International Registry of Acute Aortic Dissection

An Introduction to Acute Aortic Dissection

IRAD LogoTwenty years after its founding, the International Registry of Acute Aortic Dissection (IRAD) has provided clinicians and patients with critical information on risk factors, the clinical course, and outcomes associated with this devastating disease. Throughout a changing diagnostic and interventional landscape, IRAD has supported rigorous investigation into best practices and corroborated outcomes in order to provide optimal patient care. The 81 manuscripts published in top tier, peer reviewed journals are testament to the dedication of IRAD investigators.

Despite its longevity, IRAD is well-poised to continue its investigative efforts. A program supporting expansion to new centers has helped the registry grow to 49 active sites in 12 countries, with more additions on the horizon. The influx of additional data and centers will support reinvestigation of previous topics with a larger dataset, as well as facilitate evaluation of regional- and hospital-based nuances of dissection care.

The enthusiasm of IRAD investigators has spurred the formation of several working groups, supporting additional investigative efforts into pertinent topics. The Interventional Cohort, or IRAD-IVC, has described over 2200 surgical, endovascular, and hybrid procedures from 26 centers. These data permit detailed investigations of interventional procedures, topics that remain controversial. The seminal publication from this group, Changes in Operative Strategy for Patients Enrolled in the IRAD-Interventional Cohort Program, was recently presented at the American Association for Thoracic Surgery Aortic Symposium, and accepted into the Journal of Thoracic and Cardiovascular Surgery.

Despite IRAD’s successes in distributing information to emergency room clinicians, cardiologists, and aortic interventionalists world-wide, there remains a dearth of patient-centered information. The lack of standardized recommendations and a central repository to which patients can be referred has inspired the IRAD Patients and Families website, due to launch in March of this year. Here, individuals who have suffered an aortic dissection can find plain-language introductions to the disease, as well as organized, consortium-reviewed information on post-discharge care. We are hopeful that this website will improve outcomes and support patients partnering with clinicians to optimize their care.

The International Registry of Acute Aortic Dissection has succeeded as a result of the dedication, compassion, and collaboration exemplified by its investigators. Despite two decades of work and a myriad of publications already published or in press, the 69 active projects and enthusiastic interest from new centers leaves IRAD poised to continue its efforts into the future.

Site Map


Eva Kline-Rogers, RN, MSN, NP

Elise Woznicki, BS
IRAD Database Manager

Principal Investigators:

  1. University of Michigan – Kim A. Eagle, MD
  2. Mayo Clinic – Kevin Greason, MD
  3. Brigham & Women’s Hospital – Patrick O’Gara, MD; Marc P. Bonaca, MD, MPH
  4. University of Rostock – Christoph A. Nienaber, MD
  5. Hadassah University Hospital – Dan Gilon, MD
  6. Hospital Universitario “12 de Octubre” – Alberto Forteza, MD, PhD
  7. Hospital General Universitari Vall D’Hebron – Arturo Evangelista, MD
  8. Massachusetts General Hospital – Eric M. Isselbacher, MD
  9. University of Tokyo – Toru Suzuki, MD, PhD
  10. University Hospital S. Orsola – Marco Di Eusanio, MD, PhD
  11. Robert-Bosch Krankenhaus – Udo Sechtem, MD
  12. University of Massachusetts Hospital – Linda A. Pape, MD
  13. St. Michaels Hospital – Mark D. Peterson, MD, PhD
  14. IRCCS Policlinico San Donato – Santi Trimarchi, MD
  15. Tromso University Hospital – Truls Myrmel, MD, PhD
  16. Hopital Bichat – P. Gabriel Steg, MD
  17. Medical University of Graz – Peter J. Oberwalder, MD
  18. Minneapolis Heart Institute – Kevin M. Harris, MD
  19. University of Pennsylvania School of Medicine – Reed E. Pyeritz, MD, PhD
  20. University of Vienna – Marek P. Ehrlich, MD
  21. Washington University School of Medicine – Alan C. Braverman, MD
  22. Duke University Medical Center – G. Chad Hughes, MD
  23. University of Salerno – Eduardo Bossone, MD, PhD
  24. Dartmouth-Hitchcock Medical Center – Anthony Discipio, MD
  25. University of Calgary – Stuart Hutchison, MD
  26. University of Colorado Hospital – Brett Reece, MD
  27. University of Pittsburgh – Thomas G. Gleason, MD, MS
  28. University of Virginia Health System – Gilbert R. Upchurch Jr., MD; Lori D. Conklin, MD
  29. University of Minnesota Physicians Heart Practice – Emil D. Missov, MD, PhD
  30. University of Chicago – Takeyoshi Ota, MD, PhD
  31. Cedars-Sinai Medical Center – Ali Khoynezhad, MD, PhD
  32. University of Maryland – Bradley Taylor, MD
  33. Henry Ford Health System – Khaled Abdul-Nour, MD
  34. Advocate Health – Pat Pappas, MD
  35. Medanta the Medicity – Anil Bhan, MD
  36. Mission Health – Mark A. Groh, MD
  37. Royal Prince Alfred Hospital – Fabio Ramponi, MD
  38. The Technische Universitat Munchen – Hans-Henning Eckstein, MD
  39. Toronto General Hospital – Maral Ouzounian, MD, PhD
  40. University of Washington – Sherene Shalhub, MD, MPH
  41. North Shore – LIJ Health System – Derek R. Brinster, MD
  42. Emory University – Edward P. Chen, MD
  43. Monaldi Hospital – Alessandro Della Corte, MD, PhD
  44. Houston Methodist Hospital – Jean Bismuth, MD
  45. University of Wisconsin – Paul Tang, MD, PhD
  46. Policlinico di Monza Hospital – Valerio Tolva, MD, PhD
  47. Vanderbilt University Medical Center – Clayton A. Kaiser, MD
  48. Beth Israel Deaconess Medical Center – Marc Schermerhorn, MD


IRAD Website