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NOVEMBER 2009, Vol. 27


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HEADLINES

Monday, November 16, 2009 – “Science and Technology Investments and Policy in the Obama Administration”
Kei Koizumi

Monday, November 16, 2009
4:00 - 5:30 PM
Gerald R. Ford School of Public Policy - Betty Ford Classroom 1110
(Reception to follow.)

Speaker:
Kei Koizumi, Assistant Director, Federal Research and Development, Office of Science and Technology Policy, Executive Office of the President

With commentary by:
Jason Owen-Smith, Associate Professor, Sociology and Organizational Studies, University of Michigan

Science, Technology, and Public Policy (STPP) Lecture Series
Sponsored by The Herbert H. and Grace A. Dow Foundation
Co-sponsored by the University of Michigan Office of the Vice President for Research and the University of Michigan College of Engineering

Abstract – The Obama Administration is committed to harnessing S&T to make progress on four key national challenges of (1) economic recovery and renewed growth; (2) dealing with the interrelated challenges of energy, the environment, and climate; (3) a healthier American people; and (4) a secure America within a global world. To accomplish these goals, the Office of Science and Technology Policy (OSTP) is harnessing significant resources for Federal research and development (R&D) investments and attempting to implement new science policy practices.

OSTP and the National Economic Council (NEC) recently released A Strategy for American Innovation that provides a framework for understanding past, current, and future Obama Administration policies in science, technology, entrepreneurship, education, workforce, and infrastructure. This lecture will discuss the Obama Administration’s strategies for innovation, investments in R&D, and the policy initiatives that have been designed to address these four national challenges.

Kei Koizumi is the Assistant Director for Federal Research and Development at the White House Office of Science and Technology Policy (OSTP). Koizumi joined OSTP in mid-February after having served on the Obama transition team as part of the Technology, Innovation & Government Reform Policy Working Group. Before joining OSTP, Koizumi served as the longtime Director of the R&D Budget and Policy Program at the American Association for the Advancement of Science (AAAS). Koizumi received his M.A. from the Center for International Science, Technology, and Public Policy program at George Washington University, and received his B.A. in Political Science and Economics from Boston University.

New Capabilities in siRNA Screening at the Center for Chemical Genomics

The Center for Chemical Genomics (CCG) in the Life Sciences Institute is pleased to announce its new capabilities in siRNA screening. The High-Throughput Screening (HTS) Core has the Dharmacon Human and Mouse siGenome libraries available in 384-well format. Investigators are asked to submit an application for screening which will be reviewed by the siRNA Review Committee. The HTS Core is able to assist researchers with many aspects of screen development and transition to HTS format.

Application instructions, the application and information about the siRNA library can be found on the website. Please visit the CCG website (http://www.lsi.umich.edu/ccg) for more information about siRNA screening, HTS services and announcements.

FREE Training on the Innovation Process Now Open for Registration

The Innovation Module Series offered by the Medical Innovation Center (MIC) is comprised of seventeen 20-minute videos that focus on the "front end" of the innovation process – identifying and validating strong clinical needs for ideas that will actually be adopted. The series is based on the philosophy that a medical innovation idea is more likely to impact human health if someone is willing to buy/use it, make it or sell/distribute it.

More than just an academic discussion of innovation, the series identifies specific tools and techniques to increase the possibility that a medical innovation will ultimately be adopted and thereby improve human health.

Each week, participants view one or two 20-minute videos. Accompanying readings are highly suggested but are not required. This format enables obtaining “the basics” at a time and place convenient to participants. A 2-hour interactive, professionally facilitated discussion is then held on the topics covered in the week’s videos. Because the sessions will be attended by individuals from multiple schools and colleges, participants are exposed to views from different disciplines. The discussion sessions are offered on two different evenings each week to accommodate the busy and changing schedules of the participants.

Participation in the Winter 2010 Medical Innovation Center’s Innovation Module Series is available to University of Michigan faculty, fellows, residents and students of any school or college. The schedule can be found on the MIC website (http://www.med.umich.edu/ummic/resources/index.shtml#TIP). To sign up for the series, please contact Jennifer Stovall at (jstovall@med.umich.edu). Space is limited.

This development of this important series was made possible by a grant from the Michigan Institute for Clinical and Health Research (MICHR). You can find other resources available to medical innovators at (http://www.med.umich.edu/ummic/resources).

MIC Design and Prototype Lab Available for Medical Innovators
MIC Lab

The Medical Innovation Center (MIC) Design and Prototyping Lab is available to help medical device innovators advance their product ideas. Located at 300 North Ingalls, the Lab is a fully equipped machine shop that also includes rapid prototyping equipment, several of which were made possible by a generous grant from the Michigan Institute for Clinical and Health Research (MICHR).

The Lab operates on a “fee for service” basis – materials expenses plus labor rates of between $100 and $150 per hour. The Lab operations are managed by Toby Donajkowski who draws on over 20 years of medical instrument and device design and manufacture. If you’re looking to include prototyping services in a grant application or proposal, please contact the Lab in advance of submission so that we can provide a cost estimate for you.

If you are interested in having your idea considered as a project in the Lab, contact us at (UM-MICLab@med.umich.edu). Please include the following information:

  • Name and phone number
  • Department
  • Brief description of your request

We evaluate all new requests on a bi-weekly basis.

Health System Invests in Clinical Research Analysis; Seeks Clinical Research Team Members Input

The U-M Health System is investing in a holistic, enterprise-wide analysis of its clinical research infrastructure, and is gathering input from faculty and staff.

“While many groups have put great effort into improving individual aspects of the system, this is the first time the institution as a whole has stepped back to evaluate the entire clinical research process,” says Kenneth J. Pienta, M.D., Associate Dean for Clinical and Translational Research. “This represents an opportunity to truly transform clinical research and elevate our role as a national leader, and faculty and research team member input is critical to our success.”

At the request of UMHS leadership, the evaluation is being conducted by the same Strategic and Enterprise Analysis group that previously evaluated the purchase of the former Pfizer property. The group has already interviewed more than 60 researchers, study coordinators, and administrators, and is now conducting a survey to further understand the barriers to research faced by research teams. To ensure that the analysis accurately captures team needs, members who would like to participate in further interviews are invited to contact project manager Joan Scheske at (jscheske@umich.edu) or 734-615-7200.

Visit this link to take the survey. You may take the survey any time through Monday, November 23, 2009.

University Michigan Hosts Tech Fest 2009 and Brings Together Entrepreneurial Community

by Amy L. Klinke, Assistant Director for Small Business Initiatives, Center for Entrepreneurship

Tech Fest

The University of Michigan Center for Entrepreneurship (CFE) in partnership with the College of Engineering, Medical School, Office of Technology Transfer and the Michigan Economic Development Corporation hosted the first annual Tech Fest on Friday, October 23, 2009.

Business leaders, venture capitalists, angel investors, scientists and entrepreneurs from the California Bay Area, San Diego, Chicago, Cleveland and Boston gathered in Ann Arbor to tour the College of Engineering Solid State Electronics and Nanofabrication Facility, the Advanced Civil Engineering-Materials Research Lab and the Walter Wilson Student Team Project Center. Demonstrations of cutting-edge technology were showcased as were the Solar Car, Formula SAE car and Solar Bubbles.

Additionally, tours and discussions were held at the Biomedical Science Research Building to view innovative therapeutic leads for neurodegenerative disorders, tissue engineering and renal replacement technology and molecular imaging technology.

“We are passionate about engaging our entrepreneurial ecosystem,” said Doug Neal, Managing Director of the CFE. “Many of the participants felt that this event brought together the right mixture of technology innovation, engagement and entrepreneurial networking that is so hard to achieve.”

Capping the event was a cocktail reception in the Office of Technology Transfer where guests participated in networking and brainstorming events to discuss the engagement and expansion of participants.

For more information on how to get involved, contact the Center for Entrepreneurship (http://cfe.engin.umich.edu/).

Tech Fest

The Institute for Social Research to Conduct Second Survey of Investigator Experiences in Human Research

The Institute for Social Research (ISR) will conduct the second online “Survey of Investigator Experiences in Human Research” this fall. The results from the first survey, conducted in the fall of 2007, established a set of empirically-based benchmarks describing experience with the IRB review and approval process, the usability of the eResearch system, access to and use of resources related to human subjects research, and attitudes towards research practices. The results also provided information for decision making to IRB administrators on the Ann Arbor campus about investigator experience with the regulatory system for conducting human subjects research. The surveys are being conducted in collaboration with the Office of the Vice President for Research. ISR retains all data from the surveys and results are reported only in summary form.

A copy of the results from the first survey are available at (http://www.src.isr.umich.edu/). Key findings from the first survey include:

  • Investigators support the concept of an ethical/regulatory review of research, but often take exception with the way it is operationalized and implemented in practice by the IRBs, especially the length of time it takes to review and approve an application.
  • A majority of applications are returned to investigators to make changes before approved. Typically, changes involve the informed consent document or process.
  • eResearch is widely viewed as challenging to use.
  • IRB staff members are generally viewed as knowledgeable, respectful, and approachable.
  • Investigators are interested in learning about ways to navigate the regulatory process more quickly and efficiently.

“We’re conducting this second survey to understand the nature of any changes that have occurred over time in how investigators experience the regulatory system on campus for conducting human subjects research. To make this assessment it will be important that researchers from a broad range of disciplines take the opportunity to talk about their experiences with the IRB review process,” said Jim Lepkowski, the Research Professor leading the small team of ISR researchers conducting the survey.

The participants in the survey will be selected from campus principal investigators—faculty, staff, and students—who have active research projects involving human subjects in the eResearch system. “We know that concerns about confidentiality may determine, in part, whether someone participates in a survey. ISR has been protecting the identity of research participants for more 60 years. We’ll keep the identity of survey participants confidential and known only to the small ISR research team,” said Lepkowski.

The survey was scheduled to begin in early November 2009. Investigators selected for the survey will receive a formal invitation from ISR. Preliminary findings from the survey are planned for release in early 2010.

$9.3 Million NIH Award will Boost Promising Nanoparticle-based Vaccine Research

The National Institute of Allergy and Infectious Diseases (NIAID) has awarded the Michigan Nanotechnology Institute for Medicine and Biological Sciences (MNIMBS) a contract for $9,340,522 over five years (BAA-NIH-NIAID-DAIT-08-037 – “Innate Immune Receptors and Adjuvant Discovery”). Of that total, $5,224,548 will fund research at the MNIMBS, and $4,115,974 will fund work at Ann Arbor-based NanoBio Corporation (NanoBio), the institute’s research partner for the project. The MNIMBS principal investigator is James R. Baker Jr., M.D.

This contract will allow MNIMBS and NanoBio to develop the process to apply our nanoemulsion technology to almost any form of antigen. This should facilitate a number of new vaccines as well as improve existing vaccines. A nanoemulsion vaccine consists of a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The nanoemulsion acts as an adjuvant, an ingredient in most vaccines that enhances the immune response to the weakened or partial pathogen. Nanoemulsions, a technology developed and patented by UM and licensed to NanoBio, have been proven to be effective adjuvants. The new research aims to discover how specific nanoemulsion formulations act upon certain receptors on cells that play key roles in innate immunity, a crucial first line of defense against invading pathogens. As part of its subcontract, NanoBio Corporation will develop large numbers of nanoemulsion formulations to be tested for their immunity-producing capacity in different disease models. Later stages of the U-M research will include preclinical testing of adjuvant candidates in laboratory studies with human cells, followed by animal studies using the best candidates.

Other U-M scientists who will be involved in the new research include co-investigators Douglas Smith, Ph.D., and Anna U. Bielinska, Ph.D., both Research Assistant Professors in the Department of Internal Medicine and the MNIMBS. The NanoBio principal investigator is Tarek Hamouda, M.D., Ph.D., M.B.A.

Clinical Research Pricing Tool

The Medical School Office of Research recently launched the new Clinical Research Pricing Tool, an online application to assist clinical researchers and staff in obtaining research prices for tests and procedures needed for efficient preparation of accurate budgets for their studies. Created based on your feedback, both hospital and professional fees at federal and non-federal research discounted rates are now available in a single location.

The link to the Clinical Research Pricing Tool is (https://www.umms.med.umich.edu/crprices/). If you think you will benefit from this tool and are unable to open the application with the link above, please contact your Medical School department, division, or center administrator for access to the application. If your administrator has problems granting you access, please contact (clinical-research-pricing-admins@umich.edu), or if you need a Level 2 login please send your request to (msishelp@umich.edu).

To assist you in using this new tool, the Office of Research hosted three training demonstrations in October 2009. If you were unable to attend a demonstration, you can access a step-by-step tutorial located in the upper right hand corner of the tool. It is the same tutorial that was presented at the demonstrations. The Office of Research will also continue to educate on the pricing tool integrated with other clinical research education and training sessions.

Office of Research Launches Grant Proposal Sampler

In response to faculty suggestions from our survey last year, the Medical School Office of Research has launched a new website, the Medical School Grant Proposal Sampler (https://wiki.umms.med.umich.edu/x/UZIgBQ).

The Grant Proposal Sampler is a repository of sample proposal and proposal sections that have been donated by Medical School faculty members. The purpose of this repository is to offer insight into proposal development, including: proposal writing (e.g., organization, detail), responding to reviewers’ comments, sample sections and tables, etc. Please note that the site is password-protected, with the contents restricted to Medical School faculty, staff, and postdoctoral fellows. Users are required to login using their uniqname and Level 1 (Kerberos) password.

Currently, the site contains six research proposals (R21s, R01s, P01), including NIH reviewers’ comments and revisions. A sample T32 proposal and a sample K23 application are also included.

We are soliciting more examples, and are especially interested in: K awards; future proposals reviewed, revised and awarded using the new NIH scoring metrics (i.e., 10 - 90); future proposals responding to the new NIH page limit guidelines (FY2011); and sections of proposals, e.g., Human Subject Protection, Vertebrate Animals, resource sharing, letters of support.

Please contact Chris Black at (ckblack@umich.edu) with samples that you are willing to share, or suggestions or comments about the sample proposal site.


SEMINARS + MAJOR EVENTS AND CONFERENCES

Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!


RESEARCH COMPLIANCE TRAINING AND EDUCATION


Human Research

IRBMED Holiday Season Schedule

As the weather grows colder and the holiday season approaches, the IRBMED Office would like to remind you that:

  • IRBMED review boards do not meet on Thursday, November 26, 2009 (Thanksgiving Day), nor on Friday, November 27, 2009 (the day following Thanksgiving).
  • IRBMED review boards do not meet during the holiday closure (12/25/09 through 1/3/10). The last meetings of 2009 are Friday, December 18, and Thursday, December 24. The first meeting of 2010 will be Thursday, January 7.
  • The IRBMED Office is not open for regular business during the holiday closure beginning the afternoon of December 24. The office will reopen on Monday, January 4, 2010, at 8:30 AM. The drop-box outside our offices at 517 W. William will remain open to receive submissions, though mail will not be opened until January 4, 2010. In addition, campus mail will not be delivered during the holiday closure.

 

Animal Research

ULAM Training Core

Animal care training is based on regulatory requirements (Public Health Service Policy and the Animal Welfare Act) and the commitment of the University of Michigan to ensure that animal research performed here is done in the most humane and effective manner. All of the training provided by ULAM and UCUCA is combined into the centralized unit called the ULAM Training Core. The ULAM Training Core offers training in research animal use such as regulations, standard laboratory techniques, and surgery. The training core offices and wet lab are located in the Life Sciences Building (LSI).

Training Core Offices:
Location: 1016 LSI
Phone: 734-763-8039
Email: ulamtraining@umich.edu
Website: http://www.ulam.umich.edu/training.htm

Vaporizer Use

As a result of the recent Association for the Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) site visit, the UCUCA office now needs to be notified of the existence of vaporizers and the last date the machine underwent the required yearly maintenance. ULAM has arranged to have a service technician visit campus twice yearly to service anesthetic machines and vaporizers and can arrange to provide service to your machine at that time. The next visit will be December 2 through December 4, 2009. If you have not received the initial email to sign up for service at this time, please email Amy Saski (alss@umich.edu) to arrange a visit. Machines are required to undergo at least yearly maintenance as required by the “UM Program for Monitoring Anesthetic Machines and Vaporizers.” Please feel free to contact the UCUCA Office if you have any questions or concerns at 734-763-8028 or (ucuca.office@umich.edu).


EDUCATIONAL OPPORTUNITIES


New Faculty Orientation to U-M Clinical Research Practices

Friday, December 4, 2009
8:00 AM - 12:30 PM
M-3330 Med Sci I

New faculty and U-M faculty who are new to the practice of clinical research are invited to attend this half-day workshop, which gives an overview and resources for navigating the U-M clinical research environment. Personnel and faculty from offices that manage and govern clinical research practices will present key information on the topics of initiating, conducting and collaborating on clinical and translational research. Visit this link for more information or to register.


KUDOS


Massimo (Max) Pietropaolo Appointed Chair of NIH Study Section

Dr. Massimo (Max) Pietropaolo, Professor of Pediatrics and Communicable Diseases, has been appointed Chair of the following NIH study section: Diabetes, Endrocrinology and Metabolic Diseases B Subcommittee of the Diabetes and Digestive and Kidney Diseases Initial Review Group, NIDDK. The term is from July 2009 to June 30, 2010.


FUNDING / AWARD OPPORTUNITIES

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.

Follow this link to search for other funding and recognition opportunities. This webpage contains a link to M-Quest (a database of opportunities for grants, honors, prizes and fellowships created and maintained by the Office of Research) as well as information on email alert groups.


Internal Submissions

Medical Innovation Center Recruiting for Its July 2010 Fellowship Team
Deadline: December 1, 2009

The University of Michigan Medical Innovation Center's (MIC) Fellowship Program builds tomorrow's innovation leaders today! MIC is currently recruiting for its innovation fellowship for July 2010. The theme for this fellowship is “Pediatric Devices” based on the goals of the M-PED Pediatric Device Consortium being operated by the MIC. A $2 million award from the FDA will support a one-year, full-time fellowship program with the objective of developing solutions for unmet clinical pediatric device needs.

The MIC Fellowship is a multidisciplinary "team" training program for talented post-graduate professionals with medical, dental, doctorate, or master's degrees, who are committed to addressing real healthcare issues through innovation excellence. Innovation Fellows are expected to function as a cohesive team, blurring the boundaries of their respective disciplines. Teams will be comprised of medical (M.D., D.O.), business (M.B.A.) and engineering (Master or above) members who will collaborate in this unique program.

This program draws on the strengths of Michigan's renowned schools and colleges to develop a new type of medical innovator with the knowledge and integrated, cross-disciplinary skills necessary to transform problems into practical solutions and discoveries into products. This intensive program provides practical training through experiential learning that allows innovation knowledge to be applied to the medical arena and beyond. Residents (procedure oriented specialties preferred) who have completed a minimum of two years of training are eligible to apply. To learn about the Fellowship scope, the application process or get answers to frequently asked questions, please visit the website (http://www.med.umich.edu/ummic/fellowship).

OVPR Staff Service Awards Program
Deadline: January 22, 2010

The Office of the Vice President for Research (OVPR) invites nominations of outstanding staff members for two awards (listed below) established to recognize exceptional and distinguished contributions or performance in the support of the University of Michigan’s research mission. Nomination guidelines for these awards are available from the OVPR website (http://research.umich.edu/ovpr/recognition-programs). For questions, contact Jane Ritter at 734-763-1290 or (ritterj@umich.edu).

  • Distinguished Research Administrator Award – This award honors individuals who have demonstrated over a number of years distinguished service exemplifying the goals of professional research administration. Staff members from any unit of the University whose duties are primarily research administration are eligible. The award recipient(s) will receive a personal honorarium of $1,250 and a plaque.
  • OVPR Exceptional Service Award – This award honors individuals or teams of people involved in any area of work who have made outstanding contributions that go beyond the ordinary fulfillment of the position's duties. This award is open to staff who work in OVPR or any unit that reports to OVPR (see list online). The award recipient(s) will receive a personal honorarium of $1,250 and a plaque.


External Limited Submissions


These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

Edward Mallinckrodt, Jr. Foundation Grant Program
Internal Deadline: December 7, 2009

The basic aim of the Edward Mallinckrodt, Jr. Foundation is to advance knowledge in the various fields of medical and health research. It is further the general aims to (1) confine contributions to those worthy projects that are in need of initial start-up funding to move the projects forward to the point of other independent support or (2) support highly promising young investigators (e.g. have not been a PI on an R01) at the time when start-up funds are limited and initial progress is dependent on additional funding. The Foundation is most interested in basic research with upstream potential for impacting disease. The applicant must have an appointment in the Medical School. Clinical instructors are not eligible.

It is not the intent to support projects that are already under way and are already receiving significant grant support to provide long-range funding beyond an initial three-year period of support. The Foundation will not fund overhead, and grants will be made and restricted to domestic institutions.

Grants are made in the amount of $50,000 - $75,000 per year for a period of one to three years and are contingent upon a yearly progress report by the applicant. The Foundation reviews applications three times a year. The next Foundation deadline is February 1, 2010. The University of Michigan may submit a maximum of three proposals.

For consideration as an institutional nominee, submit the following electronically in a single PDF document by December 7, 2009 to (limitedsubmissions@umich.edu): a 2- to 4-page research plan (double-spaced), a NIH formatted biosketch, and a nominating letter from the department chair. We acknowledge receipt of all electronic submissions. If you do not receive a response from us by the end of the next business day, please call us at 734-763-4086. Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions. Please visit the Foundation website for complete guidelines.

Camille Dreyfus Teacher-Scholar Awards Program
Internal Deadline: December 11, 2009
Foundation Deadline: February 11, 2010

The Camille Dreyfus Teacher-Scholar Awards Program supports the research and teaching careers of talented young faculty in the chemical sciences. Criteria for selection include an independent body of scholarship attained within the first five years of appointment as an independent researcher and a demonstrated commitment to education, signaling the promise of continuing outstanding contributions to both research and teaching. Nominations must provide compelling evidence of the advance of important knowledge in the chemical sciences by the nominee. Further, the nomination should describe dedication and contributions to education in the chemical sciences, particularly with respect to undergraduates.

Nominees must hold a full-time tenure-track academic appointment and are normally expected to be within the first five years of their independent academic careers, with appointment date no earlier than mid-year 2004. The University of Michigan is allowed to nominate only one faculty member for this award. For consideration as the institutional nominee, submit the following electronically in a single PDF document by December 11, 2009 to (OVPRlimitedsubmissions@umich.edu):

  • NIH formatted biosketch, including a list of relevant publications.
  • Letter of nomination from an institutional representative (typically the department chair) highlighting the nominee’s achievements, and the basis for selection.
  • A description (no more than 2 pages) of the nominee's research plans as well as a statement on teaching.
  • A budget (less than 1 page) describing how award funds will be used.
  • The names only of three people outside of the UM personally familiar with the candidate’s work and creative ability. At least one of the names must be from a person who has had no supervisory or collaborative contact with the candidate.

Visit the foundation website for more information. Contact Jane Ritter (ritterj@umich.edu or 734-763-1290) with any questions.

Mary Kay Foundation Grants for Innovative Translational Cancer Research
Internal Deadline: December 14, 2009

The Mary Kay Foundation is accepting grant applications for innovative translational research in ovarian, uterine, breast or cervical cancer. Translational research is broadly defined as research that will provide a scientific link between laboratory research and the clinic. Ultimately such research would lead to improvements in diagnosis, prognosis, prevention, or treatment of cancer. The award will be up to $100,000 (combined direct and indirect costs) for a two-year period. The University of Michigan may submit TWO applications: one through the Medical School and one through the School of Public Health. Deadline for submission of an application to the Foundation is February 12, 2010.

For consideration as an institutional nominee, submit the following electronically in a single PDF document by December 14, 2009: a 3-page research plan, a NIH formatted biosketch, and a nominating letter from the department chair. We acknowledge receipt of all electronic submissions.

For applications through the Medical School: send to (limitedsubmissions@umich.edu). For applications through the School of Public Health: send to (philbert@umich.edu). Contact Kathryn Ridner at 734-763-4086 or (kridner@umich.edu) with any questions. Visit (http://www.mkacf.org/Pages/CancerGrantProgram.aspx) for more information and to download an application.

The Ellison Medical Foundation New Scholar Award in Aging
Internal Deadline: January 8, 2010
Foundation Deadline: February 25, 2010

The University of Michigan has been invited to nominate two candidates to apply for The Ellison Medical Foundation New Scholar Award in Aging. Each award provides up to $100,000 per year for a four-year period. Funding for years two, three and four is contingent upon submission of an acceptable progress report.

Eligible candidates: The objective of The Ellison Medical Foundation New Scholars Program is to support new investigators of outstanding promise in the basic biological sciences relevant to understanding lifespan development processes and age-related diseases and disabilities. These awards are intended for investigators who are in the first three years of their research career following their postdoctoral fellowship experience. For the 2010 competition, as of March 1, 2010, nominees must hold regular full time appointments (tenure or non-tenure) on the faculty of the sponsoring institution and they must not have been in such an appointment, at the sponsoring institution or other institution(s), for more than three years as of July 15, 2010, i.e., the appointment having been made no earlier than July 15, 2007. Nominees may hold one other career development award from a private source concurrently for up to one year. The limitation is with regard to overlap of funding type, even in the absence of scientific overlap.

