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DECEMBER 2009, Vol. 27


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HEADLINES

The Office of Research Welcomes Mary Kratz
Mary Kratz

The Medical School Office of Research is pleased to announce our newest addition to the team – Mary E. Kratz, M.T. (A.S.C.P.). Mary joins us as Associate Director of Business Development and Information Technology.

Mary joined the University of Michigan in 1986, and is accomplished and seasoned in laboratory medicine with extensive knowledge in information communication technology and medical informatics. Licensed by the American College of Pathology and a member of the American Medical Informatics Association, Mary joins the Office of Research as an Academic IT Specialist, focusing on public/private partnerships with IT related entities, and helping to ensure that the Medical School maximizes the use of IT to improve research and education mission delivery and performance. In this capacity she provides national leadership as the Executive Vice President of the HealthGrid.US Alliance, and numerous board positions with external organizations.

Additionally, she holds an inter-personal act contract with the United States Department of Defense HIV/AIDS Prevention Program as a Senior Advisor on Strategic Information to the President’s Emergency Plan for AIDS Relief (PEPFAR). She is responsible for technical assistance to the Office of the Global AIDS Coordinator in formulating and articulating the program's policy, position, or response on current or emerging information communication technology and its relationship to the Department of Defense (DoD) and its mission to PEPFAR. Mary is a convener of PEPFAR’s public private-partnership initiative focused on information communication technology. She has worked in over 30 countries, and provided technical assistance to over a dozen eHealth and mHealth programs.

Prior to joining PEPFAR, Ms. Kratz was the HealthGrid lead for the U.S. Army Telemedicine & Advanced Technology Research Center. In more than fifteen years experience in project management, she has documented successes in IT operations, planning, and management positions.

Mary lives in Manchester, Michigan with her husband Kevin, an equine veterinarian. Kevin and Mary have two grown children. Her daughter recently graduated from the University of Michigan with high honors and is pursuing a Ph.D. in Forestry at Michigan Technological University. Her son is presently in his third year of undergraduate study at the University of Michigan and is pursuing medical school, aspiring to become an oncologist.

Mary will join the Office of Research, working with Connie Chang on business development initiatives and Dr. Joe Kolars on global health programs. Please join us in welcoming Mary to the Office of Research. She can be contacted at (mkratz@umich.edu) or 734-763-5505.

Distinguished Faculty Lectureship Award in Biomedical Research
Deadline: Friday, February 12, 2010

The Distinguished Faculty Lectureship Award in Biomedical Research is the highest honor bestowed upon a faculty member in the biomedical sciences by the Medical School. The recipient of this award is an exceptional leader in research, whose landmark contributions are recognized both nationally and internationally. Their contributions are usually linked to pivotal discoveries that have wide-ranging impact for the advancement of scientific knowledge. The recipient of this award also excels in teaching, mentoring, and service to our institution and to their colleagues in the scientific community at large. Nominations are open to all Health Sciences faculty. The recipient receives an award in discretionary funds and gives a public lecture followed by a reception in the Spring. Additional information and a list of previous recipients can be found at the website. Chairs and Directors should submit the following nomination materials:

  • A nomination letter from the department chair, division head or unit/center director.
  • Research description – a three-page (maximum) summation of the nominee’s research.
  • Two or more letters of support from University of Michigan faculty.
  • Two or more letters of support from outside the University.
  • A current curriculum vitae for the nominee.

Please submit all materials (in the order listed above) electronically in a single PDF document by February 12, 2010 to (DFLsubmit@umich.edu). We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-615-8802. Please direct any questions to Camille Mrozowski at (cmrozow@umich.edu).

BMRC Bridging Support Program for Basic Science Research
Deadline: Friday, January 15, 2010

The Medical School's Biomedical Research Council (BMRC) is accepting applications for a competitive Bridging Support Program for Basic Science Research. This program provides support to bridge federally funded basic science research grants with a very strong demonstrated likelihood of continued federal funding pending resubmission. Up to $40,000 is available to maintain projects for up to one year. Matching funds from the PI's department are required. Eligibility is limited to full-time, on-campus instructional and research faculty with primary appointments in the Medical School. Grants to be bridged must reside in the Medical School. Visit the website for complete details. For questions, call 734-615-8802 or email (BMRCsubmit@umich.edu).

Message from Drs. Lichter and Hutchinson on Conflict of Interest Considerations in Physician-Industry Interactions

Dear Colleagues:

The importance of addressing real or perceived conflict of interest in physician-industry interactions cannot be overstated.

Over the past several months, much work has been done across the Medical School to frame an approach to potential conflict of interest in education and clinical care for this institution. The Conflict of Interest Group (COIG), a committee chaired by Paul Lichter, spent considerable time reviewing evidence-based studies about the influence on clinical faculty of gifts from industry, including CME funded by industry, speakers bureaus, consulting, and more. The COIG developed a series of recommendations and will soon present its final report. Earlier this summer, the Dean held a town hall meeting to solicit input from faculty on clinical COI in what proved to be a very impassioned discussion.

These efforts are important given the impact of clinical COI policies on our institution, departments, individual physicians and staff, and potentially other providers within the Health System. Of course, the range of approaches to this complex issue is broad, and each approach has its benefits and challenges. Most essential is that we continue the discourse - with sound reason, good judgment, critical thinking, and the requirements of evidence and peer-review that make up the scholarly process, our stock in trade.

To that end, we intend to schedule in early 2010 a series of educational discussions on several clinical COI issues. These discussions will include the perspectives of COIG, faculty, and other stakeholders as appropriate. Critical to the discussion will be presentation of evidence supporting the positions espoused. The discussion will be led by a moderator to help keep the presenters to a timetable and to keep the interchange on target. There will be time allotted for Q&A. We may also be able to electronically gather and share participants sentiments during the discussion. These meetings will build on the work that is already underway such as not accepting industry funding of our CME programs, a policy in the process of implementation. However, this and other subjects will be a part of the educational discussions.

We would like to gather your ideas about specific clinical COI topics you feel warrant discussion, potential speakers and moderators, and any materials you feel would add value to the discussions. We greatly value your input and will use it to drive the agenda for these upcoming discussions. Please send any suggestions to Ray Hutchinson at (rhutchin@umich.edu). Details and logistics will be distributed once we’ve had a chance to incorporate faculty suggestions and finalize the programs. In the mean time, if faculty members wish to meet with the COIG prior to the educational sessions outlined above, please let Paul Lichter know at (plichter@umich.edu), and a meeting will be arranged as time and schedules permit.

Thank you for your active participation in these important efforts.

Paul R. Lichter, M.D., F. Bruce Fralick Professor of Ophthalmology, Chair and Professor of Ophthalmology and Visual Sciences

Raymond J. Hutchinson, M.D., Professor of Pediatrics and Communicable Diseases and Associate Dean for Regulatory Affairs


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Human Research

IRBMED Holiday Season Schedule

As the weather grows colder and the holiday season approaches, the IRBMED Office would like to remind you that:

  • IRBMED review boards do not meet during the holiday closure (12/25/09 through 1/3/10). The last meetings of 2009 are Friday, December 18, and Thursday, December 24. The first meeting of 2010 will be Thursday, January 7.
  • The IRBMED Office is not open for regular business during the holiday closure beginning the afternoon of December 24. The office will reopen on Monday, January 4, 2010, at 8:30 AM. The drop-box outside our offices at 517 W. William will remain open to receive submissions, though mail will not be opened until January 4, 2010. In addition, campus mail will not be delivered during the holiday closure.
IRBMED News and Important Reminders
  • Alex Blackwood M.D., Ph.D., Named IRBMED Vice Chair
    Dr. Alex Blackwood, Associate Professor, Department of Pediatrics and Communicable Diseases, and Assistant Director of Pediatric Education was made a Vice Chair of the B1 IRBMED on September 1, 2009. Dr. Blackwood has served a member of the IRBMED since October 15, 2004. Please join us in thanking him for taking on this additional responsibility for human subjects research conducted at the UM Health System.
  • Non-English Speaking or Reading Subjects
    If your subject signed only the English informed consent document and cannot read English, you do not have legally effective informed consent. Subjects must consent to research on a form written in a language they understand. If you have subjects that did not sign consent forms in their language, please report this to the IRBMED immediately using the ORIO-Deviation form and, where appropriate, make arrangements to reconsent the subjects. Consent forms in Arabic, Chinese, Spanish, Russian and French are available on the IRBMED’s website (http://med.umich.edu/irbmed/ict.htm) along with the instructions for using the forms in conjunction with your English language document which will serve as the script for the translator. The entire script must be reviewed. In most cases a family member should not serve as the translator.
  • Adult Subjects Unable to Give Consent
    Effective January 2008, the University implemented a new policy regarding adult subjects who cannot provide consent for themselves and require a legally authorized representative, usually a family member, to provide proxy consent. If you plan to recruit such subjects, whether their impairment is temporary or permanent, you need specific approval from the IRB to do so; you will need to complete the “cognitively impaired” section in the eResearch application.
  • eResearch Updated November 15, 2009
    The release included enhancements and changes in the IRB reviewer functionality, updated questions related to drug and device information, as well as, in the risks and benefits section where studies with more than one arm or cohort will be required to provide additional information if those arms differ in their risk/benefit profile. As with all releases, on the next amendment you complete, there may be additional required questions. For a detailed list of changes with the release please review the eResearch Regulatory Management homepage under “Release Notes” (http://www.umich.edu/~eresinfo/rm.html).
  • IRBMED Workshops
    The IRBMED offers 13 different workshops providing detailed information about eResearch, informed consent, research involving special populations, and more. A new “History 101” workshop has been added this month. We provide the workshops to your unit or group upon request and on Wednesday afternoons. We can also tailor workshops for the specific needs and timeframe of your group. Register for workshops at (http://med.umich.edu/irbmed/education.htm#work). Please email June Insco (insco@umich.edu) to set up a group presentation.
  • IRBMED Consults
    When planning a new project or amending an approved one, the IRBMED is here to assist the Principal Investigator and/or study team personnel. We especially encourage researchers whose projects will involve registries or special populations—pregnant women, fetuses, neonates of uncertain viability, etc. to contact us early in the process. Federal regulations and University policies restrict the types of research including these populations that IRBs can approve without further approval from HHS or the UM Office of the Vice President for Research. Consultation services can be requested for individuals and groups as necessary.

If you have any questions about this article, please contact Jan Hewett in the IRBMED office at 734-763-4768.

 

Animal Research

Use of Controlled Substances in Research

As of January 2, 2010, the Unit for Laboratory Animal Medicine (ULAM) will no longer supply controlled substances to Principal Investigators for research purposes. Researchers may obtain controlled substances through the University of Michigan Inpatient B2 pharmacy or through outside vendors. ULAM will continue to provide non-controlled substances, such as antibiotics, non-steroidal anti-inflammatory drugs, xylazine, isoflurane, and miscellaneous supplies.

The Office of the Vice President for Research has designated a Controlled Substance Program Coordinator within the ULAM-UCUCA office to assist in matters relating to controlled substance licensing, registration, storage, record keeping, and disposal. The UCUCA (University Committee on Use and Care of Animals) office will monitor controlled substance storage requirements and record keeping compliance as part of their semi-annual laboratory inspections.

For more information, please visit the UCUCA website at (http://www.ucuca.umich.edu/csubs.htm) or contact Dr. Patrick Lester, R.Ph., D.V.M., M.S., Use of Controlled Substances in Research – Program Coordinator (734-936-4519 or plester@umich.edu).

The Next Issue of The Backbone Is Now Available!

The October 2009 issue of The Backbone, the UCUCA’s quarterly newsletter for animal care and use personnel and researchers, is now available on the UCUCA website at (http://www.ucuca.umich.edu/backbone.htm).


FYI CORNER


Biomedical Research Core Facilities (BRCF)
Holiday Closing Schedules

Many of the staff in the BRCF will be using their University Season Days between December 25, 2009 and January 1, 2010. The schedule for the individual laboratories during the holidays is given below.

  • Biomedical Research Store (2580 MSRB II; 2297 LSI; A681 BSRB) The Biomedical Research Store will be open for business until 5:00 PM December 24. All store sites will reopen at 8:15 AM on January 4. The deadline for special orders to be placed will be 10:00 AM on December 22.
  • DNA Sequencing Core (2568 MSRB II) The DNA Sequencing Core's remote sample drop-off locations will follow their normal schedules on Thursday, December 24: the Kraus site will close at noon, and the LSI site will close at 3:30 PM. The main sample drop-off desk in 2560 MSRB II will close at 4:45 PM. All Core operations will remain closed, reopening at 8:15 AM on Monday January 4. To receive results before the December 24 closing, please watch the Core’s website for notice of turnaround times and any holiday deadlines.
  • Transgenic Animal Model Core (2578 MSRB II/2526 MSRB I) Services will not be available after 5:00 PM December 24. The Core will reopen at 9:00 AM January 4.
  • Flow Cytometry Core
    • 7416 Cancer and Geriatrics Center – The Flow Core will be closed December 24-25 and January 1. The Flow Core will operate with reduced capacity and reduced hours (9:00 AM - 5:00 PM) December 28-31. Experiments should be scheduled in advance as usual. However, since the week before Christmas tends to be very busy, investigators who wish to have experiments performed during that time (December 14-23) should schedule their experiments as soon as possible.
    • 3222 Life Sciences Institute – The Flow Cytometry Core Satellite will be closed December 24 through January 1.
    • A701 BSRB – The Flow Cytometry Core Satellite will be closed December 24 through January 1.
  • Protein Structure Core (2552/2558/2574 MSRB II) Services will not be available after 2:00 PM on December 23. The Core will resume services at 8:30 AM on January 4.
  • NMR Core (1553 CC Little) Please contact Scott Woehler, Ph.D., (734-763-9284) for the specific holiday schedule.
  • Biosafety Level 3 (BL3) Core (3566 MSRB II) Please contact Steven King, Ph.D., (734-763-4859) for the specific holiday schedule.


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains a link to M-Quest (a database of opportunities for grants, honors, prizes and fellowships created and maintained by the Office of Research) as well as information on email alert groups.


Internal Submissions

The Michigan Meetings: An Annual Interdisciplinary Event
Deadline: January 15, 2010

The Horace H. Rackham School of Graduate Studies is pleased to invite proposals for The Michigan Meetings, a series of annual interdisciplinary meetings of national and international scope on topics of broad interest and contemporary importance to both the public and the academic community. University of Michigan faculty are invited to submit proposals for meetings to be held in May 2011. Rackham will provide both financial support and meeting venues. Up to two meetings will receive support. You can view descriptions of the Michigan Meetings to be held in May 2010 at (http://www.ur.umich.edu/0809/May04_09/56.php).

The Rackham Graduate School, through the establishment of these meetings, seeks to provide a visible and viable venue to address topics of interdisciplinary and global importance. The Michigan Meetings are designed to both support and enhance the ability of University of Michigan faculty to address such issues and to identify Ann Arbor as an international center for scholarly and social discourse. The Michigan Meetingswill bring together faculty and students at UM with colleagues from around the nation and the world to create intellectually exciting events of both scholarly and practical importance. Each meeting is intended to be a one-time event. The Rackham Graduate School will provide both the venue for the meeting and financial support up to $50,000 per meeting, depending on the anticipated number of participants and format. For complete information, visit (http://www.rackham.umich.edu/academic_information/rii/michigan_meetings/).

