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Summer 2007 Newsletter

Message from Dr. William Herman, Director

We wanted to keep you informed of the status of the MDRTC competing renewal which will undergo review later this month. The key dates for the MDRTC Competing Renewal are as follows:

We anticipate that we will receive notification of our score sometime in August and will keep you apprised of the status. Typically, the NIH funds five Diabetes Research and Training Centers nationally, and while we fully expect to be funded, we understand the process is quite competitive this year.

I want to encourage you to maintain your membership in the MDRTC. We continue to streamline the application process for ease of access. I also encourage you to ask new faculty involved in diabetes- related research to become members of the MDRTC so they can take advantage of our many Core services.

This newsletter highlights: 1) new and exciting services in the Animal Phenotyping, Cell and Molecular Biology and Protein Cores, 2) information on the application process for the MDRTC Pilot and Feasibility and Diabetes Interdisciplinary Study Program grants 3) the many accomplishments of the MDRTC and its members over the past several months. I hope you find this information useful to you.

New Services Are Being Offered by MDRTC Cores

Animal Phenotyping Core: The MDRTC supported the purchase of a Comprehensive Lab Animal Monitoring System (CLAMS) for the Animal Phenotyping Core. The CLAMS unit allows for the capture of a diverse range of measurements regarding feeding, activity and metabolic rate (and integrates them into a system capable of simultaneously monitoring multiple) of rats or mice. This unit was delivered and installed in the Core facility in June 2007. Pilot studies to ensure proper functioning of the instrument have been completed and MDRTC investigator-initiated studies have begun. Please contact the Core if you are interested in initiating studies with the CLAMS unit. The Core has also completed several studies involving the longitudinal monitoring of animals treated with various compounds or on differing genetic backgrounds. Insulin and Glucose Tolerance Tests and Euglycemic Hyperinsulinemic Clamp studies have also been performed. The Core has seen an increase in the number of users, leading to the hiring of two new research assistants in order to increase the speed at which studies are performed. Please contact the Core if you are interested in these or other Metabolic Phenotyping Services.

Cell and Molecular Biology Core: Substantial progress has been made in setting up the Bacterial Artificial Chromosome (BAC) Recombineering Core associated with the Cell and Molecular Biology Core. In addition to procuring funding support, laboratory space has been assigned and remodeled to accommodate wet lab space and equipment. A technician with experience in DNA cloning was hired on February 1, 2007. The first three months of his tenure were used to organize a library of plasmids and bacteria and to conduct preliminary experiments. At this time, recombineering has been successful with positive controls.

The BAC Core is currently soliciting proposals for pilot proposals for the BAC Recombineering Core to work on and develop expertise in the methods and experimental design. Proposal and submission instructions are available on the Transgenic Core Web site. The deadline for applications is July 31, 2007.

In addition, the new Illumina BeadStation 500GX (high-throughput SNP typing system) has been received by the DNA sequencing core. This service will be available following hiring and training of a new technician.

Protein Core: After thorough method development and rigorous validation of its new state-of-the-art Waters UPLC/Qtof mass spectrometer, the Protein Core is now offering Protein Identification Services using LC-MS/MS technology. The Protein ID services comprise SDS-PAGE, in-gel digestion, LC-MS/MS and database search and include project consultation, instructions for sample preparation, and data interpretation. Protein characterization by LC-MS analysis, molecular weight measurement of intact proteins and peptide mass fingerprinting are also available. Interested investigators are required to consult with the facility director prior to preparing samples for submission. You may contact Dr. Henriette Remmer at hremmer@umich.edu.

More information about sample submission and recharge rates is provided on the Protein Core’s web page www.med.umich.edu/medschool/brcf/protein or http://www.med.umich.edu/mdrtc/cores/ProteinCore/.

N-terminal sequence analysis services will be terminated as of July 31, 2007. Due to decreasing user demand for this service during the past two years, the instrument cannot be operated in a cost-effective manner. However, assistance will be provided for members to obtain data from other sources or by other technologies.

