University of Michigan Health System

Michigan Diabetes Research and Training Center

Simulation Results for the Michigan Model of Diabetes Progression 11-May-2009

To validate the Michigan Model of Diabetes Progression, we applied the model to a simulated sample of 1138 subjects corresponding to the conventionally treated cohort of the United Kingdom Prospective Diabetes Study (UKPDS). The results presented here reflect statistics for 100 repetitions of a 10 year simulation for the simulated sample of 1138 individuals. The statistics includes mean, standard deviation (SD), median, min and max values with respect to repetitions of the simulation. Values for a single repetition correspond to the calculation method defined in the row heading that are explained below.

The table below shows the statistics for the 100 repetitions of the 10 year simulation considering natural progression of the disease. The statistics shown in the first columns are the mean, std, min, median, and max results for the entire simulation time period considering the 100 repetitions. The last set of columns shows means over 100 repetitions while focusing on specific time periods. Note that the column statistics per repetition are calculated after the row statistics (per individual / time) have been calculated for a certain repetition of simulation.

Note that the model for retinopathy is still under development; the results for blindness do not match between the simulated results and the UKPDS observed results.

Please use the following link to open the table below in a different window to help scrolling it horizontally.

Parameter	Calculation Method	UKPDS	Mean	SD	Min	Median	Max	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean
	Start Step		1	1	1	1	1	0	1	2	3	4	5	6	7	8	9	10	1	6	1
	End Step		10	10	10	10	10	0	1	2	3	4	5	6	7	8	9	10	5	10	10
	Rec Count		10562.53	56.06	10409.00	10566.00	10662.00	1138.00	1138.00	1124.97	1109.72	1092.01	1073.46	1052.72	1030.63	1006.67	980.95	953.40	5538.16	5024.37	10562.53
	Dem. Count		1138	0	1138	1138	1138	1138	1138.00	1124.97	1109.72	1092.01	1073.46	1052.72	1030.63	1006.67	980.95	953.40	1138.00	1052.72	1138.00
Age	Avg Dem.		53.56	0.00	53.56	53.56	53.56	52.56	53.56	54.51	55.45	56.37	57.29	58.21	59.12	60.03	60.93	61.81	53.56	58.21	53.56
Male	Avg Dem.		0.61	0.00	0.61	0.61	0.61	0.61	0.61	0.61	0.60	0.60	0.60	0.60	0.60	0.59	0.59	0.59	0.61	0.60	0.61
A1c_Start	Avg Dem.		7.06	0.00	7.06	7.06	7.06	7.06	7.06	7.06	7.06	7.06	7.06	7.05	7.05	7.05	7.05	7.05	7.06	7.05	7.06
A1c	Avg All		7.84	0.03	7.79	7.84	7.90	7.06	7.43	7.53	7.62	7.71	7.79	7.89	7.99	8.10	8.21	8.32	7.61	8.10	7.84
SBP	Avg Dem.		134.51	0.00	134.51	134.51	134.51	134.51	134.51	134.49	134.48	134.47	134.46	134.44	134.42	134.39	134.35	134.32	134.51	134.44	134.51
Smoke	Avg Dem.		0.319	0.00	0.319	0.319	0.319	0.319	0.319	0.3187	0.3182	0.3179	0.3173	0.3166	0.3157	0.3147	0.3137	0.3128	0.319	0.3166	0.319
BMI	Avg Dem.		27.88	0.00	27.88	27.88	27.88	27.88	27.88	27.88	27.88	27.88	27.89	27.88	27.89	27.89	27.89	27.90	27.88	27.88	27.88
HDLCholesterol	Avg Dem.		1.08	0.00	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08	1.08
TotalCholesterol	Avg Dem.		5.38	0.00	5.38	5.38	5.38	5.38	5.38	5.38	5.38	5.38	5.38	5.37	5.37	5.37	5.37	5.37	5.38	5.37	5.38
LipidRatio	Avg Dem.		5.28	0.00	5.28	5.28	5.28	5.28	5.28	5.28	5.27	5.27	5.26	5.26	5.25	5.24	5.23	5.22	5.28	5.26	5.28
AF	Avg Dem.		0.0053	0.00	0.0053	0.0053	0.0053	0.0053	0.0053	0.0053	0.0052	0.0051	0.005	0.0049	0.0048	0.0047	0.0046	0.0044	0.0053	0.0049	0.0053
UKPDS33_Aggregate_DiabetesRelatedDeaths	Sum All	129	135.35	9.77	111	135	164	0.00	6.93	9.09	10.64	11.22	12.84	14.39	15.72	16.88	17.95	19.69	50.72	84.63	135.35
UKPDS33_Aggregate_AllCauseMortality	Sum All	213	213.89	12.16	181	213	255	0.00	13.03	15.25	17.71	18.55	20.74	22.09	23.96	25.72	27.55	29.29	85.28	128.61	213.89
UKPDS33_Aggregate_MI	Sum LOCF	186	189.93	11.11	159	189	219	0.00	15.00	30.67	47.69	65.48	84.48	105.21	126.00	146.34	167.61	189.93	84.48	189.93	189.93
UKPDS33_Aggregate_Stroke	Sum LOCF	55	48.17	6.21	32	48	63	0.00	2.79	6.03	9.74	13.84	18.29	22.95	28.50	34.52	40.79	48.17	18.29	48.17	48.17
UKPDS33_Aggregate_MicroVascular	Sum LOCF	121	101.72	8.98	80	101	132	0.00	10.55	20.81	31.75	42.67	53.43	63.37	73.16	83.23	92.56	101.72	53.43	101.72	101.72
UKPDS33_SingleEndPoint_MI_Plus_SuddenDeath	Sum All	108	109.17	9.19	87	110	135	0.00	6.34	7.97	9.02	9.39	10.63	11.66	12.36	13.31	13.61	14.88	43.35	65.82	109.17
UKPDS33_SingleEndPoint_NonFatalMI	Sum LOCF	101	101.39	9.53	76	101.5	125	0.00	8.66	16.90	25.86	35.47	45.85	57.12	68.18	78.64	89.98	101.39	45.85	101.39	101.39
UKPDS33_SingleEndPoint_Angina	Sum All	72	69.56	7.76	54	69	91	0.00	8.42	7.35	7.07	7.30	7.08	7.14	6.72	6.30	6.41	5.77	37.22	32.34	69.56
UKPDS33_SingleEndPoint_FatalStroke	Sum All	15	12.74	3.25	6	13	21	0.00	0.59	0.87	0.91	1.07	1.16	1.19	1.63	1.52	1.72	2.08	4.60	8.14	12.74
UKPDS33_SingleEndPoint_NonFatalStroke	Sum LOCF	44	36.65	5.16	24	37	50	0.00	2.20	4.62	7.47	10.59	14.00	17.63	21.71	26.48	31.14	36.65	14.00	36.65	36.65
UKPDS33_SingleEndPoint_Amputation	Sum All	18	22.24	4.40	10	22.5	32	0.00	0.00	0.84	1.28	1.76	1.94	2.67	2.98	3.38	3.64	3.75	5.82	16.42	22.24
UKPDS33_SingleEndPoint_DeathFromRenalDisease	Sum All	2	3.19	1.74	0	3	10	0.00	0.00	0.06	0.11	0.19	0.20	0.28	0.41	0.41	0.62	0.91	0.56	2.63	3.19
UKPDS33_SingleEndPoint_RenalFailure	Sum All	9	7.62	2.82	1	7.5	16	0.00	0.29	0.25	0.28	0.55	0.65	0.76	1.00	1.18	1.28	1.38	2.02	5.60	7.62
UKPDS33_SingleEndPoint_RetinalPhotocoagulation	Sum All	117	114.89	9.23	95	115	146	0.00	10.26	10.43	11.80	11.82	11.78	11.58	11.73	11.93	11.70	11.86	56.09	58.80	114.89
UKPDS33_SingleEndPoint_DeathFrom_Hyperglycemia_ Hypoglycemia_PVD_Accident_Cancer_Other_Unknown	Sum All	88	78.54	7.70	60	79	102	0.00	6.10	6.16	7.07	7.33	7.90	7.70	8.24	8.84	9.60	9.60	34.56	43.98	78.54
Death_Entered	Sum All		213.89	12.16	181	213	255	0.00	13.03	15.25	17.71	18.55	20.74	22.09	23.96	25.72	27.55	29.29	85.28	128.61	213.89
Other_Death_Entered	Sum All		78.54	7.70	60	79	102	0.00	6.10	6.16	7.07	7.33	7.90	7.70	8.24	8.84	9.60	9.60	34.56	43.98	78.54
Fatal_Stroke	Sum All		12.74	3.25	6	13	21	0.00	0.59	0.87	0.91	1.07	1.16	1.19	1.63	1.52	1.72	2.08	4.60	8.14	12.74
