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SEPTEMBER 2009, Vol. 27

How do you like our new format? We want to hear from you!
Please send your comments or questions to (biomednews@umich.edu) or call us 734-763-4086.

Steven KunkelSteven L. Kunkel, Ph.D., Senior Associate Dean for Research, Endowed Professor in Pathology Research

My congratulations to all who have received notices of approval for research grant funding from the federal government's stimulus program. We are still waiting to hear about numerous other submitted proposals.

Recently, the University announced that 159 federal stimulus-package research grants have been received so far, totaling $61.1 million. This includes 113 National Institutes of Health stimulus awards that totaled $21.1 million; most of these went to Medical School researchers. The announcement is online here.

Obviously, there are many more exciting and innovative studies represented by the other research grants, and we look forward to watching the work progress. We are also optimistic that there will be additional stimulus grants approved for Medical School researchers who have applied for them.

 

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HEADLINES

Medical Innovation Center Translates Two Ideas into Products

Every invention starts with a problem.

patient imageJim Geiger | Scott Soderberg, U-M Photo Services

Problem 1 – For Jim Geiger, M.D. — a young pediatric surgeon at the U-M Health System in the late 1990s — it was an unwieldy surgical clamp. Geiger often operated on infants with pyloric stenosis — an obstruction in the pyloric muscle that connects the stomach to the small intestine. In the beginning of his career,Geiger had to make a large abdominal incision to reach the pyloric muscle, but with the development of laparoscopic surgery, only a small incision was required. Less invasive surgery was better for the baby, but made it impossible for the surgeon to reach inside and hold the pyloric muscle steady before cutting it. To make it even more cumbersome, the surgical instruments used for the procedure were made for adults. Read about how Dr. Geiger developed and commercialized a clamp to solve this problem at the Medical Innovation Center.

Problem 2 – Check into any hospital or emergency room and the first thing that happens is someone shows up to stick a needle into a vein in your arm. It’s part of what medical professionals call a peripheral intravenous catheter system — an integral part of health care delivery because it is the quickest way to get painkillers, fluids or medications into the patient’s bloodstream. Intravenous catheters have their problems. If the patient moves, it’s easy for the needle to slip out of the vein, which cuts off the flow of medicine and can cause infections or blood clots. Many nurses were taught to tape the catheter to the patient’s arm or hand to hold it in place, but that takes extra time, can be uncomfortable for the patient, and doesn’t always work. Read about how the Fellows of the Medical Innovation Center have developed a product to solve this problem.

If you have an idea you would like to develop, the Medical Innovation Center can help you navigate the path to commercialization. Please contact us at (UM-MIC@med.umich.edu) or 734-998-6994. You can learn more about us at (http://www.med.umich.edu/ummic/about/index.shtml).


NIH Seeks High Risk, High Impact Proposals through NIH Director’s Pioneer, New Innovator, and Transformative R01 Initiatives

Pioneer Awards and New Innovator Awards
NIH welcomes proposals for 2010 NIH Director's Pioneer Awards and New Innovator Awards. Both programs are part of the NIH Roadmap for Medical Research (http://nihroadmap.nih.gov) and support exceptionally creative scientists who take highly innovative, potentially high-impact approaches to major challenges in biomedical or behavioral research. NIH expects to make at least seven Pioneer Awards and at least 33 New Innovator Awards in September 2010. To continue its strong record of diversity in these programs, NIH especially encourages women and members of groups that are underrepresented in NIH research to apply.

Pioneer Awards
Deadline: October 20, 2009
These awards provide up to $2.5 million in direct costs over five years and are open to scientists at any career stage. See the instructions in the RFA (RFA-RM-09-010) (http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-09-010.html) and (http://nihroadmap.nih.gov/pioneer) for more information. Send questions to (pioneer@nih.gov).

New Innovator Awards
Deadline: October 27, 2009
These awards provide up to $1.5 million in direct costs over five years and are for early stage investigators (ESI) who have not received an NIH regular research (R01) or similar NIH grant. See the instructions in the RFA (RFA-RM-09-011) (http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-09-011.html) and (http://nihroadmap.nih.gov/newinnovator) for more information. Send questions to (newinnovator@nih.gov).

Transformative R01 Program
The Transformative R01 (T-R01) supports exceptionally innovative, high risk, original and/or unconventional research projects that have the potential to create or overturn fundamental paradigms. Please check (http://nihroadmap.nih.gov/T-R01) for more information about the program and upcoming funding opportunities.

The NIH Roadmap for Medical Research, launched in 2004, is a series of initiatives designed to address fundamental knowledge gaps, develop transformative tools and technologies, and/or foster innovative approaches to complex problems. Funded through the NIH Common Fund, these programs cut across the missions of individual NIH Institutes and Centers (ICs) and are intended to accelerate the translation of research to improvements in public health. Additional information about the NIH Roadmap and Common Fund can be found at (http://www.nihroadmap.nih.gov).

The National Institutes of Health (NIH) – “The Nation's Medical Research Agency” – includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit (http://www.nih.gov).

MICHR Seeks Associate Director for Research Innovation

The Michigan Institute for Clinical & Health Research (MICHR) seeks an Associate Director for its new Research Innovation Working Group, which has two major components. First, it houses the facilities and technical cores investigators need to perform their research, including a new 7,500 square foot Clinical Research Unit, the MICHR Biorepository, and others. Second, the Research Innovation Working Group serves as the administrative home for specialized programs of research affiliated with MICHR, from the Medical Innovation Center to the Michigan Center for Oral Health Research. The new Associate Director will be charged with overseeing this enterprise, appropriately leveraging new opportunities for expansion, and integrating all activities with MICHR as a whole.

MICHR serves more than 650 investigators and trainees each year from across the University, covering the full spectrum of clinical and translational research. MICHR’s aims include creating an academic home for clinical and translational research, training the next generation of research teams, providing integrated research infrastructure, catalyzing new translational discoveries, and partnering with the national CTSA consortium. The Associate Director for Research Innovation will serve as a member of MICHR’s Executive Leadership Council, and provide substantive input to the direction and strategic planning for MICHR as a whole. In addition, the position will carry broad authority over the scope, governance structure, and priorities of the activities of the Research Innovation Working Group, which encompasses an annual operating budget of more than $3 million.

The Associate Director will continuously improve the quality, efficiency, and scientific impact of existing facilities, cores, and programs. The Associate Director will also be expected to seek new opportunities to leverage internal and external funds for appropriate expansion. Perhaps most challenging, the Associate Director will be charged with ensuring meaningful coordination between the multiple affiliated specialized research programs, such that their common connection to MICHR adds value to both their work and the investigators we all serve. The ability to form new partnerships with existing groups and cores will be crucial to the position. Finally, the Associate Director will be expected to participate in national and consortium-wide activities relevant to the Working Group.

Qualifications:

  • University of Michigan faculty appointment
  • Track record of leadership and administrative experience in relevant areas such as cores, research facilities, or research centers/institutes
  • Demonstrable experience in research innovation
  • Experience as an active independent clinical or translational researcher
  • M.D., Ph.D., or appropriate terminal degree in a relevant field
  • Commitment of up to 40% effort to the role

Interested candidates should send a cover letter and CV to Dr. Kenneth J. Pienta (kpienta@umich.edu) by September 10, 2009. Nominations or additional inquires may be directed to Dr. Pienta.

Lipodystrophy Patients Sought for Innovative Leptin Therapy

Elif Oral, M.D., Assistant Professor in the Metabolism, Endocrinology & Diabetes Division, recently received approval to treat lipodystrophy patients with recombinant human leptin therapy, making the University of Michigan the third medical center in the U.S. (and only the fourth in the world) to do so. Lipodystrophy is a rare metabolic disorder resulting in total or partial loss of body fat, abnormalities in carbohydrate and lipid metabolism, immune system dysfunction, and severe resistance to insulin.

Under a clinical trial agreement with Amylin Pharmaceuticals (San Diego, CA), Dr. Oral is treating two Michigan patients with the novel therapy who began seeing significant improvements almost immediately. The therapy works by injecting the missing fat cell hormone (leptin), similar to replacing insulin in type 1 diabetes patients. Lipodystrophy patients on thousands of units of insulin have been able to come off insulin completely while being maintained on leptin. In other cases, patients on leptin therapy can go to much lower insulin doses.

Dr. Oral is asking clinicians to be on the lookout for patients they can refer for participation in the study. Patients with the clinical diagnosis of lipodystrophy and one metabolic abnormality (diabetes mellitus and/or hypertriglyceridemia) are being sought. Patients who have high triglycerides and require hundreds of units of insulin may also qualify for the study, if they clinically display partial lipodystrophy.

The clinical trial is listed on the Engage website as HUM00021139, “Lipodystropy Research with Metreleptin, an Investigational Study Medication.” Dr. Elif Oral may also be contacted at 734-615-7271 or (eliforal@umich.edu) or through her study coordinator, Adam Neidert, at 734-615-0539 or (aneidert@umich.edu). For more information, please visit their web site.

UM to Be Site for National Clinical Trial to Explore if Anti-Inflammatory Drug Improves Glucose Control in Type 2 Diabetes

The University of Michigan Comprehensive Diabetes Center has been chosen to participate in a multi-center national clinical trial funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, and headed by the Joslin Diabetes Center in Boston. Rodica Pop-Busui, M.D., Ph.D. (Assistant Professor, Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine) is the UM Principal Investigator for the trial, which is called “Targeting Inflammation with Salsalate in Type 2 Diabetes” or TINSAL-T2D.

The TINSAL-T2D trial studies the role of inflammation in type 2 diabetes by investigating whether salsalate can reduce blood glucose levels in people with type 2 diabetes. Salsalate, which is chemically similar to aspirin but has fewer side effects, has been used for more than 40 years to treat pain in people with arthritis. Initial studies by the Joslin group showed that salsalate was effective in lowering blood sugars when given for three months, leading to the start of this larger trial of longer duration. If successful, the trial could lead one day to an inexpensive way to treat this most common form of diabetes.

Approximately 560 adults ages 18 to 75 whose glucose levels are poorly controlled and who don’t take insulin will be sought for the one-year clinical trial. Participants must be using no more than one or two oral medications, among other criteria. Besides the Joslin Center and the University of Michigan, several other medical institutions across the nation will participate in the TINSAL-T2D.

The University of Michigan will also participate in a sub-study conducted in only few other academic institutions in which the researchers will also study whether reducing inflammation decreases the risk for coronary heart disease. Dr. Robert Brook, Associate Professor, Division of Cardiovascular Medicine at the University of Michigan, a co-investigator in this study, will oversee the vascular studies for our site as a co-investigator in this study.

For more information about the trial at the University of Michigan, contact Rodica Pop-Busui, M.D., Ph.D., or clinical study coordinator Cynthia Plunkett, R.N., at 734-936-8065 or (rpbusui@umich.edu). Detailed information can also be found by visiting the study website (http://tinsalt2d.org).

Funds Available for Subsidized Use of UM Research Resource Cores for Research on Problems in Aging

The Nathan Shock Center of Excellence in the Basic Biology of Aging announces the availability of subsidy funds to help UM faculty members purchase services from the University's family of research resource cores.

The funds can be used to help pay a portion (40%) of the costs at any UM core that has published user fees or recharge rates. Some examples of these cores include, among others:

  • Center for Integrative Genomics
  • Metabolomics and Obesity Center
  • Protein Structure Facility
  • DNA Sequencing Core
  • Center for Molecular Imaging
  • Center for Chemical Genomics
  • Affymetrix and DNA Microarray Core
  • shRNA Library Core

The research project must address questions related to the physiology, cell biology, genetics, or molecular biology of aging. For detailed information go to “Funding Info. For Use of UM Research Cores”.


SEMINARS + MAJOR EVENTS AND CONFERENCES


Please visit the calendar links on the right side menu to make sure you're "in the loop" with current events!

RESEARCH COMPLIANCE TRAINING AND EDUCATION

Human Research

Welcome to the IRBMED Open House!