MDRTC Members Extremely Productive

Since the renewal application was submitted in December 2006, MDRTC members have published more than 119 articles.

Acknowledgement of the MDRTC in Publications is Essential for Continued MDRTC Funding

The MDRTC should be listed as an “additional supporting entity” when MDRTC resources and cores have been used. Failure to acknowledge MDRTC support in our publications could seriously compromise our position with NIH and NIDDK. Whenever possible and appropriate, please include in the acknowledgment section of manuscripts the following:

"This work used the _______core(s) of the MDRTC funded by NIH (5P60 DK20572) from the NIDDK."

Accolades to MDRTC Members

Eva L. Feldman, M.D., Ph.D., the Russell N. Dejong Professor of Neurology, was honored with a 2006 Excellence in Leadership Award by the American Diabetes Association.

Sean Morrison, Ph.D., the Henry Sewall Professor in Medicine, Investigator, Howard Hughes Medical Institute, and Director, University of Michigan Center for Stem Cell Biology, was designated Detroit News Michiganian of the Year in 2006 and Pfizer Young Michigan Biomedical Investigator of the Year in 2007.

Carey Lumeng, M.D., Ph.D., Clinical Lecturer, Department of Pediatrics and Communicable Diseases, was awarded the Jannette Ferrantino Investigator Award from the University of Michigan.

MDRTC Well Represented at Annual Meetings of American Diabetes Association (ADA) and Endocrine Society

67th Scientific Sessions of the American Diabetes Association (June 22-26, 2007)
ADA Symposia:

Improving Communication-Listening With Old Ears. Robert M. Anderson, EdD

Gene Therapy for Neuropathy and Neuropathic Pain-Fact of Fiction? David J. Fink, MD

National Standards for Diabetes Self-Management Education-Overview.
Martha Funnell, MS, RN, CDE

Economics of Type 2 Diabetes Prevention. William H. Herman, MD, MPH

The Effects of Weight Loss on Fat Oxidation and Colocalization pf Fat/CD36 With CPT l in Human Skeletal Muscle. Jeffrey F. Horowitz, PhD

Role of Wnt Signaling on Development of Adipose Tissues and Bone. Ormond A. MacDougald, PhD

ADA Oral Presentations:

Progression of Kidney Disease in Diabetic Patients: The TRIAD Study. Kingsley Onyemere, Ed Tierney, Susan Johnson, William H. Herman

Determinants of Monotherapy Failure in ADOPT (A Diabetes Outcomes Progression Trial). Rury R. Holman, Steven E. Kahn, Steven M. Haffner, Bernard Zinman, Giancarlo F. Veberti, William H. Herman, John M. Lachin, Barbara G. Kravitz, Mark A. Heise

Diet-Induced Obesity Generates Tissue-Specific Alterations In Macrophage Activation State. Carey N. Lumeng, Jennifer L. Bodzin, Alan R. Saltiel

Prevalence of Diabetic Peripheral Neuropathy (DPN) and Relation to Glycemic Control Strategies at Baseline in the BARI 2D Cohort. Rodica Pop-Busui, Jiang Lu, Neuza Lopes, Teresa L. Jones

The Association Between Inflammatory Markers and the Extent of Atherosclerosis in the Veterans Affairs Diabetes Trial (VADT). Aramesh Saremi, Robert Anderson, Ping Luo, Tom Mortiz, Dawn Schwenke, Matthew Allision, Peter D. Reaven

Mechanisms of SH2B1-Stimulation of Insulin Signaling. David L. Morse, Liangyou Rui

Neuronal SH2B1 Is a Key Positive Regulator of Leptin Regulation of Energy and Glucose Homeostasis. Yingjiang Zhou, Zhiqin Li, Decheng Ren, Liangyou Rui

Primary Care Physicians Lack Consensus of Some Insulin Therapy Attitudes. Risa P. Hayes, James T. Fitzgerald

ADA Poster Presentations:

Social Support, Quality of Life and Self-Care Behaviors Among African Americans with Type 2 Diabetes. Tricia S. Tang, Morton B. Brown, Martha M. Funnell, Robert M. Anderson

