ROBERT PAINE, III, M.D.,
Associate Professor of Internal Medicine

Education and Training: M.D., Washington University School of Medicine, St. Louis, MO Residency: Yale-New Haven Hospital, New Haven, CT Clinical and Research Training: Pulmonary Fellowship, Boston University Pulmonary Center, Boston, MA Major Clinical Interests: Critical care medicine, exercise physiology, pulmonary rehabilitation and transtracheal oxygen therapy Major Research Interests: Cellular and molecular biology of the alveolar epithelium, with focus on the role of alveolar epithelial cells in pulmonary inflammatory responses; alveolar epithelial cell differentiation; role of lung volume reduction surgery in the care of patients with emphysema.

• Brough-Holub E, Toews GB, vanIwaarden JF, Strieter RM, Kunkel SL, Paine R III, Standiford TJ. Alveolar macrophages are required for protective pulmonary defenses in murine Klbesiella pneumonia: elimination of alveolar macrophages increases neutrophil recruitment but decreases bacterial clearance of survival. Infect Immun 1997; 65:1139-1146.
• Clark-Ojo T, Martinez F, Paine R III, Christensen PJ, Curtis JL, Weg JG, Kazerooni EA, Whyte R. Lung Volume Reduction Surgery alters management of pulmonary nodules in patients with severe COPD. Chest 1997; 112:1494-1500.
• O'Brien AD, Standiford TJ, Christensen PJ, Wilcoxen SE, Paine R III. Chemotaxis of alveolar macrophages in response to signals derived from alveolar epithelial cells. J Lab Clin Med 1998; 131:417-424.
• Beck JM, Preston AM, Wegner JG, Wilcoxen SE, Hossler P, Meshnick SR, Paine R III. Interaction of rat pneumocystis carinii and rat alveolar epithelial cells in vitro. Am J Physiol 1998; 275 (Lung Cell Mol Physiol 19):L118-L125.

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