Research Summary:

Current research project involvement includes co-investigator of multi-center, prospective, cohort study of chronic kidney disease patients funded by Renal Research Institute and Amgen. This study includes collection of clinical and laboratory data on over 600 patients with chronic kidney disease with clinical follow-up. A subgroup of patients is undergoing detailed cardiovascular testing to allow identification of clinical associations with progressive cardiovascular disease. A PhaseI/II trial evaluating effects of the bioartificial kidney (RAD), an emerging technology that includes hemofiltration and metabolically-active cultured human tubule cells, on inflammatory markers in chronically inflamed hemodialysis patients has recently been funded and is actively under development.

Link to PubMed Citations

Selected Publications:

Patel U, Messana J. Chronic Renal Failure and Dialysis. In: Comprehensive Hospital Medicine. 1st Ed., Mark V. Williams and Robert Hayward (Eds.), Elsevier, Philadelphia, In Press.

Wheeler J, Messana JM, Turenne M, Hirth R, Pozniak A, Pan Q, Chuang C, Slish K, Tedeschi P, Roys E, Wolfe R. Understanding the Basic Case-mix Adjustment for the Composite Rate. Am J Kidney Dis. 47(4):666-71, 2006.

Hirth R, Roys E, Wheeler J, Messana JM, Turenne M, Pozniak A, Saran R, Wolfe R, The Economic Impact of Case-mix Adjusting the Dialysis Composite Rate. J Am Soc Nephrol, J Am Soc Nephrol 16:1172-76, 2005.

Perlman RL, Finkelstein FO, Liu L, Roys E, Kiser M, Eisele G, Burrows-Hudson S, Messana JM, Levin N, Rajagopalan S, Port FK, Wolfe RA, Saran R. Quality of life in chronic kidney disease (CKD): A cross-sectional analysis of the Renal Research Institute –CKD Study. Am J Kidney Dis 45:658-66, 2005.

Perlman RL, Kiser M, Finkelstein F, Eisele G, Roys E, Liu L, Burrows-Hudson S, Port F, Messana JM, Bailie G, Rajagopalan S, Saran R. The longitudinal chronic kidney disease study: a prospective cohort study of predialysis renal failure. Semin Dial, 16(6):418-23, Nov-Dec 2003.

Weitzel WF, Segal JH, Leavey SF, Saran R, Swartz RD, Messana JM. Effect of time on sensitivity and specificity of access flow in predicting thrombosis. Semin Dial, 16(6):498-501, Nov-Dec 2003.

Gradzki R, Dhingra RK, Port FK, Roys E, Weitzel WF, Messana JM. Use of ACE inhibitors is associated with prolonged survival of arteriovenous grafts. Am J Kid Dis, 38(6):1240-44, 2001.

Weitzel WF, Leavey SF, Messana JM, Rubin JM, Swartz RD. Analysis of variable flow (VF) doppler hemodialysis access flow measurements and comparison with ultrasound dilution. Am J Kid Dis, 38(5):935-40, 2001.

Messana JM, Block G, Swartz RD. Injury to the inferior epigastric artery complicating percutaneous peritoneal dialysis catheter insertion. Perit Dial Int, 21 (3):313-315, 2001.

Weitzel WF, Rubin JM, Swartz RD, Woltmann DJ, Messana JM. Variable flow (VF) doppler: for hemodialysis access evaluation: theory and clinical feasibility. ASAIO Journal, 46:65-69, 2000.