RICHARD H. SIMON, M.D.,
Professor of Internal Medicine

Education and Training: M.D., Duke University School of Medicine, Durham, NC Residency: University of California - San Francisco Chief Residency: University of Colorado, Denver Colorado Research Training: National Insititutes of Health Fellowship: University of Colorado, Denver, CO Major Clinical Interests: Cystic fibrosis Major Research Interests: Inflammatory lung injury, with particular focus on repair; plasminogen activation system, use of gene transfer to elucidate the pathogenic mechanisms and develop treatments; cystic fibrosis gene therapy

• Eitzman DT, McCoy RD, Fay WP, Shen T, Ginsburg D, Simon RH. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996; 97:232-237.
• Hattori N, Sisson TH, Xu Y, Simon RH. Upregulation of fibrinolysis by adenovirus-mediated transfer of urokinase-type plasminogen activator genes to lung cells in vitro and in vivo. Hum Gene Ther 1999;10:215-222.
• Sisson TH, Hattori N, Xu Y. Simon RH. Adenovirus-mediated gene transfer of urokinase plasminogen activator to upregulate fibrinolysis in the murine model of bleomycin-induced pulmonary fibrosis. Hum Gene Ther 1999;10:2315-23.

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