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MDRTC Disease Modeling Software for Clinical Research


To facilitate modeling of the progression of chronic disease such as diabetes so that investigators can evaluate the cost/utility of a proposed method of prevention, early diagnosis or intervention.



Clinical studies of a chronic disease, such as diabetes, may require a large population and a lengthy follow-up. However, it is possible to obtain estimates of the probabilities of transitions between stages of diseases, or complications, from studies with shorter-term follow up. Therefore, the progression of the disease and its complication can be simulated (modeled) over a long period of time without following subjects for the entire period. The goal of this project is to create a computer model movie that can simulate the progression of a chronic disease; we use diabetes and its associated complications as an example. Investigators can study the theoretical effect of a prevention strategy or an intervention by modifying the transition probabilities in the model to reflect the expected effect of the intervention.


Quick video introduction

For a quick introduction to the project, please click on the following links to launch narrated videos: