THOMAS G. BROCK, Ph.D.
Research Associate Professor

Education and Training: Ph.D., 1985, University of Washington, Seattle. Cell physiology.
Research Training:

·  Department of Biology, University of Michigan, Ann Arbor

·  Department of Human Genetics, University of Michigan, Ann Arbor

·  Department of Pediatrics (Hem/Onc), University of Michigan, Ann Arbor

·  Department of Internal Medicine, University of Michigan, Ann Arbor

Major Research Interests: Role of lipid mediators in immune response, in the regulation of cell function, and in disease (asthma and allergic response, aging, pulmonary hypertension, inflammation, colitis, Crohn's disease, arthritis, cancer)

 

 

·         Brock TG, Maydanski E, McNish RW, Peters-Golden M: Co-localization of leukotriene A4 hydrolase with 5-lipoxygenase in nuclei of alveolar macrophages and rat basophilic leukemia cells but not neutrophils. J Biol Chem 276:35071-35077, 2001.

·         Hemak J, Gale D, Brock TG: Structural characterization of the catalytic domain of the human 5-lipoxygenase enzyme. J Mol Model 8: 102-112, 2002.

·         Jones SM, Luo M, Healy AM, Peters-Golden M, Brock TG: Structural and functional criteria reveal a new nuclear import sequence on the 5-lipoxygenase protein. J Biol Chem 277: 38550-38556, 2002.

·         Jones SM, Luo M, Peters-Golden M, Brock TG: Identification of two novel nuclear import sequences on the 5-lipoxygenase protein. J Biol Chem 278: 10257-10263, 2003.

·         Brock TG, McNish RW, Mancuso P, Coffey, MJ, Peters-Golden M: Prolonged lipopolysaccharide inhibits leukotriene synthesis in peritoneal macrophages: mediation by nitric oxide and prostaglandins. Prostaglandins Other Lipid Mediators 71: 131-145, 2003.

·         Luo M, Jones SM, Peters-Golden M, Brock TG: Nuclear localization of 5-lipoxygenase as a determinant of leukotriene B4 synthetic capacity. Proc Natl Acad Sci USA (in press).

 

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