Research

Annual Report 2018
University of Michigan
Medical School

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Developing the next generation of innovators, breaking new ground, and improving patient health

At $1.55 billion, the University of Michigan is the #1 public university in research spending in the United States, and the Medical School is responsible for nearly half of those research expenditures. We are a significant research and economic engine in the region, and this year U.S. News & World Report ranked our hospitals #5 in the nation.

With 10,000+ faculty, students, and staff studying almost 3,000 scientific projects, it's impossible to tell you about all the breakthroughs taking place every day at the University of Michigan Medical School. We invite you to take a closer look at the following metrics and stories which offer a brief sampling of a year in research among the "leaders and best," developing new treatments and technologies that are on a path to positively impacting patients and their families.

"From basic to translational research, and on to the clinic, policy and commercialization, U-M Medical School researchers are firing on all cylinders across the research spectrum as we further scientific inquiry and ultimately work to improve human health."

Steven L. Kunkel, Ph.D.
Senior Associate Dean for Research
Interim, Chief Scientific Officer
Endowed Professor of Pathology Research

Research at the University of Michigan Medical School

FISCAL YEAR
2018

6,791

publications

$588.4

million

Total Awards

  • 7 new business startups
  • #12 NIH ranking Federal FY 2017
  • 112 license agreements with industry
  • 10.4% increase in professional foundation funding

$102.8

million

Industry-Sponsored Awards

1,796

active
clinical trials

  • In 2018, these are just a few of the companies working on multimillion-dollar collaborations with the University of Michigan:
  • AbbVie
  • Astellas Pharma
  • Bristol-Myers Squibb
  • Genentech
  • Incyte Pharmaceuticals
  • Medtronic
  • Merck

$329.8

million

NIH Awards Federal FY 2017

  • 2018 STARTUPS:
  • 5th Eye
  • Akadeum
  • New Vital Signs
  • Oncopia
  • Phenomics Health
  • PreDxion
  • Stell
  • $508.2M sponsored expenditures
  • 235 invention reports

"Discovery and translational research continue to be absolutely critical to our mission to advance healthcare in Michigan and around the world, and is and always will be of highest priority for Michigan Medicine."

Marschall S. Runge, M.D., Ph.D.
Dean, university of michigan Medical School
Executive Vice President, Medical Affairs
CEO, Michigan Medicine

Sue Hammoud, Ph.D., is an Assistant Professor of Human Genetics, Obstetrics and Gynecology, and Urology, and winner of the NIH Director's New Innovator Award.

Unlocking the secrets of cells and DNA, learning more about how these fundamental building blocks contribute to health and disease

Nearly 1 in 8 couples in the U.S. face infertility, and about half of those cases can be attributed to sperm abnormalities in the male partner. As the root causes often remain a mystery, Sue Hammoud, Ph.D., is researching how the basic biology behind sperm development could one day lead to renewed hope for people wanting to grow their families.

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On the forefront of new treatments that employ patients' own immune systems to fight disease

Harnessing the power of the body's immune system holds incredible promise for combating a range of conditions, and has transformed the way researchers are approaching cancer treatment. Weiping Zou, M.D., Ph.D., is leading a multidisciplinary laboratory that is investigating immunotherapy drugs and the human cancer microenvironment.

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Weiping Zou, M.D., Ph.D., is the Charles B. de Nancrede Professor of Pathology, Immunology, Biology, and Surgery, and Co-Director of the Cancer Hematopoiesis and Immunology Program, and Director of the Center of Excellence for Cancer Immunology and Immunotherapy.

Helen C. Kales, M.D., is a Professor of Psychiatry, member of the U-M Institute for Healthcare Policy & Innovation, and is director of the U-M Program for Positive Aging.

Clinical research – from bench to bedside helping patients today

In today's health care environment, patients and their families are being encouraged to take an active role in decision-making about prevention and treatment. For many caregivers, engagement can mean additional challenges and stress. Helen Kales, M.D., is researching both mental health issues in older patients, as well as looking at innovative support options for their caregivers.

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Collaborative breakthroughs in the nationwide opioid epidemic

According to the Centers for Disease Control and Prevention, 115 Americans die every day from an opioid overdose, many of them resulting from the abuse of prescribed medications. Michael Englesbe, M.D., along with Ryan Howard, M.D., and Jay Lee, M.D., are helping to address this dangerous epidemic through their research into safer prescribing practices.

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Michael Englesbe, M.D., F.A.C.S., Endowed Professor of Transplantation Surgery and Jay Lee, M.D., health services research fellow with the Center for Healthcare Outcomes & Policy and a General Surgery resident, are pictured together. Ryan Howard, M.D., is a General Surgery resident.

Patient Valerie Walton with Elif A. Oral, M.D., M.S., Associate Professor in the Division of Metabolism, Endocrinology & Diabetes and Medical Director of the Bariatric Surgery Program, Director of the MEND Obesity and Metabolic Disorder Program, and Director of the Post-Bariatric Surgery Care Program.

World Leader in the Search for New Treatments for a Rare Disease

Lipodystrophy is a rare, currently incurable syndrome tied to a number of diseases, and can lead to diabetes and very high triglyceride levels. Life-threatening complications are caused by a decrease in the hormone Leptin, and result in symptoms like uncontrolled body fat loss or accumulation, and a stressed liver. Elif A. Oral, M.D., M.S., currently has the largest lipodystrophy patient population in the United States, and spearheaded the development of the only approved therapy for the condition.

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$150M Transforming cancer research and care

Richard and Susan Rogel are on a mission to boost innovative cancer research and develop the next generation of cancer pioneers. In 2018 they committed $150 million to the University of Michigan Comprehensive Cancer Center to realize that vision.
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Are you ready to join a community of people who are passionate about finding cures, preventing disease, and improving the quality of life for patients and their families?

research.medicine.umich.edu/giving

behind the scenes

From proposal development to grant and regulatory reviews to core labs, throughout the year our research enterprise is supported by the many units of the Medical School Office of Research.

  • 3,447 grants processed
  • 592 training sessions and events for research faculty and staff
  • $141.4M in new funding for faculty who participated in our R01 Bootcamp over the last four years
  • $1.4M to 43 pilot grants
  • 2,500+ faculty and staff using our core labs
  • 450,000+ biospecimens in our biorepository
  • 4,000,000+ de-identified patient records in our databases
  • 37,000+ clinical trial volunteers using our umhealthresearch.org website