International Registry of Acute Aortic Dissection

An Introduction to Acute Aortic Dissection

IRAD LogoThe International Registry of Acute Aortic Dissection (IRAD) has been at the forefront of aortic disease research for over twenty years.  Throughout a changing diagnostic and interventional landscape, IRAD has supported rigorous investigation into best practices and corroborated outcomes in order to provide optimal patient care.  With 90 published manuscripts and over 100 more topics proposed or in progress, IRAD is poised to continue its influential work into the future.

Efforts to grow the registry, intended to increase geographical diversity and patient enrollment, have resulted in 6 new participating institutions in 2017.  Currently, there are 55 active sites in 12 countries, with more additions on the horizon.  Processes established to support this expansion have decreased the time to enrollment and help ensure regulatory compliance.  The influx of additional data and centers will support reinvestigation of previous topics with a larger dataset, as well as facilitate evaluation of regional- and hospital-based nuances of dissection care.

Continued growth and investigator enthusiasm has supported the formation of IRAD working groups, intended to focus on various facets of aortic dissection not anticipated in the initial study design.  The largest of these efforts, The Interventional Cohort, or IRAD-IVC, has described over 2800 surgical, endovascular, and hybrid procedures from select centers.  With surgery being offered to an increasing portion of Type A patients, and endovascular therapy becoming the mainstay of treatment for complicated and some uncomplicated Type B patients, a better understanding of these interventions and their associated outcomes are critical.  In April, the IRAD-IVC was recognized with its first podium presentation at the American Association for Thoracic Surgery annual meeting, detailing mechanical versus non-mechanical valve prostheses.

Aortic dissection is a complex and potentially devastating disease, with many patients requiring significant lifestyle modification as a result.  To help patients and their families better understand and cope with this diagnosis, the IRAD consortium has launched the Living with Dissection ( Here, individuals who have suffered an aortic dissection can find plain-language introductions to the disease, as well as organized, consortium-reviewed information on post-discharge care.  We are hopeful that this website will improve outcomes and support patients partnering with clinicians to optimize their care.

The International Registry of Acute Aortic Dissection has succeeded as a result of the dedication, compassion, and collaboration exemplified by its investigators.  Benefitting from both a detailed established database and new initiatives, IRAD intends to continue its work towards understanding and improving aortic disease outcomes into its third decade.

Site Map



Eva Kline-Rogers, RN, MSN, NP

Elise Woznicki, BS
IRAD Database Manager

Principal Investigators:

United States of America:




Abdul-Nour, Khaled MD

Henry Ford Health System

Detroit, MI

Bismuth, Jean MD

Houston Methodist Hospital

Houston, TX

Bonaca, Marc MD, MPH

Brigham & Women's Hospital

Boston, MA

Braverman, Alan C MD

Washington University School of Medicine

St Louis, MO

Brinster, Derek MD

North Shore - LIJ Health System

New York, NY

Chen, Edward MD

Emory University

Atlanta, GA

Conklin, Lori MD

University of Virginia Health System

Charlottesville, VA

Discipio, Anthony MD

Dartmouth-Hitchcock Medical Center

Lebanon, NH

Eagle,Kim MD

University of Michigan

Ann Arbor, MI

Gleason, Thomas G MD, MS

University of Pittsburgh

Pittsburgh, PA

Greason, Kevin MD

Mayo Clinic

Rochester, MN

Groh, Mark A MD

Mission Health

Asheville, NC

Hughes, G Chad MD

Duke University Medical Center

Durham, NC

Isselbacher, Eric MD

Massachusetts General Hospital

Boston, MA

Kaiser, Clayton A. MD

Vanderbilt University Medical Center

Nashville, TN

Khoynezhad, Ali MD, PhD

Cedars-Sinai Medical Center

Los Angeles, CA

Missov, Emil MD, PhD

University of Minnesota Physicians Heart Practice

Minneapolis, MN

O'Gara, Patrick MD

Brigham & Women's Hospital

Boston, MA

Ota, Takeyoshi MD, PhD

University of Chicago

Chicago, Il

Pape, Linda MD

University of Massachusetts Hospital

Worcester, MA

Pappas, Pat MD

Advocate Health

Downers Grove, Il

Pyeritz, Reed MD, PhD

University of Pennsylvania School of Medicine

Philadelphia, PA

Reece, Brett MD

University of Colorado Hospital

Aurora, CO

Schermerhorn, Marc MD

Beth Israel Deaconess Medical Center

Boston, MA

Shalhub,Sherene MD, MPH

University of Washington

Seattle, WA

Tang, PaulĀ  MD, PhD

University of Wisconsin

Madison, WI

Taylor,Bradley MD

University of Maryland

College Park, MD

Upchurch,Gilbert R MD

University of Virginia Health System

Charlottesville, VA





Hutchison, Stuart MD

University of Calgary

Calgary, AB

Ouzounian, Maral MD PhD

Toronto General Hospital

Toronto, ONT

Peterson, Mark MD PhD

St Michael’s Hospital

Toronto, ONT







Bhan, Anil MD

Medanta the Medicity

Uttar Pradesh, India

Bossone, Eduardo MD, PhD

University of Salerno Fisciano

SA, Italy

Della Corte, Alessandro MD, PhD

Monaldi Hospital

Napoli NA, Italy

DiEusanio, Marco MD, PhD

Univeristy Hospital S Orsola

Bologna, Italy

Eckstein, Hans-Henning MD

The Technische Universitat Munchen

Munchen, Germany

Ehrlich, Marek MD  

University of Vienna

Wien, Austria

Evangelista, Arturo MD

Hospital General Universitari Vall D’Hebron

Barcelona, Spain

Forteza, Alberto MD, PhD  

 Hospital Universitario “12 de Octubre”  

Madrid, Spain

Gilon, Dan MD Hadassah    

University Hospital

Jerusalem, Israel

Harris, Kevin MD

Medical University of Gra

Graz, Austria

Myrmel, Truls MD, PhD

Tromso University Hospital

Tromso, Norway

Nienaber, Christoph MD

University of Rostock    

Rostock, Germany

Oberwalder, Peter J MD    

Medical University of Graz  

Graz, Austria

Ramponi, Fabio MD    

Royal Prince Alfred Hospital  

 Camperdown, Australia

Sechtem, Udo MD

Robert-Bosch Krankenhaus    

Stutgart, Germany

Steg, P Gabriel MD  

Hopital Bichat        

Paris, France

Suzuki, Toru MD, PhD    

 University of Tokyo      

Tokyo, Japan

Tolva,Valerio  MD, PhD  

 Policlinico di Monza Hospital

Monza MD, Italy

Trimanchi, Santi MD IRCCS    

Policlinico San Donato

Milanese MI, Italy


IRAD Website