Agpat1 Decreases Insulin Signaling by Activating the mTOR Pathway. Andrea S. Cornford, Jeffrey F. Horowitz, Simon Schenk, Charles F. Burant, Angela R. Subauste

The Role of Hepatic Glucose Production and Impaired Insulin Secretion in Age-Related Impaired Glucose Tolerance. Annette M. Chang, Marla J. Smith, Jeffrey B. Halter

Patient-Provider Perception Differences and Patient Satisfaction. James T. Fitzgerald, Brent Stansfield, Tricia S. Tang, Mary F. Oh, Alice Z. Frohna, Bette A. Armbruster, Larry D. Gruppen, Robert M. Anderson

Where Patients and Providers Don’t See Eye-to-Eye: How Attitudes Differ About Different Aspects of Diabetes. R.B. Stansfield, James T. Fitzgerald, Mary Oh, Larry D. Gruppen

Association of Diabetes and Diabetes Treatment with Risk of Dementia. Nancy A. West, Mary N. Haan

The Effectiveness of Metformin versus Glyburide in Type 2 Diabetes: Results from ADOPT (A Diabetes Outcomes Progression Trial). William H. Herman, Steven M. Haffner, Steven E. Kahn, Bernard Zinman, Rury R. Holman, Giancarlo F. Viberti, John M. Lachin, Barbara G. Kravitz, Mark A. Heise

Glucose variability in Older Adults with Type 2 Diabetes Treated with Continuous Subcutaneous Insulin Infusion (CSII) and Multiple Daily Injections of Insulin (MDI). Susan L. Johnson, Laura N. McEwen, Christopher A. Newton, Catherine L. Martin, Philip H. Raskin, William H. Herman

Rosiglitazone Decreases C-Reactive Protein (CRP) Relative to Glyburide and Metformin over Four-Years In Spite of Greater Weight Gain. Steven M. Haffner, Steven E. Kahn, Bernard Zinman, Rury R. Holman, Giancarlo F. Viberti, William H. Herman, John M. Lachin, Barbara G. Kravitz, Mark A. Heise

Potential Impact of Preventive Counseling Among Women with Histories of Gestational Diabetes Mellitus. Laura N. McEwen, John D. Piette, Eve A. Kerr, Assiamira Ferrara, William H. Herman, Catherine Kim

Weight Change Among Adults with Diabetes: The Translating Research Into Action For Diabetes (TRIAD) Study. Arleen F. Brown, Leslie F. Taub, Andrew J. Karter, Ronald T. Ackermann, Edward Gregg, David G. Marrero, Assia Ferrara, Chien-Wentseng, Tiffany L. Gary, Beth Waitzfelder, William H. Herman, David F. Williamson

Weight Change and Change in Cardiometabolic Risk Among Adults with Diabetes: The Translating Research Into Action for Diabetes (TRIAD) Study. Arleen F. Brown, Leslie F. Taub, Andrew J. Karter, Ronald T. Ackermann, Edward Gregg, David G. Marrero, Assia Ferrara, Chien-Wentseng, Tiffany L. Gary, Beth Waitzfelder, William H. Herman, David F. Williamson

Efficacy and Cost of Postpartum Screening Strategies for Diabetes Among Women with Histories of Gestational Diabetes. Catherine Kim, William H. Herman, Sandeep Vijan
Association of Medical Costs and Pre-Diabetic Dysglycemia. Gregory A. Nichols, Bhakti Arondekar, William H. Herman

Universal Versus Race Specific Waist Circumference Percentiles for Detecting Insulin Resistance in Adolescents. Joyce Lee, James Gurney

Leptin Regulates Adipose Tissue Lipogenesis Through Hypothalamic Pathways that Require Pi3k, but AreIndependent of Stat3 Signaling. Christoph Buettner, Evan D. Muse, Alesssandro Pocai, Andrew Cheng, Martin Myers, Luciano Rossetti

