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Peptide and Proteomics

The goal of the Peptide and Proteomics Core is to enhance and stimulate research in diabetes, its complications and related endocrine and metabolic disorders by MDRTC investigators by providing the broadest range of resources for the analysis of peptides and proteins. This core provides assistance with peptide synthesis, including multiply labeled, cyclic peptides and peptides with posttranslational modifications. N-terminal sequence analysis is offered for protein characterization as is Circular Dichroism Spectroscopy and state-of-the-art technology in protein analysis such as routine identification of proteins by mass spectrometry. Proteomic services include proteome mapping, protein expression profiling, protein complexes, and post-translational modifications. Technologies offered include 1) protein expression profiling using isotope enrichment, ion statistics, and two dimensional gel electrophoresis; 2) phosphorylation site mapping as well as mapping of other post-translational modifications; 3) MuDPIT analyses; 4) 1D and 2D capillary HPLC; 5) bioinformatics support and training; 6) tandem mass spectrometry; and 7) proteome informatics. The Core maintains an information management system for proteomics, providing an environment for investigators to access and curate their data.

Recharge Rates

Charges for U-M-MDRTC investigators for all services are reduced by 75%. For a list of recharge rates for Protein Mass Spectrometry, click here. For a list of recharge rates for Peptide Synthesis, click here.

Services

A. Protein Mass Spectrometry and Analysis:

B. Peptide Synthesis (available at the Protein Structure Facility)

Equipment:

Sample Preparation, Request Submission and Other Information:

Key Personnel

Philip C. Andrews, PhD, Director, Peptide and Proteomics Core and Proteome Consortium
andrewsp@umich.edu; 734 763-3130

Henriette Remmer, Ph.D., Co-director, Peptide and Proteomics Core,
hremmer@umich.edu
; 734-763-6285