Fatal_Survive_Stroke	Sum All		10.25	2.72	3	10	18	0.00	0.00	0.19	0.60	0.57	0.85	1.26	1.32	1.64	2.00	1.82	2.21	8.04	10.25
Stroke_Death_Entered	Sum All		22.99	4.63	13	23	35	0.00	0.59	1.06	1.51	1.64	2.01	2.45	2.95	3.16	3.72	3.90	6.81	16.18	22.99
Fatal_Angina	Sum All		11.34	3.27	4	11	20	0.00	0.00	0.39	0.63	0.98	1.06	1.27	1.60	1.54	1.72	2.15	3.06	8.28	11.34
Fatal_MI	Sum All		94.50	8.61	75	95	117	0.00	6.34	7.46	8.26	8.27	9.25	9.99	10.29	11.21	11.27	12.16	39.58	54.92	94.50
Fatal_Survive_MI	Sum All		3.33	1.85	0	3	9	0.00	0.00	0.12	0.13	0.14	0.32	0.40	0.47	0.56	0.62	0.57	0.71	2.62	3.33
CVD_Death_Entered	Sum All		109.17	9.19	87	110	135	0.00	6.34	7.97	9.02	9.39	10.63	11.66	12.36	13.31	13.61	14.88	43.35	65.82	109.17
Fatal_ESRD_Dialysis	Sum All		3.09	1.71	0	3	10	0.00	0.00	0.06	0.11	0.19	0.20	0.28	0.40	0.37	0.62	0.86	0.56	2.53	3.09
Fatal_ESRD_Transplant	Sum All		0.10	0.33	0	0	2	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.01	0.04	0.00	0.05	0.00	0.10	0.10
ESRD_Death_Entered	Sum All		3.19	1.74	0	3	10	0.00	0.00	0.06	0.11	0.19	0.20	0.28	0.41	0.41	0.62	0.91	0.56	2.63	3.19
No_Cerebrovascular_Disease	Sum LOCF		1089.83	6.21	1075	1090	1106	1138.00	1135.21	1131.97	1128.26	1124.16	1119.71	1115.05	1109.50	1103.48	1097.21	1089.83	1119.71	1089.83	1089.83
Stroke_Entered	Sum All		53.52	7.14	35	54	67	0.00	2.79	3.41	3.92	4.46	4.93	5.29	6.27	6.86	7.16	8.43	19.51	34.01	53.52
Survive_Stroke_Entered	Sum All		40.78	5.96	26	41	54	0.00	2.20	2.54	3.01	3.39	3.77	4.10	4.64	5.34	5.44	6.35	14.91	25.87	40.78
Survive_Stroke	Sum LOCF		25.18	4.50	15	25	36	0.00	2.20	4.38	6.58	9.04	11.48	13.69	16.29	19.15	21.70	25.18	11.48	25.18	25.18
No_CVD	Sum LOCF		904.04	12.19	867	905	933	1138.00	1114.58	1092.41	1069.66	1046.65	1023.06	998.49	974.45	951.14	927.43	904.04	1023.06	904.04	904.04
Angina_Entered	Sum All		69.56	7.76	54	69	91	0.00	8.42	7.35	7.07	7.30	7.08	7.14	6.72	6.30	6.41	5.77	37.22	32.34	69.56
Angina	Sum LOCF		44.03	6.54	27	44	64	0.00	8.42	14.92	20.65	25.87	30.46	34.30	37.55	40.52	42.96	44.03	30.46	44.03	44.03
MI_Entered	Sum All		219.66	13.80	181	219	259	0.00	15.00	16.26	18.25	19.55	21.69	23.73	24.65	25.48	27.04	28.01	90.75	128.91	219.66
Survive_MI_Entered	Sum All		125.16	12.36	94	125	161	0.00	8.66	8.80	9.99	11.28	12.44	13.74	14.36	14.27	15.77	15.85	51.17	73.99	125.16
Survive_MI	Sum LOCF		80.76	9.15	57	81	101	0.00	8.66	16.36	24.36	32.76	41.13	50.20	58.63	65.66	73.32	80.76	41.13	80.76	80.76
No_Retinopathy	Sum LOCF		364.99	13.44	337	365.5	405	728.00	679.28	633.60	590.39	549.72	511.43	475.65	444.36	414.80	389.12	364.99	511.43	364.99	364.99
Non_Proliferative_Entered	Sum All		363.01	13.44	323	362.5	391	0.00	48.72	45.68	43.21	40.67	38.29	35.78	31.29	29.56	25.68	24.13	216.57	146.44	363.01
Non_Proliferative	Sum LOCF		461.27	14.80	427	459	498	410.00	429.42	445.06	456.04	463.54	468.91	472.99	472.29	472.07	467.30	461.27	468.91	461.27	461.27
Proliferative_Entered	Sum All		114.89	9.23	95	115	146	0.00	10.26	10.43	11.80	11.82	11.78	11.58	11.73	11.93	11.70	11.86	56.09	58.80	114.89
Proliferative	Sum LOCF		97.29	8.90	76	97	125	0.00	10.26	20.33	31.10	41.66	51.97	61.43	70.63	79.93	88.60	97.29	51.97	97.29	97.29
Started_Non_Proliferative	Sum LOCF		410	0	410	410	410	410	410	410	410	410	410	410	410	410	410	410	410	410	410
Advanced_To_Non_Proliferative	Sum LOCF		256.28	12.59	221	256	288	0.00	48.72	91.07	127.68	159.08	185.99	208.91	225.80	240.23	249.51	256.28	185.99	256.28	256.28
Macular_edema_Entered	Sum All		141.85	11.19	115	142.5	171	0.00	12.43	13.47	14.04	14.95	14.81	15.11	15.23	13.24	14.47	14.10	69.70	72.15	141.85
Macular_edema	Sum LOCF		133.13	10.97	104	132.5	164	0.00	12.43	25.72	39.41	53.80	67.75	81.77	95.79	107.75	120.59	133.13	67.75	133.13	133.13
Blindness_Entered	Sum All		81.32	7.80	64	81	97	0.00	6.61	6.68	7.77	8.22	8.66	8.22	8.77	8.52	8.94	8.93	37.94	43.38	81.32
Blindness	Sum LOCF		81.32	7.80	64	81	97	0.00	6.61	13.29	21.06	29.28	37.94	46.16	54.93	63.45	72.39	81.32	37.94	81.32	81.32
No_Nephropathy	Sum LOCF		644.88	14.92	604	647.5	682	1031.00	979.12	930.30	884.50	840.81	800.91	764.02	730.86	699.64	671.75	644.88	800.91	644.88	644.88
Micro_Albuminuria_Entered	Sum All		386.12	14.92	349	383.5	427	0.00	51.88	48.82	45.80	43.69	39.90	36.89	33.16	31.22	27.89	26.87	230.09	156.03	386.12
Micro_Albuminuria	Sum LOCF		272.06	13.39	242	271.5	314	82.00	125.57	161.65	191.23	215.59	234.60	249.11	258.72	266.26	269.46	272.06	234.60	272.06	272.06
Started_Micro_Albuminuria	Sum LOCF		82	0	82	82	82	82	82	82	82	82	82	82	82	82	82	82	82	82	82
Advanced_To_Micro_Albuminuria	Sum LOCF		241.68	12.67	208	242	275	0.00	51.88	95.24	131.38	161.48	185.78	204.86	218.50	229.74	236.14	241.68	185.78	241.68	241.68
Proteinuria_Entered	Sum All		196.06	11.17	168	196.5	217	0.00	8.31	12.74	16.22	19.33	20.89	22.38	23.55	23.68	24.69	24.27	77.49	118.57	196.06
Proteinuria	Sum LOCF		213.44	11.04	184	214.5	240	25.00	33.02	45.51	61.45	80.23	100.47	122.09	144.64	167.14	190.55	213.44	100.47	213.44	213.44
Started_Proteinuria	Sum LOCF		25	0	25	25	25	25	25	25	25	25	25	25	25	25	25	25	25	25	25
Advanced_To_Proteinuria	Sum LOCF		190.29	10.77	163	191	215	0.00	8.31	20.99	37.03	56.05	76.46	98.19	120.95	143.65	167.26	190.29	76.46	190.29	190.29
ESRD_Dialysis_Entered	Sum All		7.62	2.82	1	7.5	16	0.00	0.29	0.25	0.28	0.55	0.65	0.76	1.00	1.18	1.28	1.38	2.02	5.60	7.62
ESRD_Dialysis	Sum LOCF		3.98	1.90	0	4	9	0.00	0.29	0.47	0.63	0.96	1.35	1.72	2.25	2.99	3.55	3.98	1.35	3.98	3.98
ESRD_Transplant_Entered	Sum All		0.55	0.76	0	0	3	0.00	0.00	0.01	0.01	0.03	0.06	0.11	0.07	0.07	0.10	0.09	0.11	0.44	0.55
ESRD_Transplant	Sum LOCF		0.45	0.64	0	0	2	0.00	0.00	0.01	0.02	0.05	0.11	0.22	0.28	0.31	0.41	0.45	0.11	0.45	0.45
No_Neuropathy	Sum LOCF		704.59	17.04	653	705	744	1138.00	1080.19	1025.39	974.60	926.26	881.20	840.45	802.73	767.23	734.37	704.59	881.20	704.59	704.59
Clinical_Neuropathy_Entered	Sum All		433.41	17.04	394	433	485	0.00	57.81	54.80	50.79	48.34	45.06	40.75	37.72	35.50	32.86	29.78	256.80	176.61	433.41
Clinical_Neuropathy	Sum LOCF		411.17	16.68	373	413.5	457	0.00	57.81	111.77	161.28	207.86	250.98	289.06	323.80	355.92	385.14	411.17	250.98	411.17	411.17
Amputation_Entered	Sum All		22.24	4.40	10	22.5	32	0.00	0.00	0.84	1.28	1.76	1.94	2.67	2.98	3.38	3.64	3.75	5.82	16.42	22.24