Rosiglitazone Ameliorates Nitrosative Stress and Inflammation in Type 2 Diabetes. Rodica Pop-Busui, Sub Pennathur, Elif Oral, Jaeman Byun, Valida Bajirovic, Anuradha Vivekanandan, Aaron Kellogg, Martin Stevens

Racial Differernces in Long-Term Adherence Hypoglycemic Therapy. Connie M. Trinacty, Alyce S. Adams, Stephen B. Soumerai, Fang Zhang, James B. Meigs, John D. Piette, Dennis Ross-Degnan

Essential Role of Mitochondrial-Associated Mediators in Stimulation of Autophagy by Diabetic Neuropathic Sera. Roberto Towns, Chunfang Guo, Shuansong Hong, Suqing Wang, John W. Wiley

89th Annual Meeting of the Endocrine Society (June 2-5, 2007)

Endocrine Society Plenary Lecture:

Nanotechnology for the Enhancement of Human Health. James R. Baker, Jr. MD

Endocrine Society Symposia:
JAK2 Autophosphorylation Sites and Their Role in GH Signaling. Christin Carter-Su

Developmental Origin of PCOS: Is Maternal Hyperandrogenism the Culprit? Vasantha Padmanabhan

The Structural and Functional Evolution of Leptin. Robert J Denver

Endocrine Society Meet the Professor:

Diabetic Neuropathy Eva L. Feldman, MD, PhD, Russell N. Dejong Professor of Neurology

Endocrine Society Oral Sessions:

Androgen Receptors Varying in Q-Tract Length Differentially Affect Both Androgen-Dependent and -Independent Prostate Cancer in Mice. Diane M Robins, Orla A O'Mahony, Michele Brogley, Jeffrey Tosoian, Stephanie Daignault, Kirk Wojno, Megan A Albertelli

Developmental Programming: Obesity Amplifies Reproductive Cycle Defects in Prenatally Testosterone-Treated Sheep. Teresa Steckler, Anastasia Alekseyev, Vasantha Padmanabhan

Endothelial Knockout of PPARγ Increases Inflammatory Response to IL-1β and Abrogates Anti-Inflammatory TZD Action. Christine Y Ivashchenko, Sheng Zhong Duan, Richard M Mortensen

Endocrine Society Poster Presentations:

ACTH-Mediated SF-1-Dependent Transcriptional Activation in Adrenocortical Cancer Cells: Role of SF-1 SUMOylation and Phosphorylation. Wei-Hsiung Yang, Gary D Hammer

Analysis of Profiles of Growth Hormone-Regulated Genes Suggests Genes Implicated in Insulin Resistance. Yili Chen, Jeffrey Huo, Zhaohui Qin, David States, Jessica Schwartz

Assessment of Circulating Androgens in Mid-Aged Women: Direct Immunoassay for Testosterone Correlates with GCMS and RIA. Daniel McConnell, MaryFran Sowers, Jaingang Chen, Bill Lasley

Biochemical and Functional Characterizations of the Duplicated Zebrafish IGFBP-1 Genes. Hiroyasu Kamei, Lisbeth S Laursen, Claus Oxvig, Cunming Duan

Caloric Expenditure Rather Than Exercise Intensity Is a Stimulus for GH Secretion and GH Pulse Advance. Katarina T Borer, Elizabeth CN Wuorinen, Charles Burant


Canonical Wnt Signaling in Adrenocortical Development. Alex C Kim, Kerri A Serecky, Nathan C Bingham, Keith L Parker, Gary D Hammer

Change in Adipocytokines and Ghrelin with Menopause. MaryFran R Sowers, Rachel P Wildman, Peter Mancuso, Aimee D Eyvazzadeh, Carrie A Karvonen-Gutierrez, Eileen Rillamas-Sun, Xizhao Li

Characterization of Insulin-Like Growth Factor Pathway Inhibitors in Adrenocortical Carcinoma Cell Lines. Ferdous Barlaskar, Aaron C Spalding, Mary Davis, Edgar Ben-Josef, Gary D Hammer

