Book Description:
In the late 1990ies, Prof. Donald K. MacCallum put together an extremely useful hands-on histology lab manual that was based on his experience from teaching histology to many generations of University of Michigan students. Unfortunately, that original digital manual is no longer compatible with today's computer systems. The authors have updated and revised the original manual as an eBook version that allows histology learners to link the theoretical knowledge acquired in lectures and textbooks with the appearance of cells and organs as seen through a light microscope. Starting with a chapter on staining methods and histological artifacts, the four volumes cover all basic tissues, organs and organ systems of the human body. Images of superb histological preparations produced by Prof. MacCallum are accompanied by a concise description that highlights the important aspects of each tissue's structure and correlates the appearance of these tissues at the light microscope level with their cellular organization and functions. Brief multiple choice quizzes for each chapter reinforce major learning objectives.

Don MacCallum's Michigan Histology is issued in 4 volumes covering all important human tissues, organs and organ systems.

The Authors:
Stephen C. Kempf has been a faculty member at Auburn University in Alabama since 1985 where he teaches courses in Histology and Vertebrate Development and also pursues research focused on the histological and ultrastructural aspects of Symbiodinium (zooxanthella) symbiosis and Molluscan larval neurodevelopment. He may be contacted at

Michael Hortsch is an Associate Professor in the Department of Cell and Developmental Biology at the University of Michigan Medical School in Ann Arbor, Michigan. Since 1991 he has taught medical and dental Histology and in 2012 he received the University of Michigan Medical School's Kaiser Permanente Award for Excellence in Pre-clinical Teaching. His "SecondLook eHistology" iPad app was the winner of the 2013 University of Michigan Provost's Teaching Innovations Prize ( He may be contacted at

Donald K. MacCallum retired in 2003 from the University of Michigan as a Professor in the Department of Cell and Developmental Biology. During his 34 years of tenure at the University of Michigan he was not only an extraordinary histologist and researcher, but also a dedicated teacher at both the Dental and the Medical School. Most of the superb histological images in the eBook are the result of his own work, reflecting his uncompromising pursuit of excellence.


  • 26 chapters covering all basic tissues and major organs/organ systems of human histology
  • More than 1100 high quality histological images on 724 pages
  • 236 image-based multiple choice review questions
  • Volume 1: Introduction, Epithelia, Connective Tissue, Cartilage, Bone, Blood
  • Volume 2: Muscle, Nervous System, Eye, Ear, Circulatory System, Lymphatic System
  • Volume 3: Respiratory System, Integument, Oral Glands, Oral Cavity, Gastrointestinal Tract, Liver, Gall Bladder & Pancreas
  • Volume 4: Endocrine Organs, Urinary System, Male Reproductive System, Female Reproductive System, Mammary Gland

"Don MacCallum's Michigan Histology" is complemented by the Michigan Histology Virtual Slide Collections, which can be accessed for free via the Internet at

screen2Hundreds of high quality histological images are described and explained by a concise, yet comprehensive text.
"Don MacCallum's Michigan Histology" helps the beginner, as well as the more experience student of histology, to navigate and comprehend the complexity of human tissues at the microscopic scale. It also provides an excellent review of the important aspects of histological structures.










Currently the manual requires an iPad running iBooks 1.3.1 or later and iOS 4.3.3 or later. When Apple's new Mavericks operating system is available it will be possible to use this manual on any MacIntosh computer running that system.

A free sample consisting of two chapters from Vol. 1 is available at Apple's iTunes bookstore. Each complete volume of "Don MacCallum's Michigan Histology" can be downloaded for $9.99. All proceeds go to the University of Michigan and Auburn University.

For purchase, please click the following buttons.

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Questions or comments:
Please contact Dr. Kempf at and/or Dr. Hortsch at