N, Blennow K, Raskind M, Sabbagh M, Honig L, Doody R, van Dyck C, Mulnard R, Mulnard R, Gregg K, Liu E, Lieberburg I, Schenk D, Black R, Grundman M for the Bapineuzumab 201 Clinical Trial Investigators. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimers disease Neurology 2009;73:1-10.

Dauer WT, Worman HJ. The nuclear envelope as a signaling node in development and disease. Dev Cell. 2009 Nov;17(5):626-38.

Tanabe LM, Kim CE, Alagem N, Dauer WT. Primary dystonia: molecules and mechanisms. Nat Rev Neurol. 2009 Nov;5(11):598-609. Epub 2009 Oct 13. 

Martin JN, Bair TB, Bode N, Dauer WT, Gonzalez-Alegre P. Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia.  Neuroscience. 2009 Dec 1;164(2):563-72. Epub 2009 Aug 6.

Neurosurgery

Collins KL, Lehmann EM, Patil PG. Deep Brain Stimulation for Movement Disorders. Neurobiol Dis. 2009 Dec 4. [Epub ahead of print]

Zhang H, Wang L, Park JB, Park P, Yang VC, Hollister SJ, La Marca F, Lin CY. Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. Arthritis Res Ther. 2009 Nov 13;11(6):R172. [Epub ahead of print]

Obstetrics & Gynecology

Domino SE, Hurd EA, Thomsson KA, Karnak DM, Holmen Larsson JM, Thomsson E, Backstrom M, Hansson GC: Cervical Mucins Carry alpha(1,2)Fucosylated Glycans that Partly Protect from Experimental Vaginal Candidiasis. Glycoconj J 2009 Dec;26(9):1125-34.

Otolaryngology

Li Y, Atkin GM, Morales MM, Liu LQ, Tong M, Duncan RK. Developmental expression of BK channels in chick cochlear hair cells. BMC Dev Biol. 2009 Dec 15;9:67. PubMed PMID: 20003519; PubMed Central PMCID: PMC2803478.

Pediatrics & Communicable Diseases

Aiyagari R, Gelehrter S, Bove E, Ohye R, Devaney EJ, Hirsch J, Gurney J, Charpie J. Effects of N-acetylcysteine on renal dysfunction in neonates undergoing the arterial switch operation.  J Thorac Cardiovasc Surg. 2009 Nov 25 [Epub ahead of print]

Ashraf S, Hoskins BE, Chaib H, Hoefele J, Pasch A, Saisawat P, Trefz F, Hacker HW, Nuernberg G, Nuernberg P, Otto EA, Hildebrandt F. Mapping of a new locus for congenital anomalies of the kidney and urinary tract on chromosome 8q24. Nephrol Dial Transplant. [Epub ahead of print]

Aucoin DP, Crump RB, Thorkildson P, Nuti DE, LiPuma JJ, Kozel TR. Identification of Burkholderia cepacia complex bacteria with a lipopolysaccharide-specific monoclonal antibody. J Med Microbiol. 2010 Jan;59(Pt 1):41-7

Carmody LA, Gill JJ, Summer EJ, Sajjan US, Gonzalez CF, Young RF, LiPuma JJ. Efficacy of Bacteriophage Therapy in a Model of Burkholderia cenocepacia Pulmonary Infection. J Infect Dis. [Epub ahead of print]

Collins KL. Ambulatory treatment of infants with presumed febrile urinary tract infection may be feasible. J Pediatr. 2010 Jan;156(1):166-7

Cooper VS, Carlson WA, LiPuma JJ. Susceptibility of Caenorhabditis elegans to Burkholderia infection depends on prior diet and secreted bacterial attractants. PLoS One. 2009 Nov 23;4(11):e7961.

Davis RN, Caldwell CH, Clark SJ, Davis MM. Depressive symptoms in nonresident African-American fathers and involvement with their sons. Pediatrics. 2009 Dec;124(6):1611-8

Dillman JR, Adler J, Zimmermann EM, Strouse PJ. Erratum to:  CT enterography of pediatric Crohn disease. Pediatr Radiol. [Epub ahead of print]

Dombkowski KJ, Harrison SR, Cohn LM, Lewis TC, Clark SJ. Continuity of prescribers of short-acting beta agonists among children with asthma. J Pediatr. 2009 Dec;155(6):788-94

Dziuban EJ, Castle VP, Haftel HM. Microscopic polyangiitis in an adolescent presenting as severe anemia and syncope. Rheumatol Int [Epub ahead of print]

Fredericks EM. Nonadherence and the transition to adulthood. Liver Transpl. 2009 Nov;15 Suppl 2:S63-9

Gaies MG, Goldberg CS, Ohye RG, Devaney EJ, Hirsch JC, Bove EL. Early and intermediate outcome after anatomic repair of congenitally corrected transposition of the great arteries. Ann Thorac Surg. 2009 Dec;88(6):1952-60

Heeringa SF, Moller CC, Du J,  Yue L, Hinkes B, Chernin G, Vlangos CN, Hoyer PF, Reiser J, Hildebrandt F. A novel TRPC6 mutation that causes childhood FSGS. PLoS One. 2009 Nov 10;4(11):e7771

Kelly BP, Gajarski, RJ, Ohye RG, Charpie JR. Intravenous Induction of Therapeutic Hypothermia in the Management of Junctional Ectopic Tachycardia:  A Pilot Study. Pediatr Cardiol. 2009 Dec 1 [Epub ahead of print]

