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Research Summary:

While a key member of the Division of Nephrology, Dr. Saran is based at the Kidney Epidemiology and Cost Center (KECC) in downtown Ann Arbor, because of his interest in outcomes research. His main research interests revolve around Cardiovascular Disease in Chronic Kidney Disease, and the epidemiology of Vascular Access in Hemodialysis. He is PI on a 4-center CKD study and is co-investigator on a number of observational studies (DOPPS, CRIC, PPS) and involved with multi-center clinical trials (FHD). Trainees from Nephrology and Internal Medicine regularly participate in bimonthly research meetings with a designated Cardio-Renal Group and weekly to bimonthly research meetings at the KECC as well as at the Arbor Research Collaborative for Health (formerly the University Renal Research and Educational Association (URREA)), an internationally recognized not-for-profit research organization closely affiliated with KECC where there is ample opportunity to be involved with projects under his supervision.

Link to PubMed Citations

Selected Publications:

Saran R, Hedgeman E, Plantinga L, Burrows NR, Gillespie BW, Young EW, Coresh J, Pavkov M, Williams D, Powe NR; for the CKD Surveillance Team. Establishing a National Chronic Kidney Disease Surveillance System for the United States. Clin J Am Soc Nephrol. 2009 Dec 3. [Epub ahead of print]

Sengstock D, Sands RL, Gillespie BW, Zhang X, Kiser M, Eisele G, Vaitkevicius P, Kuhlmann M, Levin NW, Hinderliter A, Rajagopalan S, Saran R. Dominance of traditional cardiovascular risk factors over renal function in predicting arterial stiffness in subjects with chronic kidney disease. Nephrol Dial Transplant. 2009 Oct 23. [Epub ahead of print]

Plantinga LC, Miller ER 3rd, Stevens LA, Saran R, Messer K, Flowers N, Geiss L, Powe NR; Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team. Blood pressure control among persons without and with chronic kidney disease: US trends and risk factors 1999-2006. Hypertension. 2009 Jul;54(1):47-56. Epub 2009 May 26.

Frankenfield DL, Krishnan SM, Ashby VB, Shearon TH, Rocco MV, Saran R. Differences in mortality among Mexican-American, Puerto Rican, and Cuban-American dialysis patients in the United States. Am J Kidney Dis. 2009 Apr;53(4):647-57. Epub 2009 Jan 15.

Powe NR, Plantinga L, Saran R. Public health surveillance of CKD: principles, steps, and challenges. Am J Kidney Dis. 2009 Mar;53(3 Suppl 3):S37-45.

Pisoni RL, Arrington CJ, Albert JM, Ethier J, Kimata N, Krishnan M, Rayner HC, Saito A, Sands JJ, Saran R, Gillespie B, Wolfe RA, Port FK. Facility hemodialysis vascular access use and mortality in countries participating in DOPPS: an instrumental variable analysis. Am J Kidney Dis. 2009 Mar;53(3):475-91. Epub 2009 Jan 15.

Tentori F, Albert JM, Young EW, Blayney MJ, Robinson BM, Pisoni RL, Akiba T, Greenwood RN, Kimata N, Levin NW, Piera LM, Saran R, Wolfe RA, Port FK. The survival advantage for haemodialysis patients taking vitamin D is questioned: findings from the Dialysis Outcomes and Practice Patterns Study. Nephrol Dial Transplant. 2009 Mar;24(3):963-72. Epub 2008 Nov 21.

Pitt B, Saran R. The role of aldosterone blockade in end-stage renal disease. Cardiology. 2009;114(1):30-1. Epub 2009 Apr 3.

Plantinga LC, Boulware LE, Coresh J, Stevens LA, Miller ER 3rd, Saran R, Messer KL, Levey AS, Powe NR. Patient awareness of chronic kidney disease: trends and predictors. Arch Intern Med. 2008 Nov 10;168(20):2268-75.

Saran R, Elder SJ, Goodkin DA, Akiba T, Ethier J, Rayner HC, Saito A, Young EW, Gillespie BW, Merion RM, Pisoni RL. Enhanced training in vascular access creation predicts arteriovenous fistula placement and patency in hemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study. Ann Surg. 2008 May;247(5):885-91.

Moist LM, Bragg-Gresham JL, Pisoni RL, Saran R, Akiba T, Jacobson SH, Fukuhara S, Mapes DL, Rayner HC, Saito A, Port FK. Travel time to dialysis as a predictor of health-related quality of life, adherence, and mortality: the Dialysis Outcomes and Practice Patterns Study (DOPPS). Am J Kidney Dis. 2008 Apr;51(4):641-50. Epub 2008 Mar 3.

Elder SJ, Pisoni RL, Akizawa T, Fissell R, Andreucci VE, Fukuhara S, Kurokawa K, Rayner HC, Furniss AL, Port FK, Saran R. Sleep quality predicts quality of life and mortality risk in haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant. 2008 Mar;23(3):998-1004. Epub 2007 Oct 1.