Amputation	Sum LOCF		22.24	4.40	10	22.5	32	0.00	0.00	0.84	2.12	3.88	5.82	8.49	11.47	14.85	18.49	22.24	5.82	22.24	22.24
Diabetes_with_treatment_by_diet___exercise	Sum LOCF		413.56	12.20	385	412	445	1138.00	968.29	826.72	714.55	629.83	566.85	520.12	484.47	455.60	432.93	413.56	566.85	413.56	413.56
Diabetes_with_treatment_by_oral_meds	Sum LOCF		336.96	13.27	311	338	383	0.00	107.58	185.77	243.55	281.40	304.70	319.24	328.30	333.70	336.27	336.96	304.70	336.96	336.96
Diabetes_with_treatment_by_Insulin	Sum LOCF		387.48	14.16	350	387	417	0.00	62.13	125.51	179.90	226.77	266.45	298.64	325.23	348.70	368.80	387.48	266.45	387.48	387.48
ProbOptDeathFromESRD_Dialysis	Avg All		0.2555	0.0006	0.2539	0.2555	0.2567	0.00	0.2294	0.2347	0.2404	0.2459	0.2529	0.2592	0.2653	0.2719	0.2787	0.287	0.2405	0.2721	0.2555
YearlyCost	Avg All		3205	53	3057	3193	3358	0	2399	2597	2789	2967	3149	3344	3516	3683	3855	4040	2775	3679	3205
TotalCost	Avg LOCF		29746	492	28455	29687	30897	0	2399	4966	7685	10532	13503	16596	19780	23039	26362	29746	13503	29746	29746
TotalCost	Sum LOCF		33851087	559821	32382016	33783493	35160245	0	2730331	5651503	8746041	11985834	15366192	18886300	22509899	26217969	29999406	33851087	15366192	33851087	33851087
HealthUtilityScoreThisYear	Avg All		0.6249	0.0011	0.6224	0.6248	0.6271	0.00	0.6556	0.6471	0.6392	0.632	0.6252	0.6191	0.6133	0.6078	0.6024	0.597	0.6401	0.6082	0.6249
TotalHealthUtilityScore	Avg LOCF		5.8001	0.0322	5.7223	5.7996	5.8629	0.00	0.6556	1.2954	1.9187	2.5251	3.1149	3.6876	4.2431	4.7807	5.2999	5.8001	3.1149	5.8001	5.8001
TotalHealthUtilityScore	Sum LOCF		6600	37	6512	6600	6672	0	746	1474	2183	2874	3545	4197	4829	5440	6031	6600	3545	6600	6600
ProbOptTransNo_CVD_To_MI	Avg All		0.0172	0.0002	0.0168	0.0172	0.0176	0.00	0.0127	0.0136	0.0145	0.0155	0.0166	0.0177	0.0188	0.02	0.0213	0.0226	0.0146	0.02	0.0172
ProbOptTransAngina_To_MI	Avg All		0.055	0.00	0.055	0.055	0.055	0.00	0.055	0.055	0.055	0.055	0.055	0.055	0.055	0.055	0.055	0.055	0.055	0.055	0.055
ProbOptTransSurvive_MI_To_MI	Avg All		0.1159	0.00	0.1159	0.1159	0.1159	0.00	0.1159	0.1159	0.1159	0.1159	0.1159	0.1159	0.1159	0.1159	0.1159	0.1159	0.1159	0.1159	0.1159
ProbOptDeathFromAngina	Avg All		0.0476	0.00	0.0476	0.0476	0.0476	0.00	0.0476	0.0476	0.0476	0.0476	0.0476	0.0476	0.0476	0.0476	0.0476	0.0476	0.0476	0.0476	0.0476
ProbOptDeathFromMI	Avg All		0.4257	0.0002	0.4252	0.4257	0.4263	0.00	0.4263	0.4262	0.4261	0.4259	0.4258	0.4257	0.4255	0.4253	0.4252	0.425	0.4261	0.4253	0.4257
ProbOptDeathFromSurviveMI	Avg All		0.0076	0.00	0.0076	0.0076	0.0077	0.00	0.0061	0.0064	0.0067	0.0071	0.0075	0.0079	0.0083	0.0087	0.0091	0.0094	0.0067	0.0086	0.0076
ProbOptDeathFromESRD	Avg All		0.0003	0.0002	0.00	0.0003	0.0009	0.00	0.00	0.0001	0.0001	0.0001	0.0002	0.0003	0.0004	0.0006	0.0008	0.001	0.0001	0.0006	0.0003
ProbOptDeathFromESRD_Dialysis	Avg All		0.2555	0.0006	0.2539	0.2555	0.2567	0.00	0.2294	0.2347	0.2404	0.2459	0.2529	0.2592	0.2653	0.2719	0.2787	0.287	0.2405	0.2721	0.2555
ProbOptDeathFromESRD_Dialysis	Avg All		0.2555	0.0006	0.2539	0.2555	0.2567	0.00	0.2294	0.2347	0.2404	0.2459	0.2529	0.2592	0.2653	0.2719	0.2787	0.287	0.2405	0.2721	0.2555