Details on the goals of the program, eligibility requirements, and terms of the award may be found on the Foundation’s website (http://www.ellisonfoundation.org).

NOTE: Not all eligibility criteria may be listed in this abstract. Before submitting an application for this internal competition, it is the applicant’s responsibility to visit the foundation website and verify that both the applicant and their project meet ALL eligibility criteria. For consideration as an institutional nominee, submit the following electronically in a single PDF document by January 8, 2010 to (OVPRlimitedsubmissions@umich.edu):

  1. 1-2 page letter of intent responsive to the RFP, including:
    Description of research proposal, its significance, how it will be carried out and how it is likely to have an impact in the field of biomedical aspects of aging.
  2. Personal statement describing goals in the field of biomedical aspects of aging.
  3. NIH formatted biosketch.
  4. Nominating letter from dean(s) or department chair(s).

Direct any questions to Jane Ritter (ritterj@umich.edu or 734-763-1290) in the Office of the Vice President for Research, University of Michigan.


External Open Submissions

Jefferson Science Fellowships at the U.S. Department of State
Internal Deadline: November 30, 2009
National Academies Deadline: January 15, 2010

The National Academies is calling for nominations/applications for the Jefferson Science Fellowship for 2010. Nominations and applications are invited for tenured academic scientists, technologists, and engineers. Ten Fellows will be selected for the 2010 program. Each Fellow will spend one year at the Department of State in Washington D.C. in either a regional or functional bureau and may coordinate with embassies overseas. Following the fellowship year, the Fellow will return to his/her academic career but will remain available to the U.S. government for short-term projects.

The Jefferson Science Fellow will be paid a per diem of up to $50,000 to cover living expenses for a full year in the D.C. area. In addition, $10,000 will be made available for travel associated with assignment(s) at the U.S. Department of State. Salary and benefits will be paid by the academic institution.

Eligibility Requirements for Nominees/Applicants:

  • Must be a U.S. citizen.
  • Must be a scientist, technologist, or engineer holding a tenured faculty position at a U.S. college or university.
  • If awarded, candidate must successfully complete and maintain security clearances at the U.S. Department of State/USAID.

Applicants are evaluated on:

  • Stature, recognition and experience in the national and international scientific or engineering community.
  • Ability to rapidly and accurately understand scientific advancements outside his/her discipline area.
  • Ability to articulate science and technology issues to non-specialists audiences.
  • Interest and experience in policy issues and open-mindedness.

U-M is institutionally entitled to nominate two faculty. However, additional applications may come directly from the faculty with the understanding that the provisions of the Memorandum of Understanding between the U-M and the U.S. Department of State will apply if they are selected. The selected institutional nominees and all applicants will be required to submit a Proposal Approval Form for salary and benefits (through eResearch Proposal Management – eRPM).

Please contact Sharyn Sivyer (ssivyer@umich.edu) as soon as possible if you are interested in applying for a Jefferson Science Fellowship. Additional information and guidelines may be found at (http://sites.nationalacademies.org/pga/jefferson).

Sharyn I. Sivyer, Sr. Project Representative and FSO
Division of Research Development & Administration
Phone: 734-936-1296
Fax: 734-763-4053
Email: ssivyer@umich.edu

The Kavli Prize
Deadline: December 15, 2009

The Kavli Prize honors scientists for outstanding achievement in advancing our knowledge and understanding in the fields of astrophysics, nanoscience and neuroscience. The Kavli Prize is a partnership between The Norwegian Academy of Science and Letters, The Kavli Foundation (US) and The Norwegian Ministry of Education and Research. Each Kavli prize consists of a scroll, a medal and a cash award of US $1,000,000.

The nomination process is open to all who wish to nominate candidates, but self-nominations will not be accepted. The Kavli Prize will be awarded at a ceremony in Oslo, Norway in September 2010. For complete information on submitting a nomination, visit (http://www.kavliprize.no/).

Pfizer Fellowships / Visiting Professorships
Deadline: January 31, 2010

Through their Medical and Academic Partnerships (MAP) grant program, Pfizer offers funding through the mechanisms listed below. Visit (http://www.pfizermap.com) for complete information.

  • Fellowships – Support the career development and promotion of talented junior physician-scientists or researchers with fellowship funding. These nationally competitive awards support talented postdoctoral researchers early in their careers. Fellowships are offered in the areas of (1) Clinical Practice, (2) Health Disparities, (3) Health Policy, and (4) Public Health. Awards are $65,000 a year for two years.
  • Visiting Professorships – Enable U.S. medical schools, teaching hospitals, or organizations to invite a distinguished expert for three days of teaching and professional exchange with students, faculty, research fellows, physicians, nurses, community members, and others at the host institution. Awards are in the amount of $7,500 each and are offered in the fields of Alzheimer's disease, diabetes, endocrinology, health literacy, infectious diseases, neurology/psychiatry, obesity, oncology, ophthalmology, pain medicine, pulmonary vascular disease, pulmonology, rheumatology, and urology.
Vodafone Americas Foundation Wireless Innovation Project
Deadline: February 1, 2010

The Vodafone Wireless Innovation Project will make awards of $100K, $200K, and $300K (in equal installments over three years) to fund the best innovations using wireless related technology to address critical social issues around the world. Projects must demonstrate a multi-disciplinary approach that uses an innovation in wireless related technology to address a critical global issue in one or more of the following areas: access to communication, education, economic development, environment, or health. The project must be at a stage of research where an advanced prototype or field/market test can occur during the award period. The technology should have the potential for replication and large scale impact. Applicants should also have a business plan or a basic framework for financial sustainability and rollout. There is no limit on the number of submissions per institution and one person can submit more than one project if they would like, just as long as they are completely separate projects. Visit (http://project.vodafone-us.com) for complete details.


UMMS AWARDED GRANTS

External Awarded Grants

Currently, due to limitations on data collection, we are unable to identify projects awarded with multiple PIs. As the eRPM system is used for proposals in 2009, we will be able to publish those awards accurately. We apologize for any misleading project information this causes.

Click here to view.

Biological Chemistry

PI: Banerjee, Ruma
Title: THE SULFUR/GLUTAMATE CIRCUITRY IN THE NEUROIMMUNE SYSTEM
Sponsor: NIH 2 R01 DK 064959 07 A2
Project Dates and Amount of Award: 09/30/09-08/31/11; $724,055

PI: Trievel, Raymond
Title: IDENTIFICATION OF INHIBITORS OF PLU-1, A HISTONE DEMETHYLASE THAT PROMOTES BREAST CANCER PROGRESSION
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 09/15/09-10/14/10; $115,875

Cell & Developmental Biology

PI: Tsai, Billy
Title: TRANSPORT OF POLYOMARIRUS ACROSS THE ER MEMBRANE
Sponsor: NIH 3 R01 AI 064296 04 S1
Project Dates and Amount of Award: 09/22/09-08/31/10; $409,000

Center for Computational Medicine and Bioinformatics

PI: Athey, Brian
Title: TRAINING PROGRAM IN BIOINFORMATICS
Sponsor: NIH 3 T32 GM 070449 05 S1
Project Dates and Amount of Award: 08/03/09-07/31/10; $45,612

Dermatology

PI: Anderson, Thomas
Title: FORODESINE CTCL
Sponsor: Prologue Research Intl, Inc. TO Biocryst Pharmaceuticals, Inc.
Project Dates and Amount of Award: 08/31/09-12/31/10; $157,575

PI: Fisher, Gary
Title: NON-IDENTIFIABLE SKIN SAMPLE EVALUATION FOR ALTERED COLLAGEN CROSS-LINKING
Sponsor: Access Business Group
Project Dates and Amount of Award: 09/22/09-05/31/10; $28,000

Emergency Medicine

PI: Barsan, William
Co-I: Giordani, Bruno (Psychiatry-Neuropsychology) / Silbergleit, Robert (Emergency Medicine UM Adult)
Title: PROGESTERONE FOR TRAUMATIC BRAIN INJURY - EXPERIMENTAL CLINICAL TREATMENT
Sponsor: NIH - Subcontracts TO Emory University R01
Project Dates and Amount of Award: 07/01/09-06/30/10; $672,090

Family Medicine

PI: Fetters, Michael
Co-I: Sen, Ananda (Ctr Statistical Consul & Res)
Title: PROVIDING CULTURALLY APPROPRIATE HEALTH CARE SERVICES IN QATAR: DEVELOPMENT OF A MULTILINGUAL "PATIENT CULTURAL ASSESSMENT OF QUALITY" INSTRUMENT
Sponsor: Qatar Foundation TO Weill Cornell Medical College-Qatar
Project Dates and Amount of Award: 09/01/09-08/31/12; $349,412

PI: Zick, Suzie
Title: GINGER FOR CHEMOPREVENTION OF COLORECTAL CANCER
Sponsor: NIH 3 K07 CA 102592 05 S1
Project Dates and Amount of Award: 08/01/09-07/31/11; $98,022

Human Genetics

PI: Camper, Sally
Title: MYOSIN 15: GENETICS, PATHOLOGY AND THERAPEUTIC POTENTIAL
Sponsor: NIH 2 R01 DC 005053 06 A2
Project Dates and Amount of Award: 09/18/09-08/31/14; $1,591,281

PI: Meisler, Miriam
Co-I: Isom, Lori (Pharmacology Department) / Parent, Jack (Neurology Department)
Title: STEM CELL DERIVED NEURONS AND INHERITED EPILEPSY
Sponsor: NIH 1 RC1 NS 068684 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $989,593

PI: Rosenberg, Noah
Title: POPULATION GENETIC STUDIES FOR ASSOCIATION MAPPING
Sponsor: NIH 3 R01 GM 081441 03 S1
Project Dates and Amount of Award: 08/31/09-07/31/11; $321,124

Internal Medicine

PI: Aaronson, Keith
Title: DURAHEART HUMAN FACTORS ENGINEERING PROTOCOL, PATIENT AND CAREGIVER
Sponsor: Terumo Heart
Project Dates and Amount of Award: 08/24/09-01/31/10; $38,050

PI: Baker, Laurence
Title: SWOG TREATMENT GRANT ADOPT ADMINISTRATIVE SUPPLEMENT
Sponsor: NIH 3 U10 CA 032102 30 S3
Project Dates and Amount of Award: 09/30/09-09/29/10; $683,499

PI: Baptist, Alan
Title: ASTHMA HOSPITALIZATIONS-PATIENT AND PHYSICIAN PERSPECTIVES
Sponsor: Blue Cross Blue Shield Of Mi.
Project Dates and Amount of Award: 09/01/09-08/31/10; $10,000

PI: Beck, James
Co-I: Christensen, Paul (Int Med-Pulm./Critical Care) / Cinti, Sandro (Int Med-Infectious Diseases) / Huffnagle, Gary (Int Med-Pulm./Critical Care) / Riddell Iv, James (Int Med-Infectious Diseases) / Young, Vincent (Int Med-Infectious Diseases)
Title: UNDERSTANDING THE LUNG MICROBIOME IN HIV-INFECTED AND HIV-UNINFECTED INDIVIDUALS
Sponsor: NIH 1 U01 HL 098961 01
Project Dates and Amount of Award: 09/23/09-07/31/14; $3,764,532

PI: Bernal-Mizrachi, Ernesto
Title: AKT AND REGULATION OF PANCREAS DEVELOPMENT AND CELL PLASTICITY
Sponsor: Juvenile Diabetes Research Foundation International (JDRF)
Project Dates and Amount of Award: 07/01/09-02/28/11; $280,091

PI: Brosius III, Frank
Title: RECAPITULATING TRANSCRIPTIONAL PATHWAYS OF HUMAN DIABETIC NEPHROPATHY IN MICE
Sponsor: NIH 3 U01 DK 076139 04 S1
Project Dates and Amount of Award: 07/01/09-06/30/11; $124,266

PI: Chan, Kevin
Co-I: Han, Meilan (Int Med-Pulm./Critical Care)
Title: FLUTICASONE PROPIONATE/SALMETEROL DISKUS(TM) 250/50MCG BID AND PLACEBO ON ARTERIAL STIFFNESS IN SUBJECTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COP)(A RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP, 16-WEEK STUDY TO EVALUATE THE EFFECT OF)
Sponsor: Glaxosmithkline
Project Dates and Amount of Award: 02/12/09-05/31/10; $74,515

PI: Collins, Katherine
Title: MOLECULAR MECHANISMS OF HIV DISEASE PATHOGENESIS
Sponsor: NIH 3 R01 AI 051192 07 S1
Project Dates and Amount of Award: 09/22/09-08/31/10; $25,839