UM Research Partnership Program
Deadline: February 1, 2010

The Research Partnership Program includes the following funding opportunities available to faculty and graduate students. Be sure to review the materials and websites carefully to note the differing purposes of the two types of awards and apply to the most appropriate program.

  • The Spring/Summer Research Grants Program was significantly expanded this year. Up to 100 grants will be awarded to faculty members who plan to work with Ph.D. students on scholarly projects during the spring and summer terms. These grants provide a stipend of $6,000 to the doctoral student. They support faculty scholarship while also providing financial support opportunities for professional and intellectual development for participating students. Preference is given to faculty members who include a thoughtful plan for student mentoring in their applications. For summer 2010, the stipend for students will be $6,000. Additional information is available here.
  • The Distinguished Faculty and Graduate Student Seminars Program will provide a maximum of five awards to groups of faculty, students or graduate programs proposing innovative seminars and colloquia to foster collaboration and stimulate new research. Awards will range from $5,000 to $10,000 and may be used to complement funds from department, college or external sponsors. Additional information is available here.
UM Geriatrics Center Pilot Grant Competition
Deadline: February 15, 2010

The University of Michigan Geriatrics Center announces the availability of funds to support pilot/feasibility research in Geriatrics and in the Biology of Aging.  Funding for pilot project grants is provided by the National Institute on Aging via the Claude D. Pepper Older Americans Independence Center, directed by Jeffrey B. Halter, M.D., the Nathan Shock Center of Excellence in Aging Research, directed by Richard Miller, M.D., Ph.D., and the Michigan Institute for Clinical & Health Research, directed by Kenneth Pienta, M.D..  This year’s grant competition is organized by the Pepper Center’s Pilot and Exploratory Studies Core, directed by Drs. Caroline Blaum and Raymond Yung.

Proposals may involve biomedical science, clinical physiology and pathophysiology, health services research, behavioral and social science research, or investigations into the basic biology of aging.  The Pepper Center has a particular interest in studies that relate to the connections between the aging process and methods that might improve the health and independence of elderly people .  The Nathan Shock Center is particularly interested in proposals that address fundamental questions in the genetics and cell and molecular biology of aging, as well as mechanisms of aging in specific organ systems.

Only those with full-time faculty positions at the University of Michigan are eligible to apply.  Most pilot grants will be awarded to junior faculty members, but more senior scientists are also encouraged to apply if they are seeking support for new initiatives in aging or geriatrics research. Projects are supported for one year.  A second year of funding is sometimes possible, but requires a competitive renewal application.  Individual awards will not exceed $40,000 per year, plus applicable indirect costs. For more information, visit (http://www.med.umich.edu/geriatrics/research/resources/pilotgrants.htm)

OVPR UM Research Faculty Awards
Deadline: February 19, 2010

OVPR is accepting nominations for three awards honoring excellence by UM Research Faculty for their contributions to the intellectual life of the University. Award winners will receive an honorarium and will be invited to attend the annual Faculty Awards Ceremony and dinner hosted by the President in the fall. Nominees must hold at least a 75% appointment in the research faculty track to be eligible for these awards. Tenured and tenure-track instructional faculty members are not eligible. Details are posted on the website.

  • Collegiate Research Professorship – presented to recognize exceptional scholarly achievement and impact on advancing knowledge in science, engineering, health, education, the arts, the humanities or other academic field of study by full Research Professors.
  • Research Faculty Achievement Award – presented to recognize outstanding scholarly achievements, as represented by significant contributions to an academic field of study over time, a specific outstanding discovery, or the development of innovative technology by a Research Professor, Research Associate Professor, Research Scientist, or Associate Research Scientist.
  • Research Faculty Recognition Award – presented to recognize exceptional scholarly achievements, as evidenced by publications and/or other scholarly activities in any academic field of study by a Research Associate Professor, Research Assistant Professor, Associate Research Scientist, or Assistant Research Scientist.


External Limited Submissions


These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

Damon Runyon Clinical Investigator Award
Internal Deadline: January 13, 2010

The Damon Runyon Cancer Research Foundation’s Clinical Investigator Award was created to protect and cultivate those promising young physician-scientists willing to devote their careers to the development and application of new diagnostic approaches and therapeutic strategies for cancer and cancer prevention through clinical investigation. In addition to candidates working in translational clinical oncology, the Foundation is interested in candidates whose research relates to or uses imaging technologies and molecular imaging in cancer. The Foundation is seeking investigators demonstrating innovation and creativity and gives preference to those whose research adheres to the “Handshake Rule,” meaning that the physician will meet each patient in their research studies. The award will provide financial support for the investigator ($100,000 per year for three years) and a research allowance ($50,000 per year for three years). The Foundation will also retire up to $100,000 of any qualifying medical school debt still owed by the awardee.

Eligibility Criteria:

    • Applicants must be U.S. citizens or permanent legal residents.
    • Applicants must have a M.D. or M.D./Ph.D. degree from an accredited institution and be board-eligible.
    • The applicant may apply during the final year of their subspecialty training or within the first four years of their initial assistant professorship appointment (cut-off July 1, 2006). Candidates may apply up to three times during this eligibility period. Candidates holding or awarded R01s at the time of application are not eligible to apply.
    • The applicant must hold or be in the process of securing a tenure-track position at his/her institution.
    • The applicant must commit to spending 80% of their time conducting research.
    • The applicant is required to apply in conjunction with a mentor who is established in the field of clinical translational cancer research, cancer prevention and/or epidemiology and can provide the critical guidance needed during the period of the award. No more than two Damon Runyon Clinical Investigators will be funded to work with the same mentor at any given time.
    • Investigators may receive funding from other sources to support their research. However, no other physician-scientist career development award from a private source (non-federal government) may be held concurrently with the Clinical Investigator Award.
    • Scientific or budgetary overlap with other funded projects is not allowed.

NOTE: Not all eligibility criteria may be listed in this abstract. Before submitting an application for this internal competition, it is the applicant’s responsibility to visit the foundation website (http://www.damonrunyon.org/for_scientists/categories/category/awards) and verify that both the applicant and their project meet ALL eligibility criteria. Deadline for submission of an application to Damon Runyon is March 1, 2010.

UM may nominate three candidates. For consideration as an institutional nominee, submit the following electronically in a single PDF document by January 13, 2010 to (limitedsubmissions@umich.edu): a 3-page research plan, a NIH formatted biosketch, and a nominating letter from the department chair. We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions.


Deadline Watch

Click here to view.

The Ellison Medical Foundation New Scholar Award in Aging
Internal Deadline: January 8, 2010
Foundation Deadline: February 25, 2010

(http://www.ellisonfoundation.org)
Direct any questions to Jane Ritter (ritterj@umich.edu or 734-763-1290) in the Office of the Vice President for Research, University of Michigan.


OVPR Staff Service Awards Program
Deadline: January 22, 2010

(http://research.umich.edu/ovpr/recognition-programs)
For questions, contact Jane Ritter at 734-763-1290 or (ritterj@umich.edu).

  • Distinguished Research Administrator Award
  • OVPR Exceptional Service Award

Pfizer Fellowships / Visiting Professorships
Deadline: January 31, 2010

 (http://www.pfizermap.com)


Vodafone Americas Foundation Wireless Innovation Project
Deadline: February 1, 2010

(http://project.vodafone-us.com)


UMMS AWARDED GRANTS

External Awarded Grants

Currently, due to limitations on data collection, we are unable to identify projects awarded with multiple PIs. As the eRPM system is used for proposals in 2009, we will be able to publish those awards accurately. We apologize for any misleading project information this causes.

Click here to view.

Anesthesiology

PI: Clauw, Daniel
Co-I: Clemens, James (Urology Surgery)
Title: University of Michigan MAPP Research Network Discovery Site (F021318)
Sponsor: NIH 3 U01 DK 082345 02 S1
Project Dates and Amount of Award: 09/28/09-09/27/11; $200,850

PI: Waskell, Lucy
Title: PARTICIPATION IN CYTOCHROME B5 IN ANESTHETIC METABOLISM
Sponsor: NIH 2 R01 GM 035533 21 A2
Project Dates and Amount of Award: 09/30/09-08/31/11; $622,948

Biological Chemistry

PI: Kaufman, Randal
Co-I: Fribley, Andrew (Biological Chemistry Dept)
Title: HTP CHEMICAL GENOMIC SCREENS TO IDENTIFY POSITIVE REGULATORS OF THE UNFOLDED PROTEIN RESPONSE
Sponsor: NIH 1 R03 MH 089782 01
Project Dates and Amount of Award: 09/30/09-05/31/11; $77,250

PI: Kerppola, Tom
Title: OPTIMIZATION OF BIOMOLECULAR FLUORESCENCE COMPLEMENTATION PROBES FOR NEW IMAGING FUNCTION
Sponsor: NIH 3 R01 GM 086213 02 S1
Project Dates and Amount of Award: 09/30/09-08/31/10; $115,873

PI: Smith, William
Title: CATALYSIS BY PROSTAGLANDIN ENDOPEROXIDE H SYNTHASES
Sponsor: NIH 3 R01 GM 068848 07 S1
Project Dates and Amount of Award: 09/30/09-07/31/11; $229,036

PI: Trievel, Raymond
Title: STRUCTURE AND FUNCTIONS OF SET DOMAIN METHYLTRANSFERASES
Sponsor: NIH 3 R01 GM 073839 04 S1
Project Dates and Amount of Award: 09/30/09-01/31/11; $133,753

Cell & Developmental Biology

PI: Barald, Kate
Title: SIGNALS REGULATING SAG DEVELOPMENT
Sponsor: NIH - Subcontracts TO Indiana University R01 DC 006436
Project Dates and Amount of Award: 09/11/09-08/31/10; $70,000

PI: Engel, James
Co-I: Tanabe, Osamu (Cell and Developmental Biology)
Title: REACTIVATION OF FETAL GAMMA-GLOBIN GENES FOR THE TREATMENT OF BETA-GLOBIN DISORDERS
Sponsor: NIH 1 RC1 DK 086056 01
Project Dates and Amount of Award: 09/30/09-07/31/11; $984,303

PI: Verhey, Kristen
Co-I: Meyhofer, Edgar (Mechanical Engineering)
Title: SINGLE MOLECULE IMAGING OF KINESIN MOTORS IN LIVE CELLS
Sponsor: NIH 3 R01 GM 083254 03 S1
Project Dates and Amount of Award: 09/30/09-08/31/10; $53,900

Comprehensive Cancer Center

PI: Wicha, Max
Title: ADMINISTRATIVE SUPPLEMENT FOR ADOPTION OF NEW TECHNOLOGIES FOR REMOTE DATA CAPTURE & PROTOCOL AUTHORIZING
Sponsor: NIH 3 P30 CA 046592 22 S2
Project Dates and Amount of Award: 09/30/09-09/29/11; $49,022

PI: Wicha, Max
Title: ADMIN SUPPLEMENT FOR RECRUITMENT OF NEW FACULTY-HEMATOLOGIC MALIGNANCIES
Sponsor: NIH 3 P30 CA 046592 22 S3
Project Dates and Amount of Award: 09/30/09-09/29/11; $1,363,286

Dermatology

PI: Elder, James
Title: GENOTYPING THE NPF BIOBANK FOR PSORIASIS SUSCEPTIBILITY GENES
Sponsor: NIH 1 RC1 AR 058315 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $992,987

PI: Elder, James
Title: LINKAGE ANALYSIS OF FAMILIAL PSORIASIS
Sponsor: NIH 2 R01 AR 042742 15 A1
Project Dates and Amount of Award: 09/28/09-08/31/14; $3,412,525

PI: Elder, James
Co-I: Abecasis, Goncalo (Biostatistics Department) / Ike, Robert (Internal Medicine Department)
Title: IDENTIFICATION OF PSORIATIC ARTHRITIS GENES
Sponsor: NIH 2 R01 AR 050511 06 A1
Project Dates and Amount of Award: 09/28/09-07/31/14; $3,227,822

PI: Fisher, Gary
Co-I: Quan, Taihao (Dermatology Department)
Title: REVISION-COLLAGENASE DEGRADATION OF EXTRACELLULAR MATRIX IN AGING
Sponsor: NIH 3 R01 AG 025186 04 S1
Project Dates and Amount of Award: 09/30/09-08/31/11; $421,070

PI: Orringer, Jeffrey
Co-I: Fisher, Gary (Dermatology Department) / Ludgate, Mathew (Dermatology Department)
Title: MOLECULAR EFFECTS OF FRACTIONATED CARBON DIOXIDE LASER RESURFACING: A QUANTITATIVE COMPARISON WITH TRADITIONAL ABLATIVE LASER RESURFACING
Sponsor: American Society for Dermatologic Surgery
Project Dates and Amount of Award: 10/01/09-09/30/10; $20,000

PI: Quan, Taihao
Co-I: Fisher, Gary (Dermatology Department)
Title: CYR61-A NOVEL MEDIATOR OF PHOTOAGED HUMAN SKIN
Sponsor: NIH 3 R01 ES 014697 03 S1
Project Dates and Amount of Award: 09/25/09-06/30/11; $337,690

PI: Sachs, Dana
Co-I: Ludgate, Mathew (Dermatology Department)
Title: NON-INVASIVE EVALUATION OF APPEARANCE-ENHANCING PROCEDURES
Sponsor: Access Business Group
Project Dates and Amount of Award: 10/15/09-10/14/10; $52,113

Emergency Medicine

PI: Scott, Phillip
Title: CARDIOVASCULAR HEALTH GRANT YEAR 3
Sponsor: CDC-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $11,520

PI: Scott, Phillip
Title: THE COMBINED APPROACH TO LYSIS UTILIZING EPTIFIBATIDE AND RT-PA-ENHANCED REGIMEN
Sponsor: NIH - Subcontracts TO University of Cincinnati P50 NS 044283
Project Dates and Amount of Award: 05/01/09-04/30/10; $23,943

Family Medicine

PI: Reed, Barbara
Co-I: Harris, Richard (Anesthesiology Department) / Sen, Ananda (Department of Family Medicine)
Title: CHARACTERIZATION OF PAIN PROCESSING IN VULVODYNIA
Sponsor: NIH 3 R01 HD 045661 03 S1
Project Dates and Amount of Award: 09/30/09-09/29/10; $74,832

Human Genetics

PI: Antonellis, Anthony
Title: STUDIES ON TRANSFER RNA
Sponsor: NIH - Subcontracts TO Yale University
Project Dates and Amount of Award: 09/15/09-03/31/10; $33,144

PI: Camper, Sally
Title: CELL SPECIFIC EXPRESSION IN THE PITUITARY GLAND
Sponsor: NIH 2 R01 HD 034283 14
Project Dates and Amount of Award: 09/18/09-08/31/11; $974,463

PI: Glover, Thomas
Co-I: Arlt, Martin (Human Genetics Department) / Qin, Zhaohui (Biostatistics Department) / Wilson, Thomas (Pathology Department Roll Up)
Title: ENVIRONMENTAL RISK FACTORS FOR COPY NUMBER VARIATION IN HUMAN CHROMOSOMES
Sponsor: NIH 1 RC1 ES 018672 01
Project Dates and Amount of Award: 09/28/09-06/30/11; $985,501

PI: Kalantry, Sundeep
Title: EPIGENETIC MECHANISMS OF X-CHROMOSOME INACTIVATION
Sponsor: NIH 4 R00 HD 055333 03
Project Dates and Amount of Award: 08/01/09-07/31/12; $745,454

