GARY B. HUFFNAGLE, Ph.D.
Associate Professor of Internal Medicine
Senior Associate Research Scientist

Education and Training: Ph.D. Immunology, University of Texas Southwestern Medical Center, Dallas, TX Research Training: Postdoctoral Research Fellowship, Immunopathology, University of Texas Southwestern Medical Center, Dallas, TX Major Research Interests: Mechanisms of pulmonary immunity to infectious diseases (C. neoformans). Interaction between cryptococcal virulence factors and host defenses in the lungs. Role of TNF and chemokines in pulmonary cell-mediated immunity.

· Huffnagle GB, Toews GB, Burdick MD, McAllister KS, McDonald RA, Boyd MB, Kunkel SL, Strieter RM. Afferent phase production of TNFa is required for the development of protective T cell immunity to Crytococcus neoformans. J Immunol 1996; 157:4529-4536.

· Huffnagle GB, Strieter RM, McDonald RA, McNeil LK, Burdick MD, Kunkel SL, Toews GB. Macrophage inflammatory protein-1a (MIP-1a) is required for the efferent phase of pulmonary cell-mediated immunity to a Cryptococcus neoformans infection. J Immunol 1997; 159:318-327.

· Huffnagle GB, Boyd MB, Street NE, Lipscomb MF. IL-5 is required for eosinophil recruitment, crystal deposition, and mononuclear cell recruitment into the lungs of genetically "susceptible" mice (C57BL/6) during pulmonary cryptococcosis. J Immunol (in press).

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