Cytomegalovirus (CMV) infection and new onset diabetes after transplantation (NODAT) are two of the most common non-immunological complications in kidney transplant patients. Research of the genetic predisposition of their occurrence will improve our understanding and potentially lead to better preventive strategies, which can result in improvement of post-transplant outcomes.
Long-term transplant outcomes - patient and graft survival - remain inadequate despite advancement in transplant surgery and medicine over the past 2 decades. Epidemiological studies of transplant outcomes, using either national registry data or single center data, are important tools to improve our understanding of the problem, identify risk factors associated with poor clinical outcomes and thus provide rationales for future clinical studies.
Link to PubMed Citations
Luan FL , Steffick DE , Ojo AO. Steroid-free maintenance immunosuppression in kidney transplantation: is it time to consider it as a standard therapy? Kidney Int. 2009 Jul 22.
Luan FL. Glucose control and vascular complications in type 2 diabetes. N Engl J Med. 2009 May 7;360(19):2031-2; author reply 2032.
Schena FP, Pascoe MD, Alberu J, del Carmen Rial M, Oberbauer R, Brennan DC, Campistol JM, Racusen L, Polinsky MS, Goldberg-Alberts R, Li H, Scarola J, Neylan JF; Sirolimus CONVERT Trial Study Group. Conversion from calcineurin inhibitors to sirolimus maintenance therapy in renal allograft recipients: 24-month efficacy and safety results from the CONVERT trial. Transplantation. 2009 Jan 27;87(2):233-42.
Luan FL, Trillsch F, Henger A, Eichinger F, Norman S, Appelman H, Kretzler M. A pilot study of gene expression-based categorization of pancreas transplant biopsies. Transplantation. 2009 Jan 27;87(2):222-6. Erratum in: Transplantation. 2009 Mar 27;87(6):945.
Luan FL, Steffick DE, Gadegbeku C, Norman SP, Wolfe R, Ojo AO. Graft and patient survival in kidney transplant recipients selected for de novo steroid-free maintenance immunosuppression. Am J Transplant. 2009 Jan;9(1):160-8. Epub 2008 Oct 24.
Luan FL , Nguyen K. Intensive glucose control in type 2 diabetes. N Engl J Med. 2008 Oct 2;359(14):1519-20; author reply 1520-1.
Luan FL, Zhang H, Schaubel DE, Miles CD, Cibrik D, Norman S, Ojo AO. Comparative risk of impaired glucose metabolism associated with cyclosporine versus tacrolimus in the late posttransplant period. Am J Transplant. 2008 Sep;8(9):1871-7.
Luan FL, Schaubel DE, Zhang H, Jia X, Pelletier SJ, Port FK, Magee JC, Sung RS. Impact of immunosuppressive regimen on survival of kidney transplant recipients with hepatitis C. Transplantation. 2008 Jun 15;85(11):1601-6.
Luan FL , Miles CD, Cibrik DM, Ojo AO. Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus. Transplantation. 2007 Aug 27;84(4):541-4.
Luan FL, Chopra P, Park J, Norman S, Cibrik D, Ojo A. Efficacy of valganciclovir in the treatment of cytomegalovirus disease in kidney and pancreas transplant recipients. Transplant Proc. 2006 Dec;38(10):3673-5.
Park JM, Luan FL. Management of hypertension in solid-organ transplantation. Prog Transplant. 2005 Mar;15(1):17-22. Review.