Overview
The 43 Program Faculty (from 13 Departments and 5 Schools/Colleges) have a broad spectrum of research interests in Nephrology, ranging from studies at the molecular level to those involving the quality and costs of patient care. Most of the faculty have substantial training records, and all faculty have adequate facilities and resources to support the research programs of their respective trainees. Expertise is available from the Program Faculty to provide outstanding guidance and mentoring to M.D. trainees in either a Basic Science or Bioengineering Track, or a Clinical Investigation and Epidemiology Track. In addition, expertise is present among the program Faculty to provide mentoring to Ph.D. trainees interested in additional basic science research or biomedical engineering training. Given the considerable scientific collaboration among the various members of the Program Faculty, there are also outstanding opportunities for individual trainees to gain research experience in more than one research setting during their training experience, depending on the goals of their research program. The current Program Faculty and their research interests are listed below. All of the Program Faculty listed are potential research mentors for trainees.
Basic Science Track
Lawrence B. Holzman, M.D.
Assoc. Professor, Int. Med. – Nephrology
Nephrology Fellowship Training Program Director |
Podocyte Biology, Signal Transduction Biochemistry (JNK pathway) |
D. Keith Bishop, Ph.D.
Professor, Department of Surgery
(Professor, Department of Microbiology/Immunology) |
Immunobiology |
Patrick D. Brophy, M.D.
Asst. Professor, Pediatric Nephrology |
Kidney Development |
Frank C. Brosius III, M.D.
Professor, Int. Med. – Nephrology
(Professor, Molecular and Integrative Physiology) |
Glucose transporters in diabetic nephropathy or hypertension |
Sally A. Camper, Ph.D.
Professor, Human Genetics
(Professor, Int. Med. – Medical Genetics)
(Director, Michigan Transgenic Mouse Core) |
Transcriptional regulation of pituitary development using transgenic mouse approach |
Christin Carter-Su, Ph.D.
Professor, Molecular and Integrative Physiology
Assoc. Director and Chief, Biomedical Research Division, Michigan Diabetes Research and Training Center |
Signal transduction biochemistry (JAK-STAT signaling), Growth hormone dependent signaling in diabetes and growth |
Gregory R. Dressler, Ph.D.
Assoc. Professor, Pathology
(Co-Director, Center for Organogenesis) |
Kidney development |
Eva L. Feldman, M.D., Ph.D.
Professor, Neurology |
Diabetic neuropathy and molecular signaling |
David Ginsburg, Ph.D.
Professor, Int. Med. – Medical Genetics and Human Genetics
(Investigator, Howard Hughes Medical Institute) |
Genetics of coagulation system |
Kun-Liang Guan, Ph.D.
Professor, Biological Chemistry |
Signal transduction pathways involved in cell growth regulation, cancer biology, and neurobiology |
Friedhelm Hildebrandt, M.D.
Professor, Pediatrics
(Professor, Human Genetics) |
Molecular genetics of renal cystic diseases and glomerular disease |
Lori L. Isom, Ph.D.
Assoc. Professor, Pharmacology |
Signal transduction and the intercellular junction |
David Kershaw, M.D.
Assoc. Professor, Pediatrics |
Podocyte Biology |
Ronald J. Koenig, M.D., Ph.D.
Professor, Int. Med. – Endocrinology and Metabolism |
Regulation of gene expression by nuclear hormone receptors |
Steven L. Kunkel, Ph.D.
Endowed Professor, Pathology
(Assoc. Dean, Rackham Graduate School) |
Cytokine networks that are operative in different immune/inflammatory reactions |
John B. Lowe, M.D.
Professor, Pathology
(Investigator, Howard Hughes Medical Institute.; Professor, Int. Med.) |
Biology of cell surface glycans in mammals |
Benjamin Margolis, M.D.
Professor, Int. Med. - Nephrology and Biological Chemistry
(Assoc. Investigator, Howard Hughes Medical Institute) |
Cell biology and biochemistry of epithelial cell polarity and tight junction formation |
Gabriel Nuñez, M.D.