Differential Responses of IGF-1 and Substrate Metabolism to Continuous or Pulsatile Administration of Growth Hormone in Obesity. Sowmya Surya, Naila Goldenberg, Alla Sakharova, Matthew Harber, Kathleen Symons, Jeffrey Horowitz, Ariel Barkan

Disruption of ObR in Pancreas Promotes Islet Lipid Accumulation. Tomoaki Morioka, Chong Wee Liew, Jiang Hu, Esra Asilmaz, Martin G Myers, Jr, Rohit N Kulkarni

Endogenous Growth Hormone Regulates Fuel Mobilization during Fasting. Alla Sakharova, Sowmya Surya, Naila Goldenberg, Matthew Harber, Kathleen Symons, Jeffrey Horowitz, Ariel Barkan

Follicle Stimulating Hormone Increases Tuberin Phosphorylation through an Akt Independent Pathway in Rat Granulosa Cells. Pradeep P Kayampilly, KMJ Menon

GH-Dependent Regulation of ZEB-2/SIP1 Expression in Glomerular Podocytes: A Novel Crosstalk between GH and TGF-β Pathways and Its Implication for Development of Diabetic Nephropathy. Kateryna V Kotlyarevska, Prapai Dejkhamron, Rajashekhar Reddy Gaddamedi, Jamuna Thimmarayappa, Jinhong Sun, Chunxia Lu, Ram K Menon

GH Increases Glucose-Dependent Apoptosis of the Glomerular Podocyte: Implications for the Pathogenesis of DM Nephropathy. Rajashekhar Reddy Gaddameedi, Jinhong Sun, Jamuna Thimmarayappa, Ram K Menon

Glycosylation Impedes Formation of Disulfide Bonds in the Human Insulin-Like Peptide 6 (Insl6). Chunxia Lu, Ram Menon

Hypoxia Inhibits Muscle Differentiation by Differentially Regulating the IGF and Notch Signaling Pathways. Hongxia Ren, Cunming Duan

Identification of Interacting Proteins Associated with Luteinizing Hormone Receptor mRNA Binding Protein, a Trans-Factor Involved in the Regulation of Luteinizing Hormone Receptor mRNA in the Ovary. Lei Wang, KMJ Menon

Influence of Prenatal Androgens on Dynorphin and NKB-Expressing Neurons in the Mediobasal Hypothalamus of the Sheep. Guanliang Cheng, Lique M Coolen, Meghan Reale, Robert L Goodman, Vasantha Padmanabhan, Michael N Lehman

MAPK-Dependent Phosphorylation of Mouse C/EBPß at T188 Plays a Role in Recruitment of p300 to the c-Fos Promoter in Response to Growth Hormone. Tracy X Cui, Christina Fulton, Jessica Schwartz

Night-Time Ghrelin Is Related to 24-Hour Luteinizing Hormone Concentrations in Adolescent Girls: Impact of Fatness, Fitness and Ethnicity. Josephine Z Kasa-Vubu, Amnon Rosenthal, Erica G Murdock, Kathy B Welch

Novel Approaches To Probe the Mechanisms Responsible for SUMOylation-Dependent Inhibition of Nuclear Receptor Transcriptional Synergy. Holly Brevig, Jorge Iniguez Lluhi

Novel Expression of CRH Receptor 1 (CRH-R1) in Multiple Endocrine Cell Types in the Murine Anterior Pituitary. Ryan T Evans, Nicole J Westphal, Audrey F Seasholtz

Peripubertal Girls Have Less GnrRH Contribution to Pituitary FSH Release Than Do Peripubertal Boys. Carol M Foster, Vasantha Padmanabhan, Pamela Olton

Profiling of Androgen Receptor Mutations in Mouse and Human Prostate Cancer.
Mara P Steinkamp, Orla A O'Mahony, Megan A Albertelli, Michele Brogley, Taleah Butler, Jennifer Gerber, Diane M Robins