PI: Sing, Charles
Title: GENOMIC APPROACHES TO COMMON CHRONIC DISEASE
Sponsor: NIH 3 P50 GM 065509 08 S1
Project Dates and Amount of Award: 09/30/09-08/31/10; $313,873

Internal Medicine

PI: Baker, Laurence
Co-I: Erba, Harry (Int Med-Hematology/Oncology)
Title: SWOG TREATMENT GRANT ACTNOW PROGRAM: S0816
Sponsor: NIH 3 U10 CA 032102 30 S1
Project Dates and Amount of Award: 06/01/09-05/31/11; $768,702

PI: Burant, Charles
Title: Recharge: Metabolomics Core Baylor College of Medicine
Sponsor: NIH - Subcontracts TO Baylor College of Medicine
Project Dates and Amount of Award: 09/01/09-08/31/10; $1,794

PI: Fearon, Eric
Co-I: Cho, Kathleen (Pathology Department) / Ferguson, David (Pathology Department) / Zhu, Yuan (Int Med-Molecular Med&Genetics)
Title: CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCER
Sponsor: NIH 2 R01 CA 082223 11
Project Dates and Amount of Award: 09/01/09-08/31/10; $305,550

PI: Gadegbeku, Crystal
Title: RETINOPATHY AND CHRONIC RENAL INSUFFICIENCY (RCRIC) FOLLOW-UP STUDY
Sponsor: NIH - Subcontracts TO University of Pennsylvania
Project Dates and Amount of Award: 09/28/09-08/31/11; $68,734

PI: Gianchandani, Roma
Co-I: Blum, James (Anesthesiology Department)
Title: Feasibility Evaluation of Continuous Monitoring in Hospitalized Critically Ill Patients
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 10/19/09-12/31/09; $29,486

PI: Good, Eric
Title: EFFICACY AND SAFETY OF CELIVARONE AT 50, 100 OR 300 MG OD WITH AMIODARONE AS CALIBRATOR FOR THE PREVENTION OF ICD INTERVENTIONS OR DEATH (CELIVARONE STUDY)
Sponsor: Sanofi-Aventis Pharmaceuticals
Project Dates and Amount of Award: 11/02/09-08/31/11; $95,864

PI: Halter, Jeffrey
Co-I: Alexander, Neil (Int Med-Geriatric Medicine) / Ashton-Miller, James (Mechanical Engineering) / Blaum, Caroline (Int Med-Geriatric Medicine) / Bluhm, Rick (Int Med-Geriatric Medicine) / Burke, David (Int Med-Rheumatology) / Desai, Anjali (Int Med-Geriatric Medicine) / Fries, Brant (Institute of Gerontology) / Galecki, Andrzej (Int Med-Geriatric Medicine) / Lee, Pearl (Int Med-Geriatric Medicine) / Liang, Jersey (Health Management and Policy) / Lombard, David (Pathology Department) / Miller, Richard (Pathology Department) / Nyquist, Linda (Institute of Gerontology) / Ruff, Tanya (Int Med-Geriatric Medicine) / Seidler, Rachael (School of Kinesiology) / Ye, Wen (Biostatistics Department) / Yung, Raymond (Int Med-Geriatric Medicine)
Title: CLAUDE D. PEPPER OLDER AMERICANS INDEPENDENCE CENTERS (OAICS)(P30)
Sponsor: NIH 2 P30 AG 024824 06
Project Dates and Amount of Award: 09/30/09-08/31/14; $6,584,507

PI: Han, Zhe
Title: A NOVEL G PROTEIN SIGNALING PATHWAY CONTROLLING DROSOPHILA CARDIAC MORPHOGENESIS
Sponsor: NIH 3 R01 HL 090801 02 S1
Project Dates and Amount of Award: 07/15/09-06/30/11; $243,558

PI: Henry, Norah
Title: 2009.073: A Phase 3, Multi-Center, Open-Label, Randomized Study of Gemcitabine/Carboplatin, with or without BSI-201, in Patients with ER-, PR-, and HER2-Negative Metastatic Breast Cancer
Sponsor:
Project Dates and Amount of Award: 11/10/09-11/10/12; $699,200

PI: Holoshitz, Joseph
Co-I: Kaplan, Mariana (Int Med-Rheumatology)
Title: MHC CLASS II-ASSOCIATED ENDOTHELIAL DYSFUNCTION
Sponsor: NIH 1 R21 AR 056786 01 A1
Project Dates and Amount of Award: 09/22/09-09/21/11; $379,397

PI: Humes, H
Title: DEVELOPMENT AND ASSESSMENT OF A BPICS IN A CHRONIC DIABETIC SHEEP MODEL
Sponsor: Defense, Department of-Army, Department of the-Subcontracts TO Innovative BioTherapies
Project Dates and Amount of Award: 01/01/09-08/31/10; $177,936

PI: Jakubowiak, Andrzej
Title: DETERMINE THE MAXIMUM TOLERATED DOSE, SAFETY AND EFFICACY OF CC-4047 ALONE OR IN COMBINATION WITH DEXAMETHASONE IN PATIENTS WITH RELAPSED AND REFRACTORY MULTIPLE MYELOMA 2008.082: A PHASE 1/2 MULTI-CENTER, RANDOMIZED, OPEN LABEL DOSE ESCALATION STUDY TO
Sponsor: Celgene Corporation
Project Dates and Amount of Award: 11/23/09-12/31/14; $808,700

PI: Jakubowiak, Andrzej
Title: AN OPEN LABEL, DOSE ESCALATION, PHASE 1/2 STUDY OF THE ORAL FORM OF MLN9708, A SECOND GENERATION PROTEASOME INHIBITOR, IN ADULT PATIENTS WITH RELAPSED AND REFRACTORY MULTIPLE MYELOMA
Sponsor: Millennium Pharm, Inc. TO Quintiles, Inc.
Project Dates and Amount of Award: 09/28/09-09/27/12; $787,298

PI: Jakubowiak, Andrzej
Title: 2009.056: MULTICENTER, OPEN-LABEL, SINGLE-ARM, PHASE 1B/2 STUDY OF THE SAFETY AND EFFICACY OF COMBINATION TREATMENT WITH CARFILZOMIB, LENALIDOMIDE AND DEXAMETHASONE (CRD) IN SUBJECTS WITH NEWLY DIAGNOSED, PREVIOUSLY UNTREATED MULTIPLE MYELOMA REQUIRING SYSTEMIC CHEMOTHERAPY
Sponsor: Multiple Myeloma Research Consortium
Project Dates and Amount of Award: 10/12/09-10/11/13; $100,000

PI: Jakubowiak, Andrzej
Title: PROTEOMICS PROFILES OF MM CELLS TREATED WITH CARFLIZOMIB
Sponsor: Proteolix, Inc.
Project Dates and Amount of Award: 10/01/09-09/30/11; $50,729

PI: Jakubowiak, Andrzej
Title: 2009.056: MULTICENTER, OPEN-LABEL, SINGLE-ARM, PHASE 1B/2 STUDY OF THE SAFETY AND EFFICACY OF COMBINATION TREATMENT WITH CARFILZOMIB, LENALIDOMIDE AND DEXAMETHASONE (CRD) IN SUBJECTS WITH NEWLY DIAGNOSED, PREVIOUSLY UNTREATED MULTIPLE MYELOMA REQUIRING SYSTEMIC CHEMOTHERAPY
Sponsor: Various Sponsors
Project Dates and Amount of Award: 10/12/09-10/31/13; $500,000

PI: Jalife, Jose
Co-I: Delmar, Mario (Int Med-Cardiology) / Oral, Hakan (Int Med-Cardiology)
Title: STRUCTURAL ALTERATIONS IN THE MYOCARDIUM AND THE SUBSTRATE FOR CARDIAC FIBRILLATION
Sponsor: Foundation Leducq
Project Dates and Amount of Award: 10/01/09-09/30/14; $2,600,232

PI: James, Mary
Co-I: Fries, Brant (Institute of Gerontology)
Title: UNIVERSITY OF MICHIGAN LONG TERM CARE DATA ARCHIVE
Sponsor: Education, Department of-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $300,000

PI: Kretzler, Matthias
Co-I: Holzman, Lawrence (Int Med-Nephrology) / Ojo, Akinlolu (Int Med-Nephrology) / Song, Peter (Biostatistics Department)
Title: NEPHROTIC SYNDROME RARE DISEASE CLINICAL RESEARCH NETWORK
Sponsor: NephCure Foundation
Project Dates and Amount of Award: 09/08/09-09/07/14; $1,984,730

PI: Lao, Christopher
Title: 2008.090: A double-blind, randomized, placebo-controlled Phase III study to assess the efficacy of RecMAGE-A3 + AS15 ASCI as adjuvant therapy in patients with MAGE-A3-positive Resected Stage III Melanoma
Sponsor: Glaxosmithkline
Project Dates and Amount of Award: 09/15/09-08/14/14; $214,333

PI: Lok, Anna
Co-I: Tsodikov, Alexander (Biostatistics Department)
Title: APPLICATION OF NOVEL ORGAN-SPECIFIC PLASMA PROTEIN BIOMARKER CANDIDATES TO DIAGNOSE HEPATIC FIBROSIS IN HEPATITIS C PATIENTS TO HALT-C TRIAL
Sponsor: Government Of Luxembourg TO Institute For Systems Biology
Project Dates and Amount of Award: 08/01/09-09/30/10; $61,480

PI: Luther, Jay
Co-I: Merchant, Juanita (Int Med-Gastroenterology)
Title: MECHANISM OF H. PYLORI-INDUCED RISK REDUCTION FOR INFLAMMATORY BOWEL DISEASE
Sponsor: NIH 1 F32 DK 084694 01 A1
Project Dates and Amount of Award: 09/28/09-09/27/10; $50,054

PI: Malek, Sami
Co-I: Shedden, Kerby (LSA Statistics)
Title: THE INSULIN RECEPTOR AS A DIAGNOSTIC AND THERAPEUTIC TARGET IN CHRONIC LYMPHOCYTIC LEUKEMIA (LCLL)
Sponsor: Leukemia and Lymphoma Society
Project Dates and Amount of Award: 10/01/09-09/30/12; $600,000

PI: Margolis, Benjamin
Title: NOVEL CILIA TRAFFICKING MECHANISMS
Sponsor: NIH 1 R01 DK 084725 01
Project Dates and Amount of Award: 09/28/09-07/31/11; $701,878

PI: Markovitz, David
Co-I: Adams, Barbara (Pediatrics) / Mor-Vaknin, Nirit (Int Med-Infectious Diseases) / Zhao, Lili (Univ of Mich Cancer Center)
Title: DEK AND TNF INHIBITORS IN JUVENILE ARTHRITIS
Sponsor: NIH 1 R01 AI 087128 01
Project Dates and Amount of Award: 09/01/09-08/31/13; $1,545,000

PI: Markovitz, David
Co-I: Al-Hashimi, Hashim (LSA Biophysics) / Gitlin, Scott (Int Med-Hematology/Oncology) / Kaplan, Mark (Int Med-Infectious Diseases) / Meng, Fan (Psych Labs and Bioinformatics) / Omenn, Gilbert (Int Med-Molecular Med&Genetics) / Ono, Akira (Microbiology and Immunology) / Sartor, Maureen (Computational Medicine and Bio)
Title: REPLICATION OF HUMAN ENDOGENOUS RETROVIRUSES IN MODERN HUMANS
Sponsor: NIH 1 R01 CA 144043 01
Project Dates and Amount of Award: 09/28/09-08/31/14; $6,814,174

PI: Markovitz, David
Co-I: Contreras, Rafael (Int Med-Infectious Diseases)
Title: THE ENDOGENOUS RETROVIRUS HERV-K AS A CANCER MARKER
Sponsor: Novartis
Project Dates and Amount of Award: 06/01/09-06/30/11; $84,975

PI: Martinez, Fernando
Co-I: Hogaboam, Cory (Pathology Department) / Lama, Vibha (Int Med-Pulm./Critical Care) / Moore, Thomas (Int Med-Pulm./Critical Care) / Murray, Susan (Biostatistics Department) / Spino, Catherine (Biostatistics Department) / Toews, Galen (Int Med-Pulm./Critical Care) / White, Eric (Int Med-Pulm./Critical Care)
Title: MOLECULAR PHENOTYPES OF RAPIDLY PROGRESSIVE IDIOPATHIC PULMONARY FIBROSIS
Sponsor: NIH 1 RC2 HL 101740 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $7,915,507

PI: Owyang, Chung
Title: GASTROINTESTINAL HORMONE RESEARCH CORE CENTER
Sponsor: NIH 3 P30 DK 034933 24 S1
Project Dates and Amount of Award: 07/25/09-05/31/11; $300,000

PI: Pelosi Jr, Frank
Title: St. Jude Medical Foundation 2009-2010 CCEP Fellowship Program
Sponsor: St. Jude Medical Foundation
Project Dates and Amount of Award: 07/01/09-06/30/10; $75,000

PI: Peters-Golden, Marc
Title: CONTRACT EXPERIMENTS TO TEST EP2 ANTAGONISTS FOR SANOFI-AVENTIS
Sponsor: Sanofi-Aventis Pharmaceuticals
Project Dates and Amount of Award: 10/30/09-03/01/10; $22,040

PI: Pienta, Kenneth
Co-I: Zhang, Jian (Int Med-Hematology/Oncology)
Title: Evaluation of the effect of CCL2 blockade utilizing MRI imaging
Sponsor: Centocor, Inc.
Project Dates and Amount of Award: 11/09/09-11/08/10; $197,283

PI: Pienta, Kenneth
Title: PCF CHALLENGE AWARD
Sponsor: Prostate Cancer Foundation
Project Dates and Amount of Award: 07/01/09-06/30/10; $90,000

PI: Pinsky, David
Title: HUMAN MOLECULAR GENETICS OF VASCULAR DISEASE
Sponsor: NIH 1 P30 HL 101290 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $1,393,524

PI: Ross, Theodora
Title: HUNTINGTON INTERACTING PROTEIN-1 (HIP1) AND THE PROMOTION OF NEOPLASIA
Sponsor: NIH 3 R01 CA 098730 06 S1
Project Dates and Amount of Award: 08/01/09-07/31/11; $281,370

PI: Saran, Rajiv
Co-I: Gillespie, Brenda (Ctr Statistical Consul & Res) / Shahinian, Vahakn (Int Med-Nephrology)
Title: ESTABLISHING A SURVEILLANCE SYSTEM FOR CHRONIC KIDNEY DISEASE
Sponsor: CDC-Subcontracts TO Association of American Medical Colleges
Project Dates and Amount of Award: 09/30/09-09/29/10; $220,000

PI: Schiopu, Elena
Co-I: Phillips, Kristine (Int Med-Rheumatology)
Title: Digital Ischemic Lesions in Scleroderma Treated with Oral Treprostinil Diethanolamine (DISTOL-EXT)
Sponsor: United Therapeutics Corp
Project Dates and Amount of Award: 11/12/09-10/31/14; $272,603

