VICTOR J. THANNICKAL, M.D.
Associate Professor of Internal Medicine

Undergraduate: Southern California College, Costa Mesa, CA Medical School: Oral Roberts University School of Medicine, Tulsa, OK Residency: University of Oklahoma College of Medicine, Tulsa, OK Fellowship: Tufts-New England Medical Center, Boston, MA Major Clinical Interests: Interstitial Lung Disease, ARDS Major Research Interests: Mechanisms of lung repair; Biochemistry of reactive oxygen species; Oxidative stress in inflammation and fibrosis

· Horowitz JC, Lee DY, Zhang H, Keshamouni VG, Thomas PE, White ES, Cui Z, Thannickal VJ. Activation of the pro-survival PI3K/Akt pathway by transforming growth factor-b1 in mesenchymal cells is mediated by p38 MAPK-dependent induction of an autocrine growth factor. J Biol Chem 2004 (In Press)

· Thannickal VJ, Toews GB, Lynch JP, Martinez, FJ. Mechanisms of pulmonary fibrosis. Ann Rev Med 2004 (In Press)

· Thannickal VJ, Lee DY, White ES, Cui Z, Larios JM, Chacon R, Horowitz JC, Day RM, Thomas PE. Myofibroblast differentiation by TGF-beta 1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase. J Biol Chem 2003; 278: 12384-12389.

· Larios JM, Budhiraja R, Fanburg BL and Thannickal VJ. Oxidative protein cross-linking reactions involving L-tyrosine in TGF-b1-stimulated fibroblasts. J Biol Chem 2001; 276:17437-17441.

· Thannickal VJ and Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol (Lung Cell Mol Physiol) 2000; 279:L1005-L1028.

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