PI: Cooney, Kathleen
Title: GENETIC ANALYSIS OF HEREDITARY PROSTATE CANCER FAMILIES-SUPPLEMENT
Sponsor: NIH 3 R01 CA 079596 10 S1
Project Dates and Amount of Award: 09/30/09-09/29/10; $225,051

PI: Day, Sharlene
Title: REGULATION OF PROTEASOME FUNCTION IN CARDIOMYOPATHIES
Sponsor: NIH 1 R01 HL 093338 01 A1
Project Dates and Amount of Award: 08/17/09-07/31/14; $1,940,467

PI: Delmar, Mario
Title: STEM CELLS AND THE FIBROBLAST/ADIPOCYTE LINEAGE IN ARRHYTHMOGENIC CARDIOMYOPATHY
Sponsor: NIH 1 RC1 HL 100111 01
Project Dates and Amount of Award: 09/30/09-08/31/11; $999,229

PI: Flaherty, Kevin
Title: CNTO 888 ADMINISTERED INTRAVENOUSLY IN SUBJECTS WITH IDIOPATHIC PULMONARY FIBROSIS (CNTO888-PUL-2001 - A PHASE 2, MULTICENTER, MULTINATIONAL, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL-GROUP, DOSE-RANGING STUDY EVALUATING THE EFFICACY AND SAFETY OF)
Sponsor: Centocor, Inc. TO Johnson & Johnson
Project Dates and Amount of Award: 01/06/09-12/26/12; $181,647

PI: Gadegbeku, Crystal
Title: CAROTID INTIMA-MEDIA THICKNESS IN CHRONIC KIDNEY DISEASE: A CRIC ANCILLARY STUDY
Sponsor: NIH - Subcontracts TO University of Pennsylvania R01 DK 080033
Project Dates and Amount of Award: 09/15/08-06/30/10; $37,878

PI: Glaser, Thomas
Title: GENETIC ANALYSIS OF RETINAL GANGLION CELL FUNCTION, DEVELOPMENT AND DISEASE
Sponsor: NIH 2 R01 EY 014259 04 A1
Project Dates and Amount of Award: 07/01/09-06/30/14; $1,813,699

PI: Hasler, William
Title: VISCERAL AFFERENT DYSFUNCTION IN DIABETIC GASTROPATHY
Sponsor: NIH 3 U01 DK 073985 04 S1
Project Dates and Amount of Award: 09/01/09-08/31/10; $100,000

PI: Holoshitz, Joseph
Title: CLASS II MHC ALLELE-SPECIFIC SIGNALING: A NEW PARADIGM IN DISEASE PATHOGENESIS
Sponsor: NIH 1 R01 GM 088560 01
Project Dates and Amount of Award: 09/01/09-07/31/13; $1,231,640

PI: Hussain, Maha
Title: UMCC 2009.025 PHASE II TRIAL OF COMBINATION ABI-007, CARBOPLATIN, AND GEMCITABINE FOR FIRST LINE TREATMENT OF ADVANCED UROTHELIAL CANCER
Sponsor: Abraxis BioScience, Inc.
Project Dates and Amount of Award: 09/01/09-12/31/12; $185,016

PI: Katz, Steven
Title: QUALITY OF CANCER CARE EVALUATION AND INTERVENTIONS
Sponsor: NIH 3 K05 CA 111340 03 S1
Project Dates and Amount of Award: 09/30/09-09/29/11; $108,000

PI: Kretzler, Matthias
Co-I: Holzman, Lawrence (Int Med-Nephrology) / Ojo, Akinlolu (Int Med-Nephrology) / Song, Peter (Biostatistics Department)
Title: NEPHROTIC SYNDROME RARE DISEASE CLINICAL RESEARCH NETWORK
Sponsor: NIH 1 U54 DK 083912 01
Project Dates and Amount of Award: 09/08/09-06/30/14; $6,237,975

PI: Li, Qing
Co-I: Ginsburg, David (Life Sciences Institute-Admin) / Malek, Sami (Int Med-Hematology/Oncology) / Morrison, Sean (Life Sciences Institute-Admin) / Talpaz, Moshe (Int Med-Hematology/Oncology)
Title: THE ROLE OF ONCOGENIC RAS IN LEUKEMOGENEIS AND RESPONSE TO TARGETED THERAPIES
Sponsor: NIH 7 K08 CA 134649 02
Project Dates and Amount of Award: 09/01/09-08/31/13; $508,680

PI: Merchant, Juanita
Title: MECHANISMS OF GASTROINTESTINAL GROWTH & TRANSFORMATION
Sponsor: NIH 3 R01 DK 055732 10 S1
Project Dates and Amount of Award: 08/15/09-06/30/10; $73,718

PI: Miller, Richard
Title: NEW DEMOGRAPHIC ENDPOINTS FOR COMPARATIVE GERONTOLOGY
Sponsor: NIH 3 P30 AG 013283 15 S1
Project Dates and Amount of Award: 09/15/09-08/31/10; $124,759

PI: Mody, Lona
Title: CLINICAL EVALUATION OF THE XPERT MRSA/SA ASSAY IN NASAL SWABS
Sponsor: Cepheid
Project Dates and Amount of Award: 05/01/09-05/01/11; $61,000

PI: Mody, Lona
Co-I: Bradley, Suzanne (Int Med-Infectious Diseases) / Galecki, Andrzej (Int Med-Geriatric Medicine) / Krein, Sarah (Int Med-General Medicine)
Title: TARGETED INFECTION-CONTROL PROGRAM (TIP) TO REDUCE RESISTANT PATHOGENS AND INFECTIONS IN NHS
Sponsor: NIH 1 R01 AG 032298 01 A1
Project Dates and Amount of Award: 09/15/09-08/31/14; $1,781,088

PI: Moore, Bethany
Co-I: Seibold, James (Int Med-Rheumatology)
Title: BIOMARKER DISCOVERY IN FIBROTIC LUNG DISEASE
Sponsor: Pfizer Incorporated
Project Dates and Amount of Award: 09/02/09-09/01/10; $15,642

PI: Myers Jr, Martin
Title: ROLE OF THE LATERAL HYPOTHALAMIC AREA IN LEPTIN ACTION
Sponsor: NIH 3 R01 DK 078056 02 S1
Project Dates and Amount of Award: 09/20/09-12/31/10; $234,405

PI: Ojo, Akinlolu
Title: RENAL AND CARDIOVASCULAR EVENTS IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Sponsor: NIH 2 K24 DK 062234 06 A2
Project Dates and Amount of Award: 09/01/09-08/31/14; $977,052

PI: Ojo, Akinlolu
Title: CHRONIC RENAL INSUFFICIENCY COHORT STUDY
Sponsor: NIH 3 U01 DK 061028 09 S1
Project Dates and Amount of Award: 09/04/09-08/31/11; $275,730

PI: Patel, Sanjeevkumar
Co-I: Dressler, Gregory (Pathology Department)
Title: MECHANISM OF GENE REPRESSION IN THE KIDNEY
Sponsor: NIH 1 R01 DK 082409 01 A1
Project Dates and Amount of Award: 08/24/09-05/31/14; $1,534,354

PI: Richardson, Bruce
Co-I: Peters-Golden, Marc (Int Med-Pulm./Critical Care) / Yung, Raymond (Int Med-Geriatric Medicine)
Title: ROLE OF T CELLS IN THE INDUCTION OF LUPUS
Sponsor: NIH 2 R01 AR 042525 15 A2
Project Dates and Amount of Award: 09/23/09-07/31/14; $1,717,213

PI: Smith, Dylan
Co-I: Brown, Stephanie (Int Med-General Medicine) / Seng, Julia (Inst/Research Women & Gender)
Title: MEASURING HEALTH-RELATED QUALITY OF LIFE IN OLDER ADULTS WITH CHRONIC ILLNESS
Sponsor: NIH 3 R21 AG 030177 02 S1
Project Dates and Amount of Award: 09/15/09-08/31/10; $126,125

PI: Tsui, Cynthia
Title: GDNF AND RET ARE CRITICAL FOR GLOMERULAR DEVELOPMENT, MAINTENANCE, AND PROTECTION
Sponsor: NIH 1 K08 DK 084210 01
Project Dates and Amount of Award: 09/17/09-08/31/14; $776,520

PI: Wang, Shaomeng
Co-I: Lu, Jianfeng (Int Med-Hematology/Oncology) / Mceachern, Donna (Int Med-Hematology/Oncology) / Sun, Haiying (Int Med-Hematology/Oncology)
Title: DESIGN AND DEVELOPMENT OF NEW THERAPY FOR THE TREATMENT OF HUMAN BREAST CANCER BY OVERCOMING APOPTOSIS RESISTANCE OF BREAST CANCER CELLS
Sponsor: Breast Cancer Research Fdn
Project Dates and Amount of Award: 10/01/09-09/30/10; $200,000

PI: Wicha, Max
Title: REGULATION OF BREAST STEM CELLS BY THE MICROENVIRONMENT
Sponsor: NIH 2 R01 CA 101860 06
Project Dates and Amount of Award: 09/16/09-05/31/14; $1,261,315

PI: Wiggins, Roger
Co-I: Karnovsky, Alla (CCMB-Initiatives)
Title: THE UNIVERSITY OF MICHIGAN GEORGE M. O'BRIEN RENAL CORE CENTER
Sponsor: NIH 3 P30 DK 081943 02 S1
Project Dates and Amount of Award: 09/01/09-08/31/11; $309,000

PI: Wiley, John
Title: AUTOIMMUNE MECHANISMS IN DIABETIC NEUROPATHY
Sponsor: NIH 3 R01 DK 056997 09 S1
Project Dates and Amount of Award: 09/30/09-08/31/10; $100,000

PI: Yung, Raymond
Co-I: Richardson, Bruce (Int Med-Rheumatology)
Title: LEUKOCYTE-ENDOTHELIAL CELL INTERACTION IN AGING
Sponsor: NIH 2 R56 AG 020628 06
Project Dates and Amount of Award: 09/01/09-08/31/10; $373,715

Medical Education

PI: Moyer, Cheryl
Title: EVALUATING THE READINESS OF TH EDUCATIONAL SYSTEMS IN RWANDA, KENYA, AND ETHIOPIA
Sponsor: Gates, William H., Foundation
Project Dates and Amount of Award: 09/15/09-10/31/10; $399,997

Michigan Institute for Clinical and Health Research

PI: Sampselle, Carolyn
Title: IMPROVING THE HEALTH OF CHILDREN AND YOUTH THROUGH COMMUNITY ENGAGED RESEARCH
Sponsor: CDC-Subcontracts TO Association for Prevention Teaching and Research
Project Dates and Amount of Award: 09/01/09-09/30/10; $29,904

Michigan Nanotechnology Institute for Medicine and Biological Sciences

PI: Baker Jr, James
Title: DNA-LINKED DENDRIMER NANOPARTICLE SYSTEM FOR CANCER DIAGNOSIS AND TREATMENT
Sponsor: NIH 3 R01 CA 119409 05 01
Project Dates and Amount of Award: 08/01/09-07/31/10; $145,903

Molecular & Behavioral Neuroscience Institute

PI: Villafuerte Monje, Sandra
Title: SEROTONIN, DOPAMIN AND GABA SYSTEMS IN THE DEVELOPMENT OF ALCOHOL USE DISORDER
Sponsor: NIH 1 R03 AA 019576 01
Project Dates and Amount of Award: 09/25/09-08/31/11; $77,250

PI: Zubieta, Jon
Co-I: Green, Carmen (Anesthesiology Department) / Koeppe, Robert (Radiology Department) / Smith, Yolanda (Obstetrics and Gynecology Dept)
Title: INTERACTION OF SMOKING AND CHRONIC PAIN AT NEUROCHEMICAL AND PHENOTYPE LEVELS
Sponsor: NIH 1 R01 DA 027494 01
Project Dates and Amount of Award: 09/30/09-06/30/14; $2,682,010

PI: Zubieta, Jon
Co-I: Burmeister, Margit (Molecular & Behav Neurosc Inst) / Langenecker, Scott (Psychiatry Department) / Sen, Ananda (College of Engineering) / Taylor, Stephan (Psychiatry Department) / Welsh, Robert (Radiology Department)
Title: PREDICTING PLACEBO RESPONSES ACROSS DISEASE STATES
Sponsor: NIH 1 R01 MH 086858 01
Project Dates and Amount of Award: 09/16/09-06/30/13; $1,248,699

Molecular & Integrative Physiology

PI: Omary, Bishr
Title: PATHOGENESIS OF KERATIN-CONTAINING INCLUSIONS IN LIVER DISEASE
Sponsor: NIH 3 R01 DK 052951 13 S1
Project Dates and Amount of Award: 09/05/09-08/31/10; $100,000