PI: Schteingart, David
Co-I: Hammer, Gary (Metabolism, Endo & Diabetes)
Title: AN OPEN LABEL EXTENSION STUDY OF THE EFFICACY AND SAFETY OF CORLUX (MIFEPRISTONE) IN THE TREATMENT OF THE SIGNS AND SYMPTOMS OF ENDOGENOUS CUSHING'S SYNDROME
Sponsor: Corcept Therapeutics, Inc.
Project Dates and Amount of Award: 09/23/09-09/23/11; $71,202

PI: Seibold, James
Co-I: Phillips, Kristine (Int Med-Cardiology)
Title: SINGLE AND MULTIPLE INTRAVENOUS DOSES OF MEDI-546, A FULLY HUMAN MONOCLONAL ANTIBODY DIRECTED AGAINST SUBUNIT 1 OF THE TYPE 1 OF THE TYPE I INTERFERON RECEPTOR, IN ADULT SUBJECTS WITH SCLERODERMA
Sponsor: MedImmune, Inc.
Project Dates and Amount of Award: 07/28/09-07/31/12; $202,776

PI: Smith, David
Title: 2009.042 A RANDOMIZED PHASE 2 CLINICAL TRIAL OF TWO DOSE-LEVELS OF ITRACONAZOLE IN PATIENTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
Sponsor: Johns Hopkins University
Project Dates and Amount of Award: 06/01/09-05/31/12; $49,300

PI: Talpaz, Moshe
Title: 2009-010: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE JAK INHIBITOR INCB018424
Sponsor: Incyte Pharmaceuticals, Inc. TO PPD, Inc.
Project Dates and Amount of Award: 10/05/09-04/04/14; $2,112,408

PI: Weitzel III, William
Co-I: Kruger, Grant (Mechanical Engineering) / Rubin, Jonathan (Radiology Department)
Title: VF DOPPLER SMART SENSOR FOR DIALYSIS AND VASCULAR APPLICATIONS
Sponsor: NIH 1 RC1 HL 101881 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $1,000,000

PI: Weitzel III, William
Co-I: Kershaw, David (Pediatrics-Nephrology) / Rubin, Jonathan (Radiology Department)
Title: REAL-TIME ARTERIAL ELASTICITY IMAGING
Sponsor: NIH - Subcontracts TO Pixel Velocity
Project Dates and Amount of Award: 08/01/09-07/31/10; $124,583

PI: Wellik, Deneen
Title: HOX GENES IN LIMB PATTERNING
Sponsor: NIH 1 R01 AR 057018 01 A1
Project Dates and Amount of Award: 09/22/09-09/21/11; $745,250

PI: Wellik, Deneen
Title: PATTERNING MODULES IN THE EVOLUTION AND DEVELOPMENT OF THE VERTEBRATE MESODERM
Sponsor: National Science Foundation-Subcontracts TO Wesleyan University
Project Dates and Amount of Award: 08/01/09-07/31/10; $31,915

PI: Wicha, Max
Title: REGULATION OF BREAST CANCER STEM CELLS BY TISSUE HYPOXIA
Sponsor: Breast Cancer Research Fdn
Project Dates and Amount of Award: 10/01/09-09/30/10; $200,000

PI: Wicha, Max
Title: THE SONIC HEDGEHOG SMOOTHENED ANTAGON GDC-0449 (NSC# 747691) PLUS PAN-NOTCH INHIBITOR RO4929097 (NSC# 749225) ADMINISTERED IN PATIENTS WITH BREAST CANCER (CORRELATIVE STUDIES FOR A PHASE I DOSE-ESCALATION STUDY OF)
Sponsor: NIH - Subcontracts TO Wayne State University U01 CA 062487
Project Dates and Amount of Award: 06/01/09-05/31/11; $116,078

PI: Yu, Xiaochun
Title: REGULATION OF IONIZING RADIATION INDUCED DNA DAMAGE RESPONSE
Sponsor: NIH 1 R01 CA 130899 01 A2
Project Dates and Amount of Award: 05/01/09-02/28/14; $1,541,725

PI: Zimmermann, Ellen
Title: DETECTION OF INFLAMMATION VERSUS INTESTINAL FIBROSIS IN CROHN'S DISEASE
Sponsor: NIH 3 R01 DK 073992 03 S1
Project Dates and Amount of Award: 09/30/09-08/31/10; $100,000

Medical School Administration

PI: Pienta, Kenneth
Title: HEALTH DISPARITIES SUMMER IMMERSION PROGRAM
Sponsor: AHRQ 3 UL1 RR 024986 03 S1
Project Dates and Amount of Award: 09/24/09-09/23/11; $317,307

Michigan Nanotechnology Institute for Medicine and Biological Sciences

PI: Baker Jr, James
Co-I: Bielinska, Anna (MI Nanotechnology Institute) / Smith, Douglas (MI Nanotechnology Institute)
Title: INNATE IMMUNE RECEPTORS AND ADJUVANT DISCOVERY
Sponsor: NIH 1 N01 AI 090031 01
Project Dates and Amount of Award: 09/30/09-09/29/14; $9,340,523

Microbiology and Immunology

PI: Anderson, Kelsi
Title: CHLORIDE TRANSPORT FACILITATES LISTERIA MONOCYTOGENES VACUOLE ESCAPE
Sponsor: NIH 1 F32 AI 084431 01
Project Dates and Amount of Award: 09/01/09-08/31/11; $92,428

PI: Raghavan, Malini
Title: CALRETICULIN'S FUNCTIONS IN THE ADAPTIVE IMMUNE RESPONSE
Sponsor: NIH 3 R01 AI 066131 03 S1
Project Dates and Amount of Award: 09/30/09-08/31/11; $389,120

PI: Swanson, Michele
Title: AUTOPHAGY AS A COMPONENT OF THE INNATE IMMUNE RESPONSE
Sponsor: NIH 3 R56 AI 076300 01 A1S1
Project Dates and Amount of Award: 08/14/09-08/31/10; $374,137

Molecular & Integrative Physiology

PI: Carter-Su, Christin
Title: GROWTH HORMONE REGULATION OF SH2B1
Sponsor: NIH 2 R56 DK 054222 11
Project Dates and Amount of Award: 08/25/09-07/31/10; $193,125

PI: Linford, Nancy
Title: MOLECULAR PATHWAYS ALTERING CIRCADIAN RHYTHM IN AGING
Sponsor: NIH 7 K01 AG 031917 03
Project Dates and Amount of Award: 09/15/09-04/30/13; $475,957

PI: Low, Malcolm
Title: NEUROCHEMISTRY/PHYSIOLOGY OF PROOPIOMELANOCORTIN NEURONS
Sponsor: NIH 2 R01 DK 066604 05 A1
Project Dates and Amount of Award: 09/10/09-08/31/14; $2,035,950

PI: Pletcher, Scott
Title: MECHANISMS OF DIETARY RESTRICTION IN DROSOPHILA
Sponsor: NIH 2 R56 AG 023166 06
Project Dates and Amount of Award: 09/01/09-08/31/10; $386,250

PI: Yin, Lei
Title: BIOLOGY OF THE ORPHAN NUCLEAR RECEPTOR REV-ERBA AND ITS REGULATION IN CIRCADIAN RHYTHM AND METABOLISM
Sponsor: NIH 4 R00 DK 077449 03
Project Dates and Amount of Award: 09/23/09-08/31/12; $726,593

Neurology

PI: Feldman, Eva
Title: BIOMARKERS IN DIABETIC NEUROPATHY
Sponsor: NIH 1 RC1 NS 068182 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $518,832

PI: Kerber, Kevin
Co-I: Brown, Devin (Neurology Department) / Fendrick, A (Int Med-General Medicine) / Hoeffner, Ellen (Radiology Department) / Hofer, Timothy (Int Med-General Medicine) / Meurer, William (Emergency Medicine UM Adult) / Morgenstern, Lewis (Neurology Department) / Tsodikov, Alexander (Sch of Public Hlth-Dean's Ofc)
Title: SOLUTIONS FOR VERTIGO PRESENTATIONS IN THE EMERGENCY DEPARTMENT (SOLVE) PROJECT
Sponsor: AHRQ 1 R18 HS 017690 01 A1
Project Dates and Amount of Award: 09/30/09-07/31/13; $639,749

PI: Parent, Jack
Co-I: Murphy, Geoffrey (Molecular & Behav Neurosc Inst)
Title: ABERRANT NEUROGENESIS IN EXPERIMENTAL TEMPORAL LOBE EPILEPSY
Sponsor: NIH 1 R01 NS 058585 01 A2
Project Dates and Amount of Award: 09/28/09-07/31/14; $1,606,934

PI: Todi, Sokol
Title: POSTTRANSLATIONAL MODIFICATION OF DEUBIQUITINATING ENZYMES IN NEURODEGENERATION
Sponsor: NIH 1 K99 NS 064097 01 A1
Project Dates and Amount of Award: 09/30/09-06/30/11; $173,189

Obstetrics & Gynecology

PI: Christman, Gregory
Title: COOPERATIVE MULTICENTER REPRODUCTIVE MEDICINE NETWORK (U10)
Sponsor: NIH 3 U10 HD 055936 03 S1
Project Dates and Amount of Award: 09/30/09-09/29/11; $331,198

PI: DeLancey, John
Title: BIRTH, MUSCLE, INJURY AND PELVIC FLOOR DYSFUNCTION (SCOR PROJECT 3)
Sponsor: NIH 3 P50 HD 044406 08 S1
Project Dates and Amount of Award: 09/30/09-09/29/10; $46,350

PI: Menon, K M Jairam
Title: REGULATION OF OVARIAN FUNCTION BY GONADOTROPIN
Sponsor: NIH 3 R37 HD 006656 34 S1
Project Dates and Amount of Award: 09/30/09-09/29/11; $153,456

Ophthalmology & Visual Sciences

PI: Richards, Julia
Title: ADMIXTURE MAPPING OF GLAUCOMA GENES IN AFRICAN AMERICANS
Sponsor: NIH - Subcontracts TO Duke University EY 019126
Project Dates and Amount of Award: 09/01/09-08/31/10; $165,319

PI: Sugar, Alan
Co-I: Mian, Shahzad (Ophthalmology & Visual Science)
Title: CYCLOSPORINE OPHTHALMIC SOLUTION 0.010% COMPARED WITH ITS VEHICLE ADMINISTERED QID FOR 3 MONTHS FOLLOWED BY A 9 MONTH FULL TITLE ON AGREEMENT (A MULTICENTER, RANDOMIZED, DOUBLE-MASKED, PARALLEL-GROUP STUDY EVALUATING THE EFFICACY AND SAFETY OF)
Sponsor: Allergan Pharmaceuticals, Inc.
Project Dates and Amount of Award: 10/15/09-07/31/12; $94,475

Orthopaedic Surgery

PI: Goldstein, Steven
Co-I: Cartee, Gregory (School of Kinesiology)
Title: FACULTY RECRUITMENT TO MUSCULOSKELETAL RESEARCH CONSORTIUM
Sponsor: NIH 1 P30 AR 058920 01
Project Dates and Amount of Award: 09/25/09-08/31/11; $780,298

PI: Graziano, Gregory
Title: Resident Journal Club in Orthopaedic Surgery
Sponsor: Orthopaedic Research and Education Foundation
Project Dates and Amount of Award: 09/01/09-06/30/10; $2,000

Otolaryngology

PI: Lesperance, Marci
Co-I: Thorne, Marc (Otorhinolaryngology Department) / Zwolan, Teresa (Otorhinolaryngology Department)
Title: SOUND SUPPORT PROGRAM
Sponsor: Health and Human Services, Department of-Centers for Medicare and Medicaid Services-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $279,746

PI: Miller, Josef
Co-I: Green, Glenn (Kresge Hearing Research Inst) / Guire, Kenneth (Biostatistics Department)
Title: MICRONUTRIENT INTERVENTION TO REDUCE NOISE INDUCED HEARING LOSS
Sponsor: NIH 3 U01 DC 008423 02 S1
Project Dates and Amount of Award: 09/17/09-08/31/11; $297,519

Pathology

PI: Ateeq, Bushra
Title: ROLE OF ANGIOTENSIN II TYPE I RECEPTOR (AGTR1) IN A SUBSET OF BREAST CANCER
Sponsor: Expedition Inspiration Fund for Breast Cancer Research
Project Dates and Amount of Award: 09/01/09-08/31/10; $10,000

PI: Duckett, Colin
Title: CONTROL OF APOPTOSIS AND SIGNALING BY XIAP
Sponsor: NIH 3 R01 GM 067827 05 S1
Project Dates and Amount of Award: 09/18/09-03/31/10; $67,594

PI: Giordano, Thomas
Title: MOLECULAR CHARACTERIZATION OF A HUMAN SALIVARY GLAND TUMOR XENOGRAFT BANK
Sponsor: NIH - Subcontracts TO University of Virginia RC1 DE 020687
Project Dates and Amount of Award: 09/17/09-08/31/10; $33,242

PI: Johnson, Kent
Title: IDENTIFICATION AND VALIDATION OF BIOMARKERS FOR VASCULITIS
Sponsor: NIH - Subcontracts TO Boston University RC1 AR 058303
Project Dates and Amount of Award: 09/30/09-08/03/10; $152,457

PI: Lnu, Sooryanarayana
Title: THE ROLE OF JNJ26481585, CNTO888 AND CNTO328 ON TMPRSS2-ETS FUSION AND EZH2 EXPRESSION AND ACTIVITY
Sponsor: Johnson & Johnson
Project Dates and Amount of Award: 11/16/09-11/15/10; $154,500

PI: Miller, Richard
Title: CONSORTIUM TO STUDY THE GENETICS OF LONGEVITY. SUBPROJECT TITLE = CRITICAL ANTI-AGING PATHWAYS FROM INTER-SPECIES COMPARISONS
Sponsor: NIH - Subcontracts TO California Pacific Medical Center
Project Dates and Amount of Award: 07/01/09-06/30/10; $23,692

PI: Newton, Duane
Co-I: Lebar, William (UMH Microbiol Pathology)
Title: MRS SELECT-A DIRECT CULTURE METHOD FOR THE IDENTIFICATION OF MRSA FROM SKIN AND SOFT-TISSUE WOUND SPECIMENS
Sponsor: Mdc Associates TO Bio-Rad
Project Dates and Amount of Award: 09/01/09-06/30/10; $28,000

PI: Newton, Duane
Title: CMV VIRAL LOAD VALIDATION MATERIAL
Sponsor: Roche Molecular Systems, Inc.
Project Dates and Amount of Award: 10/01/09-09/20/10; $20,000

PI: Phan, Sem
Title: THE ROLE OF C/EBPBETA IN PULMONARY FIBROSIS
Sponsor: NIH - Subcontracts TO University of Minnesota P50 HL 091775
Project Dates and Amount of Award: 04/01/09-03/31/10; $397,350

PI: Zochowska, Anuska
Co-I: Keep, Richard (Neurosurgery)
Title: THE BLOOD BRAIN BARRIER IN NEUROINFLAMMATION
Sponsor: NIH 1 R01 NS 062853 01 A2
Project Dates and Amount of Award: 09/30/09-08/31/11; $660,313

Pediatrics & Communicable Diseases

PI: Boxer, Laurence
Co-I: Al-Zoubi, Ammar (Int Med-Hematology/Oncology)
Title: PHASE 2 RANDOMIZED STUDY OF EZATIOSTAT HYDROCHLORIDE FOR TREATMENT OF SEVERE CHRONIC NEUTROPENIA
Sponsor: Telik, Inc.
Project Dates and Amount of Award: 09/24/09-08/31/11; $47,650