Friday, October 2, 2009
2:00 - 4:00 PM
Argus I Building (517 W. William)

The IRBMED (Institutional Review Boards of the University of Michigan Medical School), is having an Open House to provide an opportunity for the research and medical community to visit us. Please mark your calendars and plan on attending this informative, fun-filled event. The afternoon will offer guided tours, door prizes, a chance to meet and mingle with IRBMED staff, and much, much more! Light refreshments will be provided. For more information, please contact Maria Camilleri (734-615-5220 or mgcamill@med.umich.edu) or Colleen Bouton (734-647-2037 or cbouton@med.umich.edu).

 

eResearch Compliance with 21 CFR Part 11

Sponsors frequently ask UM researchers if eResearch complies with the Food and Drug Administration’s (FDA) requirements (found in 21 CFR 11) regarding electronic “signatures.” The UM Office of the Vice President for Research (OVPR) has posted a letter (http://www.hrpp.umich.edu/Certification.pdf) on the Human Research Protection Program website (http://www.hrpp.umich.edu/) certifying the university’s compliance with these requirements. You may use this letter to respond to sponsor requests. IRBMED links to the letter from several places on our website:

The attestation check boxes in eResearch serve as the electronic signatures. The principal investigator “signs” the application by checking the box in the “Investigator Assurances” section of the submission form. The co-investigators make their attestations when they accept their roles in a study.

If you have any questions about this article, please contact Jan Hewett in the IRBMED office at 734-763-4768.

Animal Research

UCUCA Semi-Annual Townhalls in September

The University Committee on Use and Care of Animals will be holding their semi-annual townhall meetings in September. After many requests, there will be separate meetings on separate days to help facilitate people being able to attend.

Medical Campus:
Tuesday, September 15, 2009
10:00 AM
M3330 Med Sci I

Main Campus:
Wednesday, September 16, 2009
10:00 AM
G390 Dental School

There will be short presentations on the policy changes for “Acquisition and Oversight of Controlled Substances,” “Surgical Record & Tumor Monitoring Record Requirements” and an “Overview of Behavior Based Interviewing.” While these topics will be covered, there will also be an open forum at the end for questions. The UCUCA Compliance Associates will be available after the meeting for more one-on-one assistance. Refreshments will be served. For more information please contact the UCUCA Office at 734-763-8028, (ucuca.office@umich.edu) or (http://www.ucuca.umich.edu).

New Resource Guide: Literature Searches for Alternatives

The literature search for alternatives is a component of applications for vertebrate animal use in research, teaching, or testing protocols submitted to the University Committee on Use and Care of Animals (UCUCA) for approval. The Health Sciences Library (HSL) has published a new resource guide to aid investigators in their alternatives literature searches. Available at (http://guides.lib.umich.edu/ucuca), the resource guide provides links to relevant bibliographic and scientific databases, sample PubMed terms and search strategies, and links to information about the Animal Welfare Act and the three Rs of humane experimental technique: Reduction, Refinement, and Replacement. The guide was created and is maintained by Marisa Conte, the Clinical and Translational Science Liaison at the HSL. For assistance with an alternatives literature search, contact Marisa at 734-615-8889 or (meese@umich.edu).


EDUCATIONAL OPPORTUNITIES


All Are Welcome at the University Library Open House

Thursday, September 10, 2009
2:00 - 5:00 PM
Library Gallery, First Floor of Hatcher Graduate Library

The University Library cordially invites everyone — especially new faculty and graduate student instructors — to our open house. You can learn about library services and collections that support teaching and research, find ways to improve the research and technology skills of your students, and meet the librarian(s) for your discipline. Come chat and relax with your colleagues and library staff, or choose to participate in brief presentations and discussions on topics such as information resources, copyright, and intellectual property. We hope you’ll take a few moments to explore the Library! Light refreshments will be served. No need to register or RSVP – just drop by. For questions, please contact Darlene Nichols (dpn@umich.edu).

B Cell Biology and Transplantation Conference

Thursday, September 17, 2009 – 8:00 AM - 4:30 PM
Friday, September 18, 2009 – 8:00 AM - 1:00 PM
Palmer Commons and the Biomedical Sciences Research Building
Sponsored by the UM Division of Transplantation and the Office of the Vice President for Research.

With increasing ability to control cellular immune responses, humoral immunity poses the most vexing barrier to clinical transplantation. Unfortunately, knowledge about the cellular basis of humoral immunity to transplantation is remarkably thin and few transplantation immunologists are trained in the fundamental biology of B cells. This conference will bring together leading basic and clinical scientists to focus on this timely subject. The conference will consist of three components: an educational session, a mini symposium in two sessions, and a workshop.

To register and for more information, visit (http://surgery.med.umich.edu/bcb).

The Herbert D. Doan Nanotechnology Symposium

Monday, September 21, 2009 (Register by September 11)
2:00 - 5:45 PM
Biomedical Science Research Building (BSRB) Kahn Auditorium
Hosted by Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS)

Keynote Speaker:
Eric Betzig, Ph.D., Howard Hughes Medical Institute, Janelia Farm Research Campus
“Pushing the Envelope in Biological Imaging”

Other Speakers:
Kathryn Uhrich, Ph.D., Biocompatible Polymers Program, Rutgers, The State University of New Jersey
Gregory N. Tew, Ph.D., Polymer Science and Engineering , University of Massachusetts Amherst

The program will be concluded with a poster session by Certificate in NanBiology students and other Ph.D. students.

Registration Deadline: September 11, 2009
Registration is required for these sessions due to limited space. Please register by sending an email to (MINanotech@umich.edu) with your name and interest in attending.
Visit Nano Web site for more information.

Open House - Center for Integrative Genomics

Thursday, September 24, 2009 and
Thursday, October 29, 2009
10:00 - 11:00 AM
7623 Med Sci II

The Center for Integrative Genomics offers a variety of phenotyping instrumentation for mice and rats including ultrasound imaging, rota-rod, calimetric cages, behavior screening and more. Come to our open house for a tour, meet the staff and learn about what we have to offer. No pre-registration necessary. For more information, contact Janet Hoff at (jhlvt@umich.edu) or 734-615-6906.

New Resources from the National Center for Biotechnology Information

Tuesday, September 29, 2009
2:00 - 3:00 PM
2802 Med Sci II (Taubman Library Classroom)
Sponsored by Health Sciences Libraries, Taubman Medical Library

Scientists from the National Center for Biotechnology Information (NCBI) will present a webinar on new NCBI resources. These include: the NCBI Discovery Project and changes in the Entrez system, sequence database changes, new Entrez databases (Peptidome – peptide and protein mass spectrometry data, the Short Read Archive – next generation sequencing project data, BioSystems – biochemical and signaling pathways), new BLAST services, and the new PubChem small molecule views and standalone viewer.

Space is limited so please register at (https://www-a1.lsa.umich.edu/es_conf/app/DisplaySession.asp?sessionid=3367).

"Endocrinology and Diabetes Update" Conference

Saturday, October 10, 2009
7:30 AM - 3:45 PM
Inn at St. John's, Plymouth, MI
Presented by the Division of Metabolism, Endocrinology & Diabetes (MEND), Department of Internal Medicine

This annual conference covers the latest research and recommendations in endocrinology and diabetes, presented by experts from the MEND faculty. The program is geared to primary care physicians, endocrinologists, physician assistants and nurse practitioners. Attendees can receive 6.5 AMA PRA Category 1 credits™.

Topics will include: management of hyperglycemia in an inpatient setting and in patients with high cardiovascular risk, initial workup and treatment algorithms for patients with lipid disorders, therapeutic targets and practical considerations of incretin agents in patients with type 2 diabetes, clinical manifestations and therapeutic options for the most common endocrine disorders in the elderly, and the role of vitamin D in health and disease.

Registration Deadline: September 28, 2009 (to ensure availability of educational materials)
Registration Fee: $65
To register and see the agenda / brochure, please visit (http://cme.med.umich.edu/events/course.asp?no=U022466).

Fourth Annual Michigan Metabolomics and Obesity Center (MMOC) Symposium

Monday, October 12, 2009
8:00 AM - 4:30 PM
Forum Hall, Palmer Commons
Sponsored by the Michigan Metabolomics and Obesity Center with support from the Michigan Institute for Clinical & Health Research (MICHR)

The University of Michigan scientific community is encouraged to attend this event, which will feature speakers from University of Cambridge, Northwestern University, Wayne State University, and the University of Texas Southwestern Medical Center as well as the University of Michigan. There will be seven presentations, each followed by Q&A sessions, and concurrent poster displays. CME credit is offered.

Deadline for Abstract Submission and Registration: October 1, 2009
To register and see complete information, please visit (http://www.med.umich.edu/mmoc/events).

 

A New Era in Medicine Symposium

Friday, October 16, 2009
8:00 - 10:00 AM – Posters
10:00 AM - 12:00 PM – Speakers
Dow Auditorium
Sponsored by the A. Alfred Taubman Medical Research Institute and the Michigan Institute for Clinical & Health Research (MICHR)

Keynote Speaker:
Ezekiel Emanuel, M.D., Ph.D., Head of the Department of Bioethics at The Clinical Center of the NIH
“The Physician-Patient Relationship in the Future”

Featured Speakers:
Kenneth Pienta, M.D.; David Pinsky, M.D.; James Dowling, M.D., Ph.D.

Registration Deadline: October 12, 2009.
Registration for the symposium is free. To register for the symposium and for more information, visit (http://sitemaker.umich.edu/taubmansymposium.2009/home). Please contact us as 734-615-7282 if you have any questions.

   


GRADUATE AND POSTDOC STUDIES


Graduate Student Awards Ceremony and Ice Cream Social

Thursday, September 24, 2009
3:00 - 4:30 PM
MSRB III / Med Sci II Courtyard (In case of rain: 2955 Taubman Medical Library-GAPS Conference Room/Lounge)

The Graduate Student Council (GSC) cordially invites you to the Graduate Student Awards Ceremony and Ice Cream Social. The Graduate Student Awards for Excellence in (1) Research and (2) Teaching and Service will be presented. Please contact PIBS at 734-647-7005 for further information.


KUDOS


MEND Fellow Wins Lilly Endocrine Scholars Award

Victoria Hsiao, M.D., Ph.D., Clinical Lecturer of Internal Medicine, Division of Metabolism, Endocrinology & Diabetes, is the recipient of the 2009 Lilly Endocrine Scholars Award. The national award is sponsored by The Endocrine Society and supported by Eli Lilly and Company.

The one-year fellowship is awarded to perform clinical research related to pituitary disorders, bone disorders or diabetes mellitus (in vivo studies or in vitro studies with human tissue or human cell lines). Applicants must be postdoctoral fellows who have either enrolled in or completed a U.S. adult or pediatric clinical training endocrinology program. One winner is chosen each year.

Dr. Hsiao’s winning proposal is entitled “Associations Between Hyperglycemia and Bone Marrow Transplantation Outcomes.” Dr. Hsiao’s mentor on the project is William H. Herman, M.D., M.P.H. To investigate the role of high blood sugar in bone marrow transplantation (BMT) outcomes, Dr. Hsiao will study 1,232 patients who received BMT at the University of Michigan Hospital. The results will be used to develop a feasibility study on the implementation of intensive insulin therapy in patients hospitalized for BMT.

The Lilly Endocrine Scholars Award provides $50,000 in funding, which includes a stipend, fringe benefits and indirect costs. To read more about Dr. Hsiao’s study, visit
(http://www.med.umich.edu/diabetes/news/lillyaward_hsiao.htm).


L to R: Dr. Robert Carey, the President of the Endocrine Society; award winner Vicky Hsiao, M.D., Ph.D.; and Dr. Agnes Schonbrunn, Chair of the Awards Committee.


FUNDING / AWARD OPPORTUNITIES

Funding opportunities listed below are for external limited submissions and/or opportunities within the University of Michigan only. Follow this link to search for other funding and recognition opportunities, . This webpage contains a link to M-Quest (a database of opportunities for grants, honors, prizes and fellowships created and maintained by the Office of Research) as well as information on email alert groups.