PI: Pletcher, Scott
Title: MECHANISMS OF OLFACTORY MODULATION OF AGING IN DROSOPHILA
Sponsor: NIH 7 R01 AG 030593 03
Project Dates and Amount of Award: 06/01/09-05/31/12; $981,016

PI: Williams, John
Co-I: Ernst, Stephen (Cell and Developmental Biology)
Title: CALCIUM AND PANCREATIC STIMULUS-SECRETION COUPING
Sponsor: NIH 3 R37 DK 041122 18 S1
Project Dates and Amount of Award: 09/20/09-08/31/10; $83,315

Neurology

PI: Brown, Devin
Title: IMPROVING ATRIAL FIBRILLATION CARE IN MICHIGAN
Sponsor: Blue Cross Blue Shield of Michigan Foundation
Project Dates and Amount of Award: 09/01/09-08/31/11; $124,456

PI: Gruis, Kirsten
Co-I: Chervin, Ronald (Neurology Department) / Clauw, Daniel (Int Med-Rheumatology) / Feldman, Eva (Neurology Department) / Martinez, Fernando (Int Med-Pulm./Critical Care) / Rothman, Edward (Ctr Statistical Consul & Res)
Title: PILOT PLACEBO-CONTROLLED TRIAL OF EARLY NONINVASIVE VENTILATION FOR ALS
Sponsor: NIH 3 K23 NS 055200 03 S1
Project Dates and Amount of Award: 09/01/09-08/31/11; $86,400

PI: Paulson, Henry
Co-I: Albin, Roger (Neurology Department) / Elenitoba-Johnson, Kojo (Pathology Department) / Lieberman, Andrew (Pathology Department)
Title: INTEGRATING QUALITY CONTROL: STUDIES OF CHIP IN AGE-RELATED NEURODEGENERATION
Sponsor: NIH 1 R01 AG 034228 01
Project Dates and Amount of Award: 09/15/09-07/31/14; $1,545,664

PI: Paulson, Pamela
Co-I: Morrow, Thomas (Neurology Department)
Title: NEUROIMAGING OF CNS INTERACTIONS IN ADDICTION, CHRONIC PAIN AND ANALGESIA
Sponsor: NIH 1 R21 DA 027504 01
Project Dates and Amount of Award: 09/15/09-08/31/11; $346,500

Ophthalmology & Visual Sciences

PI: Smith, Terry
Co-I: Douglas, Raymond (Ophthalmology & Visual Science)
Title: IMMUNOGLOBULIN ACTIVATION OF FIBROBLASTS
Sponsor: NIH 2 R01 DK 063121 06
Project Dates and Amount of Award: 09/01/09-08/31/13; $1,523,200

PI: Smith, Terry
Title: FUNCTIONAL DIVERSITY OF ORBITAL FIBROBLASTS
Sponsor: NIH 7 R01 EY 011708 14
Project Dates and Amount of Award: 09/01/09-08/31/12; $1,251,410

Otolaryngology

PI: Schacht, Jochen
Co-I: Altschuler, Richard (Kresge Hearing Research Inst) / Dolan, David (Kresge Hearing Research Inst)
Title: STRESS PATHWAYS IN AGE-RELATED HEARING LOSS
Sponsor: NIH 3 P01 AG 025164 05 S1
Project Dates and Amount of Award: 09/15/09-08/31/10; $59,833

PI: Zwolan, Teresa
Co-I: Arts, H (Otorhinolaryngology Department) / El-Kashlan, Hussam (Otorhinolaryngology Department) / Telian, Steven (Otorhinolaryngology Department)
Title: MEDEL ELECTIC-ACOUSTIC SYSTEMS (EAS) CLINICAL TRIAL
Sponsor: Med-El Corporation
Project Dates and Amount of Award: 08/15/09-06/30/11; $4,000

Pathology

PI: Chiselite, Mihaela
Title: THE ROLE OF BONE MARROW STROMAL ANTIGEN-2 (BST-2; CD317) IN THE PATHOGENESIS OF PRIMARY MEDIASTINAL LARGE B-CELL LYMOMA
Sponsor: College of American Pathologists (CAP) Foundation
Project Dates and Amount of Award: 07/01/09-06/30/10; $25,000

PI: Dressler, Gregory
Title: ADVANCES IN RESEARCH BASIC SCIENCE SYMPOSIUM ON "EPIGENETICS: REGULATING THE GENOME IN DEVELOPMENT AND DISEASE"
Sponsor: NIH 1 R13 DK 085837 01
Project Dates and Amount of Award: 09/01/09-08/31/10; $12,000

PI: Harper, James
Title: METABOLISM, LIFE HISTORY AND AGING
Sponsor: Ellison Medical Foundation
Project Dates and Amount of Award: 01/03/10-01/07/10; $5,272

PI: Miller, Richard
Title: LABORATORY FOR ANTI-GERIC TESTING, EVALUATION AND RESEARCH
Sponsor: NIH 2 U01 AG 022303 06 A1
Project Dates and Amount of Award: 07/01/09-06/30/14; $3,332,112

Pediatrics & Communicable Diseases

PI: Bitar, Khalil
Co-I: Martens, Jeffrey (Pharmacology Department) / Teitelbaum, Daniel (Surgery Department)
Title: IMPLANTATION OF PHYSIOLOGICALLY FUNCTIONAL BIOENGINEERED INNERVATED IAS CONSTRUCTS
Sponsor: NIH 1 RC1 DK 087151 01
Project Dates and Amount of Award: 09/30/09-07/31/11; $994,586

PI: Bitar, Khalil
Title: RESTORATION OF FECAL CONTINENCE IN AGING IAS
Sponsor: NIH 3 R01 DK 071614 02 S1
Project Dates and Amount of Award: 09/15/09-08/31/10; $30,240

PI: Dempsey, Peter
Title: DEVELOPMENT OF ADAM10 PRODOMAIN - FL PROTEIN AS A THERAPEUTIC AGENT
Sponsor: NIH - Subcontracts TO BioZyme Inc
Project Dates and Amount of Award: 08/01/09-07/31/10; $61,926

PI: Dombkowski, Kevin
Co-I: Clark, Sarah (Pediatrics-Ambulatory Care Pgm) / Hanauer, David (Pediatrics-Ambulatory Care Pgm) / Prosser, Lisa (Pediatrics-Ambulatory Care Pgm)
Title: TIME: TECHNOLOGY FOR IMMUNIZATION MESSAGE ENHANCEMENT
Sponsor: CDC 1 U01 IP 000316 01
Project Dates and Amount of Award: 09/01/09-08/31/11; $450,000

PI: Hildebrandt, Friedhelm
Co-I: Innis, Jeffrey (Human Genetics Department)
Title: EXON CAPTURE AND LARGE-SCALE SEQUENCING FOR DISEASE-CAUSE IDENTIFICATION, EARLY DETECTION AND DRUG DISCOVERY IN NEPHROTIC SYNDROME
Sponsor: NIH 1 RC1 DK 086542 01
Project Dates and Amount of Award: 09/30/09-07/31/11; $981,458

PI: LiPuma, John
Co-I: Cavalcoli, James (CCMB-Initiatives) / Li, Jun (Human Genetics Department) / Robinson, Courtney (Int Med-Infectious Diseases) / Young, Vincent (Int Med-Infectious Diseases) / Zhao, Jiangchao (Pediatrics-Infectious Diseases)
Title: THE LUNG MICROBIOTA IN CYSTIC FIBROSIS
Sponsor: NIH 1 RC1 HL 100809 01
Project Dates and Amount of Award: 09/01/09-08/31/11; $998,813

PI: Lumeng, Julie
Title: LITERACY RICH PEDIATRIC WAITING ROOMS
Sponsor: Target Corporation
Project Dates and Amount of Award: 07/24/09-05/07/10; $1,500

PI: Shanley, Thomas
Title: PP2A REGULATION OF THE JNK MAPK PATHWAY
Sponsor: NIH 2 R01 GM 066839 07 A2
Project Dates and Amount of Award: 08/10/09-06/30/13; $1,118,749

PI: Yanik, Gregory
Title: OUTGOING DATA USE AGREEMENT:UCSF-MIP, MIBG PHASE I
Sponsor: Molecular Insight Pharmaceuticals, Inc.
Project Dates and Amount of Award: 06/10/09-06/09/10; $1,000

Pharmacology

PI: Osawa, Yoichi
Title: DRUG-MEDIATED ALTERATION OF CYTOCHROME P450
Sponsor: NIH 3 R01 GM 077430 04 S1
Project Dates and Amount of Award: 08/31/09-04/30/11; $289,456

PI: Satin, Leslie
Title: ALTERED EXCITATORY NEUROTRANSMISSION AFTER BRAIN TRAUMA - ADMINISTRATIVE SUPPLEMENT
Sponsor: NIH 3 R01 NS 049519 04 S1
Project Dates and Amount of Award: 09/01/09-08/31/11; $80,216

PI: Woods, James
Title: DOPAMINE D2/D3 RECEPTORS IN COMPULSIVE DISORDERS
Sponsor: NIH 1 R01 DA 023897 01 A2
Project Dates and Amount of Award: 09/30/09-06/30/13; $1,839,853

Psychiatry

PI: Blow, Frederic
Co-I: Barry, Kristen (Psych HlthSvc Outcome Research) / Chermack, Stephen (Psych Substance Abuse) / Cunningham, Rebecca (Emergency Medicine Admin) / Ilgen, Mark (Psych HlthSvc Outcome Research) / Walton, Maureen (Psych Substance Abuse)
Title: OPTIMIZING SBIRT FOR DRUG-USING PATIENTS IN AN INNER-CITY EMERGENCY DEPARTMENT
Sponsor: NIH 1 R01 DA 026029 01
Project Dates and Amount of Award: 08/15/09-05/31/14; $3,458,008

PI: Hanna, Gregory
Co-I: Boehnke, Alice (Biostatistics Department)
Title: 2/3 BRAIN CHEMISTRY AND GENETICS IN PEDIATRIC OBSESSIVE-COMPULSIVE DISORDER
Sponsor: NIH 1 R01 MH 085321 01 A1
Project Dates and Amount of Award: 09/11/09-05/31/14; $1,980,987

PI: Hicks, Brian
Co-I: Burmeister, Margit (Molecular & Behav Neurosc Inst) / Shedden, Kerby (Biostatistics Department) / Zucker, Robert (Psychiatry Department)
Title: INTEGRATING GENES, ENVIRONMENT, & DEVELOPMENT IN THE ETIOLOGY OF SUBSTANCE ABUSE
Sponsor: NIH 1 K01 DA 025868 01 A1
Project Dates and Amount of Award: 09/30/09-05/31/14; $812,226

Radiation Oncology

PI: Jagsi, Reshma
Co-I: Stewart, Abigail (LSA Women's Studies) / Ubel, Peter (Int Med-General Medicine)
Title: EXAMINING HOW GENDER DIFFERENCES IN OUTCOMES DEVELOP AMONG PHYSICIAN RESEARCHERS
Sponsor: NIH 1 R01 HL 101997 01
Project Dates and Amount of Award: 09/30/09-06/30/13; $865,587

PI: Lawrence, Theodore
Title: GEMCITABINE-RADIATION FOR ADVANCED PANCREATIC CANCER
Sponsor: NIH 3 R01 CA 078554 10 S2
Project Dates and Amount of Award: 08/01/09-07/31/11; $139,473

PI: Xu, Liang
Co-I: Simeone, Diane (General Surgery Section)
Title: TUMOR-TARGETED SILENCING OF BCL-2/BCL-XL BY THE SELF-ASSEMBLED SIRNA-NANOVECTORS
Sponsor: NIH 3 R01 CA 121830 04 S1
Project Dates and Amount of Award: 09/01/09-07/31/11; $614,396

Radiology

PI: Agarwal, Prachi
Title: PREMATURE CORONARY ARTERY DISEASE IN SEVERE PSORIASIS
Sponsor: GE Healthcare
Project Dates and Amount of Award: 07/01/09-06/30/11; $140,000

PI: Carson, Paul
Co-I: Fowlkes, J (Radiology Department) / Wang, Xueding (Radiology Department)
Title: COMBINED DIGITAL X-RAY, OPTICAL, AND ULTRASOUND BREAST IMAGING
Sponsor: NIH 3 R01 CA 091713 07 S1
Project Dates and Amount of Award: 08/01/09-07/31/11; $853,883

PI: Helvie, Mark
Co-I: Nees, Alexis (Radiology Department) / Roubidoux, Marilyn (Radiology Department)
Title: A MULTICENTER STUDY TO TEST THE NON-INFERIORITY OF DIGITAL BREAST TOMOSYNTHESIS COMPARED TO FULL-FIELD DIGITAL MAMMOGRAPHY IN DETECTING BREAST CANCER - PART 4. DATA COMPILATION AND ANALYSIS BASED ON BLINDED CENTRAL READ
Sponsor: General Electric Company
Project Dates and Amount of Award: 09/04/09-03/31/10; $62,250