PI: Davis, Matthew
Co-I: Freed, Gary (Pediatrics-Ambulatory Care Pgm) / Wheeler, John (Health Management and Policy)
Title: ECONOMICS OF VACCINES
Sponsor: CDC
Project Dates and Amount of Award: 09/22/09-09/21/11; $498,038

PI: Freed, Gary
Co-I: Macy, Michelle (Pediatrics-Ambulatory Care Pgm)
Title: PEDIATRIC EMERGENCY DEPARTMENT OBSERVATION PROTOCOLS
Sponsor: Center for Healthcare Research & Transformation
Project Dates and Amount of Award: 07/01/09-11/30/10; $60,000

PI: Freed, Gary
Co-I: Clark, Sarah (Pediatrics-Ambulatory Care Pgm) / Dombkowski, Kevin (Pediatrics-Ambulatory Care Pgm) / Prosser, Lisa (Pediatrics-Ambulatory Care Pgm)
Title: PEDIATRIC AND MANAGED CARE ISSUES-MEDICAID
Sponsor: Health and Human Services, Department of-Centers for Medicare and Medicaid Services-Subcontracts TO MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $306,946

PI: Innis, Jeffrey
Title: PEDIATRIC GENETIC OUTREACH CLINIC
Sponsor: MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $56,000

PI: Martin, Donna
Title: DEVELOPMENT MECHANISMS OF THE CHROMODOMAIN GENE CHD7 SUPPLEMENT (EQUIPMENT)
Sponsor: NIH 3 R01 DC 009410 01 A1S1
Project Dates and Amount of Award: 07/17/09-06/30/11; $264,156

PI: Menon, Ram
Co-I: Chen, Ming (Pediatrics-Endocrinology) / Nasr, Samya (Pediatrics-Pulmonary Medicine)
Title: STATE NEWBORN SCREENING 2009-2010
Sponsor: MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $520,159

PI: Mody, Rajen
Title: Children's Oncology Group Phase I/Pilot Consortium - 2009-2010 ARRA (Subcontract 19195)
Sponsor: NIH - Subcontracts TO National Childhood Cancer Foundation 3 U01 CA 097452 S1
Project Dates and Amount of Award: 06/01/09-05/31/11; $25,371

PI: Nasr, Samya
Co-I: Simon, Richard (Int Med-Pulm./Critical Care)
Title: CYSTIC FIBROSIS CENTER GRANT 2009-2010
Sponsor: Cystic Fibrosis Foundation
Project Dates and Amount of Award: 07/01/09-06/30/10; $170,490

PI: Nasr, Samya
Co-I: Filbrun, Amy (Pediatrics-Pulmonary Medicine) / Lumeng, Carey (Pediatrics-Pulmonary Medicine)
Title: STUDY 08-114: OPEN-LABEL EXTENSION OF STUDY 08-110-A MULTI-CENTER STUDY OF DENUFOSOL TETRASODIUM INHALATION SOLUTION IN PATIENTS WITH CYSTIC FIBROSIS LUNG DISEASE
Sponsor: Inspire Pharmaceuticals, Inc.
Project Dates and Amount of Award: 07/13/09-06/30/11; $54,738

PI: Niedner, Matthew
Title: NACHRI FACULTY STEERING COMMITTEE-CATHETER RELATED BLOOD STREAM INFECTION INITIATIVE
Sponsor: National Association of Children's Hospitals and Related Institutions (NACHRI)
Project Dates and Amount of Award: 10/31/09-10/31/10; $18,000

PI: Paczesny, Sophie
Co-I: Braun, Thomas (Biostatistics Department) / Paczesny, Sophie (Pediatrics-Hematology/Oncology)
Title: GRAFT VERSUS HOST DISEASE BIOMARKERS: PREDICTION OF ONSET AND RESPONSE TO THERAPY
Sponsor: NIH 1 RC1 HL 101102 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $999,999

PI: Padmanabhan, Vasantha
Title: ENDOCRINE DISRUPTORS AND FETAL DEVELOPMENT
Sponsor: NIH 1 R01 ES 017005 01
Project Dates and Amount of Award: 09/17/09-07/31/11; $998,345

PI: Padmanabhan, Vasantha
Co-I: Brown, Morton (Biostatistics Department) / Love, Theresa (LSA Psychology) / Thompson, Robert (Molecular & Behav Neurosc Inst)
Title: PRENATAL PROGRAMMING OF REPRODUCTIVE HEALTH AND DISEASE
Sponsor: NIH 2 P01 HD 044232 06 A1
Project Dates and Amount of Award: 09/30/09-07/31/14; $8,516,754

PI: Pipe, Steven
Title: TRANSGENIC MICE STUDY
Sponsor: NIH - Subcontracts TO University of Nebraska R01 HL 078944
Project Dates and Amount of Award: 09/01/09-08/31/10; $95,020

PI: Prosser, Lisa
Title: IMPROVING PRIMARY CARE TO PREVENT CHILDHOOD OBESITY (HIGH FIVE FOR KIDS)
Sponsor: NIH - Subcontracts TO Harvard Pilgrim Health Care
Project Dates and Amount of Award: 07/01/09-06/30/10; $34,776

PI: Robertson, Patricia
Title: CHILDREN'S ONCOLOGY GROUP CHAIR'S GRANT
Sponsor: NIH - Subcontracts TO National Childhood Cancer Foundation
Project Dates and Amount of Award: 03/01/09-02/28/10; $14,348

PI: Sandberg, David
Co-I: Fetters, Michael (Department of Family Medicine) / Hanauer, David (Pediatrics-Ambulatory Care Pgm)
Title: QUALITY OF LIFE IN INTERSEXUALITY: A PEDIATRIC CLINICAL AND RESEARCH TOOL
Sponsor: NIH 3 R01 HD 053637 02 S1
Project Dates and Amount of Award: 09/30/09-09/29/10; $119,603

PI: Sandberg, David
Co-I: Tarini, Beth (Pediatrics-Ambulatory Care Pgm)
Title: FAMILY EDUCATION FOR CONFIRMED POSITIVE NEWBORN SCREEN
Sponsor: NIH - Subcontracts TO Full Circle Studios, LLC HD 057714
Project Dates and Amount of Award: 09/28/09-08/31/10; $51,318

PI: Sandberg, David
Title: DISORDERS IN SEX DEVELOPMENT
Sponsor: Univ Of California Los Angeles TO Duke, Doris, Charitable Fdn
Project Dates and Amount of Award: 01/01/09-12/31/09; $41,889

PI: Thoene, Jess
Co-I: Iyer, Ramaswamy (Pediatrics-Genetics)
Title: FEASIBILITY OF CYSTINOSIS REPLACEMENT THERAPY IN CYSTINOSIS
Sponsor: Cystinosis Research Network
Project Dates and Amount of Award: 09/01/09-08/31/11; $165,733

Pharmacology

PI: Neubig, Richard
Title: CELL-BASED SCREEN FOR RGS MODULATORS
Sponsor: NIH 1 R03 MH 087441 01 A1
Project Dates and Amount of Award: 09/30/09-05/31/11; $77,250

PI: Neubig, Richard
Co-I: Sjogren, Jenny (Pharmacology Department)
Title: ASSAY DEVELOPMENT FOR CELLULAR RGS7 FAMILY MODULATORS
Sponsor: NIH 1 R21 NS 067617 01
Project Dates and Amount of Award: 09/25/09-08/31/10; $154,500

PI: Winger, Gail
Title: IMPULSIVITY AND DEMAND FOR DRUG IN RHESUS MONKEYS
Sponsor: NIH 1 R01 DA 023992 01 A2
Project Dates and Amount of Award: 09/15/09-08/31/13; $1,428,096

Physical Medicine & Rehabilitation

PI: Morton, Christina
Co-I: Ashton-Miller, James (Mechanical Engineering) / Delancey, John (Obstetrics and Gynecology Dept) / Richardson, James (Physical Medicine & Rehab Dept)
Title: NOVEL INTRAVAGINAL EMG ELECTRODE TO STUDY LEVATOR ANI MUSCLE EMG ACTIVITY AND RELATION TO VAGINAL CLOSURE FORCE IN WOMEN WITH AND WITHOUT PELVIC ORGAN PROLAPSE AND/OR LEVATOR ANI DEFECTS
Sponsor: NIH - Subcontracts TO University of Pittsburgh K12 HD 001097
Project Dates and Amount of Award: 07/01/09-06/30/10; $124,200

Psychiatry

PI: Jibson, Michael
Title: FORENSIC RESIDENCY TRAINING PROGRAM
Sponsor: MI, State Of Community Health
Project Dates and Amount of Award: 10/01/09-09/30/10; $116,000

PI: Sen, Srijan
Title: INVESTIGATION INTO THE ROLE OF GENES AND STRESS IN DEPRESSION AND SUICIDE AMONG MEDICAL INTERNS
Sponsor: American Foundation for Suicide Prevention
Project Dates and Amount of Award: 01/01/10-12/31/11; $85,000

PI: Taylor, Stephan
Co-I: Abelson, James (Psychiatry-ASAP) / Phan, Kinh (Psych Vamc) / Welsh, Robert (Radiology Department)
Title: GABA MODULATION AND NEGATIVE AFFECT IN PSYCHOSIS
Sponsor: NIH 1 R21 MH 086701 01
Project Dates and Amount of Award: 09/01/09-08/31/11; $424,875

Radiation Oncology

PI: Lawrence, Theodore
Co-I: Maybaum, Jonathan (Pharmacology Department) / Morgan, Meredith (Radiation Oncology - Ann Arbor)
Title: TARGETING CHK1 TO IMPROVE GEMCITABINE-RADIATION THERAPY IN PANCREATIC CANCER
Sponsor: NIH 3 R01 CA 078554 10 S1
Project Dates and Amount of Award: 09/30/09-07/31/11; $487,829

PI: Ljungman, Mats
Title: REGULATION OF MYC AND MICRORNA IN SMALL CELL LUNG CANCER
Sponsor: LUNGevity Foundation TO Uniting Against Lung Cancer
Project Dates and Amount of Award: 10/01/09-09/30/11; $100,000

Radiology

PI: Carlos, Ruth
Co-I: Dalton, Vanessa (Obstetrics and Gynecology Dept) / Dempsey, Amanda (Pediatrics-Ambulatory Care Pgm) / Myles, James (Mich Inst for Clin & Hlth Resr) / Patel, Divya (Obstetrics and Gynecology Dept) / Strecher, Victor (Hlth Behavior & Hlth Ed Dept)
Title: USING MATERNAL CANCER SCREENING VISITS TO IMPROVE ADOLESCENT HPV VACCINATION
Sponsor: NIH 1 R21 CA 133333 01 A2
Project Dates and Amount of Award: 09/29/09-08/31/11; $373,890

PI: Chenevert, Thomas
Title: UNIVERSAL DIFFUSION PHANTOM FOR MRI SYSTEM ASSESSMENT
Sponsor: NIH - Subcontracts TO Science Applications International Corporation SAIC
Project Dates and Amount of Award: 09/01/09-08/31/10; $112,198

PI: Jiang, John
Title: THREE DIMENSIONAL CORTICAL AND TRABECULAR MICROSTRUCTURE OF THE ILIAC CREST IN PATIENTS TREATED WITH STRONTIUM RANELATE OR A BISPHOPHONATE
Sponsor: Adir TO Institut de Recherches Internationales Servier
Project Dates and Amount of Award: 03/01/09-06/30/13; $259,200

PI: Jiang, John
Co-I: Dai, Ruchun (Radiology Department) / Dai, Zhehao (Radiology Department)
Title: EVALUATION OF BONE LENGTH MEASUREMENT USING LUNAR IDXA
Sponsor: GE Healthcare
Project Dates and Amount of Award: 09/24/09-12/31/10; $21,255

PI: Jiang, John
Co-I: Dai, Ruchun (Radiology Department) / Jacobson, Jon (Radiology Department)
Title: TRADITIONAL COBB ANGLE MEASUREMENT OF KYPHOSIS AND SCOLIOSIS USING LUNAR IDXA
Sponsor: GE Healthcare
Project Dates and Amount of Award: 09/24/09-12/31/10; $34,049

PI: Kaza, Ravi
Co-I: Al-Hawary, Mahmoud (Radiology Department) / Ellis, James (Radiology Department) / Francis, Isaac (Radiology Department) / Liu, Peter (Radiology Department)
Title: GE-145 PHASE 1 CONTRAST STUDY
Sponsor: GE Healthcare
Project Dates and Amount of Award: 09/01/09-08/31/10; $280,617

PI: Muller, Martijn
Title: WHITE MATTER LESIONS AND CORTICAL SEROTONERGIC DEAFFERENTATION IN OLDER ADULTS
Sponsor: NIH 1 R03 AG 034338 01
Project Dates and Amount of Award: 09/15/09-08/31/11; $126,690

PI: Rubin, Jonathan
Title: INTEGRATED MULTIFUNCTIONAL IMAGING OF DEEP VEIN THROMBOSIS
Sponsor: NIH - Subcontracts TO Winprobe Corporation
Project Dates and Amount of Award: 10/01/09-06/30/10; $126,000

PI: Shah, Gaurang
Co-I: Mukherji, Suresh (Radiology Department) / Wesolowski, Jeffrey (Radiology Department)
Title: GUERBET DOTAREM CERVICAL PROTOCOL
Sponsor: Certus International, Inc TO Guerbet
Project Dates and Amount of Award: 09/25/09-08/31/10; $106,032

Surgery

PI: Alderman, Amy
Title: THE USE OF ALLODERM IN TISSUE EXPANDER/IMPLANT BREAST RECONSTRUCTION: A MULTICENTER, RANDOMIZED-CONTROLLED TRIAL
Sponsor: Plastic Surgery Educational Foundation TO Sloan-Kettering Cancer Institute
Project Dates and Amount of Award: 01/01/08-12/31/09; $46,200

PI: Birkmeyer, John
Title: CAUSES AND CONSEQUENCES OF HEALTH CARE EFFICIENCY
Sponsor: NIH - Subcontracts TO Dartmouth College AG 019783
Project Dates and Amount of Award: 04/01/09-02/28/10; $107,232

PI: Culbertson, Eric
Title: ROLE OF MECHANICAL STRAIN IN INCISIONAL HERNIA FIBROBLAST FUNCTION
Sponsor: NIH 1 F32 GM 088873 01
Project Dates and Amount of Award: 09/25/09-09/24/11; $105,064

PI: Devaney, Eric
Co-I: Pinsky, David (Int Med-Cardiology) / Westfall, Margaret (Cardiac Surgery Section)
Title: GENETIC MODIFICATION OF CARDIAC MOTOR PROTEINS IN NORMAL AND FAILING MYOCYTES
Sponsor: NIH 1 K08 HL 088018 01 A1
Project Dates and Amount of Award: 09/25/09-07/31/14; $669,600