External Limited Submissions

These are opportunities in which the sponsor has limited the number of proposals allowed from an institution. These competitions require an internal review to select the proposals to submit to the sponsor from the University of Michigan.

Abstracts listed here are general information about these funding programs. We strongly urge interested applicants to visit the listed website to verify complete eligibility, program information, and application procedures before submitting an application.


The Greenwall Foundation Faculty Scholars Program in Bioethics
Internal Deadline: October 1, 2009
Foundation Deadline: November 20, 2009 (Preliminary Application)

The Greenwall Faculty Scholars Program in Bioethics is a career development award that enables outstanding junior faculty members to carry out original research on policy and moral dilemmas at the intersection of ethics and the life sciences. To maximize Scholars' development, three years of support are provided, requiring a 50% time commitment (carefully monitored) in each of the three years.

Each year, the Scholars participate in a learner-centered educational program that includes required attendance at two workshops (spring and fall). Continued involvement in this activity, after each scholar’s support period is over, provides Scholar-alumni/ae with ongoing professional development and engages them in the training of successor cohorts.

Faculty Scholars will be selected on the basis of their achievements, the strength of their research project, their commitment to the field of bioethics, and support from their home institution. While the amount of an applicant’s original work in bioethics will count favorably towards his/her application, outstanding candidates with less direct experience in bioethics will also be considered.

Applicants must be junior faculty members holding at least a 60% appointment. Priority will be given to applicants who are below the rank of Associate Professor, who have not received a comparable career development award, and whose work will have an impact on public policy or clinical practice.

UM has been invited to submit one proposal for the 2010 competition. The Office of the Vice President for Research will coordinate the internal review process. For consideration as the institutional nominee, submit the following electronically in a single PDF document to (OVPRlimitedsubmissions@umich.edu) by October 1, 2009:

  1. Two-page letter of intent responsive to the RFP, including a description of research proposal, its significance, how it will be carried out and how it is likely to have an impact on public policy or clinical practice.
  2. Personal statement describing goals in the field of bioethics.
  3. NIH formatted biosketch.
  4. Nominating letter from dean or department chair.

More information is available at the Foundation website (http://www.greenwallfsp.org). Direct any questions to Jane Ritter (ritterj@umich.edu or 734-763-1290).

Fred Hutchinson Cancer Research Center Weintraub Graduate Student Award
Deadline: December 15, 2009

The Harold M. Weintraub Graduate Student Award recognizes outstanding achievement during graduate studies in the biological sciences. Awardees will participate in a scientific symposium honoring Hal Weintraub and his commitment to innovative science. The award symposium will consist of scientific presentations by the graduate student awardees and informal gatherings of students and faculty. The graduate student awardees are expected to be advanced students near the completion of their studies. Nominated students should not have graduated before September 2009. The Fred Hutchinson Weintraub and Groudine Fund, established to foster intellectual exchange through the promotion of programs for graduate students, fellows and visiting scholars, will cover expenses for the graduate student awardees. Only one nomination may be submitted per department or program. Visit (http://www.fhcrc.org/science/basic/weintraub/index.html) for complete information.

Internal Submissions

Michigan Society of Fellows Postdoctoral Fellowships
Deadline: September 30, 2009

Each year the Society selects eight outstanding applicants for appointment to three-year postdoctoral fellowships in the humanities, the arts, the social, physical, and life sciences, and in the professional schools. The newly appointed Postdoctoral Fellows join a unique interdisciplinary community composed of their peers as well as Senior Fellows of the Society.

The Society invites applications from qualified candidates who are at the beginning of their academic careers, having received the Ph.D. or comparable professional or artistic degree between June 1, 2007, and September 1, 2010. Fellows are appointed as Assistant Professors or Research Scientists in appropriate departments and as Postdoctoral Scholars in the Michigan Society of Fellows. They are expected to be in residence during the academic years of the fellowship, to teach for the equivalent of one academic year, to participate in the informal intellectual life of the Society, and to devote time to their independent research or artistic projects. Applications from degree candidates and recipients of the Ph.D. from the University of Michigan will not be considered. The annual stipend will be $51,500. Visit (http://www.rackham.umich.edu/faculty_staff/sof/) for complete information.

Medical Innovation Center – Call for Grant Proposals
Application Deadline: October 14, 2009 (5:00 PM)

The Medical Innovation Center (MIC) is pleased to announce its second grant program made possible by the Bud Williamson Innovation Fund and the Michigan Institute for Clinical Health Research (MICHR). The awards are intended to help inventors move a medical technology idea (device or software) to the next step on the path to commercialization.

Grants may range from $2,000 to $10,000 for a period of up to one year. In addition to the grants provided, award recipients will have access to Medical Innovation Center resources to optimize their project’s success. Winning an award in this program is not just a grant of money, it is also a commitment to help you successfully move to the next step in the commercialization of your idea.

All faculty (12 month and 9 month appointments) and postdoctoral trainees from all schools and colleges at the University of Michigan are eligible to apply as Principal Investigators. As the application questions may cover topics that might not be familiar to all PIs, we recommend attending one of our information sessions:

Monday, September 21, 2009
5:00 - 6:00 PM
Ford Auditorium

Wednesday, September 23, 2009
7:30 - 8:30 AM
Ford Auditorium

For the application and guidelines, visit (http://www.med.umich.edu/ummic/about/mic_grant.shtml).

   

. . . Deadline Watch . . .

Click here to view



UMMS AWARDED GRANTS

External Awarded Grants

Currently, due to limitations on data collection, we are unable to identify projects awarded with multiple PIs. As the eRPM system is used for proposals in 2009, we will be able to publish those awards accurately. We apologize for any misleading project information this causes.

Click here to view.

Anesthesiology

PI: Clauw, Daniel
Co-I: Williams, David (Anesthesiology Department)
Title: COMPLETION OF STUDIES DEPLOYING BEHAVIORAL HEALTH INTERVENTIONS TO RURAL PATIENT POPULATIONS
Sponsor: Defense, Department of-Army, Department of the-Subcontracts TO Avera Research Institute
Project Dates and Amount of Award: 04/01/09-03/31/10; $350,000

Comprehensive Cancer Center

PI: Erba, Harry
Title: MLN4924, A NOVEL INHIBITOR OF NEDD8-ACTIVATING ENZYME, IN ADULT PATIENTS WITH ACUTE MYELOGENOUS LEUKEMIA AND HIGH-GRADE MYELODYSPLASTIC SYNDROME (AN OPEN-LABEL, DOSE ESCALATION, PHASE 1 STUDY OF)
Sponsor: Millenium Pharm, Inc.
Project Dates and Amount of Award: 04/21/09-06/30/11; $673,400

PI: Pienta, Kenneth
Co-I: Day, Mark (Urology Surgery) / Hussain, Maha (Int Med-Hematology/Oncology)
Title: SPORE IN PROSTATE CANCER
Sponsor: NIH 3 P50 CA 068568 11 S1
Project Dates and Amount of Award: 06/01/09-09/30/10; $163,548

Cell & Developmental Biology

PI: Dishinger, John
Title: REGULATION OF NEURON DEVELOPMENT & CILIARY FUNCTION BY MICROTUBULE GLUTAMYLATION
Sponsor: NIH 1 F32 GM 089034 01
Project Dates and Amount of Award: 07/01/09-06/30/12; $148,974

PI: Durance, Michelle
Title: EFFECTS OF HEDGEHOG SIGNALING IN MICE OF INTESTINAL IMMUNE DEVELOPMENT
Sponsor: Chron''S And Colitis Foundation
Project Dates and Amount of Award: 06/15/09-06/14/10; $2,500

PI: Obara, Naoshi
Title: FUNCTIONAL ANALYSIS OF THE DRED REPRESSOR: SEARCH FOR LIGANDS AND VALIDATION OF CO-REPRESSOR COMPLEXES
Sponsor: Cooley'S Anemia Foundation
Project Dates and Amount of Award: 07/01/09-06/30/10; $40,000

Emergency Medicine

PI: Younger, John
Co-I: Solomon, Michael (Chemical Engineering Dept)
Title: BIOMECHANICS OF BLOOD STREAM INFECTIONS
Sponsor: NIH 1 R01 GM 081702 01 A2
Project Dates and Amount of Award: 06/01/09-04/30/13; $1,753,602

Family Medicine

PI: Longworth, Zora
Title: A MEDITERRANEAN DIET IN COLON CANCER PREVENTION
Sponsor: NIH 3 R01 CA 120381 03 S1
Project Dates and Amount of Award: 06/01/09-09/30/10; $38,112

Human Genetics

PI: Mustapha-Chaib, Mirna
Title: UNDERSTANDING THYROID HORMONE REGULATION OF NEUROGENESIS IN THE COCHLEA
Sponsor: NIH 1 R01 DC 009590 01 A1
Project Dates and Amount of Award: 07/01/09-06/30/14; $1,579,025

Internal Medicine

PI: Baptist, Alan
Title: ASTHMA SELF-MANAGEMENT FOR OLDER ADULTS
Sponsor: American Academy of Allergy, Asthma and Immunology (AAAAI)
Project Dates and Amount of Award: 07/01/09-06/30/12; $150,000

PI: Brook, Robert
Title: CARDIO-METABOLIC RESPONSES TO SUB-ACUTE TIME PERIODS OF PM2.5 EXPOSURE
Sponsor: Electric Power Research Institute (EPRI)
Project Dates and Amount of Award: 03/09/09-12/31/10; $250,638

PI: Brook, Robert
Co-I: Dvonch, Joseph (School of Public Health)
Title: AIR POLLUTION AND HYPERTENSION: VASCULAR MECHANISMS
Sponsor: NIH - Subcontracts TO Ohio State University Research Foundation
Project Dates and Amount of Award: 01/01/09-12/31/09; $115,260

PI: Campagnaro, Erica
Title: UMCC 2008.084: AN OPEN-LABEL, SINGLE-ARM PHASE II STUDY OF RAD001 (EVEROLIMUS) IN PATIENTS WITH REFRACTORY MANTLE CELL LYMPHOMA
Sponsor: Novartis Pharmaceuticals
Project Dates and Amount of Award: 05/06/09-05/04/12; $202,572

PI: Chandra, Preeti
Title: HEART RATE VARIABILITY IN CHRONIC KIDNEY DISEASE
Sponsor: National Kidney Foundation
Project Dates and Amount of Award: 07/01/09-06/30/11; $100,000

PI: Chang, Lin
Title: THE ROLE OF NRF2 IN NITROALKENE-PROTECTED VASCULAR LESION FORMATION
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/09-06/30/12; $214,499

PI: Cibrik, Diane
Title: CP-690, 550 IN RENAL ALLOGRAFT RECIPIENTS: JAK III EXTENSION
Sponsor: Pfizer Incorporated TO ICON Clinical Research, Inc.
Project Dates and Amount of Award: 05/01/10-04/30/12; $58,593

PI: Cooney, Kathleen
Title: GENOME-WIDE SCAN FOR GENETIC VARIANTS ASSOCIATED WITH EARLY-ONSET PROSTATE CANCER
Sponsor: NIH 1 R01 CA 136621 01 A1
Project Dates and Amount of Award: 07/01/09-06/30/12; $2,413,595

PI: Fendrick, A
Title: IMPLICATIONS OF POOR ADHERENCE TO GASTROPROTECTIVE THERAPY IN PATIENTS RECEIVING CHRONIC NSAIDS
Sponsor: AstraZeneca plc
Project Dates and Amount of Award: 01/16/09-11/30/09; $12,000

PI: Gitlin, Scott
Title: HEMATOLOGY/ONCOLOGY FELLOWSHIP
Sponsor: Amgen, Inc.
Project Dates and Amount of Award: 05/19/09-06/30/10; $40,000

PI: Gitlin, Scott
Title: INFRASTRUCTURE SUPPORT-HEMATOLOGY/ONCOLOGY FELLOWSHIP
Sponsor: Sanofi-Aventis Pharmaceuticals
Project Dates and Amount of Award: 07/01/09-06/30/10; $74,750