PI: Miller, Douglas
Co-I: Eitzman, Daniel (Int Med-Cardiology) / Liu, Ming (Metabolism, Endo & Diabetes) / Lucchesi, Benedict (Pharmacology Department) / Wiggins, Roger (Int Med-Nephrology)
Title: BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
Sponsor: NIH 2 R01 EB 000338 27
Project Dates and Amount of Award: 08/01/09-07/31/10; $457,259

Surgery

PI: Birkmeyer, John
Co-I: Sonnenday, Christopher (General Surgery Section)
Title: UNDERSTANDING RACIAL DISPARITIES IN CANCER SURGERY
Sponsor: NIH 3 K05 CA 115571 03 S1
Project Dates and Amount of Award: 09/30/09-09/29/11; $100,333

PI: Bolling, Steven
Title: Carpentier-Edwards PERIMOUNT Magna Mitral Pericardial Bioprostheses Models 7000/7000TFX
Sponsor: Edwards Lifesciences Llc
Project Dates and Amount of Award: 08/03/09-06/30/19; $335,069

PI: Deeb, G
Title: TRAINING FOR SAFE AND EFFECTIVE USE OF MEDTRONIC'S FREESTYLE BIOPROSTHETIC VALVE
Sponsor: Medtronic, Inc.
Project Dates and Amount of Award: 05/15/09-05/14/10; $40,000

PI: Hauge, Linnea
Title: ASSESSING THE EFFECTIVENESS OF A SURGERY INTERN PREPAREDNESS COURSE: A SURVEY OF LEARNERS AND THEIR CLINICAL SUPERVISORS
Sponsor: CGEA
Project Dates and Amount of Award: 09/01/09-03/31/11; $5,000

PI: Liu, Yang
Title: FOXP3 AS THE X-LINKED BREAST CANCER SUPPRESSOR GENE
Sponsor: NIH 3 R01 CA 120901 03 S1
Project Dates and Amount of Award: 08/01/09-07/31/11; $304,163

PI: Magee, John
Co-I: Spino, Catherine (Biostatistics Department)
Title: CHILDHOOD LIVER DISEASE RESEARCH AND EDUCATION NETWORK DATA COORDINATING CENTER
Sponsor: NIH 2 U01 DK 062456 08
Project Dates and Amount of Award: 09/15/09-05/31/14; $7,345,299

PI: Magee, John
Co-I: Spino, Catherine (Biostatistics Department)
Title: RARE LIVER DISEASE NETWORK
Sponsor: NIH - Subcontracts TO The Children's Hospital Association U54 DK 078377
Project Dates and Amount of Award: 08/01/08-07/31/10; $434,292

PI: Merion, Robert
Title: CLINICAL OUTCOMES OF LIVE ORGAN DONORS DATA COORDINATING CENTER
Sponsor: NIH 3 U01 AI 069491 04 S1
Project Dates and Amount of Award: 09/22/09-08/31/10; $272,133

PI: Park, Pauline
Co-I: Blum, James (Anesthesiology Department)
Title: OSCILLATION FOR ARDS TREATED EARLY (OSCILLATE)
Sponsor: McMaster University TO Canadian Institute of Health Research (CIHR)
Project Dates and Amount of Award: 08/10/09-08/09/14; $46,910

Urology

PI: Keller, Evan
Title: S0622: PHASE II STUDIES OF TWO DIFFERENT SCHEDULES OF DASATINIB IN BONE METASTASIS PREDOMINANT METASTATIC BREAST CANCER
Sponsor: Southwest Oncology Group
Project Dates and Amount of Award: 09/01/09-08/31/10; $148,811

PI: Liebert, Monica
Title: INCREASE IN BREAST CANCER STEM CELLS IN RESPONSE TO PROSTAGLAND IN E2
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 09/08/09-10/07/10; $114,934

PI: Wei, John
Co-I: Shah, Rajal (Pathology Department)
Title: EDRN PCA3 VALIDATION TRIAL AND URINARY REFERENCE SET
Sponsor: NIH - Subcontracts TO Johns Hopkins University
Project Dates and Amount of Award: 07/15/09-07/14/10; $940,086

PI: Wood Jr, David
Title: VIVUS TA-303 ERECTILE DYSFUNCTION STUDY
Sponsor: Vivus, Inc.
Project Dates and Amount of Award: 09/01/09-04/30/11; $102,124


UMMS RESEARCH PUBLICATIONS


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Biological Chemistry

Aminoff D, Bochar DA, Fuller AA, Mapp AK, Showalter HD, Kirchhoff PD. Research into selective biomarkers of erythrocyte exposure to organophosphorus compounds. Anal Biochem. 2009 Sep 15; 392(2): 155-61.

Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW Jr, Glick GD. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem Pharmacol. 2009 Oct 15; 78(8): 966-73.

Bulfer SL, Scott EM, Couture JF, Pillus L, Trievel RC. Crystal structure and functional analysis of homocitrate synthase, an essential enzyme in lysine biosynthesis. J Biol Chem. 2009 Sep 22. (Epub ahead of print).

Chueh BH, Zheng Y, Torisawa YS, Hsiao AY, Ge C, Hsiong S, Huebsch N, Franceschi R, Mooney DJ, Takayama S. Patterning alginate hydrogels using light-directed release of caged calcium in a microfluidic device. Biomed Microdevices. 2009 Oct 15. (Epub ahead of print).

Evans RT, Seasholtz AF. Soluble corticotropin-releasing hormone receptor 2alpha splice variant is efficiently translated but not trafficked for secretion. Endocrinology. 2009 Sep; 150(9): 4191-202.

Ge C, Xiao G, Jiang D, Yang Q, Hatch NE, Franceschi RT. Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor. J Biol Chem. 2009 Sep 30. (Epub ahead of print).

Gropman AL, Sailasuta N, Harris KC, Abulseoud O, Ross BD. Ornithine transcarbamylase deficiency with persistent abnormality in cerebral glutamate metabolism in adults. Radiology. 2009 Sep; 252(3): 833-41.

Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, Håkansson K, Smith JL, Sherman DH. Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis. J Am Chem Soc. 2009 Oct 16. (Epub ahead of print).

Hurst TK, Wang D, Thompson RB, Fierke CA. Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives. Biochim Biophys Acta. 2009 Oct 8. (Epub ahead of print).

Jinwal UK, Miyata Y, Koren J 3rd, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. J Neurosci. 2009 Sep 30; 29(39): 12079-88.

Johnson KM, Swenson L, Opipari AW Jr, Reuter R, Zarrabi N, Fierke CA, Börsch M, Glick GD. Mechanistic basis for differential inhibition of the F1Fo-ATPase by aurovertin. Biopolymers. 2009 Oct; 91(10): 830-40.

Kim J, Hannibal L, Gherasim C, Jacobsen DW, Banerjee R. A human B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins. J Biol Chem. 2009 Oct 2. (Epub ahead of print).

Koutmos M, Datta S, Pattridge KA, Smith JL, Matthews RG. Insights into the reactivation of cobalamin-dependent methionine synthase. Proc Natl Acad Sci USA. 2009 Oct 21. (Epub ahead of print).

Kow RL, Whicher JR, McDonald CA, Palfey BA, Fagan RL. Disruption of the proton relay network in the class 2 dihydroorotate dehydrogenase from Escherichia coli. Biochemistry. 2009 Oct 20; 48(41): 9801-9.

Kwee TC, Galbán CJ, Tsien C, Junck L, Sundgren PC, Ivancevic MK, Johnson TD, Meyer CR, Rehemtulla A, Ross BD, Chenevert TL. Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas. NMR Biomed. 2009 Sep 23. (Epub ahead of print).

Lazarus O, Woolerton TW, Parkin A, Lukey MJ, Reisner E, Seravalli J, Pierce E, Ragsdale SW, Sargent F, Armstrong FA. Water-gas shift reaction catalyzed by redox enzymes on conducting graphite platelets. J Am Chem Soc. 2009 Oct 14; 131(40): 14154-5.

Marvin MC, Engelke DR. Broadening the mission of an RNA enzyme. J Cell Biochem. 2009 Oct 20. (Epub ahead of print).

Strunk BS, Karbstein K. Powering through ribosome assembly. RNA. 2009 Oct 22. (Epub ahead of print).

Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO J. 2009 Oct 15. (Epub ahead of print).

Wu J, Bu W, Sheppard K, Kitabatake M, Kwon ST, Söll D, Smith JL. Insights into tRNA-dependent amidotransferase evolution and catalysis from the structure of the Aquifex aeolicus enzyme. J Mol Biol. 2009 Aug 28; 391(4): 703-16.

Yu S, Franceschi RT, Luo M, Fan J, Jiang D, Cao H, Kwon TG, Lai Y, Zhang J, Patrene K, Hankenson K, Roodman GD, Xiao G. Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone. PLoS One. 2009 Oct 23; 4(10): e7583.

Cell & Developmental Biology

Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC. Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol Cell Biol. 2009 Aug; 29(15): 4308-24.

Cai D, McEwen DP, Martens JR, Meyhofer E, Verhey KJ. Single molecule imaging reveals differences in microtubule track selection between Kinesin motors. PLoS Biol. 2009 Oct; 7(10): e1000216.

Dlugosz AA, Talpaz M. Following the hedgehog to new cancer therapies. N Engl J Med. 2009 Sep 17; 361(12): 1202-5.

Han YG, Kim HJ, Dlugosz AA, Ellison DW, Gilbertson RJ, Alvarez-Buylla A. Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med. 2009 Sep; 15(9): 1062-5.

Sandy AR, Maillard I. Notch signaling in the hematopoietic system. Expert Opin Biol Ther. 2009 Nov; 9(11): 1383-98.

Villanueva EC, Münzberg H, Cota D, Leshan RL, Kopp K, Ishida-Takahashi R, Jones JC, Fingar DC, Seeley RJ, Myers MG Jr. Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology. 2009 Oct; 150(10): 4541-51.

Wong SY, Seol AD, So PL, Ermilov AN, Bichakjian CK, Epstein EH Jr, Dlugosz AA, Reiter JF. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med. 2009 Sep; 15(9): 1055-61.

Yoo Y, Ho HJ, Wang C, Guan JL. Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway. Oncogene. 2009 Oct 5. (Epub ahead of print).

Human Genetics

Stine ZE, Huynh JL, Loftus SK, Gorkin DU, Salmasi AH, Novak T, Purves T, Miller RA, Antonellis A, Gearhart JP, Pavan WJ, McCallion AS. Oligodendroglial and pan-neural crest expression of Cre recombinase directed by Sox10 enhancer. Genesis. 2009 Oct 14. (Epub ahead of print).

Uhlmann WR. Response to Robert G. Resta Commentary (Unprepared, Understaffed, and Unplanned: Thoughts on the Practical Implications of Discovering New Breast and Ovarian Cancer Causing Genes). J Genet Couns. 2009 Oct 2. (Epub ahead of print).

Villafuerte SM, Vallabhaneni K, Sliwerska E, McMahon FJ, Young EA, Burmeister M. SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. Psychiatr Genet. 2009 Oct 13. (Epub ahead of print).

Internal Medicine

Infectious Diseases:
Baddley JW, Marr KA, Andes DR, Walsh TJ, Kauffman CA, Kontoyiannis DP, Ito JI, Balajee SA, Pappas PG, Moser SA. Patterns of Susceptibility of Aspergillus Isolates Recovered from Patients Enrolled in the Transplant-Associated Infection Surveillance Network. J Clin Microbiol. 2009; 47(10): 3271-3275.

Pogue JM, DePestel DD, Kaul DR, Khaled Y, Frame DG. Systemic absorption of oral vancomycin in a peripheral blood stem cell transplant patient with severe graft-versus-host disease of the gastrointestinal tract. Transpl Infect Dis. 2009; 11(5): 467-470.

Yax JA, Famon EC, Engleberg NC. Successful Immunization of an Allogeneic Bone Marrow Transplant Recipient with Live, Attenuated Yellow Fever Vaccine. J Travel Med. 2009; 16(5): 365-367.

Microbiology and Immunology

Alteri CJ, Smith SN, Mobley HL. Fitness of Escherichia coli during urinary tract infection requires gluconeogenesis and the TCA cycle. PLoS Pathog. 2009 May; 5(5): e1000448.

Carlson PE Jr, Carr KA, Janes BK, Anderson EC, Hanna PC. Transcriptional profiling of Bacillus anthracis Sterne (34F2) during iron starvation. PLoS One. 2009 Sep 21; 4(9): e6988.

