Biostatistics and Economic Modeling
The Biostatistics and Economic Modeling Core helps investigators make quantitative inferences about the causes, control and prevention of diabetes or other endocrine-related conditions by consulting and collaborating on research related to diabetes. The core provides experimental design, data management and data analysis.
The Biostatistics and Economic Modeling Core has developed a model to estimate the probabilities of the progression of diabetes and of its complications. The model also estimates the costs and the effect on quality of life associated with these disease states. The program can be accessed by clicking on Disease Modeling.
Goals
- Help investigators design their studies prior to submission of grant proposals to the National Institutes of Health or other funding agencies
- Provide advice and assistance in the management of data
- Provide assistance and training in performance of analyses when the statistical methods are routine
- Design and perform appropriate statistical analyses when the analyses are not routine
- Continue to develop a comprehensive economic model of type 2 diabetes and evaluate the cost-effectiveness of proposed interventions
- Collaborate on the analysis of data from experiments using microarrays (i.e., data mining techniques)
- Provide Web-based information dissemination and data collection
- Provide infrastructure for investigators desiring to implement multi-center clinical trials
- Develop novel biostatistical techniques that are necessary for the analysis of data when nonstandard techniques are necessary, or to implement new methodology that can be applied to recurring problems in diabetes research
Examples of such biostatistical techniques include:
- methods of data mining from microarray experiments
- estimation of pulses in a time series of hormone samples
- fitting of spline models to identify circadian rhythms in hormone secretion
- development of models to estimate association between the levels of two different hormones in treatment or health delivery regimens on disease progression, quality of life and cost
- development of models of natural history of disease progression using morphometric and electrophysiological endpoints and
- a model to study the potential utility of interventions either by changes in treatment or health delivery regimens
Access
Access to the facilities of the Core is obtained by contacting the Core Director:
Morton B. Brown, PhD.
Department of Biostatistics
Room 4507, School of Public Health II
Phone: 734-936-0992
Fax: 734-647-3711
E-mail: mbb@umich.edu
There is no charge for consultation by the unit. However, when long-term collaboration develops, it is anticipated that the investigators will include funds for statistical analysis and data management in their grant applications.
Key Personnel
Morton B. Brown, Ph.D., Core Director, mbb@umich.edu; 734-936-0992
William H. Herman, M.D., M.P.H., Significant Contributor, wherman@umich.edu; 734-936-8279Wen Ye, Ph.D., wye@umich.edu; 734 615 9051
Sarah Krein, Ph.D., skrein@umich.edu; 734-845-3621
Mariann Christy, M.S., Database Manager, mchristy@umich.edu; 734-647-0202
