MARGARET R. GYETKO, M.D.
Associate Professor Internal Medicine
Assistant Chief, Medical Service, VA Medical Center
Associate Chair for Faculty Affairs, Department of Internal Medicine

Education and Training: M.D., Michigan State University, East Lansing, MI Residency: University of Michigan Medical Center, Ann Arbor, MI Clinical and Research Training; Pulmonary and Critical. Care Medicine Fellowship, University of Michigan, Ann Arbor, MI Major Clinical Interests: Acute lung injury and immunologically mediated lung diseases, inflammatory lung diseases, role of lymphocyte populations in acute lung inflammation Major Research Interests: Regulation of macrophage functions. Genetic regulation of protease/antiprotease systems in the lung. The role of urokinase in the modulation of pulmonary inflammation. Protease/cytokine interactions. The role of the urokinase receptor in cell movement and recruitment.

· Gyetko MR, Sud S, Kendall T, Standiford TJ. Urokinase Receptor-Deficient Transgenic Mice have Impaired Neutrophil Recruitment in Response to Pulmonary Pseudomonas Infection. Journal of Immunology 165, August 2000 (in press).

· Gyetko MR, Todd RF, Wilkinson CC, Mizukami I, Sitrin RG. The urokinase receptor is required for human monocyte chemotaxis in vitro. J Clin Invest 93:1380-1387, 1994.

· Gyetko MR, Sitrin RG, Fuller JA, Todd III RF, Petty H, Standiford TJ. Function of the urokinase receptor (CD87) in neutrophil chemotaxis. J. Leuk. Bio 58: 533-538, 1995.

· Gyetko MR, Chen GH, McDonald RA, Goodman R, Huffnagle G, Wilkinson CC, Fuller JA, Toews GB. Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans: A murine transgenic model. J. Clin. Invest 97:1818-1826, 1996.

· Sitrin RG, Todd III RF, Petty HR, Brock TG, Shollenberger SB, Albrecht E, Gyetko MR. The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. J. Clin. Invest 97:1942-1951, 1996.

· Beck JM, Preston AM, Gyetko MR. Urokinase-type plasminogen activator in inflammatory cell recruitment and host defense against Pneumocystis carinii in mice. Infection and immunity 67:879-884, 1999

Return to the Listing of Pulmonary Faculty
Return to the Pulmonary Division Homepage