PI: Hayward, Rodney
Title: RWJ CLINICAL SCHOLARS COHORT 2009-2011
Sponsor: Johnson, Robert Wood, Fdn.
Project Dates and Amount of Award: 07/01/09-06/30/11; $1,085,885

PI: Henry, N.
Title: PREDICTORS OF OVARIAN FUNCTION IN WOMEN TREATED WITH ARMOMATASE INHIBITORS
Sponsor: NIH 1 K07 CA 134747 01 A1
Project Dates and Amount of Award: 08/01/09-07/31/14; $860,360

PI: Hsiao, Victoria
Title: ASSOCIATIONS BETWEEN HYPERGLYCEMIA AND BONE MARROW TRANSPLANTATION OUTCOMES
Sponsor: Endocrine Society, The
Project Dates and Amount of Award: 07/01/09-06/30/10; $50,000

PI: Kaminski, Mark
Title: 2008.109: A PHASE II STUDY OF ORAL PANOBINOSTAT IN ADULT PATIENTS WITH RELAPSED/REFRACTORY CLASSICAL HODGKIN'S LYMPHOMA
Sponsor: Novartis Pharmaceuticals
Project Dates and Amount of Award: 06/15/09-06/14/12; $418,632

PI: Kappes, Ferdinand
Title: POSTTRANSLATIONAL MODIFICATIONS OF DEK AND THEIR ROLE IN AUTOIMMUNITY
Sponsor: Arthritis Foundation, The
Project Dates and Amount of Award: 07/01/09-06/30/10; $50,000

PI: Kaul, Daniel
Title: CMX001 IN POSTTRANSPLANT SUBJECTS WITH BK VIRUS VIRURIA (A MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, MULTIPLE DOSE STUDY OF THE SAFETY, TOLERABILITY AND POPULATION PHARMACOKINETICS OF)
Sponsor: Chimerix, Inc. TO Ppd Development, Lp
Project Dates and Amount of Award: 06/04/09-06/03/11; $52,616

PI: Leichtman, Alan
Title: COST: THE CORONARY SCREENING FOR KIDNEY TRANSPLANTATION (COST) FEASIBILITY STUDY
Sponsor: NIH - Subcontracts TO University of Minnesota
Project Dates and Amount of Award: 01/02/09-12/31/09; $5,000

PI: Lok, Anna
Title: TREATMENT WITH HCV PROTEASE INHIBITOR R05190591 IN COMBINATION WITH PEGASYS AND COPEGUS IN TREATMENNAIVE PATIENTS WITH CHRONIC HEP C GENOTYPE 1 VIRUS INFECTION PROTOCOL NV21075
Sponsor: Hoffmann-Laroche, Inc
Project Dates and Amount of Award: 08/12/09-11/30/11; $203,342

PI: Lundy, Steven
Title: DEPENDENCE OF ARTHRITIS ANTIGEN-SPECIFIC TH17 CELL DEVELOPMENT ON B CELLS
Sponsor: Arthritis Foundation, The
Project Dates and Amount of Award: 07/01/09-06/30/10; $85,500

PI: Marks, Rory
Title: ACR/REF RHEUMATOLOGY FELLOWSHIP TRAINING AWARD
Sponsor: Amer College of Rheumatology
Project Dates and Amount of Award: 07/01/09-06/30/10; $25,000

PI: Martini, Sebastian
Title: TOWARDS PERSONALIZED MOLECULAR MEDICINE OF NEPHROTIC SYNDROME: TRANSCRIPTIONAL NETWORK ANALYSIS TO PREDICT TREATMENT RESPONSE IN FSGS
Sponsor: NephCure Foundation
Project Dates and Amount of Award: 07/01/09-06/30/11; $130,000

PI: McLaughlin, Vallerie
Title: ACT-064992 IN PATIENTS WITH SYMPTOMATIC PULMONARY ARTERIAL HYPERTENSION (LONG-TERM SINGLE-ARM OPEN-LABEL EXTENSION STUDY OF THE SERAPHIN STUDY, TO ASSESS THE SAFETY AND TOLERABILITY OF)
Sponsor: Actelion
Project Dates and Amount of Award: 06/17/09-06/16/14; $174,075

PI: McLaughlin, Vallerie
Title: ACT-064992 ON MORBIDITY AND MORTALITY IN PATIENTS WITH SYMPTOMATIC PULMONARY ARTERIAL HYPERTENSION (A MULTICENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED PARALLEL GROUP, EVENT-DRIVEN PHASE III STUDY TO ASSESS THE EFFECTS OF)
Sponsor: Actelion
Project Dates and Amount of Award: 06/18/09-06/17/13; $190,420

PI: Mor-Vaknin, Nirit
Co-I: Koch, Alisa (Int Med-Rheumatology) / Markovitz, David (Int Med-Infectious Diseases)
Title: THE ROLE OF DEK IN THE DEVELOPMENT OF ARTHRITIS
Sponsor: NIH 1 K01 AR 055620 01 A2
Project Dates and Amount of Award: 07/01/09-05/31/14; $639,301

PI: Owyang, Chung
Co-I: Turgeon, Danielle (Int Med-Gastroenterology) / Wang, Thomas (Int Med-Gastroenterology)
Title: A TOXICOLOGY STUDY OF FLUORESCENCE LABELED PEPTIDES
Sponsor: Olympus Corporation
Project Dates and Amount of Award: 06/23/09-03/31/10; $100,000

PI: Schuetze, Scott
Title: 2008.102: A RANDOMIZED, OPEN-LABELED, MULTI-CENTER PHASE III STUDY TO EVALUATE THE EFFICACY AND SAFETY OF NILOTINIB VERSUS IMATINIB IN ADULTS PATIENTS WITH UNRESECTABLE OR METASTATIC GASTROINTESTINAL STROMAL TUMORS (GIST)
Sponsor: Novartis
Project Dates and Amount of Award: 06/02/09-06/01/22; $800,955

PI: Seibold, James
Co-I: Mahmood, Fazle (Int Med-Rheumatology)
Title: A STUDY OF A TOPICAL FORMULATION OF NITROGLYCERIN, VASCANA(MQX-503), AND MATCHING VEHICLE IN THE TREATMENT AND PREVENTION OF SYMPTOMS ASSOCIATED WITH RAYNAUD'S PHENOMENON (MEDIQUEST-VASCANA)
Sponsor: Mediquest Therapeutics, Inc.
Project Dates and Amount of Award: 06/16/09-06/15/10; $188,723

PI: Shayman, James
Co-I: Bodary, Peter (Division of Kinesiology) / Pennathur, Subramaniam (Int Med-Nephrology)
Title: THE PHARMACOLOGICAL TREATMENT OF FABRY DISEASE
Sponsor: NIH 2 R01 DK 055823 09 A1
Project Dates and Amount of Award: 07/01/09-04/30/14; $1,700,337

PI: Vaidyanathan, Ravi
Title: REGULATION OF KIR2 CHANNELS IN A MACROMOLECULAR COMPLEX
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 01/01/09-12/31/11; $52,000

PI: Xie, Changqing
Title: MIR-10A IS A NOVEL DETERMINANT TO CONTROL SMOOTH MUSCLE CELL DIFFERENTIATION
Sponsor: American Heart Assoc, Inc.
Project Dates and Amount of Award: 07/01/09-06/30/13; $308,000

PI: Young, Vincent
Co-I: Cavalcoli, James (Computational Medicine and Bio) / Huffnagle, Gary (Int Med-Pulm./Critical Care)
Title: THE ROLE OF THE GUT MICROBIOTA IN ULCERATIVE COLITIS
Sponsor: NIH 1 UH2 DK 083993 01
Project Dates and Amount of Award: 06/01/09-05/31/10; $1,087,800

Microbiology and Immunology

PI: Dirita, Victor
Title: MOLECULAR MECHANISMS OF MICROBIAL PATHOGENESIS TRAINING PROGRAM
Sponsor: NIH 2 T32 AI 007528 11 A1
Project Dates and Amount of Award: 07/01/09-06/30/14; $1,749,175

PI: Imperiale, Michael
Title: ENCAPSIDATION OF ADENOVIRUS DNA
Sponsor: NIH 2 R01 AI 052150 06 A2
Project Dates and Amount of Award: 05/22/09-04/30/11; $695,250

PI: Imperiale, Michael
Co-I: Cibrik, Diane (Int Med-Nephrology)
Title: PARAMETERS GOVERNING KIDNEY CELL INFECTION WITH BKV
Sponsor: NIH 3 R01 AI 060584 05 S1
Project Dates and Amount of Award: 06/05/09-10/31/09; $19,056

PI: Raghavan, Malini
Title: CALRETICULIN'S FUNCTIONS IN THE ADAPTIVE IMMUNE RESPONSE
Sponsor: NIH 3 R01 AI 066131 03 S1
Project Dates and Amount of Award: 07/14/09-09/30/10; $22,866

PI: Sandkvist, Maria
Title: TARGETING OF TYPE II SECRETION, A COMMON VIRULENCE PATHWAY
Sponsor: NIH 1 R01 AI 081705 01
Project Dates and Amount of Award: 06/01/09-05/31/11; $759,922

PI: Sandkvist, Maria
Title: ORGANIZATION AND FUNCTION OF A TYPE II SECRETION COMPLEX
Sponsor: NIH 2 R01 AI 049294 08 A2
Project Dates and Amount of Award: 06/01/09-05/31/11; $760,358

PI: Spindler, Katherine
Title: CLONING A MAJOR GENE FOR MOUSE ADENOVIRUS SUSCEPTIBILITY
Sponsor: NIH 3 R01 AI 068645 04 S1
Project Dates and Amount of Award: 06/05/09-09/30/10; $76,014

PI: Swanson, Joel
Title: COORDINATION OF SIGNALING DURING PHAGOCYTOSIS
Sponsor: NIH 3 R01 AI 064668 05 S1
Project Dates and Amount of Award: 06/05/09-10/31/09; $21,630

PI: Swanson, Michele
Title: ANALYSIS OF L. PNEUMOPHILIA VIRULENCE REGULATION
Sponsor: NIH 3 R01 AI 044212 09 S1
Project Dates and Amount of Award: 06/05/09-10/31/09; $15,759

Molecular & Behavioral Neuroscience Institute

PI: Flagel, Shelly
Title: INDIVIDUAL DIFFERENCES IN INCENTIVE SALIENCE ATTRIBUTION: RELEVANCE TO ADDICTION
Sponsor: NIH 1 R03 DA 024768 01 A2
Project Dates and Amount of Award: 06/01/09-05/31/11; $151,750

PI: Lopez, Juan
Co-I: Patel, Paresh (Molecular & Behav Neurosc Inst)
Title: MATERNAL BEHAVIOR AND EFFECTS OF PATERNAL AFFILIATION IN 5-HT1A OVEREXPRESSING MICE
Sponsor: NIH 1 R21 MH 083311 01
Project Dates and Amount of Award: 06/08/09-05/31/11; $413,430

PI: Young, Elizabeth
Co-I: Lopez, Juan (Molecular & Behav Neurosc Inst) / Seyfried, Lisa (Psychiatry Department)
Title: MR:GR BALANCE IN DEPRESSION
Sponsor: NIH 1 R01 MH 083670 01 A1
Project Dates and Amount of Award: 05/15/09-04/30/13; $1,545,000

Molecular & Integrative Physiology

PI: Faulkner, John
Title: REACTIVE OXYGEN SPECIES: STRESS AND DAMAGE IN OLD MUSCLES (09-060 SUPP)
Sponsor: NIH 3 P01 AG 020591 07 S1
Project Dates and Amount of Award: 07/01/09-10/31/10; $78,684

PI: Herzog, Susan
Title: MECHANISMS UNDERLYING MECHANICAL PROPERTIES OF MUSCLE-TENDON UNITS
Sponsor: NIH 3 R01 AR 055624 02 S2
Project Dates and Amount of Award: 06/10/09-08/31/10; $60,256

PI: Larkin, Lisa
Title: ENGINEERING INNERVATED MUSCLE-TENDON CONSTRUCTS FOR TISSUE REGENERATION
Sponsor: NIH 3 R01 AR 054778 03 S1
Project Dates and Amount of Award: 06/10/09-08/31/10; $86,192

PI: MacDougald, Ormond
Title: REGULATION OF ADIPOCYTE DIFFERENTIATION AND METABOLISM
Sponsor: NIH 3 R01 DK 051563 12 S1
Project Dates and Amount of Award: 05/13/09-06/30/11; $38,218

PI: Samuelson, Linda
Title: MECHANISMS OF GASTRIC MUCOSAL TRANSFORMATION IN HIP1R-DEFICIENT MICE (09-060 SUPP)
Sponsor: NIH 3 R01 DK 078927 02 S1
Project Dates and Amount of Award: 06/15/09-05/31/11; $38,218

PI: Stuenkel, Edward
Title: MECHANISMS OF RAB27 REGULATION OF INSULIN SECRETION (09-056 SUPP)
Sponsor: NIH 3 R01 DK 077050 01 A2S1
Project Dates and Amount of Award: 05/11/09-06/30/11; $24,182

PI: Williams, John
Title: DIETARY REGULATION OF PANCREATIC DIGESTIVE ENZYMES
Sponsor: NIH 3 R01 DK 059578 06 A2S1
Project Dates and Amount of Award: 06/15/09-05/31/11; $38,218

Neurology

PI: Morgenstern, Lewis
Co-I: Brown, Devin (Neurology Department)
Title: STROKE HEALTH AND RISK EDUCATION (SHARE)
Sponsor: NIH 1 R01 NS 062675 01 A1
Project Dates and Amount of Award: 06/15/09-05/31/14; $3,207,503

PI: O'Brien, Louise
Co-I: Chervin, Ronald (Neurology Department) / Johnson, Timothy (Obstetrics and Gynecology Dept)
Title: USE OF PAP IN WOMEN WITH PRE-ECLAMPSIA
Sponsor: NIH 1 K23 HL 095739 01
Project Dates and Amount of Award: 06/01/09-01/31/14; $604,036

PI: O'Brien, Louise
Co-I: Chervin, Ronald (Neurology Department) / Kalbfleisch, John (Biostatistics Department) / Warschausky, Seth (Physical Medicine & Rehab Dept)
Title: SLEEP AND NEUROBEHAVIORAL PERFORMANCE AFTER CLEFT PALATE REPAIR
Sponsor: NIH 1 R21 HL 087819 01 A2
Project Dates and Amount of Award: 07/01/09-06/30/11; $416,966

PI: O'Brien, Louise
Co-I: Bullough, Alexandra (Anesthesiology Department) / Chervin, Ronald (Neurology Department) / Kalbfleisch, John (Biostatistics Department) / Mhyre, Jill (Anesthesiology Department)
Title: THE IMPACT OF SLEEP-DISORDERED BREATHING ON ADVERSE PREGNANCY OUTCOMES
Sponsor: NIH 1 R21 HL 089918 01 A2
Project Dates and Amount of Award: 07/01/09-06/30/11; $424,832

Neurosurgery

PI: Valdivia, Juan Martin
Title: DEPUY SPINE FELLOWSHIP CLINICAL TRAINING GRANT
Sponsor: DePuy Spine Inc.
Project Dates and Amount of Award: 07/01/09-06/30/10; $80,000

Obstetrics & Gynecology

PI: Harris, Lisa
Co-I: Hassinger, Jane (Inst/Research Women & Gender)
Title: STRENGTHENING HUMAN RESOURCES FOR ABORTION: SELF-CARE FOR THE ABORTION TEAM
Sponsor: Society of Family Planning
Project Dates and Amount of Award: 10/01/09-10/01/11; $120,000

Ophthalmology & Visual Sciences

PI: Kahana, Alon
Title: ZEBRAFISH AS A MODEL FOR STUDYING TWIST GENE REGULATION AND FUNCTION IN MESENCHYMAL CELLS AND BREAST CANCER
Sponsor: Research To Prevent Blindness
Project Dates and Amount of Award: 07/01/09-06/30/13; $200,000

PI: Khanna, Hemant
Title: CILIA-DEPENDENT SIGNAL TRANSDUCTION AND PHOTORECEPTOR DEGENERATION
Sponsor: Midwest Eye Banks and Transplantation Center
Project Dates and Amount of Award: 07/01/09-06/30/10; $15,000

PI: Mian, Shahzad
Title: FEMTOSECOND LASER ASSISTED KERATOPLASTY: CLINICAL OUTCOMES
Sponsor: Midwest Eye Banks and Transplantation Center
Project Dates and Amount of Award: 07/01/09-06/30/10; $15,000

PI: Moroi, Sayoko
Title: IDENTIFYING GENOMIC DETERMINANTS OF A THIN CENTRAL CORNEA AS A RISK FACTOR FOR GLAUCOMA
Sponsor: Midwest Eye Banks and Transplantation Center
Project Dates and Amount of Award: 07/01/09-06/30/10; $15,000

PI: Musch, David
Title: INSIGHTS ON GLAUCOMA FROM ANALYSIS OF CIGTS OUTCOME DATA
Sponsor: Research To Prevent Blindness
Project Dates and Amount of Award: 07/01/09-06/30/10; $60,000

PI: Petty, Howard
Title: RETINAL METABOLIC ANALYSIS OF GLAUCOMA
Sponsor: Midwest Eye Banks and Transplantation Center
Project Dates and Amount of Award: 07/01/09-06/30/10; $15,000

PI: Richards, Julia
Title: MOLECULAR GENETICS OF PRIMARY OPEN-ANGLE GLAUCOMA
Sponsor: NIH 2 R01 EY 011671 09 A2
Project Dates and Amount of Award: 07/01/09-06/30/12; $2,136,016

PI: Zacks, David
Title: ACTIVATION OF AUTOPHAGY DURING RETINAL DETACHMENT
Sponsor: Midwest Eye Banks and Transplantation Center
Project Dates and Amount of Award: 07/01/09-06/30/10; $15,000

PI: Zacks, David
Title: ACTIVATION OF AUTOPHAGY DURING RETINAL DETACHMENT - BESIRLI
Sponsor: Midwest Eye Banks and Transplantation Center
Project Dates and Amount of Award: 07/01/09-06/30/10; $2,500

PI: Zacks, David
Title: X-LINKED INHIBITOR OF APOPTOSIS AS A MODULATOR OF PHOTORECEPTOR CELL DEATH DURING RETINAL DETACHMENT
Sponsor: Research To Prevent Blindness
Project Dates and Amount of Award: 07/01/09-06/30/11; $55,000

Otolaryngology

PI: Garadat, Soha
Co-I: Zwolan, Teresa (Otorhinolaryngology Department)
Title: ACROSS-SITE PATTERNS OF MODULATION DETECTION: RELATION TO SPEECH RECOGNITION
Sponsor: NIH 1 F32 DC 010318 01
Project Dates and Amount of Award: 06/23/09-06/22/11; $97,264

PI: King, William
Co-I: Raphael, Yehoash (Kresge Hearing Research Inst)
Title: VESTIBULAR REFLEXES IN GUINEA PIGS
Sponsor: NIH 1 R21 DC 009293 01
Project Dates and Amount of Award: 06/05/09-05/31/11; $418,766

PI: Kohrman, David
Co-I: Aldridge, J (Neurology Department) / Altschuler, Richard (Kresge Hearing Research Inst) / Barald, Kate (Cell and Developmental Biology) / Berridge, Kent (LSA Psychology) / Bradley, Robert (Biologic and Materials Science) / Burmeister, Margit (Human Genetics Department) / Camper, Sally (Human Genetics Department) / Carey, Thomas (Kresge Hearing Research Inst) / Dolan, David (Kresge Hearing Research Inst) / Duncan, Robert (Kresge Hearing Research Inst) / Glaser, Thomas (Int Med-Molecular Med&Genetics) / Grosh, Karl (Biomedical Engineering) / King, William (Otorhinolaryngology Department) / Kipke, Daryl (Biomedical Engineering) / Lesperance, Marci (Otorhinolaryngology Department) / Lomax, Margaret (Kresge Hearing Research Inst) / Martens, Jeffrey (Pharmacology Department) / Martin, Donna (Human Genetics Department) / Meisler, Miriam (Human Genetics Department) / Miller, Josef (Kresge Hearing Research Inst) / Mistretta, Charlotte (Biologic and Materials Science) / Najafi, Khalil (Biomedical Engineering) / Pfingst, Bryan (Kresge Hearing Research Inst) / Raphael, Yehoash (Kresge Hearing Research Inst) / Schacht, Helga (Kresge Hearing Research Inst) / Shore, Susan (Kresge Hearing Research Inst) / Zochowski, Michal (LSA Biophysics)
Title: SENSORY MECHANISMS AND DISORDERS
Sponsor: NIH 2 T32 DC 000011 31
Project Dates and Amount of Award: 07/01/09-06/30/14; $1,770,590

PI: Lesperance, Marci
Co-I: Burmeister, Margit (Molecular & Behav Neurosc Inst)
Title: AN INTEGRATIVE GENOMIC APPROACH TO DISCOVERING OTOSCLEROSIS GENES
Sponsor: Amer Otological Society, Inc.
Project Dates and Amount of Award: 07/01/09-06/30/10; $55,000

PI: Papagerakis, Silvana
Co-I: Prince, Mark (Otorhinolaryngology Department)
Title: METASTATIC AND INVASIVE BEHAVIOR OF HEAD AND NECK CANCER STEM CELLS
Sponsor: American Academy of Otolaryngology - Head & Neck Surgery Foundation, Inc.
Project Dates and Amount of Award: 07/01/09-06/30/10; $25,000

PI: Schacht, Jochen
Title: PROTECTION FROM AMINOGLYCOSIDE OTOTOXICITY
Sponsor: NIH 2 R01 DC 003685 11 A2
Project Dates and Amount of Award: 07/01/09-06/30/14; $1,628,590

Pathology

PI: Chensue, Stephen
Title: CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
Sponsor: NIH 2 R01 AI 043460 09 A2
Project Dates and Amount of Award: 07/01/09-11/30/13; $1,260,000

PI: Chinnaiyan, Arul
Title: THE GENENTECH FOUNDATION FELLOWSHIP PROGRAM AT THE MICHIGAN CENTER FOR TRANSLATIONAL PATHOLOGY
Sponsor: Genentech Foundation
Project Dates and Amount of Award: 09/01/09-08/31/12; $183,818

PI: Kumar, Chandan
Co-I: Chinnaiyan, Arul (Ctr fr Translational Pathology)
Title: DISCOVERY OF CHIMERIC TRANSCRIPTS IN PANCREATIC CANCER USING HIGH-THROUGHPUT SEQUENCING
Sponsor: Lustgarten, Foundation for Pancreatic Cancer Research
Project Dates and Amount of Award: 01/01/09-12/31/09; $100,000

PI: Lukacs, Nicholas
Title: THE ROLE OF CC CHEMOKINES IN EOSINOPHIL AIRWAY INFLAMMATION
Sponsor: NIH 3 R01 AI 036302 12 S1
Project Dates and Amount of Award: 06/01/09-09/30/10; $66,435

PI: Lukacs, Nicholas
Title: TESTING COMPOUNDS SPECIFIC FOR CXCR2 IN A MODEL OF RSV-INDUCED DISEASE
Sponsor: Novartis Pharmaceuticals
Project Dates and Amount of Award: 07/01/09-06/30/10; $48,685

PI: Nikolovska-Coleska, Zaneta
Title: DISCOVERY OF NOVEL DOT1L INHIBITORS USING MULTIPLE HIGH-THROUGHPUT SCREENING
Sponsor: Leukemia Res. Fdn. Inc.
Project Dates and Amount of Award: 07/01/09-06/30/10; $96,350

PI: Schaller, Matthew
Title: SSEA4 MARKS A NOVEL STEM CELL IN THE LUNG
Sponsor: Francis Families Foundation
Project Dates and Amount of Award: 07/01/09-06/30/12; $156,000