Lopes AA, Elder SJ, Ginsberg N, Andreucci VE, Cruz JM, Fukuhara S, Mapes DL, Saito A, Pisoni RL, Saran R, Port FK. Lack of appetite in haemodialysis patients--associations with patient characteristics, indicators of nutritional status and outcomes in the international DOPPS. Nephrol Dial Transplant. 2007 Dec;22(12):3538-46. Epub 2007 Sep 24.

Saran R, Mehta K. Age as a factor in the decision to refer patients with chronic kidney disease for vascular access creation. Nat Clin Pract Nephrol. 2007 Aug;3(8):416-7. Epub 2007 Jul 3.

Rao PS, Schaubel DE, Jia X, Li S, Port FK, Saran R. Survival on dialysis post-kidney transplant failure: results from the Scientific Registry of Transplant Recipients. Am J Kidney Dis. 2007 Feb;49(2):294-300.

Pisoni RL, Wikström B, Elder SJ, Akizawa T, Asano Y, Keen ML, Saran R, Mendelssohn DC, Young EW, Port FK. Pruritus in haemodialysis patients: International results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant. 2006 Dec;21(12):3495-505. Epub 2006 Sep 12.

Rajagopalan S, Dellegrottaglie S, Furniss AL, Gillespie BW, Satayathum S, Lameire N, Saito A, Akiba T, Jadoul M, Ginsberg N, Keen M, Port FK, Mukherjee D, Saran R. Peripheral arterial disease in patients with end-stage renal disease: observations from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Circulation. 2006 Oct 31;114(18):1914-22. Epub 2006 Oct 23.

Dellegrottaglie S, Saran R, Gillespie B, Zhang X, Chung S, Finkelstein F, Kiser M, Sanz J, Eisele G, Hinderliter AL, Kuhlmann M, Levin NW, Rajagopalan S. Prevalence and predictors of cardiovascular calcium in chronic kidney disease (from the Prospective Longitudinal RRI-CKD Study). Am J Cardiol. 2006 Sep 1;98(5):571-6. Epub 2006 Jun 28.

Mendelssohn DC, Ethier J, Elder SJ, Saran R, Port FK, Pisoni RL. Haemodialysis vascular access problems in Canada: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS II). Nephrol Dial Transplant. 2006 Mar;21(3):721-8. Epub 2005 Nov 25.

Dellegrottaglie S, Saran R, Rajagopalan S. Vascular calcification in patients with renal failure: culprit or innocent bystander? Cardiol Clin. 2005 Aug;23(3):373-84. Review.

Bailie GR, Eisele G, Liu L, Roys E, Kiser M, Finkelstein F, Wolfe R, Port F, Burrows-Hudson S, Saran R. Patterns of medication use in the RRI-CKD study: focus on medications with cardiovascular effects. Nephrol Dial Transplant. 2005 Jun;20(6):1110-5. Epub 2005 Mar 15.

Hirth RA, Roys EC, Wheeler JR, Messana JM, Turenne MN, Saran R, Pozniak AS, Wolfe RA. Economic impact of case-mix adjusting the dialysis composite rate. J Am Soc Nephrol. 2005 May;16(5):1172-6. Epub 2005 Mar 30.

Perlman RL, Finkelstein FO, Liu L, Roys E, Kiser M, Eisele G, Burrows-Hudson S, Messana JM, Levin N, Rajagopalan S, Port FK, Wolfe RA, Saran R. Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study. Am J Kidney Dis. 2005 Apr;45(4):658-66.

Saran R, Pisoni RL, Young EW. Timing of first cannulation of arteriovenous fistula: are we waiting too long? Nephrol Dial Transplant. 2005 Apr;20(4):688-90.

Rao PS, Schaubel DE, Saran R. Impact of graft failure on patient survival on dialysis: a comparison of transplant-naive and post-graft failure mortality rates. Nephrol Dial Transplant. 2005 Feb;20(2):387-91. Epub 2004 Dec 7.

Saran R, Canaud BJ, Depner TA, Keen ML, McCullough KP, Marshall MR, Port FK. Dose of dialysis: key lessons from major observational studies and clinical trials. Am J Kidney Dis. 2004 Nov;44(5 Suppl 2):47-53.

Saran R, Dykstra DM, Pisoni RL, Akiba T, Akizawa T, Canaud B, Chen K, Piera L, Saito A, Young EW. Timing of first cannulation and vascular access failure in haemodialysis: an analysis of practice patterns at dialysis facilities in the DOPPS. Nephrol Dial Transplant. 2004 Sep;19(9):2334-40. Epub 2004 Jul 13.

Saran R, Pisoni RL, Weitzel WF. Epidemiology of vascular access for hemodialysis and related practice patterns. Contrib Nephrol. 2004;142:14-28. Review.

 
     
   

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