ProbOptDeathFromESRD_Transplant	Avg All		0.082	0.0001	0.0817	0.082	0.0822	0.00	0.072	0.0744	0.0769	0.0793	0.0819	0.084	0.0859	0.0876	0.0896	0.0915	0.0768	0.0876	0.082
ProbOptTransNo_Cereb_To_Stroke	Avg All		0.0047	0.0001	0.0045	0.0047	0.0048	0.00	0.0026	0.0029	0.0033	0.0038	0.0042	0.0048	0.0054	0.0061	0.0068	0.0077	0.0034	0.0061	0.0047
ProbOptTransSurviveStroke_To_Stroke	Avg All		0.0567	0.00	0.0567	0.0567	0.0567	0.00	0.0567	0.0567	0.0567	0.0567	0.0567	0.0567	0.0567	0.0567	0.0567	0.0567	0.0567	0.0567	0.0567
ProbOptDeathFromStroke	Avg All		0.241	0.00	0.241	0.241	0.241	0.00	0.241	0.241	0.241	0.241	0.241	0.241	0.241	0.241	0.241	0.241	0.241	0.241	0.241
ProbOptDeathFromSurviveStroke	Avg All		0.1064	0.00	0.1064	0.1064	0.1064	0.00	0.1064	0.1064	0.1064	0.1064	0.1064	0.1064	0.1064	0.1064	0.1064	0.1064	0.1064	0.1064	0.1064
ProbOptDeathFromOtherCauses	Avg All		0.0114	0.0001	0.0112	0.0114	0.0117	0.00	0.0079	0.0086	0.0093	0.0101	0.0109	0.0118	0.0127	0.0137	0.0148	0.0159	0.0094	0.0137	0.0114
ProbOptDeathFromESRD	Avg All		0.0003	0.0002	0.00	0.0003	0.0009	0.00	0.00	0.0001	0.0001	0.0001	0.0002	0.0003	0.0004	0.0006	0.0008	0.001	0.0001	0.0006	0.0003
ProbOptDeathFromCerebrovascularDisease	Avg All		0.0022	0.0002	0.0017	0.0022	0.0028	0.00	0.0006	0.0009	0.0013	0.0016	0.002	0.0024	0.0027	0.0032	0.0036	0.0041	0.0013	0.0032	0.0022
ProbOptDeathFromCVD	Avg All		0.0105	0.0003	0.0099	0.0104	0.0112	0.00	0.0055	0.0068	0.0079	0.009	0.0101	0.0112	0.0123	0.0134	0.0145	0.0156	0.0078	0.0134	0.0105
MaxOptOfDeathProbabilities	Avg All		0.0162	0.0004	0.0155	0.0162	0.0171	0.00	0.0088	0.0106	0.0122	0.0138	0.0155	0.0172	0.019	0.0208	0.0227	0.0246	0.0121	0.0208	0.0162
SumOptOfDeathProbabilities	Avg All		0.0244	0.0005	0.0235	0.0244	0.0255	0.00	0.0141	0.0164	0.0186	0.0208	0.0232	0.0257	0.0282	0.0309	0.0337	0.0366	0.0185	0.0309	0.0244
RelativeOptMaxToSumDeathRatio	Avg All		0.6259	0.0016	0.6216	0.6261	0.629	0.00	0.6141	0.618	0.6212	0.624	0.6266	0.6288	0.6307	0.632	0.6331	0.6339	0.6207	0.6317	0.6259

Legend:

Start Step and End Step: These specify the start and end steps or cycles that are being summarized. When the start step is equal to the end step, the results apply to the single cycle shown: zero refers to the initial state of the sample before any cycle is started. When the end step is greater than the start step, the results are summarized over the cycles included in the interval. For example, 6-10 is a summary of the cycles from 6 through 10 for subjects who enter cycle 6 and 1-10 is a summary of all the subjects from cycle 1 through cycle 10. Usually a cycle corresponds to one year of elapsed time.
Rec. Count (Record Count): The total number of subject-years at risk in the interval defined by the start and stop steps. When there is only one step, it is the number of subjects entering the cycle. When there is an interval, then it is a sum over the number of subjects alive at the beginning of each cycle. Note that a person dying in a certain simulation cycle is counted in that step, yet not counted in the record count for the next step.