PI: Varani, James
Title: DIETARY MARINE ALGAE EXTRACT AND COLON CANCER CHEMOPREVENTION
Sponsor: NIH 1 R21 CA 140760 01
Project Dates and Amount of Award: 05/15/09-04/30/11; $373,893

Pediatrics & Communicable Diseases

PI: Hershenson, Marc
Title: RHINOVIRUS AND AIRWAY EPITHELIAL CELL RESPONSES #2
Sponsor: NIH 3 R01 HL 081420 04 S1
Project Dates and Amount of Award: 06/01/09-08/31/10; $23,978

PI: Kershaw, David
Co-I: Hildebrandt, Friedhelm (Pediatrics-Nephrology)
Title: RESEARCH TRAINING IN PEDIATRIC NEPHROLOGY
Sponsor: NIH 2 T32 DK 065517 06
Project Dates and Amount of Award: 07/01/09-06/30/14; $903,652

PI: Levine, John
Title: ADDITION OF ETANERCEPT AND EXTRACORPOREAL PHOTOPHERESIS TO STANDARD GVHD PROPHYLAXIS IN PATIENTS UNDERGOING REDUCED INTENSITY UNRELATED DONOR HEMATOPOIETIC STEM CELL TRANSPLANT
Sponsor: Therakos, Inc.
Project Dates and Amount of Award: 12/18/08-12/14/11; $254,325

PI: Nasr, Samya
Co-I: Filbrun, Amy (Pediatrics-Pulmonary Medicine) / Lumeng, Carey (Pediatrics-Pulmonary Medicine)
Title: EFFICACY AND SAFETY OF ULTRASE MT12 IN THE CONTROL OF STEATORRHEA IN CYSTIC FIBROSIS (CF) AND PANCREATIC INSUFFICIENT (PI) CHILDREN AGES 2 TO 6 YEARS OLD
Sponsor: Axcan Pharma
Project Dates and Amount of Award: 03/12/09-07/13/10; $43,090

PI: Nasr, Samya
Co-I: Arteta, Manuel (Pediatrics-Pulmonary Medicine) / Filbrun, Amy (Pediatrics-Pulmonary Medicine) / Lumeng, Carey (Pediatrics-Pulmonary Medicine) / Tsai, Wan (Pediatrics-Pulmonary Medicine)
Title: EVALUATING FOSFOMYCIN/TOBRAMYCIN FOR INHALATION IN PATIENTS WITH CYSTIC FIBROSIS AND PSEUDOMONAS AERUGINOSA (A PHASE 2, DOUBLE-BLIND, MULTICENTER, RANDOMIZED, PLACEBO-CONTROLLED TRIAL)
Sponsor: Gilead Sciences, Inc.
Project Dates and Amount of Award: 04/09/09-03/31/10; $50,490

PI: Pipe, Steven
Title: BAXTER PROTOCOL 060703: RETROSPECTIVE ADVATE IMMUNE TOLERANCE INDUCTION REGISTRY
Sponsor: Baxter Healthcare Corporation
Project Dates and Amount of Award: 05/07/09-05/06/10; $12,200

PI: Sajjan, Umadevi
Co-I: Hershenson, Marc (Pediatrics-Pulmonary Medicine) / Lipuma, John (Pediatrics-Infectious Diseases)
Title: CO-INFECTIONS OF RHINOVIRUS AND BACTERIA IN CHRONIC LUNG DISORDERS
Sponsor: NIH 1 R21 HL 089772 01 A1
Project Dates and Amount of Award: 06/01/09-05/31/11; $422,550

PI: Shanley, Thomas
Co-I: Ohye, Richard (Cardiac Surgery Section)
Title: EFFECTS OF GLYCEMIC CONTROL ON IMMUNITY
Sponsor: NIH 1 R01 HL 097361 01
Project Dates and Amount of Award: 06/01/09-05/31/13; $1,575,774

Pharmacology

PI: Calhoun, Jeffrey
Title: ROLE OF SODIUM CHANNEL BETA 1 IN NA+ CURRENT MODULATION AND CELL-CELL COUPLING IN THE HEART
Sponsor: American Heart Association, Midwest Affiliate
Project Dates and Amount of Award: 07/01/09-06/30/11; $52,000

PI: Chen, Rong
Co-I: Gnegy, Margaret (Pharmacology Department)
Title: DOPAMINE TRANSPORTER TRAFFICKING AND ITS INTERACTING PROTEINS
Sponsor: NIH 1 R03 DA 025954 01 A1
Project Dates and Amount of Award: 06/01/09-05/31/11; $154,500

PI: Gnegy, Margaret
Title: PHARMACOLOGY OF DOPAMINE RELEASE BY AMPHETAMINE - SUMMER RESEARCH EXPERIENCE- BG
Sponsor: NIH 3 R01 DA 011697 09 S2
Project Dates and Amount of Award: 06/01/09-10/31/09; $20,694

Psychiatry

PI: Blow, Frederic
Title: CUSTOMIZED TREATMENT ADHERENCE ENHANCEMENT IN BIPOLAR DISORDER
Sponsor: NIH - Subcontracts TO Case Western Reserve Univ R34 MH
Project Dates and Amount of Award: 07/01/08-11/30/09; $10,000

PI: Ilgen, Mark
Co-I: Blow, Frederic (Psych HlthSvc Outcome Research) / Chermack, Stephen (Psych Substance Abuse)
Title: DEVELOPING AN INTERVENTION TO ADDRESS SUICIDE RISK DURING SUBSTANCE USE DISORDER TREATMENT
Sponsor: NIH 1 R21 DA 026925 01
Project Dates and Amount of Award: 06/01/09-05/31/11; $424,875

PI: Walton, Maureen
Co-I: Barry, Kristen (Psych Substance Abuse) / Blow, Frederic (Psych HlthSvc Outcome Research) / Cunningham, Rebecca (Emergency Medicine UM Adult) / Ehrlich, Peter (Pediatric Surgery Section)
Title: OPTIMIZING BRIEF ALCOHOL INTERVENTION FOR UNDERAGE DRINKERS IN THE ER
Sponsor: NIH 1 R01 AA 018122 01
Project Dates and Amount of Award: 06/15/09-05/31/14; $3,689,934

Radiation Oncology

PI: Jagsi, Reshma
Title: A MIXED QUALITATIVE AND QUANTITATIVE INVESTIGATION INTO THE BARRIERS FACING JUNIOR PHYSICIAN FACULTY RESEARCHERS
Sponsor: Johnson, Robert Wood, Fdn.
Project Dates and Amount of Award: 07/01/09-06/30/12; $300,000

PI: Williams, Terence
Title: IDENTIFICATION OF ANTI-NEOPLASTIC FADD KINASE INHIBITORS UTILIZING A MOLECULAR IMAGING-BASED HIGH THROUGHPUT SCREEN
Sponsor: Radiological Society of North America
Project Dates and Amount of Award: 07/01/09-06/30/10; $30,000

PI: Xu, Liang
Title: PROSTATE CANCER ANDROGEN-INDEPENDENCE TRANSITION INVOLVES PROSTATE CANCER STEM CELLS THAT ARE REGULATED BY MICRORNA MIR-34
Sponsor: The Fund For Cancer Research
Project Dates and Amount of Award: 06/01/09-05/31/10; $75,000

Radiology

PI: Clinthorne, Neal
Co-I: Piert, Morand (Radiology Department)
Title: HIGH RESOLUTION PET IMAGING PROBE FOR THE DETECTION, MOLECULAR CHARACTERIZATION AND TREATMENT MONITORING OF PROSTATE CANCER
Sponsor: US DOD-Army, Department of the
Project Dates and Amount of Award: 07/01/09-07/31/12; $639,746

PI: Fowlkes, J
Co-I: Kripfgans, Oliver (Radiology Department) / Myles, James (Mich Inst for Clin & Hlth Resr) / Rubin, Jonathan (Radiology Department) / Weitzel Iii, William (Int Med-Nephrology)
Title: QUANTIFICATION OF BLOOD VOLUME FLOW USING ULTRASOUND
Sponsor: NIH 2 R01 HL 067921 04 A2
Project Dates and Amount of Award: 07/01/09-06/30/11; $681,339

PI: Kelly, Aine
Title: THE INFLUENCE OF TEACHING EVIDENCE BASED IMAGING PATHWAYS ON APPROPRIATE IMAGING UTILIZATION RATES IN A LARGE ACADEMIC RADIOLOGY DEPARTMENT
Sponsor: Radiological Society of North America
Project Dates and Amount of Award: 07/01/09-06/30/11; $150,000

PI: Kilbourn, Michael
Co-I: Shao, Xia (Radiology-Nuclear Medicine)
Title: SIMPLIFICATION OF METHODS FOR PET RADIOPHARMACEUTICAL SYNTHESES
Sponsor: U.S. Energy, Department of
Project Dates and Amount of Award: 09/15/08-09/14/10; $651,078

PI: Ross, Brian
Title: IMAGE BIOMARKER DEVELOPMENT FOR TREATMENT EFFICACY OF PROSTATE CANCER TO THE BONE
Sponsor: Karmanos Cancer Institute
Project Dates and Amount of Award: 07/01/09-07/30/10; $75,000

PI: Ross, Brian
Co-I: Bradley, Deborah (Int Med-Hematology/Oncology) / Chenevert, Thomas (Radiology Department) / Galban, Craig (Radiology Department) / Hussain, Maha (Int Med-Hematology/Oncology) / Jacobson, Jon (Radiology Department) / Johnson, Timothy (Biostatistics Department) / Meyer, Charles (Radiology Department) / Pienta, Kenneth (Int Med-Hematology/Oncology) / Rehemtulla, Alnawaz (Radiation Oncology - Ann Arbor)
Title: IMAGE BIOMARKER DEVELOPMENT FOR TREATMENT EFFICACY OF PROSTATE CANCER TO THE BONE
Sponsor: NIH 1 R01 CA 136892 01 A1
Project Dates and Amount of Award: 05/21/09-04/30/11; $1,075,349

Surgery

PI: Bartlett, Robert
Title: DEVELOPMENT OF A TOTAL ARTIFICAL LUNG
Sponsor: NIH 3 R01 HL 069420 07 S1
Project Dates and Amount of Award: 06/01/09-08/31/10; $21,717

PI: Chung, Kevin
Title: ECONOMIC ANALYSIS OF HAND TRANSPLANTATION
Sponsor: Plastic Surgery Educational Foundation
Project Dates and Amount of Award: 07/01/09-06/30/10; $50,000

PI: Criado-Pallares, Enrique
Title: CABANA: A CAROTID STENTING BOSTON SCIENTIFIC SURVEILLANCE PROGRAM
Sponsor: Boston Scientific Corporation
Project Dates and Amount of Award: 04/15/09-04/14/13; $15,800

PI: Liu, Yan
Title: MOLECULAR PATHOLOGICAL MECHANISM AND POTENTIAL THERAPEUTICS OF LAFORA DISEASE
Sponsor: NIH 1 R21 NS 062391 01 A2
Project Dates and Amount of Award: 05/15/09-04/30/11; $409,386

PI: Marcelo, Cynthia
Title: TRAINING GRANT IN TRAUMA, BURN AND WOUND HEALING RESEARCH
Sponsor: NIH 2 T32 GM 008516 11
Project Dates and Amount of Award: 07/01/09-06/30/14; $616,905

PI: Misek, David
Co-I: Lubman, David (Surgery Department) / Shedden, Kerby (LSA Statistics)
Title: DISTINCTIVE GLYCAN FINGERPRINTS OF PANCREATIC CANCER FOR PLASMA DETECTION
Sponsor: NIH 1 R01 CA 140211 01
Project Dates and Amount of Award: 07/01/09-05/31/14; $1,602,940

PI: Wang, Stewart
Title: STATE BURN COORDINATING CENTER
Sponsor: State Of Michigan Mdch
Project Dates and Amount of Award: 03/15/09-09/30/09; $111,000

