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MDRC Morphology and Image Analysis Publications

Representative manuscripts that used the MIAC to support their research.



Cheng HT, Dauch JR, Hayes JM, Yanik BM, Feldman EL Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes. Neurobiol Dis. 2012 Jan;45(1):280-7. Epub 2011 Aug 18. PMID:  21872660 PMCID: PMC3225563

Louis GW, Greenwald-Yarnell M, Phillips R, Coolen LM, Lehman MN, Myers MG Jr  Molecular Mapping of the Neural Pathways Linking Leptin to the Neuroendocrine Reproductive Axis. Endocrinology. 2011 Jun;152(6):2302-10. Epub 2011 Mar 22. PMID: 21427219 PMCID: PMC3100610

Pande M, Hur J, Hong Y, Backus C, Hayes JM, Oh SS, Kretzler M, Feldman EL Transcriptional profiling of diabetic neuropathy in the BKS db/db mouse: a model of type 2 diabetes. Diabetes. 2011 Jul;60(7):1981-9. Epub 2011 May 26. PMID: 21617178 PMCID:  PMC3121428

Williams AL, Bielopolski N, Meroz D, Lam AD, Passmore DR, Ben-Tal N, Ernst SA, Ashery U, Stuenkel EL  Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation. J Biol Chem. 2011 Apr 22;286(16):14542-53. Epub 2011 Feb 17. PMID: 21330375 PMCID: PMC3077652



Cheng HT, Dauch JR, Oh SS, Hayes JM, Hong Y, Feldman EL p38 mediates mechanical allodynia in a mouse model of type 2 diabetes. Mol Pain. 2010 May 19;6:28. PMID: 20482876 PMCID: PMC2881061

Crozier SJ, Sans MD, Wang JY, Lentz SI, Ernst SA, Williams JA  CCK-independent mTORC1 activation during dietary protein-induced exocrine pancreas growth. Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1154-63. Epub 2010 Aug 26.  PMID:  20798356  PMCID:  PMC2993171
Edwards JL, Quattrini A, Lentz SI, Figueroa-Romero C, Cerri F, Backus C, Hong Y, Feldman EL  Diabetes regulates mitochondrial biogenesis and fission in mouse neurons. Diabetologia. 2010 Jan;53(1):160-9. Epub 2009 Oct 22. PMID: 19847394

Hodish I, Liu M, Rajpal G, Larkin D, Holz RW, Adams A, Liu L, Arvan P Misfolded proinsulin affects bystander proinsulin in neonatal diabetes. J Biol Chem. 2010 Jan 1;285(1):685-94. Epub 2009 Oct 30. PMID: 19880509 PMCID: PMC2804216

Lam AD, Ismail S, Wu R, Yizhar O, Passmore DR, Ernst SA, Stuenkel EL  Mapping dynamic protein interactions to insulin secretory granule behavior with TIRF-FRET. Biophys J. 2010 Aug 9;99(4):1311-20. PMID: 20713017 PMCID: PMC2920663

Leshan RL, Opland DM, Louis GW, Leinninger GM, Patterson CM, Rhodes CJ, Müenzberg H, Myers MG Jr  Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala. J Neurosci. 2010 Apr 21;30(16):5713-23. PMID: 20410123 PMCID: PMC2864009

Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM,Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW,Labosky PA, Myers MG Jr, Gannon M, Powers AC, Dempsey PJ  Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes. 2010 Dec;59(12):3090-8. Epub 2010 Aug 29.  PMID: 20802254 PMCID: PMC2992770



Berthier CC, Zhang H, Schin M, Henger A, Nelson RG, Yee B, Boucherot A, Neusser MA, Cohen CD, Carter-Su C, Argetsinger LS, Rastaldi MP, Brosius FC, Kretzler M. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes. 2009 Feb;58(2):469-77. Epub 2008 Nov 18. PMID:  19017763  PMCID: PMC2628622

Kellogg AP, Converso K, Wiggin T, Stevens M, Pop-Busui R  Effects of cyclooxygenase-2 gene inactivation on cardiac autonomic and left ventricular function in experimental diabetes. Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H453-61. Epub 2008 Dec 5. PMID:  19060127  PMCID: PMC2643890

Mori H, Inoki K, Opland D, Muenzberg H, Villanueva EC, Faouzi M, Ikenoue T Kwiatkowski D, Macdougald OA, Myers Jr MG, Guan KL  Critical roles for the TSC-mTOR pathway in {beta}-cell function. Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1013-22. Epub 2009 Aug 18.  PMID: 19690069 PMCID:  PMC2781354

Vincent AM, Hayes JM, McLean LL, Vivekanandan-Giri A, Pennathur S, Feldman EL  Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1. Diabetes. 2009 Oct;58(10):2376-85. Epub 2009 Jul 10.  PMID:  19592619  PMCID: PMC2750230 



Gelling RW, Yan W, Al-Noori S, Pardini A, Morton GJ, Ogimoto K, Schwartz MW, Dempsey PJ  Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology. 2008 Dec;149(12):6053-64. Epub 2008 Aug 7.  PMID:  18687778  PMCID: PMC2734496

Russell JW, Berent-Spillson A, Vincent AM, Freimann CL, Sullivan KA, Feldman EL  Oxidative injury and neuropathy in diabetes and impaired glucose tolerance. Neurobiol Dis. 2008 Jun;30(3):420-9. Epub 2008 Mar 15.  PMID:  18424057  PMCID: PMC2453225