PI: Geiger, James
Co-I: Annich, Gail (Pediatrics-Intensive Care) / Ashton-Miller, James (Mechanical Engineering) / Balis, Ulysses (Pathology Department) / Bartlett, Robert (General Surgery Section) / Brei, Diann (Mechanical Engineering) / Eckner, James (Physical Medicine & Rehab Dept) / Faley, Timothy (ROSS SCH Zell Lurie Institute) / Fowlkes, J (Radiology Department) / Giannobile, William (DENT Periodontics and Oral Med) / Kinnear, Thomas (Ross School of Business) / Kripfgans, Oliver (Radiology Department) / Kurabayashi, Katsuo (Mechanical Engineering) / Luntz, Jonathan (Mechanical Engineering) / Myles, James (Mich Inst for Clin & Hlth Resr) / Najafi, Khalil (COE EECS - ECE Division) / Richardson, James (Physical Medicine & Rehab Dept) / Rubin, Jonathan (Radiology Department) / Shih, Albert (Mechanical Engineering) / Takayama, Shuichi (Biomedical Engineering) / Teitelbaum, Daniel (Pediatric Surgery Section) / Yanik, Gregory (Pediatrics-Hematology/Oncology)
Title: THE UNIVERSITY OF MICHIGAN PEDIATRIC DEVICE CONSORTIUM
Sponsor: FDA 1 P50 FD 003787 01
Project Dates and Amount of Award: 09/25/09-07/31/11; $2,000,000

PI: Liu, Yang
Co-I: Qin, Zhaohui (Biostatistics Department) / Segal, Benjamin (General Surgery Section)
Title: X-LINKED GENES AND GENDER BIAS IN MULTIPLE SCLEROSIS
Sponsor: National Multiple Sclerosis Society
Project Dates and Amount of Award: 10/01/09-09/30/12; $513,087

PI: Merion, Robert
Co-I: Lok, Anna (Int Med-Gastroenterology) / Ojo, Akinlolu (Int Med-Nephrology)
Title: ADULT-TO-ADULT LIVING DONOR LIVER TRANSPLANTATION STUDY DATA COORDINATING CENTER
Sponsor: NIH 2 U01 DK 062498 08
Project Dates and Amount of Award: 09/30/09-08/31/14; $4,436,000

PI: Newman, Lisa
Title: UNIVERSITY OF MICHIGAN INTERNATIONAL PROGRAM TO STUDY TRIPLE NEGATIVE BREAST CANCER AND AFRICAN ANCESTRY
Sponsor: Susan G. Komen For The Cure
Project Dates and Amount of Award: 09/24/09-09/23/10; $100,000

PI: Patel, Himanshu
Co-I: Deeb, G (Cardiac Surgery Section) / Upchurch Jr, Gilbert (Vascular Surgery Section) / Williams, David (Radiology Department)
Title: ZENITH TX2 TAA ENDOVASCULAR GRAFT POST-APPROVAL STUDY
Sponsor: Cook Incorporated
Project Dates and Amount of Award: 10/01/09-12/31/14; $119,700

PI: Pelletier, Shawn
Title: LCP-TACRO TABLETS ONCE DAILY AND PROGRAF CAPSULES TWICE DAILY IN ADULT DE NOVO LIVER TRANSPLANT PATIENTS (TACRO 2018: A PHASE 2, OPEN LABEL, MULTI-CENTER, RANDOMIZED TRIAL TO DEMONSTRATE THE PHARMOCOKINETICS OF)
Sponsor: LifeCycle Pharma TO CTI Clinical Trial and Consulting Services
Project Dates and Amount of Award: 12/08/08-12/31/10; $201,597

PI: Pelletier, Shawn
Co-I: Anspach, Renee (LSA Sociology) / Kronick, Steven (Emergency Medicine Roll Up) / Punch, Jeffrey (General Surgery Section) / Volk, Michael (Int Med-Gastroenterology)
Title: EXTRACORPOREAL SUPPORT FOR EMERGENT (UNCONTROLLED) DONATION FOLLOWING CARDIAC DEATH
Sponsor: NIH 1 RC1 DK 087014 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $605,088

PI: Pelletier, Shawn
Title: Anidulafungin versus fluconazole for the prevention of invasive fungal infections in high-risk liver transplant recipients: a randomized, double-blind trial
Sponsor: Pfizer Incorporated TO University of Pittsburgh
Project Dates and Amount of Award: 11/01/09-10/31/11; $265,684

PI: Sabel, Michael
Title: ACOSOG Z1072-A PHASE II TRIAL EXPLORING THE SUCCESS OF CRYOABLATION THERAPY THE TREATMENT
Sponsor: NIH - Subcontracts TO Duke University
Project Dates and Amount of Award: 08/01/09-11/30/10; $73,500

PI: Teitelbaum, Daniel
Co-I: Larsen, Scott (College of Pharmacy) / Lucas, Peter (Pathology Department) / Showalter, Hollis (College of Pharmacy)
Title: DEVELOPMENT OF ORALLY DELIVERED, NON-ABSORBABLE AT1 RECEPTOR ANTAGONISTS FOR INFLAMMATORY BOWEL DISEASE TREATMENT
Sponsor: NIH - Subcontracts TO TSRL
Project Dates and Amount of Award: 04/01/09-03/31/10; $84,253

PI: Upchurch Jr, Gilbert
Title: ZENITH LOW PROFILE AAA ENDOVASCULAR GRAFT CLINICAL STUDY
Sponsor: Cook Incorporated
Project Dates and Amount of Award: 10/01/09-05/31/14; $72,850

PI: Wakefield, Thomas
Title: VASCULAR SURGERY: RESEARCH TRAINING IN VASCULAR BIOLOGY
Sponsor: NIH 2 T32 HL 076123 06 A2
Project Dates and Amount of Award: 09/01/09-08/31/14; $632,241

PI: Zheng, Pan
Co-I: Liu, Yang (General Surgery Section)
Title: CD24 POLYMORPHISM AND ACETAMINOPHEN TOXICITY
Sponsor: NIH 1 RC1 GM 091648 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $998,474

Unit for Laboratory Animal Medicine

PI: Dirita, Victor
Title: GENE REGULATION BY TOXR, TCPP AND TOXT IN V. CHOLERAE
Sponsor: NIH 2 R56 AI 045125 11
Project Dates and Amount of Award: 09/17/09-08/31/10; $326,934

PI: Eaton, Kathryn
Title: GERM FREE SERVICES-MICHIGAN STATE/MANSFIELD
Sponsor: NIH - Subcontracts TO Michigan State University
Project Dates and Amount of Award: 08/15/09-05/31/10; $3,000

PI: He, Yongqun
Co-I: Athey, Brian (Computational Medicine and Bio) / Mobley, Harry (Microbiology and Immunology) / Qin, Zhaohui (Biostatistics Department)
Title: ONTOLOGY-BASED INFORMATION NETWORK TO SUPPORT VACCINE RESEARCH
Sponsor: NIH 1 R01 AI 081062 01 A1
Project Dates and Amount of Award: 09/22/09-08/30/13; $1,081,500

Urology

PI: Keller, Evan
Title: POST-DOCTORAL FELLOWSHIP FOCUSED ON RODENT MODELS OF INTERACTION BETWEEN CANCER AND BONE: CELL MIGRATION AND METASTASIS
Sponsor: Pfizer Incorporated
Project Dates and Amount of Award: 11/01/09-10/31/10; $186,000

PI: Macoska, Jill
Co-I: Wei, John (Urology Surgery)
Title: CHEMOKINE PROSTATE CANCER BIOMARKERS
Sponsor: NIH - Subcontracts TO Johns Hopkins University U01 CA 084986
Project Dates and Amount of Award: 10/01/09-09/30/10; $75,495

PI: Skolarus, Ted
Title: PROSTATE CANCER EXPENDITURES FOLLOWING INITIAL THERAPY
Sponsor: American Cancer Society
Project Dates and Amount of Award: 01/01/10-12/31/10; $48,000


UMMS RESEARCH PUBLICATIONS


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Biological Chemistry

Bhattacharya P, Ross BD, Bünger R. Cardiovascular applications of hyperpolarized contrast media and metabolic tracers. Exp Biol Med (Maywood). 2009 Dec; 234(12): 1395-416.

Cracan V, Padovani D, Banerjee R. IcmF is a fusion between the radical B12 enzyme, isobutyryl-coa mutase and its G-protein chaperone. J Biol Chem. 2009 Oct 28. (Epub ahead of print).

Düser MG, Zarrabi N, Cipriano DJ, Ernst S, Glick GD, Dunn SD, Börsch M. 36 degrees step size of proton-driven c-ring rotation in FoF1-ATP synthase. EMBO J. 2009 Sep 16; 28(18): 2689-96.

Hiatt SM, Duren HM, Shyu YJ, Ellis RE, Hisamoto N, Matsumoto K, Kariya K, Kerppola TK, Hu CD. Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation. Mol Biol Cell. 2009 Sep; 20(17): 3888-95.

Hougland JL, Hicks KA, Hartman HL, Kelly RA, Watt TJ, Fierke CA. Identification of Novel Peptide Substrates for Protein Farnesyltransferase Reveals Two Substrate Classes with Distinct Sequence Selectivities. J Mol Biol.2009 Oct 28. (Epub ahead of print).

Hurd TW, Margolis B. Cystin, Cilia, and Cysts: Unraveling Trafficking Determinants. J Am Soc Nephrol. 2009 Oct 29. (Epub ahead of print).

Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, Carson WF 4th, Cavassani KA, Li X, Lukacs NW, Hogaboam CM, Dou Y, Kunkel SL. Epigenetic regulation of the alternatively activated macrophage phenotype. Blood. 2009 Oct 8; 114(15): 3244-54.

Jiang P, Ninfa AJ. alpha-Ketoglutarate Controls the Ability of the Escherichia coli PII Signal Transduction Protein To Regulate the Activities of NRII (NtrB) but Does Not Control the Binding of PII to NRII. Biochemistry. 2009 Nov 11. (Epub ahead of print).

Jiang P, Ninfa AJ. Sensation and Signaling of alpha-Ketoglutarate and Adenylylate Energy Charge by the Escherichia coli PII Signal Transduction Protein Require Cooperation of the Three Ligand-Binding Sites within the PII Trimer. Biochemistry. 2009 Nov 11. (Epub ahead of print).

Kerppola TK. Polycomb group complexes - many combinations, many functions. Trends Cell Biol. 2009 Nov 4. (Epub ahead of print).

Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. J Biol Chem. 2009 Nov 4. (Epub ahead of print).

Li X, Wu L, Corsa CA, Kunkel S, Dou Y. Two mammalian MOF complexes regulate transcription activation by distinct mechanisms. Mol Cell. 2009 Oct 23; 36(2): 290-301.

Lyons DM, O'Brien PJ. Efficient Recognition of an Unpaired Lesion by a DNA Repair Glycosylase. J Am Chem Soc. 2009 Nov 19. (Epub ahead of print).

Matthews RG. A love affair with vitamins. J Biol Chem. 2009 Sep 25; 284(39): 26217-28.

Ross BD, Bhattacharya P, Wagner S, Tran T, Sailasuta N. Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism. AJNR Am J Neuroradiol. 2009 Oct 29. (Epub ahead of print).

Sha SH, Chen FQ, Schacht J. PTEN attenuates PIP(3)/Akt signaling in the cochlea of the aging CBA/J mouse. Hear Res. 2009 Sep 15. (Epub ahead of print).

Schlüter MA, Pfarr CS, Pieczynski J, Whiteman EL, Hurd TW, Fan S, Liu CJ, Margolis B. Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation. Mol Biol Cell. 2009 Nov; 20(22): 4652-63.

Spolitak T, Funhoff EG, Ballou DP. Spectroscopic studies of the oxidation of ferric CYP153A6 by peracids: Insights into P450 higher oxidation states. Arch Biochem Biophys. 2009 Oct 30. (Epub ahead of print).

Thompson DA, Regev A. Fungal regulatory evolution: cis and trans in the balance. FEBS Lett. 2009 Nov 13. (Epub ahead of print).

Weaver DS, Zuiderweg ER. Protein proton-proton dynamics from amide proton spin flip rates. J Biomol NMR. 2009 Sep; 45(1-2): 99-119.

Wolfe AE, O'Brien PJ. Kinetic Mechanism for the Flipping and Excision of 1,N(6)-Ethenoadenine by Human Alkyladenine DNA Glycosylase. Biochemistry. 2009 Nov 11. (Epub ahead of print).

Yang W, Barth RF, Wu G, Huo T, Tjarks W, Ciesielski M, Fenstermaker RA, Ross BD, Wikstrand CJ, Riley KJ, Binns PJ. Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors. J Neurooncol. 2009 Dec; 95(3): 355-65.

Cell & Developmental Biology

Bernardi KM, Williams JM, Kikkert M, van Voorden S, Wiertz EJ, Ye Y, Tsai B. The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-translocation. Mol Biol Cell. 2009 Oct 28. (Epub ahead of print).

Cai D, McEwen DP, Martens JR, Meyhofer E, Verhey KJ. Single molecule imaging reveals differences in microtubule track selection between Kinesin motors. PLoS Biol. 2009 Oct; 7(10): e1000216.

Fan X, Khaki L, Zhu TS, Soules ME, Talsma CE, Gul N, Koh C, Zhang J, Li YM, Maciaczyk J, Nikkhah G, Dimeco F, Piccirillo S, Vescovi AL, Eberhart CG. Notch Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts. Stem Cells. 2009 Nov 10. (Epub ahead of print).

Foster KG, Acosta-Jaquez HA, Romeo Y, Ekim B, Soliman GA, Carriere A, Roux PP, Ballif BA, Fingar DC. Regulation of mTOR complex 1 (mTORC1) by raptor S863 and multi-site phosphorylation. J Biol Chem. 2009 Oct 28. (Epub ahead of print).

Li X, Udager AM, Hu C, Qiao XT, Richards N, Gumucio DL. Dynamic patterning at the pylorus: Formation of an epithelial intestine-stomach boundary in late fetal life. Dev Dyn. 2009 Oct 29; 238(12): 3205-3217.

Sandy AR, Maillard I. Notch signaling in the hematopoietic system. Expert Opin Biol Ther. 2009 Nov; 9(11): 1383-98.

Verhey KJ, Hammond JW. Traffic control: regulation of kinesin motors. Nat Rev Mol Cell Biol. 2009 Nov; 10(11): 765-77. Review.

Family Medicine

Kushner FG, Hand M, Smith SC Jr, King SB 3rd, Anderson JL, Antman EM, Bailey SR, Bates ER, Blankenship JC, Casey DE Jr, Green LA, Jacobs AK, Hochman JS, Krumholz HM, Morrison DA, Ornato JP, Pearle DL, Peterson ED, Sloan MA, Whitlow PL, Williams DO. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update): a Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Catheter Cardiovasc Interv. 2009 Nov 18. (Epub ahead of print).

Kushner FG, Hand M, Smith SC Jr, King SB 3rd, Anderson JL, Antman EM, Bailey SR, Bates ER, Blankenship JC, Casey DE Jr, Green LA, Hochman JS, Jacobs AK, Krumholz HM, Morrison DA, Ornato JP, Pearle DL, Peterson ED, Sloan MA, Whitlow PL, Williams DO. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update). A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2009 Nov 18. (Epub ahead of print).

Human Genetics

Fearon ER. PARsing the phrase "all in for Axin"- Wnt pathway targets in cancer. Cancer Cell. 2009 Nov 6; 16(5): 366-8.

Han T, Manoharan AP, Harkins TT, Bouffard P, Fitzpatrick C, Chu DS, Thierry-Mieg D, Thierry-Mieg J, Kim JK. 26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Proc Natl Acad Sci USA. 2009 Nov 3; 106(44): 18674-9.