PI: Westfall, Margaret
Title: INFLUENCE OF TROPONIN I PHOSPHORYLATION BY PKC ON CONTRACTILE FUNCTION
Sponsor: NIH 3 R01 HL 067254 07 S1
Project Dates and Amount of Award: 06/01/09-10/31/10; $21,716

PI: Wojcik, Brandon
Co-I: Myers Jr, Daniel (Vascular Surgery Section)
Title: THE EVALUATION OF ALFIMEPRASE IN A RAT MODEL OF DEEP VEIN THROMBOSIS
Sponsor: American Vascular Association (AVA)
Project Dates and Amount of Award: 05/01/09-09/30/09; $3,000

Urology

PI: Keller, Evan
Co-I: Mccauley, Laurie (Periodontics and Oral Medicine) / Pienta, Kenneth (Int Med-Hematology/Oncology) / Taichman, Russell (Periodontics and Oral Medicine)
Title: THE BIOLOGY OF PROSTATE CANCER SKELETAL METASTASES
Sponsor: NIH 2 P01 CA 093900 06 A1
Project Dates and Amount of Award: 07/03/09-04/30/14; $8,089,325

PI: Lee, Cheryl
Co-I: Hafez, Khaled (Urology Surgery) / Weizer, Alon (Urology Surgery)
Title: ALVIMOPAN FOR THE MANAGEMENT OF POSTOPERATIVE ILEUS IN SUBJECTS UNDERGOING RADICAL CYSTECTOMY (A PHASE 4 MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL STUDY OF)
Sponsor: Adolor TO PPD, Inc.
Project Dates and Amount of Award: 05/20/09-05/31/11; $139,274

 

UMMS RESEARCH PUBLICATIONS

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Biological Chemistry

Banerjee R, Gherasim C, Padovani D. The tinker, tailor, soldier in intracellular B(12) trafficking. Curr Opin Chem Biol. 2009 Aug 7 (Epub ahead of print).

Binter A, Staunig N, Jelesarov I, Lohner K, Palfey BA, Deller S, Gruber K, Macheroux P. A single intersubunit salt bridge affects oligomerization and catalytic activity in a bacterial quinone reductase. FEBS J. 2009 Aug 13 (Epub ahead of print).

Ding H, Wong PT, Lee EL, Gafni A, Steel DG. Determination of the oligomer size of amyloidogenic protein beta-amyloid(1-40) by single-molecule spectroscopy. Biophys J. 2009 Aug 5; 97(3): 912-21.

Jeong BC, Lee YS, Bae IH, Lee CH, Shin HI, Ha HJ, Franceschi RT, Choi HS, Koh JT. The Orphan Nuclear Receptor SHP is a Positive Regulator of Osteoblastic Bone Formation. J Bone Miner Res. 2009 Jul 13 (Epub ahead of print).

Marchette LD, Thompson DA, Kravtsova M, Ngansop TN, Mandal NA, Kasus-Jacobi A. Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. Free Radic Biol Med. 2009 Aug 14 (Epub ahead of print).

Mori H, Inoki K, Opland D, Muenzberg H, Villanueva EC, Faouzi M, Ikenoue T, Kwiatkowski D, Macdougald OA, Myers Jr MG, Guan KL. Critical roles for the TSC-mTOR pathway in {beta}-cell function. Am J Physiol Endocrinol Metab. 2009 Aug 18 (Epub ahead of print).

Sollner S, Deller S, Macheroux P, Palfey BA. Mechanism of Flavin Reduction and Oxidation in the Redox-Sensing Quinone Reductase Lot6p from Saccharomyces cerevisiae. Biochemistry. 2009 Aug 19 (Epub ahead of print).

Vecchi C, Montosi G, Zhang K, Lamberti I, Duncan SA, Kaufman RJ, Pietrangelo A. ER stress controls iron metabolism through induction of hepcidin. Science. 2009 Aug 14; 325(5942): 877-80.

Yue T, Goldstein IJ, Hollingsworth MA, Kaul K, Brand RE, Haab BB. The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays. Mol Cell Proteomics. 2009 Jul; 8(7): 1697-707.

Family Medicine

Kitamura K, Fetters MD, Sano K, Sato J, Ban N. Lifestyle changes of Japanese people on overseas assignment in Michigan, USA. Asia Pac Fam Med. 2009 Jun 16; 8(1): 7.

Main DS, Graham D, Nutting PA, Nease DE, Dickinson WP, Gallagher K. Integrating practices' change processes into improving quality of depression care. Jt Comm J Qual Patient Saf. 2009 Jul; 35(7): 351-7.

Zivin K, Kerber K, Kuebler J, Jiang Q, Walters H, Klinkman M, McInnis M, Valenstein M. Effectiveness of a depression disease management program in improving depression and work function--a pilot study. Int J Psychiatry Med. 2009; 39(1): 1-13.

Human Genetics

Brewer GJ, Askari F, Dick RB, Sitterly J, Fink JK, Carlson M, Kluin KJ, Lorincz MT. Treatment of Wilson's disease with tetrathiomolybdate: V. control of free copper by tetrathiomolybdate and a comparison with trientine. Transl Res. 2009 Aug; 154(2): 70-7.

Dinkelmann M, Spehalski E, Stoneham T, Buis J, Wu Y, Sekiguchi JM, Ferguson DO. Multiple functions of MRN in end-joining pathways during isotype class switching. Nat Struct Mol Biol. 2009 Aug; 16(8): 808-13.

Grover S, Stoffel EM, Mercado RC, Ford BM, Kohlman WK, Shannon KM, Conrad PG, Blanco AM, Terdiman JP, Gruber SB, Chung DC, Syngal S. Colorectal Cancer Risk Perception on the Basis of Genetic Test Results in Individuals at Risk for Lynch Syndrome. J Clin Oncol. 2009 Jul 20 (Epub ahead of print).

Lin B, Wang J, Hong X, Yan X, Hwang D, Cho JH, Yi D, Utleg AG, Fang X, Schones DE, Zhao K, Omenn GS, Hood L. Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor. PLoS One. 2009 Aug 11; 4(8): e6589.

Internal Medicine

Infectious Diseases:
Pappas PG, Kauffman CA, Calandra TF, Kullberg BJ, Sobel JD. Echinocandin-Based Initial Therapy in Fungemic Patients with Cancer: A Focus on Recent Guidelines of the Infectious Diseases Society of America Reply. Clin Infect Dis. 2009; 49(4): 639-640.

Metabolism, Endocrinology & Diabetes:
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Research Group, Nathan DM, Zinman B, Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ. Modern-day clinical course of type 1 diabetes mellitus after 30 years' duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983-2005). Arch Intern Med. 2009 Jul 27; 169(14): 1307-16.

Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S Jr, Diano S, Horvath TL, Seeley RJ, Becker JB, Münzberg H, Myers MG Jr. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metab. 2009 Aug; 10(2): 89-98.

Pop-Busui R, Low PA, Waberski BH, Martin CL, Albers JW, Feldman EL, Sommer C, Cleary PA, Lachin JM, Herman WH; DCCT/EDIC Research Group. Effects of prior intensive insulin therapy on cardiac autonomic nervous system function in type 1 diabetes mellitus: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study (DCCT/EDIC). Circulation 2009 Jun 9; 119(22): 2886-93.

Microbiology and Immunology

Anderson VE, Nguyen Y, Weinberg JB. Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection. Virology. 2009 Aug 15; 391(1): 25-32.

Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters- Golden M, Mancuso P. E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J Immunol. 2009 Aug 15; 183(4): 2642-9.

Ashley SL, Welton AR, Harwood KM, Van Rooijen N, Spindler KR. Mouse adenovirus type 1 infection of macrophages. Virology. 2009 Aug 1; 390(2): 307-14.

Chang AT, Platt JL. The role of antibodies in transplantation. Transplant Rev (Orlando). 2009 Jul 21 (Epub ahead of print).

Cheng J, Zhou W, Warner GM, Knudsen BE, Garovic VD, Gray CE, Lerman LO, Platt JL, Romero JC, Textor SC, Nath KA, Grande JP. Temporal Analysis of Signaling Pathways Activated in a Murine Model of 2-Kidney, 1-Clip Hypertension. Am J Physiol Renal Physiol. 2009 Jul 22 (Epub ahead of print).

Huynh MH, Carruthers VB. Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80. Eukaryot Cell. 2009 Apr; 8(4): 530-9.

Korotkov KV, Gray MD, Kreger A, Turley S, Sandkvist M, Hol WG. Calcium is essential for the major pseudopilin in the type 2 secretion system. J Biol Chem. 2009 Jul 29 (Epub ahead of print).

Larson ET, Parussini F, Huynh MH, Giebel JD, Kelley AM, Zhang L, Bogyo M, Merritt EA, Carruthers VB. Toxoplasma gondii cathepsin l is the primary target of the invasion inhibitory compound LHVS. J Biol Chem. 2009 Jul 17 (Epub ahead of print).

Lent MD, Petrovic LE, Swanson JA, Olson CM. Maternal mental health and the persistence of food insecurity in poor rural families. J Health Care Poor Underserved. 2009 Aug; 20(3): 645-61.

Ogle BM, Knudsen BE, Nishitai R, Ogata K, Platt JL. Toward development and production of human T cells in swine for potential use in adoptive T cell immunotherapy. Tissue Eng Part A. 2009 May; 15(5): 1031-40.

Roiko MS, Carruthers VB. New roles for perforins and proteases in apicomplexan egress. Cell Microbiol. 2009 Jul 13 (Epub ahead of print).

Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, Chung YJ, Shelley WC, Richfield EK, Ray MK, Yoder MC, Aplan PD, Blackshear PJ. Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood. 2009 Jul 24 (Epub ahead of print).

Neurology

Lipp A, Sandroni P, Ahlskog JE, Fealey RD, Kimpinski K, Iodice V, Gehrking TL, Weigand SD, Sletten DM, Gehrking JA, Nickander KK, Singer W, Maraganore DM, Gilman S, Wenning GK, Shults CM, Low PA. Prospective differentiation of multiple system atrophy from Parkinson’s disease with and without autonomic failure. Arch Neurol. 2009; 66(6): 742-750.

Knight EM, Gilman S, Selwa L. Status epilepticus in Wilson's disease. Epileptic Disord. 2009 Jun; 11(2): 138-43.

Ophthalmology & Visual Sciences

Bian ZM, Elner SG, Elner VM. Dual Involvement of Caspase-4 in Inflammatory and ER Stress-Induced Apoptotic Responses in Human Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2009 Jul 30 (Epub ahead of print).

Demb JB, Feller MB. Neuroscience: Activity acts locally. Nature. 2009; 460(7258): 961-3.

Demirci H, Frueh BR. Palpebral spring in the management of lagophthalmos and exposure keratopathy secondary to facial nerve palsy. Ophthal Plast Reconstr Surg. 2009 Jul-Aug; 25(4): 270-5.

Elner VM, Newman-Casey PA, Patil AJ, Flint A, Biswas J, Moroi SE, Pushparaj V, Edward DP. Aberrant wound-healing response in mitomycin C-treated leaking blebs: a histopathologic study. Arch Ophthalmol. 2009; 127(8): 1036-42.

Gage PJ, Zacharias AL. Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye. Dev Dyn. 2009; 238(9): 2149-2162.

Koreen IV, Flint A, Nelson CC, Frueh BR, Elner VM. Nondiagnostic conjunctival map biopsies for sebaceous carcinoma. Arch Ophthalmol. 2009; 127(8): 961-3.

Lee WB, Jacobs DS, Musch DC, Kaufman SC, Reinhart WJ, Shtein RM. Descemet's Stripping Endothelial Keratoplasty: Safety and Outcomes A Report by the American Academy of Ophthalmology. Ophthalmology. 2009 Jul 28 (Epub ahead of print).

Marchette LD, Thompson DA, Kravtsova M, Ngansop TN, Mandal NA, Kasus-Jacobi A. Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells. Free Radic Biol Med. 2009 Aug 14 (Epub ahead of print).