Regulation of Luteinizing Hormone Receptor mRNA Expression by Mevalonate Kinase: Role of the Catalytic Center in mRNA Recognition. Anil K Nair, KMJ Menon

Single Nucleotide Polymorphism (SNP) in NOD Ica1 Promoter Elements Contributes to Loss of Self-Tolerance to Islet Autoantigen. Massimo Pietropaolo, Susan Pietropaolo, Yigang Chang

SOD2 Protects Neurons from Injury in Cell Culture and Animal Models of Diabetic Neuropathy. Andrea M Vincent, James W Russell, Kelli A Sullivan, Frank C Brosius III, Eva L Feldman

Steroid-Sensitive Gene-1: A Novel JAK2 Binding Protein That Enhances GH-Induced Tyrosyl Phosphorylation of Stat Proteins. Erin E O'Leary, Lawrence S Argetsinger, Anna Mazurkiewicz-Munoz, Christin Carter-Su

SUMOylation of the Kruppel-Like Factor ZBP89 Regulates Its Ability To Engage in Homotypic and Heterotypic Synergy with Nuclear Receptors. Sergey Chupreta, Holly Brevig, Jorge A Iniguez-Lluhi

The KRAB Zinc Finger Genes, Regulator of Sex-Limitation (Rsl) 1 and 2, Act in Sex-Dependent and -Independent Mouse Liver Functions. Christopher J Krebs, Shaema Khan, Leslie Larkins, Diane M Robins

The Mineralocorticoid Receptor Directly Modulates Cytokine Transcription in Macrophages. Michael G Usher, Christine Ivashchenko, Richard Mortensen

Morris White, Ph.D., to Visit MDRTC as Pfizer Visiting Professor in Diabetes

This year, the MDRTC applied for and received a Pfizer Visiting Professorship Program in Diabetes award for Morris F. White, PhD, Professor, Department of Pediatrics Harvard Medical School, investigator in the Howard Hughes Medical Institute, and a renowned and distinguished researcher in type 2 diabetes and metabolic syndrome. Dr. White has been recognized by the American Diabetes Association with the Outstanding Scientific Achievement Award. Dr. White will give two seminars in November 2007 entitled: “Multiple Roles and Sites for IRS-protein action in metabolic regulation,” and “IRS-protein signaling and regulation- links to the metabolic syndrome and aging.” MDRTC members are invited to meet with Dr. White during his visit (contact Martin G. Myers, MD, PhD at mgmyers@med.umich.edu.)

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Applications Available for MDRTC Pilot & Feasibility and Diabetes Interdisciplinary Study Program Grants

Pilot & Feasibility Studies Proposal Deadline: Monday, September 17

The purpose of the MDRTC Pilot /Feasibility Grant Program is to promote research on diabetes by new and established University of Michigan faculty. Its goal is to enable investigators to generate a sufficient body of preliminary information for a successful application for major research funding from NIH or other national granting agencies. Grant proposals may be in areas of basic biomedical research, or in clinical, behavioral, epidemiological, health outcomes, or translational research and should address key questions in the pathogenesis, diagnosis, prevention, or control of diabetes, its complications, or related endocrine or metabolic disorders (for example: counter-regulatory proteins, obesity, metabolic syndrome). Translational research projects should focus on the translation of research advances into clinical practice and include the identification of barriers to widespread adoption of new science and the testing of interventions to reduce these barriers. The deadline to apply is September 17 with anticipated funding to begin in early February 2008. We expect that 4-5 Pilot and Feasibility studies will be funded. Please see the MDRTC Web site for more information and how to obtain an application.