Huang L, Wang C, Rosenberg NA. The Relationship between Imputation Error and Statistical Power in Genetic Association Studies in Diverse Populations. Am J Hum Genet. 2009 Nov; 85(5): 692-8.

Melcher K, Ng LM, Zhou XE, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu JK, Xu HE. A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature. 2009 Nov 6. (Epub ahead of print).

Stoffel E, Mukherjee B, Raymond VM, Tayob N, Kastrinos F, Sparr J, Wang F, Bandipalliam P, Syngal S, Gruber SB. Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome. Gastroenterology. 2009 Nov; 137(5): 1621-7.

Wang XS, Prensner JR, Chen G, Cao Q, Han B, Dhanasekaran SM, Ponnala R, Cao X, Varambally S, Thomas DG, Giordano TJ, Beer DG, Palanisamy N, Sartor MA, Omenn GS, Chinnaiyan AM. An integrative approach to reveal driver gene fusions from paired-end sequencing data in cancer. Nat Biotechnol. 2009 Nov; 27(11): 1005-11.

Internal Medicine

Infectious Diseases:
Cinti SK, Barnosky AR, Gay SE, Goold SD, Lozon MM, Kim K, Rodgers PE, Baum NM, Cadwallender BA, Collins CD, Wright CM, Winfield RA. Bacterial Pneumonias during an influenza pandemic: How will we allocate antibiotics? Biosec Bioterr-Biodefense Strat Pract Sci. 2009; 7(3): 311-316.

Kaul DR, Taranto S, Alexander C, Covington S, Marvin M, Nowicki M, Orlowski J, Pancoska C, Pruett TL, Ison MG; for the HTLV Donor Screening Advisory Group. Donor Screening for Human T-cell Lymphotrophic Virus 1/2: Changing Paradigms for Changing Testing Capacity. Am J Transplant. 2009 Oct 15. (Epub ahead of print).

Malani PN. Functional Status Assessment in the Preoperative Evaluation of Older Adults. JAMA 2009; 302(14): 1582-1583.

Serezani CH, Aronoff DM, Sitrin RG, Peters-Golden M. Fc gamma RI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. Blood. 2009; 114(15): 3316-3324.

Wada M, Saunders TL, Morrow J, Milne GL, Walker KP, Dey SK, Brock TG, Opp MR, Aronoff DM, Smith WL. Two Pathways for Cyclooxygenase-2 Protein Degradation in Vivo. J Biol Chem. 2009; 284(45): 30742-53.

Yancon AR, Kelly SG, Valsangkar B, Iyengar P, Malani PN. A multidisciplinary approach to improving women's health in semi-urban Ecuador. Int J Gynecol Obstet. 2009; 107 (1): 70-72.

Microbiology and Immunology

Alteri CJ, Hagan EC, Sivick KE, Smith SN, Mobley HL. Mucosal immunization with iron receptor antigens protects against urinary tract infection. PLoS Pathog. 2009 Sep; 5(9): e1000586.

Cheng J, Zhou W, Warner GM, Knudsen BE, Garovic VD, Gray CE, Lerman LO, Platt JL, Romero JC, Textor SC, Nath KA, Grande JP. Temporal analysis of signaling pathways activated in a murine model of two-kidney, one-clip hypertension. Am J Physiol Renal Physiol. 2009 Oct; 297(4): F1055-68.

Franz DR, Ehrlich SA, Casadevall A, Imperiale MJ, Keim PS. The "nuclearization" of biology is a threat to health and security. Biosecur Bioterror. 2009 Sep; 7(3): 243-4.

Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, Håkansson K, Smith JL, Sherman DH. Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis. J Am Chem Soc. 2009 Oct 16. (Epub ahead of print).

Korotkov KV, Gray MD, Kreger A, Turley S, Sandkvist M, Hol WG. Calcium is essential for the major pseudopilin in the type 2 secretion system. J Biol Chem. 2009 Sep 18; 284(38): 25466-70.

Li MH, Ung PM, Zajkowski J, Garneau-Tsodikova S, Sherman DH. Automated genome mining for natural products. BMC Bioinformatics. 2009 Jun 16; 10: 185.

Li S, Chaulagain MR, Knauff AR, Podust LM, Montgomery J, Sherman DH. Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase. Proc Natl Acad Sci USA. 2009 Oct 15. (Epub ahead of print).

Mason KL, Huffnagle GB. Control of mucosal polymicrobial populations by innate immunity. Cell Microbiol. 2009 Sep; 11(9): 1297-305.

Mortison JD, Kittendorf JD, Sherman DH. Synthesis and biochemical analysis of complex chain-elongation intermediates for interrogation of molecular specificity in the erythromycin and pikromycin polyketide synthases. J Am Chem Soc. 2009 Nov 4; 131(43): 15784-93.

Ono A. HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization. Future Virol. 2009; 4(3): 241-257.

Roiko MS, Carruthers VB. New roles for perforins and proteases in apicomplexan egress. Cell Microbiol. 2009 Oct; 11(10): 1444-52.

Sherman DH. Biochemistry: Enzyme's black box cracked open. Nature. 2009 Oct 22; 461(7267): 1068-9.

Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ, Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD, Blackshear PJ. Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood. 2009 Sep 17; 114(12): 2401-10.

Swanson JA, Torto B, Kells SA, Mesce KA, Tumlinson JH, Spivak M. Odorants that Induce Hygienic Behavior in Honeybees: Identification of Volatile Compounds in Chalkbrood-Infected Honeybee Larvae. J Chem Ecol. 2009 Sep; 35(9): 1108-16.

Thammavongsa V, Schaefer M, Filzen T, Collins KL, Carrington M, Bangia N, Raghavan M. Assembly and intracellular trafficking of HLA-B*3501 and HLA B*3503. Immunogenetics. 2009 Oct 17. (Epub ahead of print).

Weeks SA, Shield WP, Sahi C, Craig EA, Rospert S, Miller DJ. A Targeted Analysis of Cellular Chaperones Reveals Contrasting Roles for Heat Shock Protein 70 in Flock House Virus RNA Replication. J Virol. 2009 Oct 14. (Epub ahead of print).

Whitfield NN, Byrne BG, Swanson MS. Mouse Macrophages are Permissive to Motile Legionella Species that Fail to Trigger Pyroptosis. Infect Immun. 2009 Oct 19. (Epub ahead of print).

Neurology

Blakely PK, Kleinschmidt-DeMasters BK, Tyler KL, Irani DN. Disrupted glutamate transporter expression in the spinal cord with acute flaccid paralysis caused by West Nile virus infection. J Neuropathol Exp Neurol. 2009 Oct; 68(10): 1061-72.

Kernie SG, Parent JM. Forebrain neurogenesis after focal Ischemic and traumatic brain injury. Neurobiol Dis. 2009 Nov 10. (Epub ahead of print).

Plane JM, Andjelkovic AV, Keep RF, Parent JM. Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cells. Neurobiol Dis. 2009 Oct 23. (Epub ahead of print).

Neurosurgery

Leblanc GG, Golanov E, Awad IA, Young WL. Biology of Vascular Malformations of the Brain NINDS Workshop Collaborators. Biology of vascular malformations of the brain. Stroke. 2009 Dec; 40(12): e694-702.

Plane JM, Andjelkovic AV, Keep RF, Parent JM. Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cells. Neurobiol Dis. 2010 Jan; 37(1): 218-27.

Xi G, Keep RF, Hoff, JT. Thrombin and secondary brain damage following intracerebral hemorrhage. In: Carhuapoma RC, Mayer SA, Hanley DF (Editors). Textbook of Intracerebral Hemorrhage. Cambridge: Cambridge University Press; 2010. p. 206-216.

Obstetrics & Gynecology

Baman TS, Romero A, Kirkpatrick JN, Romero J, Lange DC, Sison EO, Tangco RV, Abelardo NS, Samson G, Grezlik R, Goldman EB, Oral H, Eagle KA. Safety and efficacy of pacemaker reuse in underdeveloped nations: a case series. J Am Coll Cardiol. 2009 Oct 13; 54(16): 1557-8.

Haefner HK, Sideri M, Reynolds RK, Lowe L. Home Study Course: Vulvar case presentation pigmented lesions. J Lower Genital Tract Disease 2009; 13: 269-272.

Lewicky-Gaupp C, Brincat C, Trowbridge ER, Delancey JO, Guire K, Patel DA, Fenner DE. Racial differences in bother for women with urinary incontinence in the Establishing the Prevalence of Incontinence (EPI) study. Am J Obstet Gynecol. 2009 Nov; 201(5): 510.e1-6.

Pouryazdanparast P, Yu L, Dalton VK, Haefner HK, Brincat C, Mandell SH, Cho KR, Fullen DR. Intravascular histiocytosis presenting with extensive vulvar necrosis. J Cutaneous Path 2009; 36(suppl)1: 1-7.

Saunders NA, Haefner HK. Vulvar lichen sclerosus in the elderly: Pathophysiology and treatment update. Drugs & Aging. 2009; 26: 803-12.

Yousuf AA, DeLancey JO, Brandon CJ, Miller JM. Pelvic structure and function at 1 month compared to 7 months by dynamic magnetic resonance after vaginal birth. Am J Obstet Gynecol. 2009 Nov; 201(5): 514.e1-7.

Ophthalmology & Visual Sciences

Banitt M, Malta JB, Soong HK, Musch DC, Mian SI. Wound integrity of clear corneal incisions closed with fibrin and N-butyl-2-cyanoacrylate adhesives. Curr Eye Res. 2009; 34(8): 706-10.

Besirli CG, Chinskey ND, Zheng QD, Zacks DN. Inhibition of Retinal Detachment-induced Apoptosis in Photoreceptors by a Small Peptide Inhibitor of the Fas Receptor. Invest Ophthalmol Vis Sci. 2009 (Epub ahead of print).

Calinescu AA, Raymond PA, Hitchcock PF. Midkine expression is regulated by the circadian clock in the retina of the zebrafish. Vis Neurosci. 2009: 1-7.

Friberg TR, Brennen PM, Freeman WR, Musch DC. Prophylactic treatment of age-related macular degeneration report number 2: 810-nanometer laser to eyes with drusen: bilaterally eligible patients. Ophthalmic Surg Lasers Imaging. 2009; 40(6): 530-8.

Huang D, Schallhorn SC, Sugar A, Farjo AA, Majmudar PA, Trattler WB, Tanzer DJ. Phakic intraocular lens implantation for the correction of myopia: a report by the American Academy of Ophthalmology. Ophthalmology 2009; 116(11): 2244-58.

Mian SI, Malta JB. Moraxella keratitis: risk factors, presentation, and management. Acta Ophthalmol 2009 (Epub ahead of print).

Paul E, Kielbasinski M, Sedivy JM, Murga-Zamalloa C, Khanna H, Klysik JE. Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse. Transgenic Res. 2009 (Epub ahead of print).

Sitrin RG, Sassanella TM, Landers JJ, Petty HR. Migrating Human Neutrophils Exhibit Dynamic Spatiotemporal Variation in Membrane Lipid Organization. Am J Respir Cell Mol Biol. 2009 (Epub ahead of print).

Trobe JD. Robert B. Daroff, MD pioneer of ocular motor research. J Neuroophthalmol. 2009; 29(4): 342-53.

Warden KF, Parmar H, Trobe JD. Perineural spread of cancer along the three trigeminal divisions. J Neuroophthalmol. 2009; 29(4): 300-7.

Weng CY, Kothary PC, Verkade AJ, Reed DM, Del Monte MA. MAP kinase pathway is involved in IGF-1-stimulated proliferation of human retinal pigment epithelial cells (hRPE). Curr Eye Res. 2009; 34(10): 867-76.

Wu DM, Khanna H, Atmaca-Sonmez P, Sieving PA, Branham K, Othman M, Swaroop A, Daiger SP, Heckenlively JR. Long-term follow-up of a family with dominant X-linked retinitis pigmentosa. Eye (Lond). 2009 (Epub ahead of print).

Otolaryngology

Ali S, Varghese L, Pereira L, Tulunay-Ugur OE, Kucuk O, Carey TE, Wolf GT, Sarkar FH. Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents. Cancer Lett. 2009 Jun 18; 278(2): 201-9.

Pediatrics & Communicable Diseases

Cheng G, Coolen LM, Padmanabhan V, Goodman RL, Lehman MN. The Kisspeptin/Neurokinin B/Dynorphin (KNDy) Cell Population of the Arcuate Nucleus: Sex Differences and Effects of Prenatal Testosterone in the Sheep. Endocrinology. 2009 Oct 30. (Epub ahead of print).

Chernin G, Heeringa SF, Vega-Warner V, Schoeb DS, Nurnberg P, Hildebrandt F. Adequate use of allele frequencies in Hispanics – a problem elucidated in nephrotic syndrome. Pediatr Nephrol. 2009 Oct 30. (Epub ahead of print).

Freed GL, Dunham KM, Lamarand KE, Research Advisory Committee of the American Board of Pediatrics. Hospitalists’ involvement in pediatrics training: perspective from pediatric residency program and clerkship directors. Acad Med. 2009 Nov; 84(11): 1617-21.

Gillespie EF, Sorbero ME, Hanauer DA, Sabel MS, Herrmann EJ, Weiser LJ, Jagielski CH, Griggs JJ. Obesity and angiolymphatic invasion in primary breast cancer. Ann Surg Oncol. 2009 Nov 7. (Epub ahead of print).

Kitko CL, Levine JE, Matthews DC, Carpenter PA. Successful unrelated donor cord blood transplantation for Glanzmann’s thrombasthenia. Pediatr Transplant. 2009 Oct 22. (Epub ahead of print).

Mody RJ, Bui C, Hutchinson RJ, Yanik GA, Castle VP, Frey KA, Shulkin BL. FDG PET imaging of childhood sarcomas. Pediatr Blood Cancer. 2009 Nov 3. (Epub ahead of print).

Nagarkar DR, Wang Q, Shim J, Zhao Y, Tsai WC, Lukacs NW, Sajjan U, Hershenson MB. CXCR2 is required for neutrophilic airway inflammation and hyperresponsiveness in a mouse model of human rhinovirus infection. J Immunol. 2009 Nov 15; 183(10): 6698-707.

Odetola FO, Clark SJ, Gurney JG, Dechert RE, Shanley TP, Freed GL. Effect of interhospital transfer on resource utilization and outcomes at a tertiary pediatric intensive care unit. J Crit Care. 2009 Sep; 24(3): 379-86.

Otto EA, Tory K, Attanasio M, Zhou W, Chaki M, Paruchuri Y, Wise EL, Wolf MT, Utsch B, Becker C, Nurnberg G, Nurnberg P, Nayir A, Saunier S, Antignac C, Hildebrandt F. Hypomorphic mutations in meckelin (MKS3/TMEM67) cause nephronophthisis with liver fibrosis (NPHP11). J Med Genet. 2009 Oct; 46(10): 663-70.

Patton SR, Piazza-Waggoner C, Modi AC, Dolan LM, Powers SW. Family functioning at meals relates to adherence in young children with type 1 diabetes. J Paediatr Child Health. 2009 Oct 26. (Epub ahead of print).

Sandstedt SA, Zhang L, Patel M, McCrea KW, Qin Z, Marrs CF, Gilsdorf JR. Comparison of laboratory –based and phylogenetic methods to distinguish between Haemophilus influenzae and H. haemolyticus. J Microbiol Methods. 2008 Oct; 75(2): 369-71.