Lee JM, Pilli S, Gebremariam A, Keirns CC, Davis MM, Vijan S, Freed GL, Herman WH, Gurney JG. Getting heavier, younger:  trajectories of obesity over the life course. Int J Obes (Lond). 2009 Dec 1. [Epub ahead of print]

Makidon PE, Knowlton J, Groom JV 2nd, Blanco LP, LiPuma JJ, Bielinska AU, Baker JR Jr. Induction of immune response to the 17 kDa OMPA Burkholderia cenocepacia polypeptide and protection against pulmonary infection in mice after nasal vaccination with an OMP nanoemulsion-based vaccine. Med Microbiol Immunol. 2009 Dec 6 [Epub ahead of print]

Mody RJ, Bui C, Hutchinson RJ, Yanik GA, Castle VP, Frey KA, Shulkin BL. FDG PET imaging of childhood sarcomas. Pediatr Blood Cancer. 2010 Feb:54(2):222-7

Moss ML, Rasmussen FH, Nudelman R, Dempsey PJ, Williams J. Fluorescent Substrates Useful as High-Throughput Screening Tools for ADAM9. Comb Chem High Throughput Screen. 2009 Dec 16 [Epub ahead of print]

Paczesny S, Hanauer D, Sun Y, Reddy P. New perspectives on the biology of acute GVHD. Bone Marrow Transplant. 2009 Nov 30 [Epub ahead of print]

Padmanabhan V, Veiga-Lopez A, Abbott DH, Recabarren SE, Herkimer C. Developmental Programming;  Impact of Prenatal Testosterone  Excess and Postnatal Weight Gain on Insulin Sensitivity Index and Transfer of Traits to Offspring of Overweight Females.  Endocrinology. 2009 Dec 4 [Epub ahead of print]

Raghavan S, Lam MT, Foster LL, Gilmont RR, Somara S, Takayama S, Bitar KN. Bioengineered three-dimensional physiological model of colonic longitudinal smooth muscle in vitro. Tissue Eng Part C Methods. [Epub ahead of print]

Shavit JA, Manichaikal A, Lemmerhirt HL, Broman KW, Ginsburg D. Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice. Blood. 2009 Dec 17;114(26):5368-74.

Stockman JA 3rd, Freed GL. Adequacy of the supply of pediatric subspecialists:  so near, yet so far. Arch Pediatr Adolesc Med. 2009 Dec;163(12):1160-1

Wang Q, Nagarkar DR, Bowman ER, Schneider D, Gosangi B, Lei J, Zhao Y, McHenry CL, Burgens RV, Miller DJ, Sajjan U, Hershenson MB. Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses. J Immunol. 2009 Dec 1;183(11):6989-97

Wong HR, Freishtat RJ, Monaco, M, Odoms K, Shanley TP. Leukocyte subset-derived genomewide expression profiles in pediatric septic shock. Pediatr Crit Care Med. [Epub ahead of print]

Zhang R, LiPuma JJ, Gonzalez CF. Two type IV secretion systems with different functions in Burkholderia cenocepacia K56-2. Microbiology. 2009 Dec;155(Pt 12):4005-13.

Psychiatry

Chermack ST, Murray RL, Winters JJ, Walton MA, Booth BM, Blow FC. Treatment needs of men and women with violence problems in substance use disorder treatment. Subst Use Misuse. 2009;44(9-10):1236-62.  

Guyer MJ, Schetky DH, Ash P.  Civil Litigation and Psychic Trauma. In: Textbook of Principles and Practice of Child and Adolescent Forensic Mental Health. (Eds. Benedek, E., Ash, P. & Scott) Am Psychiatric Assoc. Press, Inc.  Wash. D.C., 2009.

Ilgen MA, Downing K, Zivin K, Hoggatt KJ, Kim HM, Ganoczy D, Austin KL, McCarthy J, Patel JM, Valenstein M.  Exploratory Data Mining Analysis Identifying Subgroups of Patients With Depression Who Are at High Risk for Suicide. J Clin Psychiatry 2009;70(11):1495–1500.

  Kilbourne AM, Morden NE, Austin K, Ilgen MA, McCarthy JF, Dalack G, Blow FC. Excess Heart Disease-related Mortality in a National Study of Patients with Mental Disorders: Identifying Modifiable Risk Factors.  General Hospital Psychiatry 31(6): 555-563 2009.

Morden NE, Berke EM, Welsh DE, McCarthy JF, Mackenzie TA, Kilbourne AM.  Quality of Care for Cardiometabolic Disease: Associations With Mental Disorder and Rurality. Med Care. 2009 Nov 18.

Nesse RM.  Runaway social selection for displays of partner value and altruism. In: S G, editor. Understanding Altruism. Hyderbad: Icfaia University Press; 2009. p. 89-118.

Schneider R, Burnette, ML, Ilgen M, Timko C. Prevalence and Correlates of Intimate Partner Violence Victimization Among Women and Men Entering Substance Use Disorder Treatment. Violence Vict. 2009;24(6):744-756.

Villafuerte SM, Vallabhaneni K, Sliwerska E, McMahon FJ, Young EA, Burmeister M.  SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.  Psychiatr Genet. 2009 Dec;19(6):281-91.

Unit for Laboratory Animal Medicine

Bergin, IL, Wise, AG, Bolin, SR, Mullaney, TP, Kiupel, M, Maes, RK. Novel calicivirus identified in Michigan rabbits in USA. Emerg Infect Dis 2009 Dec;15(12):1955-62.