Pattnaik BR, Hughes BA. Regulation of Kir Channels in Bovine Retinal Pigment Epithelial Cells by Phosphatidylinositol 4,5-bisphosphate. Am J Physiol Cell Physiol. 2009 Jul 29 (Epub ahead of print).

Smith LB, Pynnonen MA, Flint A, Adams JL, Elner VM. Progressive eyelid and facial swelling due to follicular lymphoma. Arch Ophthalmol. 2009; 127(8): 1068-70.

Vasireddy V, Jablonski MM, Khan NW, Wang XF, Sahu P, Sparrow JR, Ayyagari R. Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin. Exp Eye Res. 2009 Aug 14 (Epub ahead of print).

Orthopaedic Surgery

Doro LC, Ladd B, Hughes RE, Chenevert TL. Validation of an adapted MRI pulse sequence for quantification of fatty infiltration in muscle. Magnetic Resonance Imaging. 2009; 27(6): 823-7.

Dougherty PJ, van Holsbeeck M, Mayer TG, Garcia AJ, Najibi S. Lead toxicity associated with a gunshot-induced femoral fracture. A case report. J Bone Joint Surg Am. 2009 Aug; 91(8): 2002-8.

Esmonde-White KA, Mandair GS, Raaii F, Jacobson JA, Miller BS, Urquhart AG, Roessler BJ, Morris MD. Raman spectroscopy of synovial fluid as a tool for diagnosing osteoarthritis. J Biomed Opt. 2009 May-Jun; 14(3): 034013.

Goulet GC, Coombe D, Martinuzzi RJ, Zernicke RF. Poroelastic evaluation of fluid movement through the lacunocanalicular system. Ann Biomed Eng. 2009 Jul; 37(7): 1390-402.

Gralow JR, Biermann JS, Farooki A, Fornier MN, Gagel RF, Kumar RN, Shapiro CL, Shields A, Smith MR, Srinivas S, Van Poznak CH. NCCN Task Force Report: Bone Health in Cancer Care. J Natl Compr Canc Netw. 2009; 7 Suppl 3: S1-S32; quiz S33-S35.

Hensinger RN. Congential Scoliosis: Etiology and Associations. Spine. 2009; 34(17): 1745-1750.

Martin RL, Mohtadi NG, Safran MR, Leunig M, Martin HD, McCarthy J, Guanche CA, Kelly BT, Byrd JW, Clohisy JC, Philippon MJ, Sekiya JK. Differences in physician and patient ratings of items used to assess hip disorders. Am J Sports Med. 2009 Aug; 37(8): 1508-12.

McAllister DR, Miller MD, Sekiya JK, Wojtys EM. Posterior cruciate ligament biomechanics and options for surgical treatment. Instr Course Lect. 2009; 58: 377-88.

Phornphutkul C, Gruber BF, Wojtys EM. Incidence of positive intraoperative allograft cultures used in knee ligament reconstruction. J Knee Surg. 2009 Jul; 22(3): 191-5.

Poulter G, Garton H, Blakemore LC, Hensinger RN, Graziano GP, Farley FA. Morbidity and mortality associated with correction of cervical hyperextension. Spine. 2009 Feb 15; 34(4): 378-383.

Zhang H, La Marca F, Hollister SJ, Goldstein SA, Lin CY. Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture. J Neurosurg Spine. 2009; 10(6): 522-30.

Pediatrics & Communicable Diseases

Bocks ML, Armstrong AK. Novel method for delivering the Amplatzer® muscular VSD occluder in a patient with double outlet right ventricle after bidirectional Glenn procedure and pulmonary artery band. Catheter Cardiovasc Interv. 2009 Jan 8; 74(3): 488-493.

Dempsey AF, Singer DD, Clark SJ, Davis MM. Adolescent Preventive Health Care: What Do Parents Want? J Pediatr. 2009 Jul 28 (Epub ahead of print).

Deng H, Hershenson MB, Lei J, Bitar KN, Fingar DC, Solway J, Bentley JK. p70 Ribosomal S6 Kinase is Required for Airway Smooth Muscle Cell Size Enlargement but not Increased Contactile Protein Expression. Am J Respir Cell Mol Biol. 2009 Jul 31 (Epub ahead of print).

Dombkowski KJ, Harrison SR, Cohn LM, Lewis TC, Clark SJ. Continuity of Prescribers of Short-Acting Beta Agonists Among Children With Asthma. J Pediatr. 2009 Aug 13 (Epub ahead of print).

Freed G. In response to: Characteristics of Pediatric Hospital Medicine Fellowships and Training Program. J Hosp Med. 2009 Aug 10; 4(6): 393.

Freed GL, Dunham KM, Singer D. Health plan use of board certification and recertification of surgeons and nonsurgical subspecialists in contracting policies. Arch Surg. 2009 Aug; 144(8): 753-8.

Freed GL, Dunham KM, Singer D. Use of board certification and recertification in hospital privileging: policies for general surgeons, surgical specialists, and nonsurgical subspecialists. Arch Surg. 2009 Aug; 144(8): 746-52.

Gaies MG, Morris SA, Hafler JP, Graham DA, Capraro AJ, Zhou J, Landrigan CP, Sandora TJ. Reforming procedural skills training for pediatric research residents: a randomized, interventional trial. Pediatrics. 2009 Aug; 124(2): 610-9.

Laverdiere C, Liu Q, Yasui Y, Nathan PC, Gurney JG, Stovall M, Diller LR, Cheung NK, Wolden S, Robison LL, Sklar CA. Long-term Outcomes in Survivors of Neuroblastoma: A Report From the Childhood Cancer Survivor Study. J Natl Cancer Inst. 2009 Jul 31 (Epub ahead of print).

Lee JM, Gebremariam A, Card-Higginson P, Shaw JL, Thompson JW, Davis MM. Poor performance of body mass index as a marker for hypercholesterolemia in children and adolescents. Arch Pediatr Adolesc Med. 2009 Aug; 163(8): 716-23.

Lipstein EA, Perrin JM, Waisbren SE, Prosser LA. Impact of false-positive newborn metabolic screening results on early health care utilization. Genet Med. 2009 Aug 5 (Epub ahead of print).

Lozoff B, Jimenez E, Wolf AW, Angelilli ML, Zatakia J, Jacobson SW, Kaciroti N, Clark KM, Tao M, Castillo M, Walter T, Pino P. Higher Infant Blood Lead Levels With Longer Duration of Breastfeeding. J Pediatr. 2009 Jul 10 (Epub ahead of print).

Markman L. Teething: facts and fiction. Pediatr Rev. 2009 Aug; 30(8): e59-64.

Springman AC, Jacobs JL, Somvanshi VS, Sundin GW, Mulks MH, Whittam TS, Viswanathan P, Gray RL, Lipuma JJ, Ciche TA. Genetic diversity and multihost pathogenicity of clinical and environmental strains of Brukholderia cenocepaciea. Appl Environ Microbiol. 2009 Aug; 75(16): 5250-60

Tarini BA, Lozano B, Christakis DA. Afraid in the hospital: Parental concern for errors during a child’s hospitalization. J Hosp Med. 2009 Aug 3 (Epub ahead of print).

Thomas IH, Ness KK, Gurney JG. Reply to Bone mineral density in young adult survivors of acute lymphoblastic leukemia. Cancer. 2009 Jul 27 (Epub ahead of print).

Vlagnos CN, O’Connor BC, Morley MJ, Krause AS, Osawa GA, Keegan CE. Caudel regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis. Dev Biol. 2009 Aug 3 (Epub ahead of print).

Psychiatry

Copeland LA, Zeber JE, Wang CP, Parchman ML, Lawrence VA, Valenstein M, Miller AL. Patterns of primary care and mortality among patients with schizophrenia or diabetes: a cluster analysis approach to the retrospective study of healthcare utilization. BMC Health Serv Res. 2009 Jul 26; 9(1): 127.

Finkenauer R, Pomerleau CS, Snedecor SM, Pomerleau OF. Race differences in factors to smoking initiation. Addict Behav. 2009 Jun 17 (Epub ahead of print).

Kilbourne AM, Perron BE, Mezuk B, Welsh D, Ilgen M, Bauer MS. Co-occurring Conditions and Health-Related Quality of Life in Patients With Bipolar Disorder. Psychosom Med. 2009 Aug 6 (Epub ahead of print).

Milner KK, Healy D, Barry KL, Blow FC, Irmiter C, De Chavez P. State mental health policy: implementation of computerized medication prescribing algorithms in a community mental health system. Psychiatr Serv. 2009 Aug; 60(8): 1010-2.

Nesse RM. Digesting Evolution. Nature. Book Review. 2009; 460: 461.

Nesse RM. Explaining depression: Neuroscience is not enough, evolution is essential. In: Pariente CM, Nesse RM, Nutt DJ, Wolpert L, editors. Understanding depression: A translational approach. Oxford, UK: Oxford University Press; 2009. p. 17-36.

Pariente CM, Nesse RM, Nutt DJ, Wolpert L, editors. Understanding depression: A translational approach. Oxford, UK: Oxford University Press; 2009.

Perron BE, Zeber JE, Kilbourne AM, Bauer MS. A brief measure of perceived clinician support by patients with bipolar spectrum disorders. J Nerv Ment Dis. 2009 Aug; 197(8): 574-9.

Pomerleau CS, Snedecor SM, Pomerleau OF. Never-smokers with a positive family history are more likely to be overweight or obese than never-smokers with a negative family smoking history. Eat Behav. 2009 Jan; 10(1): 49-51.

Ríos-Bedoya CF, Pomerleau CS, Neuman RJ, Pomerleau OF. Using MIMIC models to examine the relationship between current smoking and early smoking experiences. Nicotine Tob Res. 2009 Sep; 11(9): 1035-41.

Sexton MB, Byrd MR, von Kluge S. Measuring resilience in women experiencing infertility using the CD-RISC: Examining infertility-related stress, general distress, and coping styles. J Psychiatr Res. 2009 Aug 7 (Epub ahead of print).

Wager TD, Waugh CE, Lindquist M, Noll DC, Fredrickson BL, Taylor SF. Brain mediators of cardiovascular responses to social threat: part I: Reciprocal dorsal and ventral sub-regions of the medial prefrontal cortex and heart-rate reactivity. Neuroimage. 2009 Sep; 47(3): 821-35.

Zivin K, Kabeto MU, Kales HC, Langa KM. The Effect of Depression and Cognitive Impairment on Enrollment in Medicare Part D. J Am Geriatr Soc. 2009 Jun 8 (Epub ahead of print).

Radiation Oncology

Feng M, Kong FM, Gross M, Fernando S, Hayman JA, Ten Haken RK. Using fluorodeoxyglucose positron emission tomography to assess tumor volume during radiotherapy for non-small-cell lung cancer and its potential impact on adaptive dose escalation and normal tissue sparing. Int J Radiat Oncol Biol Phys. 2009 Mar 15; 73(4): 1228-34.

Jagsi R, Abrahamse P, Morrow M, Griggs JJ, Schwartz K, Katz SJ. Postmastectomy radiotherapy for breast cancer: patterns, correlates, communication, and insights into the decision process. Cancer. 2009 Mar 15; 115(6): 1185-93.

Lee IH, Hayman JA, Landrum MB, Tepper J, Tao ML, Goodman KA, Keating NL. Treatment recommendations for locally advanced, non-small-cell lung cancer: the influence of physician and patient factors. Int J Radiat Oncol Biol Phys. 2009 Aug 1; 74(5): 1376-84.

Surgery

General Surgery:
Wu K, Kryczek I, Chen L, Zou W, Welling T. Kupffer Cell Suppression of CD8+ T cells in Human Hepatocellular Carcinoma is Mediated by b7-H1/PD-1 Interactions. Cancer Research. 2009.

Thoracic Surgery:
Cooke DT, Lin GC, Lau CL, Zhang L, Si MS, Lee J, Chang AC, Pickens A, Orringer MB. Analysis of Cervical Esophagogastric Anastomotic Leaks after Transhiatal Esophagectomy: Risk Factors, Presentation, and Detection. Ann Thorac Surg. 2009 Jul; 88(1): 177-84.