MICHAEL J. COFFEY, M.D.
Associate Professor of Internal Medicine

Education and Training: M.B., B.Ch., B.A.O., University College, Dublin, Ireland Residency: St. Vincent's Hospital, Ireland, James Connolly Memorial Hospital, Ireland, Our Lady's Hospital for Sick Children, Ireland, Jervis Street Hospital, Ireland Clinical and Research Training: Pulmonary and Critical Care Medicine Fellowship, University of Michigan, Ann Arbor, MI Major Clinical Interests: Asthma, cystic fibrosis, respiration during sleep, opportunistic infection in AIDS Major Research Interests: Regulation of the enzyme 5-lipoxygenase in macrophages by lymphocytes. Effect of HIV infection on eicosanoid and cytokine metabolism in macrophages. Cytokine, eicosanoid effect on HIV

· Coffey MJ, Phare S, Kazanjian P, Peters-Golden M. 5-lipoxygenase metabolism in alveolar macrophages from subjects with the human immunodeficiency virus. J Immunol 1996; 157:393-399.

· Coffey MJ, Woffendin C, Phare SM, Strieter RM, Markovitz DM.  RANTES inhibits HIV-1 replication in human peripheral blood monocytes and alveolar macrophages.  Am J Physiol (Lung Cell Mol Physiol) 1997; 272:L1025-L1029.

· Coffey MJ, Phare SM, George S, Peters-Golden M, Kazanjian PH. Granulocyte colony-stimulating factor administration to HIV-infected subjects augments reduced leukotrine synthesis and anticryptococcal activity in neutrophils. J Clin Invest 1998; 102:663-670.

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