Van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG Jr, Schwartz GJ, Chua SC Jr  Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 2008 Apr;149(4):1773-85. Epub 2007 Dec 27.  PMID:  18162515 PMCID: PMC2276717

Zhang H, Saha J, Byun J, Schin M, Lorenz M, Kennedy RT, Kretzler M, Feldman EL, Pennathur S, Brosius FC 3rd  Rosiglitazone reduces renal and plasma markers of oxidative injury and reverses urinary metabolite abnormalities in the amelioration of diabetic nephropathy. Am J Physiol Renal Physiol. 2008 Oct;295(4):F1071-81. Epub 2008 Jul 30.  PMID:  18667486  PMCID: PMC2576144



Berent-Spillson A, Russell JW  Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration. J Neurochem. 2007 Apr;101(2):342-54.  PMID: 17402968

D'Andrea-Merrins M, Chang L, Lam AD, Ernst SA, Stuenkel EL  Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking. J Biol Chem. 2007 Jun 1;282(22):16553-66. Epub 2007 Apr 5.  PMID: 17412693

Kellogg AP, Wiggin TD, Larkin DD, Hayes JM, Stevens MJ, Pop-Busui R  Protective effects of cyclooxygenase-2 gene inactivation against peripheral nerve dysfunction and intraepidermal nerve fiber loss in experimental diabetes. Diabetes. 2007 Dec;56(12):2997-3005. Epub 2007 Aug 24.  PMID: 17720896

Liu M, Hodish I, Rhodes CJ, Arvan P  Proinsulin maturation, misfolding, and proteotoxicity. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15841-6. Epub 2007 Sep 26.  PMID:  17898179  PMCID: PMC2000385

Sullivan KA, Hayes JM, Wiggin TD, Backus C, Su Oh S, Lentz SI, Brosius F 3rd, Feldman EL  Mouse models of diabetic neuropathy. Neurobiol Dis. 2007 Dec;28(3):276-85. Epub 2007 Jul 31.  PMID: 17804249



Crozier SJ, Sans MD, Guo L, D'Alecy LG, Williams JA  Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice.  J Physiol. 2006 Jun 15;573(Pt 3):775-86. Epub 2006 Apr 13.  PMID:  16613881  PMCID:  PMC1779746

Leinninger GM, Backus C, Sastry AM, Yi YB, Wang CW, Feldman EL  Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1. Neurobiol Dis. 2006 Jul;23(1):11-22. Epub 2006 May 8. PMID: 16684605

Siu BB, Saha J, Smoyer WE, Sullivan KA, Brosius III FC  Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by pioic acid treatment.  BMC Nephrol. 2006 Mar 15;7:6.  PMID:  16539708  PMCID:  PMC1435876

Straight SW, Pieczynski JN, Whiteman EL, Liu CJ, Margolis B  Mammalian lin-7 stabilizes polarity protein complexes.  J Biol Chem. 2006 Dec 8;281(49):37738-47. Epub 2006 Oct 1.  PMID:  17012742



Bi Y, Page SL, Williams JA  Rho and Rac promote acinar morphological changes, actin reorganization, and amylase secretion. Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G561-70. Epub 2005 May 26.  PMID:  15920016

Bi Y, Williams JA  A role for Rho and Rac in secretagogue-induced amylase release by pancreatic acini. Am J Physiol Cell Physiol. 2005 Jul;289(1):C22-32. Epub 2005 Mar 2.  PMID:  15743890

Cowell RM, Russell JW  Nitrosative injury and antioxidant therapy in the management of diabetic neuropathy. J Investig Med. 2004 Jan;52(1):33-44.  PMID:  14989368

Kubisch C, Dimagno MJ, Tietz AB, Welsh MJ, Ernst SA, Brandt-Nedelev B, Diebold J, Wagner AC, Goke B, Williams JA, Schafer C. Overexpression of heat shock protein Hsp27 protects against cerulein-induced pancreatitis. Gastroenterology. 2004 Jul;127(1):275-86.  PMID:  15236192

Leinninger GM, Backus C, Uhler MD, Lentz SI, Feldman EL  Phosphatidylinositol 3-kinase and Akt effectors mediate insulin-like growth factor-I neuroprotection in dorsal root ganglia neurons. FASEB J. 2004 Oct;18(13):1544-6. Epub 2004 Aug 19.  PMID:  15319368

Vincent AM, Olzmann JA, Brownlee M, Sivitz WI, Russell JW  Uncoupling proteins prevent glucose-induced neuronal oxidative stress and programmed cell death. Diabetes. 2004 Mar;53(3):726-34.  PMID:  14988258

Wang X, Chen L, Maures TJ, Herrington J, Carter-Su C SH2-B is a positive regulator of nerve growth factor-mediated activation of the Akt/Forkhead pathway in PC12 cells. J Biol Chem. 2004 Jan 2;279(1):133-41. Epub 2003 Oct 16. PMID: 14565960

Treutelaar MK, Skidmore JM, Dias-Leme CL, Hara M, Zhang L, Simeone D, Martin DM, Burant CF  Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes. 2003 Oct;52(10):2503-12.  PMID:  14514633

Russell JW, Golovoy D, Vincent AM, Mahendru P, Olzmann JA, Mentzer A, Feldman EL  High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J. 2002 Nov;16(13):1738-48.  PMID:  12409316