Dem. Count (Demographic Count): Counts the number of subjects alive at the cycle listed in Start Step. Note that cycle zero is a dummy to describe the initial sample and no subjects can die during this cycle.
Sum All: The sum of the values for the variable listed in the row title over all the records in the simulation interval defined by Start Step <= Step <=End Step. In general this is appropriate for Boolean variables; i.e., those that are zeros and ones. For Booleans such as state indicators it is the number of people-cycles having this condition in the simulation interval; when the interval is only one cycle, this number divided by demographic count is the prevalence of the condition in this cycle.
Avg. All: The average of the values for the variable listed in the row title over all the records in the simulation interval defined by Start Step <= Step <= End Step, i.e. equivalent to Sum All / Rec. Count. In general this is appropriate for continuous covariates such as BMI. However, it should primarily be used when the interval contains only one cycle.
Avg. Dem.: The average of the values for the variable listed in the row title over only the records of the alive individuals entering the simulation interval starting at Start Step, i.e. equivalent to Sum (Variable over all alive individuals) / Dem. Count. This is the same as Avg. All when the interval contains only one cycle equal to Start Step.
Sum LOCF (Sum of Last Observation Carried Forward): The sum of the variables in the last record for each individual before or at the End Step. This sum is over all subjects who entered the first cycle. Note that all subjects who died before or at the End Step are included as long as they were alive at the start of the simulation. This is useful to count the number of people that had the condition at any time during the time intervals in which they participated even if they died.
Avg. LOCF (Average of Last Observation Carried Forward): LOCF is the value for the variable either at the last cycle in the interval (End Step) or at the time of death for those who died before the End Step. Avg LOCF is the average of the variables in the last record for each individual. This sum is over all subjects who entered the first cycle. Note that this includes all the individuals who died before or at the End Step as long as they were alive at the start of the simulation. This calculation is useful to reflect average of accumulated numbers such as the average of the total cost spent on an individual regardless of death.
State names represent variables that are Booleans which indicate whether the person is in that state. Row titles with State names ending with Entered represent Boolean variables that are one when the person was an incident case and entered that state in a specific year. Counting entered states is similar to counting incident cases whereas counting regular states is equivalent to counting years spent in a specific state.

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