Professor, Pathology |
Signal transduction in apoptosis & innate immunity |
Bruce C. Richardson, M.D., Ph.D.
Professor, Int. Med. – Rheumatology |
Chromatin structure in autoimmunity (SLE) |
James A. Shayman, M.D.
Professor, Int. Med. – Nephrology
(Professor, Pharmacology) |
Sphingolipid biochemistry and function |
David E. Smith, Ph.D.
Professor and Chair, Pharmaceutical Sciences |
Pharmocology of the renal peptide transport system |
William L. Smith, Ph.D.
Professor and Chair, Biological Chemistry |
Structural enzymology of cyclooxygenases (COX)-1 and -2 and the regulation of COX gene expression |
William E. Smoyer, M.D.
Assoc. Professor, Pediatrics |
Podocyte biology |
Kristen J. Verhey, Ph.D.
Asst. Professor, Cell and Developmental Biology |
Cell biology and biochemistry of motor proteins |
Peter A. Ward, M.D.
Professor, Pathology |
Regulation of the inflammatory response |
Joel M. Weinberg, M.D.
Professor, Int. Med. – Nephrology |
Cellular pathophysiology of acute renal failure |
Stephen J. Weiss, M.D.
Upjohn Professor of Medicine and Oncology; Professor, Int. Med.
(Chief, Molecular Medicine and Genetics) |
Extracellular matrix remodeling |
Deneen M. Wellik, Ph.D.
Asst. Professor, Int. Med. – Molecular Medicine and Genetics
(Asst. Professor, Cell and Developmental Biology) |
Kidney Development |
Roger C. Wiggins, M.B., B.Chir.
Professor, Int. Med. – Nephrology |
Podocyte biology |
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Bioengineering Track
H. David Humes, M.D.
Professor, Int. Med. – Nephrology |
Tissue engineering and renal replacement technology (artificial kidney development) |
Matthew O’Donnell, Ph.D.
Professor, Biomedical Engineering |
Bioengineering to explore new catheter arrays and signal processing methods for ultrasound guidance of intraluminal interventions |
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Clinical Investigation and Epidemiology Track
Crystal A. Gadegbeku, M.D.
Asst. Professor, Int. Med.– Nephrology |
Vascular physiology in humans, neuroadrenergic mechanism of hypertension |
Rodney A. Hayward, M.D.
Professor, Int. Med. – General Medicine
Professor, Health Management & Policy
Director, VA Health Services Research & Development |
Health care delivery systems to support better population-based care for diabetes |
Kenneth A. Jamerson, M.D.
Professor, Int. Med. – Cardiology, Hypertension |
Kidney disease and hypertension in the African-American population |
Alan B. Leichtman, M.D.
Assoc. Professor, Int. Med. – Nephrology |
Clinical pharmacology of immunosuppresants
Epidemiology and outcomes research in transplant population |
Robert M. Merion, M.D.
Professor, Surgery |
Epidemiology and outcomes research in transplant population
Medical informatics |
Akinlolu O. Ojo, M.D., Ph.D.
Assoc. Professor, Int. Med. – Nephrology |
Multi-center clinical trials to study hypertension, ESRD, and access to kidney transplantation and allograft survival in minority patients with ESRD |
Rajiv Saran, M.B.B.S, M.D., D.T.C.D., M.R.C.P.
Asst. Professor, Int. Med. – Nephrology |
Outcomes research on cardiovascular disease in chronic kidney disease |
Richard D. Swartz, M.D.
Professor, Int. Med. – Nephrology |
Delivery of renal replacement therapy (RRT) and outcome in acute renal failure (ARF) |
William F. Weitzel III, M.D.
Asst. Professor, Int. Med. – Nephrology |
Bioengineering and clinical investigation of dialysis access surveillance techniques |
Robert A. Wolfe, Ph.D.
Professor, Biostatistics |
Biostatistics and outcomes research in kidney disease |
Eric W. Young, M.D.
Professor, Int. Med. – Nephrology
Chief of Staff, Ann Arbor VA Health System |
Epidemiologic and clinical aspects of chronic renal failure and end-stage renal disease. |
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