Thammavongsa V, Schaefer M, Filzen T, Collins KL, Carrington M, Bangia N, Raghavan M. Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503. Immunogenetics. 2009 Oct 17. (Epub ahead of print).

Psychiatry

Erickson SR, Guthrie S, Vanetten-Lee M, Himle J, Hoffman J, Santos SF, Janeck AS, Zivin K, Abelson JL. Severity of anxiety and work-related outcomes of patients with anxiety disorders. Depress Anxiety. 2009 Oct 19. (Epub ahead of print).

Fitzgerald K, Perkins SC, Angstadt M, Johnson T, Stern ER, Welsh RC, Taylor SF. The development of performance-monitoring function in the posterior medial frontal cortex. Neuroimage. 2009 (In press).

Ilgen MA, Burnette ML, Conner KR, Czyz E, Murray R, Chermack S. The association between violence and lifetime suicidal thoughts and behaviors in individuals treated for substance use disorders. Addict Behav. 2010 Feb; 35(2): 111-5.

Ilgen MA, Walton MA, Cunningham RM, Barry KL, Chermack ST, De Chavez P, Blow FC. Recent Suicidal Ideation Among Patients in an Inner City Emergency Department. Suicide and Life-Threatening Behavior 2009 Oct; 39(5): 508-17.

Kilbourne AM, Morden NE, Austin K, Ilgen M, McCarthy JF, Dalack G, Blow FC. Excess heart-disease-related mortality in a national study of patients with mental disorders: identifying modifiable risk factors. Gen Hosp Psychiatry. 2009 Nov-Dec; 31(6): 555-63.

Muzik M, Marcus SM, Heringhausen JE, Flynn H. When Depression Complicates Childbearing: Guidelines for Screening and Treatment During Antenatal and Postpartum Obstetric Care. Obstet Gynecol Clin N Am. 2009; 36: 771-788.

Nesse RM, Bergstrom CT, Ellison PT, Flier JS, Gluckman P, Govindaraju DR, Niethammer D, Omenn GS, Perlman RL, Schwartz MD, Thomas MG, Stearns SC, Valle D. Evolution in Health and Medicine Sackler Colloquium: Making evolutionary biology a basic science for medicine. Proc Natl Acad Sci USA. 2009 Nov 16. (Epub ahead of print).

Nesse RM. L'importanza dell'evoluzione per la medicina. Lettura darwiniana della medicina; Roma: L'Arco di Giano; 2009. p. 9-35.

Perron BE, Bohnert AS, Vaughn MG, Bauer MS, Kilbourne AM. Profiles of disability among adults with bipolar spectrum disorders. Soc Psychiatry Psychiatr Epidemiol. 2009 Oct 23. (Epub ahead of print).

Perron BE, Howard MO, Nienhuis JK, Bauer MS, Woodward AT, Kilbourne AM. Prevalence and burden of general medical conditions among adults with bipolar I disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry. 2009 Oct; 70(10): 1407-15.

Swanson LM, Favorite TK, Horin E, Arnedt JT. A combined group treatment for nightmares and insomnia in combat veterans: A pilot study. J Trauma Stress. 2009 Nov 11. (Epub ahead of print).

Valenstein M, Kavanagh J, Lee T, Reilly P, Dalack GW, Grabowski J, Smelson D, Ronis DL, Ganoczy D, Woltmann E, Metreger T, Wolschon P, Jensen A, Poddig B, Blow FC. Using A Pharmacy-Based Intervention To Improve Antipsychotic Adherence Among Patients With Serious Mental Illness. Schizophr Bull. 2009 Nov 21. (Epub ahead of Print).

Radiation Oncology

Azu M, Abrahamse P, Katz SJ, Jagsi R, Morrow M. What is an Adequate Margin for Breast-Conserving Surgery? Surgeon Attitudes and Correlates. Ann Surg Oncol. 2009 Oct 22. (Epub ahead of print).

Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009 Nov; 41(11): 1238-42.

Butnor KJ, Beasley MB, Cagle PT, Grunberg SM, Kong FM, Marchevsky A, Okby NT,Roggli VL, Suster S, Tazelaar HD, Travis WD; Members of the Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from patients with primary non-small cell carcinoma, small cell carcinoma, or carcinoid tumor of the lung. Arch Pathol Lab Med. 2009 Oct; 133(10): 1552-9.

Contessa JN, Griffith KA, Wolff E, Ensminger W, Zalupski M, Lawrence TS, Ben-Josef E. Radiotherapy for pancreatic neuroendocrine tumors. Int J Radiat Oncol Biol Phys. 2009 Nov 15; 75(4): 1196-200.

Dai Y, Liu M, Tang W, Li Y, Lian J, Lawrence TS, Xu L. A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB. BMC Cancer. 2009 Nov 6; 9: 392.

Desano JT, Xu L. MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications. AAPS J. 2009 Oct 20. (Epub ahead of print).

Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, Tejasvi T, Voorhees JJ, Abecasis GR, Nair RP. Molecular Dissection of Psoriasis: Integrating Genetics and Biology. J Invest Dermatol. 2009 Oct 8. (Epub ahead of print).

Eisbruch A. Radiotherapy: IMRT reduces xerostomia and potentially improves QoL. Nat Rev Clin Oncol. 2009 Oct; 6(10): 567-8.

Hadley SW, Balter JM, Lam KL. Analysis of couch position tolerance limits to detect mistakes in patient setup. J Appl Clin Med Phys. 2009 Oct 29; 10(4): 2864.

Halyard MY, Pisansky TM, Dueck AC, Suman VJ, Pierce LJ, Solin LJ, Marks LB, Davidson N, Martino S, Kaufman P, Kutteh L, Dakhil S, Perez EA. Reply to N. Magne et Al. J Clin Oncol. 2009 Dec 1; 27(34): e240-1.

Hassan KA, Chen G, Kalemkerian GP, Wicha MS, Beer DG. An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin Cancer Res. 2009 Oct 15; 15(20): 6386-90.

Hawley ST, Griggs JJ, Hamilton AS, Graff JJ, Janz NK, Morrow M, Jagsi R, Salem B, Katz SJ. Decision involvement and receipt of mastectomy among racially and ethnically diverse breast cancer patients. J Natl Cancer Inst. 2009 Oct 7; 101(19): 1337-47.

Jagsi R, Pierce L. Postmastectomy radiation therapy for patients with locally advanced breast cancer. Semin Radiat Oncol. 2009 Oct; 19(4): 236-43.

Lee IH, Eisbruch A. Mucositis versus tumor control: the therapeutic index of adding chemotherapy to irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys. 2009 Nov 15; 75(4): 1060-3.

Morrow M, Jagsi R, Alderman AK, Griggs JJ, Hawley ST, Hamilton AS, Graff JJ, Katz SJ. Surgeon recommendations and receipt of mastectomy for treatment of breast cancer. JAMA. 2009 Oct 14; 302(14): 1551-6.

Ramos AH, Dutt A, Mermel C, Perner S, Cho J, Lafargue CJ, Johnson LA, Stiedl AC, Tanaka KE, Bass AJ, Barretina J, Weir BA, Beroukhim R, Thomas RK, Minna JD, Chirieac LR, Lindeman NI, Giordano T, Beer DG, Wagner P, Wistuba II, Rubin MA, Meyerson M. Amplification of chromosomal segment 4q12 in non-small cell lung cancer. Cancer Biol Ther. 2009 Nov 7; 8(21).

Salama JK, Haddad RI, Kies MS, Busse PM, Dong L, Brizel DM, Eisbruch A, Tishler RB, Trotti AM, Garden AS. Clinical practice guidance for radiotherapy planning after induction chemotherapy in locoregionally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009 Nov 1; 75(3): 725-33.

Shappley WV 3rd, Kenfield SA, Kasperzyk JL, Qiu W, Stampfer MJ, Sanda MG, Chan JM. Prospective study of determinants and outcomes of deferred treatment or watchful waiting among men with prostate cancer in a nationwide cohort. J Clin Oncol. 2009 Oct 20; 27(30): 4980-5.

Zielske SP, Livant DL, Lawrence TS. Radiation increases invasion of gene-modified mesenchymal stem cells into tumors. Int J Radiat Oncol Biol Phys. 2009 Nov 1; 75(3): 843-53.

Radiology

Bohnen NI, Muller ML, Koeppe RA, Studenski SA, Kilbourn MA, Frey KA, Albin RL. History of falls in Parkinson disease is associated with reduced cholinergic activity. Neurology. 2009 Nov 17; 73(20): 1670-6.

Miller DL, Dou C, Wiggins RC, Glomerular capillary hemorrhage induced in rats by diagnostic ultrasound with gas-body contrast agent produces intratubular obstruction. Ult Med Biol. 2009; 35: 869-877.

Miller DL, Dou C, Lucchesi BR, Cardiac arrhythmia and injury induced in rats by burst and pulsed mode ultrasound with a gas body contrast agent. J Ultrasound Med. 2009; 28: 1519-1526.

Narayanasamy G, LeCarpentier G, Roubidoux M, Fowlkes JB, Carson P, Spatial registration of temporally separated whole breast 3D ultrasound images. Med Physics. 2009; 36(9): 4288-4300.

Samuel S, Cooper MA, Bull JL, Fowlkes JB, Miller DL, An ex vivo study of the correlation between acoustic emission and microvascular damage. Ultrasound Med Biol. 2009; 35: 1574-1586.

Surgery

General Surgery:
Blum JM, Brunsvold ME. Non-acidotic propofol infusion syndrome. Br J Anaesth. 2009 Oct; 103(4): 617-8.

Hoesel LM, Mattar AF, Arbabi S, Niederbichler AD, Ipaktchi K, Su GL, Westfall MV, Wang SC, Hemmila MR. Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction. Surgery. 2009 Oct; 146(4): 775-85; discussion 785-6.

Napolitano LM, Brunsvold ME, Reddy RC, Hyzy RC. Community-acquired methicillin-resistant Staphylococcus aureus pneumonia and ARDS: 1-year follow-up. Chest. 2009 Nov; 136(5): 1407-12.

Napolitano LM, Kurek S, Luchette FA. Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care. Crit Care Med. 2009 Sep 17. (Epub ahead of print).

Napolitano LM. Severe soft tissue infections. Infect Dis Clin North Am. 2009 Sep; 23(3): 571-91. Review.

Platt JL, Cascalho M, West LJ. Lessons From Cardiac Transplantation in Infancy. Pediatric Transplantation. 2009; 13: 814-819.

Raghavendran K, Davidson BA, Huebschmann JA, Helinski JD, Hutson AD, Dayton MT, Notter RH, Knight PR. Superimposed Gastric Aspiration Increases the Severity of Inflammation and Permeability Injury in a Rat Model of Lung Contusion. Journal of Surgical Research. 2009; 155(2): 273-282.

Raghavendran K, Notter RH, Davidson BA, Helinski JD, Kunkel SL, Knight PR. Lung Contusion: Inflammatory mechanisms and interaction with other injuries. Shock. 2009; 32(2): 122-130.

Scannapieco F A., Yu J, Raghavendran K, Vacanti, A, Owens, S I, Wood, KMMylotte, JM. Effect of Oral Topical Chlorhexidine Gluconate Rinse, Once Or Twice A Day, On Potential Respiratory Pathogen Oral Colonization in Mechanically Ventilated-Intensive Care Patients, Critical Care. 2009; 13(4): R117.

Schecter WP, Hirshberg A, Chang DS, Harris HW, Napolitano LM, Wexner SD, Dudrick SJ. Enteric fistulas: principles of management. J Am Coll Surg. 2009 Oct; 209(4): 484-91.

Shafi S, Nathens AB, Cryer HG, Hemmila MR, Pasquale MD, Clark DE, Neal M, Goble S, Meredith JW, Fildes JJ. The Trauma Quality Improvement Program of the American College of Surgeons Committee on Trauma. J Am Coll Surg. 2009 Oct; 209(4): 521-530.e1.

Sihler KC, Hemmila MR. Injuries in nonurban areas are associated with increased disability at hospital discharge. J Trauma. 2009 Nov; 67(5): 903-9.

Wahl WL, Taddonio MA, Arbabi S, Hemmila MR. Duration of antibiotic therapy for ventilator-associated pneumonia in burn patients. J Burn Care Res. 2009 Sep-Oct; 30(5): 801-6.

Wong SL, Mangu PB, Choti MA, Crocenzi TS, Dodd GD 3rd, Dorfman GS, Eng C, Fong Y, Giusti AF, Lu D, Marsland TA, Michelson R, Poston GJ, Schrag D, Seidenfeld J, Benson AB 3rd. American Society of Clinical Oncology 2009 Clinical Evidence Review on Radiofrequency Ablation of Hepatic Metastases From Colorectal Cancer. J Clin Oncol. 2009 Oct 19. (Epub ahead of print).

Zhang, S; Simmons Ivy, J; Cobb Payton, F; Diehl, K.M. Modeling the impact of comorbidity on breast cancer patient outcomes. Health Care Management Science. 2009 (In press).

Pediatric Surgery:
Brown JK, Campbell BT, Drongowski RA, Alderman AK, Geiger JD, Teitelbaum DH, Quinn J, Coran AG, Hirschl RB. A prospective, randomized comparison of skin adhesive and subcuticular suture for closure of pediatric hernia incisions: cost and cosmetic considerations. J Pediatr Surg. 2009 Jul; 44(7): 1418-22.

Flum AS, Geiger JD, Gemmete JJ, Williams DM, Teitelbaum DH. Management of a traumatic hepatic artery pseudoaneurysm and arterioportal fistula with a combination of a stent graft and coil embolization using flow control with balloon remodeling. J Pediatr Surg. 2009 Oct; 44(10): e31-6.

Seetharamaiah R, West BT, Ignash SJ, Pakarinen MP, Koivusalo A, Rintala RJ, Liu DC, Spencer AU, Skipton K, Geiger JD, Hirschl RB, Coran AG, Teitelbaum DH. Outcomes in pediatric patients undergoing straight vs J pouch ileoanal anastomosis: a multicenter analysis. J Pediatr Surg. 2009 Jul; 44(7): 1410-7.

Vascular Surgery:
Deatrick KB, Wakefield TW, Henke PK. Chronic venous insufficiency: Current management of varicose vein disease. The American Surgeon. 2009 (In press).

Ramacciotti E, Diaz JA, Myers DD, Wakefield TW. Coagulation proteins with uncertain function: Role of galectins in venous thrombosis. Thrombosis Research. 2009 (In press).

Ramacciotti E, Hawley AE, Farris DM, Ballard NE, Wrobleski SK, Myers DD, Henke PK, Wakefield TW. Leukocyte and platelet derived MPs correlates to thrombus weight and tissue factor activity in an experimental model of venous thrombosis in mice. Thromb and Haemost. 2009; 101(4): 748-754.

Ramacciotti E, Myers DD, Wrobleski SK, Rectenwald JE, Henke PK, Scahub RG, Wakefield TW. P-selectin/PSGL-1 inhibitors versus enoxaparin in the resolution of venous thrombosis: a meta-analysis. Thrombosis Research. 2009 (In press).

Vandy FC, Wakefield TW. Thrombosis and Hemostasis. In: Hallett JW Jr, Mills J, Earnshaw JJ, Reekers JA, Rooke T (Editors). Comprehensive Vascular and Endovascular Surgery. Philadelphia, PA: Elsevier; 2009. p. 21-38.