MDRTC/Michigan Comprehensive Diabetes Center Diabetes Interdisciplinary Studies Program (DISP) Deadline: Monday, September 17

The Diabetes Interdisciplinary Studies Program (DISP) is jointly sponsored by the MDRTC and the Michigan Comprehensive Diabetes Center (MCDC). Its purpose is to promote interdisciplinary collaboration between TWO members of the University of Michigan faculty from DISTINCT disciplines to focus their combined research strengths on cutting-edge areas in diabetes research. The intent is to foster synergistic collaboration between faculty members to advance scientific inquiry. Grant proposals may be in areas of basic biomedical research, or in clinical, behavioral, epidemiological, health outcomes, or translational research and should address key questions in the pathogenesis, diagnosis, prevention, or control of diabetes, its complications, or related endocrine or metabolic disorders (for example: counter-regulatory proteins obesity, metabolic syndrome). The goal of the DISP is to enable investigators to generate a sufficient body of preliminary information for a successful application for major research funding from NIH or other national granting agencies.

The deadline to apply is September 17 with anticipated funding to begin in early February 2008. It is anticipated that one study will be funded. Please see the MDRTC Web site for more information and how to obtain an application.

Establishment of a New Quality Improvementfor Complex Chronic Conditions (QUICCC) Group headed by MDRTC Investigators

John D. Piette, Ph.D, Chief of the Prevention and Control Division of the MDRTC, was recently appointed as the Director of Quality Improvement for Complex Chronic Conditions (QUICCC), a new research group. QUICCC is funded by the University of Michigan, the Ann Arbor VA Healthcare System, and project-specific grants. Eve Kerr, M.D., M.P.H. is QUICCC’s Co-Director.

QUICCC's mission is to stimulate research on chronic illness care interventions, with a special emphasis on diabetes care. Its work is interdisciplinary and draws on experts from across the University of Michigan, including the Departments of Internal Medicine, Family Medicine, Psychiatry, the School of Public Health, and the School of Information.

QUICCC investigators are charged with 1) developing and evaluating new services to improve the cost-effectiveness of care for patients with complex chronic conditions who are served by UMHS, VAAAHCS, Blue Cross Blue Shield of Michigan, and other health systems nationwide, 2) positioning UMHS as a national leader in research and innovation in chronic illness care and quality improvement, and 3) stimulating externally-funded research across the University to develop new approaches to care management, and to help junior investigators become established in translational research.

QUICCC is focusing activities on four themes: 1) Enhancing Support from Informal Caregivers, 2) Improving the Quality of Complex Care Management 3) Promoting and Maintaining Disease Self-Management and 4) Advancing Innovation in Performance Monitoring.

For more information regarding this program, visit the QUICCC Web site.

Michigan Diabetes Run for Research raises money for MDRTC

The MDRTC was contacted by a University of Michigan student, Jon Ducastel in the spring of this year. Jon was interested in organizing a running team that would raise money for diabetes research. As he “googled” his way around the web, he came across the MDRTC and contacted our administrative office to determine if we would have interest in working with him and his teammates to raise funds for diabetes research. The Michigan Diabetes Run for Research team was born! The Run for Research team competed in the Bayshore Marathon in Traverse City, Michigan on May 26, 2007 and raised $200 for the MDRTC. “We hope our 26.2 mile journey can help improve the lives of those who suffer from diabetes and prevent the disease for future generations. If we all work together we can help create healthier communities,” says Jon Ducastel, volunteer runner and U-M student. Help us find a cure! The group is committed to competing in several other marathons this fall in the interest of diabetes research.

The MDRTC thanks Jon and his teammates for their hard work and support of diabetes research. Through efforts like these, the MDRTC can continue to advance scientific discovery to prevent and better manage this devastating disease.

Administration Core and Chemistry Laboratory to Relocate to North Ingalls Building in July

The Administration Core and the Chemistry Laboratory of the MDRTC are expected to relocate to the 400 N. Ingalls on Monday, July 23, 2007. Renovations are under way at this time. We will keep you appraised on the relocation status on the MDRTC website and periodic email communications. Directions to the Administrative Core and the Chemistry Lab will be posted on the MDRTC Web site in the near future. The new addresses for the Administration Core and the Chemistry Lab are follows:

Administration Core Chemistry Laboratory
400 N. Ingalls 400 N. Ingalls
Room No G170 Room G148
SPC No. 5488 SPC No. 5488
Telephone: (734) 764-8044 Telephone: (734) 763-5730