Eaton KA. The steele report: seeing the wood for trees. Prim Dent Care. 2009 Oct; 16(4): 135-6.

Garcia EL, Onafuwa-Nuga A, Sim S, King SR, Wolin SL, Telesnitsky A. Packaging of host mY RNAs by murine leukemia virus may occur early in Y RNA biogenesis. J Virol. 2009 Sep 23. (Epub ahead of print).

Giebel JD, Carr KA, Anderson EC, Hanna PC. The germination-specific lytic enzymes SleB, CwlJ1, and CwlJ2 each contribute to Bacillus anthracis spore germination and virulence. J Bacteriol. 2009 Sep; 191(18): 5569-76.

Gralinski LE, Ashley SL, Dixon SD, Spindler KR. Mouse adenovirus type 1-induced breakdown of the blood-brain barrier. J Virol. 2009 Sep; 83(18): 9398-410.

Jain AV, Zhang Y, Fields WB, McNamara DA, Choe MY, Chen GH, Erb-Downward J, Osterholzer JJ, Toews GB, Huffnagle GB, Olszewski MA. Th2 but not Th1 Immune Bias Results in Altered Lung Functions in Murine Model of Pulmonary Cryptococcus neoformans Infection. Infect Immun. 2009 Sep 14. (Epub ahead of print).

Lent MD, Petrovic LE, Swanson JA, Olson CM. Maternal mental health and the persistence of food insecurity in poor rural families. J Health Care Poor Underserved. 2009 Aug; 20(3): 645-61.

Lloyd AL, Smith SN, Eaton KA, Mobley HL. Uropathogenic Escherichia coli Suppresses the Host Inflammatory Response via Pathogenicity Island Genes sisA and sisB. Infect Immun. 2009 Sep 21. (Epub ahead of print).

Luker KE, Gupta M, Steele JM, Foerster BR, Luker GD. Imaging ligand-dependent activation of CXCR7. Neoplasia. 2009 Oct; 11(10): 1022-35.

Sivick KE, Mobley HL. An "omics" approach to uropathogenic Escherichia coli vaccinology. Trends Microbiol. 2009 Oct; 17(10): 431-2.

Yan J, Gupta S, Sherman DH, Reynolds KA. Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains. Chembiochem. 2009 Jun 15; 10(9): 1537-43.

Neurology

Baran AS, Chervin RD. Approach to the patient with sleep complaints. SeminNeurol. 2009 Sep; 29(4): 297-304.

Beglinger LJ, Adams WH, Paulson H, Fiedorowicz JG, Langbehn DR, Duff K, Leserman A, Paulsen JS. Randomized controlled trial of atomoxetine for cognitive dysfunction in early Huntington disease. J Clin Psychopharmacol. 2009 Oct; 29(5): 484-7.

Chervin RD, Teodorescu M, Kushwaha R, Deline AM, Brucksch CB, Ribbens-Grimm C, Ruzicka DL, Stein PK, Clauw DJ, Crofford LJ. Objective measures of disordered sleep in fibromyalgia. J Rheumatol. 2009 Sep; 36(9): 2009-16.

D'Abreu A, França MC Jr, Paulson HL, Lopes-Cendes I. Caring for Machado-Joseph disease: Current understanding and how to help patients. Parkinsonism Relat Disord. 2009 Oct 5. (Epub ahead of print).

McKeag DB, Kutcher JS. Concussion consensus: raising the bar and filling in the gaps. Clin J Sport Med. 2009 Sep; 19(5): 343-6.

Osuchowski MF, Teener J, Remick D. Noninvasive model of sciatic nerve conduction in healthy and septic mice: Reliability and normative data. Muscle Nerve. 2009 Oct; 40(4): 610-6.

Schuh LA, London Z, Neel R, Brock C, Kissela BM, Schultz L, Gelb DJ. Bias and poor interrater reliability in evaluating the neurology clinical skills examination. Neurology 2009 Sept; 73(11): 904-908.

Shakkottai VG, Paulson HL. Physiologic alterations in ataxia: channeling changes into novel therapies. Arch Neurol. 2009 Oct; 66(10): 1196-201. Review.

Neurosurgery

Al-Holou WN, Garton HJ, Muraszko KM, Ibrahim M, Maher CO. Prevalence of pineal cysts in children and young adults. Clinical article. J Neurosurg Pediatr. 2009 Sep; 4(3): 230-6.

Maher CO, Bauer SB, Goumnerova L, Proctor MR, Madsen JR, Scott RM. Urological outcome following multiple repeat spinal cord untethering operations. Clinical article. J Neurosurg Pediatr. 2009 Sep; 4(3): 275-9.

Snellings A, Sagher O, Anderson DJ, Aldridge JW. Identification of the subthalamic nucleus in deep brain stimulation surgery with a novel wavelet-derived measure of neural background activity. J Neurosurg. 2009 Oct; 111(4): 767-74.

Tubbs RS, Maher CO, Young RL, Cohen-Gadol AA. Distal revision of ventriculoperitoneal shunts using a peel-away sheath. J Neurosurg Pediatr. 2009 Oct; 4(4): 402-5.

Wang AC, Than KD, Etame AB, La Marca F, Park P. Impact of anesthesia on transcranial electric motor evoked potential monitoring during spine surgery: a review of the literature. Neurosurg Focus. 2009 Oct; 27(4): E7.

Obstetrics & Gynecology

Bauman TS. Romero A, Kirkpatrick J, Romero J, Lange D, Sison E, Tangco V, Abelardo N, Samson G, Grezlik R, Goldman EB, Oralm H. Eagle K. Safety and efficacy of pacemaker reuse in underdeveloped nations: A case series. J Am Coll Cardiol. 2009; 54: 1557-1558.

Haefner HK, Sideri M, Reynolds RK, Lowe L. Home Study Course: Vulvar Case Presentation Pigmented Lesions. J Lower Genital Tract Disease. 2009; 13(4): 269-274.

Lewicky-Gaupp C, McGuire EJ, Fenner DE. Multiple perineal abscesses and sinus tracts as a complication of vaginal mesh. Int Urogynecol J Pelvic Floor Dysfunct. 2009 Sep; 20(9): 1137-9.

Murrey H, Ficarro S, Krishnamurthy C, Domino SE, Peters E, Hsieh-Wilson L: Identification of the Plasticity-Relevant Fucose-a(1-2)-Galactose Proteome from Mouse Olfactory Bulb. Biochemistry. 2009 Aug; 48(30): 7261-70.

Seng JS; Low LK; Sperlich M; Ronis DL; Liberzon I. Prevalence, trauma history, and risk for posttraumatic stress disorder among nulliparous women in maternity care. Obstet Gynecol 2009 Oct; 114(4): 839-847.

Vahratian A. The role of a biostatistical and epidemiologic review for a clinical journal. International Journal of Gynecology and Obstetrics. 2009; 107: 91-92.

Vahratian A, Johnson TR. Maternity leave benefits in the United States: Today’s economic climate underlies deficiencies. Birth 2009; 36: 177-179.

Valerio M., Gong ZM, Wang S, Bria W, Johnson TB, Clark NM, Overweight women and management of asthma. Women’s Health Issues. 2009; 19: 300-305.

Ophthalmology & Visual Sciences

Acharya M, Lingenfelter DJ, Huang L, Gage PJ, Walter MA. Human PRKC apoptosis WT1 regulator is a novel PITX2-interacting protein that regulates PITX2 transcriptional activity in ocular cells. J Biol Chem 2009. (Epub ahead of print).

Chong DY, Johnson MW, Shen D, Chan CC, Callanan DG. Vitreous metastases of primary cutaneous B-cell lymphoma. Ocul Immunol Inflamm, 2009; 17(5): 342-4.

Ghosh AK, Murga-Zamalloa CA, Chan L, Hitchcock PF, Swaroop A, Khanna H. Human retinopathy-associated ciliary protein Retinitis Pigmentosa GTPase Regulator (RPGR) regulates cilia-dependent vertebrate development. Hum Mol Genet 2009. (Epub ahead of print).

Ip MS, Scott IU, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M, Singerman LJ, Tolentino M, Chan CK, Gonzalez VH et al. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 5. Arch Ophthalmol 2009; 127(9): 1101-14.

Scott IU, Ip MS, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M, Chan CK, Gonzalez VH, Singerman LJ, Tolentino M et al. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6. Arch Ophthalmol 2009; 127(9): 1115-28.

Stein JD, McCoy AN, Asrani S, Herndon LW, Lee PP, McKinnon SJ, Allingham RR, Challa P. Surgical management of hypotony owing to overfiltration in eyes receiving glaucoma drainage devices. J Glaucoma 2009; 18(8): 638-41.

Zhu A, Romero R, Petty HR. A sensitive fluorimetric assay for pyruvate. Anal Biochem 2009 (Epub ahead of print).

Orthopaedic Surgery

Alford AI, Terkhorn SP, Reddy AB, Hankenson KD. Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts. Bone. 2009 Sep 8. (Epub ahead of print).

Chang, P-C, Seol, Y-J, Cirelli JA, Pellegrini GR, Jin Q, Franco LM, Goldstein SA, Chandler LA, Sosnowski B, Giannobile WV. PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration. Gene Therapy 2009 (Epub ahead of print).

Daley E, Streeten EA, Sorkin JD, Kuznetsova N, Shapses SA, Carleton SM, Shuldiner AR, Marini JC, Phillips CL, Goldstein SA, Leikin S, McBride D. Variable bone fragility associated with an Amish COLIA2 variant and a knock-in mouse model. J Bone Miner Res 2009 (Epub ahead of print).

Gauger V, Kostrzewa AJ, Caird MS, Voepel-Lewis T, Vurke C, Wagner D, Farley FA. Patient-controlled epidural analgesia compared to intravenous patient-controlled analgesia following posterior spine fusion in children. Journal of Pediatric Orthopaedics. 2009; 29: 588-93.

Gauger VT, Voepel-Lewis TD, Burke CN, Kostrzewa AJ, Caird MS, Wagner DS, Farley FA. Epidural analgesia compared with intravenous analgesia after pediatric posterior spinal fusion. J Pediatr Orthop. 2009 Sep; 29(6): 588-93.

Guldberg R, Butler D, Goldstein S, et al. The impact of biomechanics in tissue engineering and regenerative medicine. Tissue Engineering, Part B: Reviews, Jul 2009 (online ahead of print).

Housner JA, Jacobson JA, Misko R. Sonographically guided percutaneous needle tenotomy for the treatment of chronic tendinosis. J Ultrasound Med. 2009 28: 1187-1192.

Kadakia AR. Correction of multiplanar deformity of the foot and ankle. Preface. Foot Ankle Clin. 2009 Sep; 14(3): ix.

Kusuma S, Urquhart AG, Hughes RE Taguchi loss function for varus/valgus alignment in total knee arthroplasty. The Open Biomedical Engineering Journal. 2009; 3: 39-42.

Meganck JA, Kozloff KM, Thornton MM, Broski SM, Goldstein SA Beam hardening artifacts in micro-computed tomography scanning can be reduced by x-ray beam filtration and the resulting images can be used to accurately measure BMD. Bone 2009 (Epub ahead of print).

Sekiya JK, Martin RL, Lesniak BP. Arthroscopic repair of delaminated acetabular articular cartilage in femoroacetabular impingement. Orthopedics. 2009 Sep; 32(9).

Tapper JE, Funakoshi Y, Hariu M, Marchuk L, Thornton GM, Ronsky JL, Zernicke RF, Shrive NG, Frank CB. ACL/MCL transection effects on intra-ligament distance of healing and remaining intact ligaments in the ovine model. Journal of Biomechanics. 2009; 42: 1825-1833.

VanderHave KL, Caird MS, Gross S, Farley FA, Graziano GA, Stauff M, Segal LS. Burst Fractures of the Thoracic and Lumbar Spine in Children and Adolescents. Journal of Pediatric Orthopaedics. 2009; 29: 713-719.

Pediatrics & Communicable Diseases

Andreae MC, Lamarand KE, Abraham L, Freed GL. Basis for immunization recommendations among countries of the World Health Organization European region. Hum Vaccin. 2009 Nov 17; 5(11).

Campbell A, Minniti CP, Nouraie M, Arteta M, Rana S, Onyekwere O, Sable C, Ensing G, Dham N, Luchtman-Jones L, Kato GJ, Gladwin MT, Castro OL, Gordeuk VR. Prospective evaluation of haemoglobin oxygen saturation at rest and after exercise in paediatric sickle cell disease patients. Br J Haematol 2009 Nov; 147(3): 352-9.

Dombkowski KJ, Wasilevich EA, Lyon-Callo S, Nguyen TQ, Medvesky MG, Lee MA. Asthma surveillance using medicaid administrative data: a call for a national framework. J Public Health Manag Pract. 2009 Nov-Dec; 15(6): 485-93.

Gaies MG, Gurney JG, Yen AH, Napoli ML, Gajarski RJ, Ohye RG, Charpie JR, Hirsch JC. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med. 2009 Sep 29. (Epub ahead of print).

Harville HM, Held S, Diaz-Font A, Davis EE, Diplas BH, Lewis RA, Borochowitz AU, Zhou W, Chaki M, Macdonald J, Kayserili H, Beales PL, Katsanis N, Otto E, Hildebrandt F. Identification of 11 novel mutations in 8 BBS genes by high-resolution homozygosity mapping. J Med Genet. 2009 Sep 24. (Epub ahead of print).

Hollingsworth JM, Davis MM, West BT, Wolf JS Jr, Hollenbeck BK. Trends in medical expulsive therapy use for urinary stone disease in U.S. emergency departments. Urology. 2009 Oct 5 (Epub ahead of print).

Kelly BP, Russell MW, Hennessy JR, Ensing GJ. Severe hypertrophic cardiomyopathy in an infant with novel PRKAG2 gene mutation: potential differences between infantile and adult onset presentation. Pediatr Cardiol. 2009 Sep 29 (Epub ahead of print).

Kormanik K, Praca J, Garton HJ, Sarkar S. Repeated tapping of ventricular reservoir in preterm infants with post-hemorrhagic ventricular dilatation does not increase the risk of reservoir infection. J Perinatol. 2009 Oct 8 (Epub ahead of print).

Lu JC, Shah SS, Owens ST, Dorfman AL, Vedre A, Goble MM, Hirsch JC, Charpie JR. Successful staged neonatal repair of Tetralogy of Fallot with long-segment hypoplasia of the aorta. Pediatr Cardiol. 2009 Sep 26 (Epub ahead of print).

Nardell K, Annich GM, Hirsch J, Fahrner C, Brownlee P, King K, Fleming G, Gajarski RJ. Risk factors for bleeding in pediatric post-cardiotomy patients requiring ECLS. Perfusion. 2009 Sep 18 (Epub ahead of print).

Paczesny S, Choi SW, Ferrara JL. Acute graft-versus-host disease: new treatment strategies. Curr Opin Hematol. 2009 Nov; 16(6): 427-36.

Shinkawa T, Polimenakos AC, Gomez-Fifer CA, Charpie JR, Hirsch JC, Devaney EJ, Bove EL, Ohye RG. Management and long-term outcome of neonatal Ebstein anomaly. J Thorac Cardiovasc Surg. 2009 Sep 21. (Epub ahead of print).

Stern AM, Cetron MS, Markel H. Closing the schools: lessons from the 1918-19 U.S. influenza pandemic. Health Aff (Millwood). 2009 Sep 29. (Epub ahead of print).

Psychiatry

Bauer MS, Biswas K, Kilbourne AM. Enhancing Multiyear Guideline Concordance for Bipolar Disorder Through Collaborative Care. Am J Psychiatry. 2009 Oct 1. (Epub ahead of print).

Bohnert AS, Tracy M, Galea S. Circumstances and witness characteristics associated with overdose fatality. Ann Emerg Med. 2009 Oct; 54(4): 618-24.

Flynn, HA. Setting the Stage for the Integration of Motivational Interviewing with Cognitive Behavioral Therapy in the Treatment of Depression. Cognitive and Behavioral Practice 2009. (In press).

Flynn, HA, Berman, D, Marcus, SM. The relationship between alcohol use problems in the year prior to pregnancy with obstetrical outcomes. Journal of Psychosomatic Obstetrics and Gynecology 2009. (In press).

Flynn HA, Henshaw E, O’Mahen, HA., Forman, J. Patient perspectives on improving the depression referral processes in prenatal care settings: A Qualitative Study. General Hospital Psychiatry 2009. (In press).

Lancaster, C., Gold, K., Flynn, H.A., Yoo, H., Marcus, S.M., Davis, M. Risk Factors for Depression During Pregnancy: A Systematic Review. American Journal of Obstetrics and Gynecology 2009. (In press).

Lancaster CA, Marcus SM, Flynn HA, Davis MM. Peripartum Length of Stay for Women with Depressive Symptoms During Pregnancy. Journal of Women’s Health 2009. (In press).

Monteleone GT, Phan KL, Nusbaum HC, Fitzgerald D, Irick JS, Fienberg SE, Cacioppo JT. Detection of deception using fMRI: better than chance, but well below perfection. Soc Neurosci. 2009; 4(6): 528-38.

Muzik M, Marcus S, Flynn HA. Psychotherapeutic Treatment Options for Perinatal Depression: Emphasis on Maternal-Infant Dyadic Outcomes. J Clin Psychiatry 2009; 70(9): 1318-9.

Nesse RM. How can evolution and neuroscience help us understand moral capacities? In: Verplaetse J, De Schrijver J, Vanneste S, Braeckman J, editors. The Moral Brain: Essays on the Evolutionary and Neuroscientific Aspects of Morality. New York: Springer Verlag; 2009. p. 201-10.

Nesse RM. Runaway social selection for displays of partner value and altruism (reprinted). In: Verplaetse J, De Schrijver J, Vanneste S, Braeckman J, editors. The Moral Brain: Essays on the Evolutionary and Neuroscientific Aspects of Morality. New York: Springer Verlag; 2009. p. 211-32.

O’Mahen HA, Flynn HA, Chermack S, Marcus S. Depression Illness Perceptions Related to Perinatal Depression Treatment Use Archives of Women’s Mental Health. 2009 May 27 (Epub ahead of print).

Phan KL, Orlichenko A, Boyd E, Angstadt M, Coccaro EF, Liberzon I, Arfanakis K. Preliminary evidence of white matter abnormality in the uncinate fasciculus in generalized social anxiety disorder. Biol Psychiatry. 2009 Oct 1; 66(7): 691-4.

Rauch SA, Defever E, Favorite T, Duroe A, Garrity C, Martis B, Liberzon I. Prolonged exposure for PTSD in a Veterans Health Administration PTSD clinic. J Trauma Stress. 2009 Feb; 22(1): 60-4.

Rauch SA, Favorite T, Giardino N, Porcari C, Defever E, Liberzon I. Relationship between anxiety, depression, and health satisfaction among veterans with PTSD. J Affect Disord. 2009 Jun 15. (Epub ahead of print).

Rauch SA, Grunfeld TE, Yadin E, Cahill SP, Hembree E, Foa EB. Changes in reported physical health symptoms and social function with prolonged exposure therapy for chronic posttraumatic stress disorder. Depress Anxiety. 2009; 26(8): 732-8.

Rosenblum KL, Dayton CJ, Muzik M. Infant Social and Emotional Development: Emerging Competence in a Relational Context. In: C. Zeanah (ed). Handbook of Infant Mental Health, 3rd edition. New York: Guilford Press (2009).

Saunders EF, Silk KR. Personality trait dimensions and the pharmacological treatment of borderline personality disorder. Journal of Clinical Psychopharmacology. 2009 Oct; 29(5): 461-7.

Swain JE. Brain-based sex differences in parenting propagate emotion expression. Behav Brain Sci. 2009 Oct; 14: 27-28.

Valenstein M, Adler DA, Berlant J, Dixon LB, Dulit RA, Goldman B, Hackman A, Oslin DW, Siris SG, Sonis WA. Implementing standardized assessments in clinical care: now's the time. Psychiatr Serv. 2009 Oct; 60(10): 1372-5.

Radiation Oncology

Bass AJ, Watanabe H, Mermel CH, Yu S, Perner S, Verhaak RG, Kim SY, Wardwell L, Tamayo P, Gat-Viks I, Ramos AH, Woo MS, Weir BA, Getz G, Beroukhim R, O'Kelly M, Dutt A, Rozenblatt-Rosen O, Dziunycz P, Komisarof J, Chirieac LR, Lafargue CJ, Scheble V, Wilbertz T, Ma C, Rao S, Nakagawa H, Stairs DB, Lin L, Giordano TJ, Wagner P, Minna JD, Gazdar AF, Zhu CQ, Brose MS, Cecconello I, Jr UR, Marie SK, Dahl O, Shivdasani RA, Tsao MS, Rubin MA, Wong KK, Regev A, Hahn WC, Beer DG, Rustgi AK, Meyerson M. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009 Oct 4. (Epub ahead of print).

Desano JT, Xu L. MicroRNA Regulation of Cancer Stem Cells and Therapeutic Implications. AAPS J. 2009 Oct 20. (Epub ahead of print).

Hassan KA, Chen G, Kalemkerian GP, Wicha MS, Beer DG. An embryonic stem cell-like signature identifies poorly differentiated lung adenocarcinoma but not squamous cell carcinoma. Clin Cancer Res. 2009 Oct 15; 15(20): 6386-90.

Ji Q, Hao X, Zhang M, Tang W, Yang M, Li L, Xiang D, Desano JT, Bommer GT, Fan D, Fearon ER, Lawrence TS, Xu L. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PLoS One. 2009 Aug 28; 4(8): e6816.

Jia L and Sun Y. F-box proteins FBX031 and FBX4 in regulation of cyclin D1 degradation upon DNA damage. Pigment Cell Melanoma Res 2009 Oct; 22(5): 518-19.

Jia L and Sun Y. RBXI/ROCI-SCF E3 ubiquitin ligase is required for mouse embryogenesis and cancer cell survival. Cell Division 2009 Aug; 4: 16.

Kwee TC, Galbán CJ, Tsien C, Junck L, Sundgren PC, Ivancevic MK, Johnson TD, Meyer CR, Rehemtulla A, Ross BD, Chenevert TL. Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas. NMR Biomed. 2009 Sep 23. (Epub ahead of print).

Moran JM, Ben-David MA, Marsh RB, Balter JM, Griffith KA, Hayman JA, Pierce LJ. Accelerated partial breast irradiation: What is dosimetric effect of advanced technology approaches? Int J Radiat Oncol Biol Phys 2009 Sept; 75(1): 294-301.

Samee A, Moorthy K, Jaipersad T, Crisp W, Cheruvu C, Elder J, Deakin M. Evaluation of the role of laparoscopic ultrasonography in the staging of oesophagogastric cancers. Surg Endosc. 2009 Sep; 23(9): 2061-5.

Wang Z, Zheng M, Li Z, Li R, Jia L, Xiong X, Southall N, Wang S, Xia M, Austin C, Zheng W, Xie Z, Sun Y. Cardiac glycosides inhibit p53 syntheses by a mechanism relieved by Src or MAPK inhibition. Can Res 2009 Aug; 69(16): 6556-64.

Surgery

General Surgery:
Bartosh SM, Ryckman FC, Shaddy R, Michaels MG, Platt JL, Sweet SC. A national conference to determine research priorities in pediatric solid organ transplantation. Pediatr Transplant, 2008; 12: 153-166.

Chang AT, Platt JL. The role of antibodies in transplantation, Transplantation Reviews, 2009; 23(4): 191-8.

Cheng J, Zhou W, Warner GM, Knudsen BE, Garovic VD, Gray CE, Lerman LO, Platt JL, Romero JC, Textor SC, Nath KA, Grande JP. Temporal Analysis of Signaling Pathways Activated in a 2 Murine Model of 2-Kidney, 1-Clip Hypertension. American Journal of Physiology - Renal Physiology. 2009; 297(4): 1055-1068.

Hoesel LM, Mattar AF, Arbabi S, Niederbichler AD, Ipaktchi K, Su GL, Westfall MV, Wang SC, Hemmila MR. Local Wound p38 MAPK Inhibition Attenuates Burn-induced cardiac dysfunction. Surgery. 2009 Oct; 146(4): 775-85; discussion 785-6.

Shafi S, Nathens AB, Cryer HF, Hemmila MR, Pasquale MD, Clark DE, Neal M, Goble S, Meredith JW, Fildes JJ. The Trauma Quality Improvement Program of the American College of Surgeons Committee on Trauma. J Am Coll Surg. 2009 Oct; 209(4): 521-530.e1.

Wahl WL, Taddonio MA, Arbabi S, Hemmila MR. Duration of antibiotic therapy for ventilator-associated pneumonia in burn patients. J Burn Care Res. 2009; 30: 799-804.

Wahl WL, Zalewski C, Wang SW, Arbabi S, Hemmila MR. ICU Core measures for burn patients. J Burn Care Res 2009. (Accepted).

Thoracic Surgery:
Chang AC, Lee JS. Resection for esophageal cancer in the elderly. Thoracic Surgical Clinics 2009. (In press). Invited review.

Chang AC, Lee JS, Sawicki KT, Pickens A and Orringer MB. Outcomes following esophagectomy in patients with prior antireflux or hiatal hernia surgery. Ann Thorac Surg 2009. (Accepted).