Research Summary:

Pharmacology of immunosuppresants; Scientific Registry of Transplant Recipients reports on the outcomes of all of the US transplant programs and organ procurement organizations on a twice-yearly basis, makes an annual report on the state of US transplantation, makes a biennial report to congress, and supports the transplant-related research needs of the Organ Procurement and Transplantation Network, the Health Resources and Services Administration, and the Secretary of Health and Human Services; The Impact of an Expedited Allocation System and Pulsatile Preservation Upon the Transplantation of Kidneys from Expanded Criteria Donors (ECD) evaluates the impact of a change in allocation rules by studying the outcomes of ECD kidneys in three participating OPOs encompassing 20 kidney transplant programs; Urine Quantitative PCR in Renal Transplant Patients and GEM and Genomics of Transplantation examines patterns of urinary cytokines as possible indicators of immune activation against renal allografts.

Link to PubMed Citations

Selected Publications:

Bernat JL. D'Alessandro AM. Port FK. Bleck TP. Heard SO. Medina J. Rosenbaum SH. Devita MA. Gaston RS. Merion RM. Barr ML. Marks WH. Nathan H. O'connor K. Rudow DL. Leichtman AB. Schwab P. Ascher NL. Metzger RA. Mc Bride V. Graham W. Wagner D. Warren J. Delmonico FL. Report of a National Conference on Donation after cardiac death. American Journal of Transplantation. 6(2):281-91, 2006 Feb.

Kim SJ, Schaubel DE, Fenton SSA, Leichtman AB, Port FK. Mortality after Kidney Transplantation: A Comparison Between the United States and Canada . Am J Transplant 6:109-114, 2006.

Sung RS, Guidinger MK, Lake CD, McBride MA, Greenstein SM, Delmonico FL, Port FK, Merion RM, Leichtman AB. Impact of the expanded criteria donor allocation system on the use of expanded criteria donor kidneys. Transplantation 79 (9): 1257-1261, 2005

Shapiro R, Young JB, Milford EL, MD; Trotter JF, Bustami RT, Leichtman AB . Immunosuppression: Evolution in practice and trends. American Journal of Transplantation. 5(4 Pt 2):874-86, 2005 Apr.

Gaston RS, Cosio FG, Davis CL, Basadonna G, Kasiske BL, Larsen J, Leichtman AB , Delmonico FL. Transplantation in the diabetic patient with advanced chronic kidney disease: a task force report . American Journal of Kidney Diseases 44, (3), 2004.

Wynn JJ, Distant DA, Pirsch JD, Norman D, Gaber AO, Ashby VB, Leichtman AB. SRTR Report on the State of Transplantation: Kidney and Pancreas Transplantation. AJT. American Journal of Transplantation. 4 Suppl 9:72-80, 2004.

Axelrod DA, Guidinger MK, McCullough KP, Leichtman AB, Punch JD, Merion RM. Association of center volume with outcome after liver and kidney transplantation. Am J Transplant. 2004 Jun;4(6):920-7.

Busami RT, Ojo AO, Wolfe RA, Merion RM, Bennett WM, McDiarmid SV, Leichtman AB, Held PJ, Port FK. Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients. Am J Transplant. 2004 Jan;4(1):87-93.

Kahan BD. Karlix JL. Ferguson RM. Leichtman AB. Mulgaonkar S. Gonwa TA. Skerjanec A. Schmouder RL. Chodoff L. Pharmacodynamics, pharmacokinetics, and safety of multiple doses of FTY720 in stable renal transplant patients: a multicenter, randomized, placebo-controlled, Phase I study. Transplantation. 76(7):1079-84, 2003.

Takemoto SK. Leichtman AB. Tolleris C. Ting A. Two-year analysis of the OPTN/UNOS CREG allocation variance. [Journal Article] Human Immunology. 64(10 Suppl):S51, 2003.

Alloway RR. Isaacs R. Lake K. Hoyer P. First R. Helderman H. Bunnapradist S. Leichtman AB. Bennett MW. Tejani A. Takemoto SK. Report of the American Society of Transplantation conference on immunosuppressive drugs and the use fo generic immunosuppressants. Am J Transplant. 3(10):1211-5, 2003.

Ojo AO, Held PJ, Port FK, Wolfe RA, Leichtman AB, Young EW, Arndorfer, J, Christensen L, Merion RM. Chronic renal failure after transplantation of a nonrenal organ. NEJM 349(10): 931-40, 2003.

Matas AJ. Bartlett ST. Leichtman AB. Delmonico FL. Morbidity and mortality after living kidney donation, 1999-2001: survey of United States transplant centers. American Journal of Transplantation. 3(7):830-4, 2003.

Gaston RS. Danovitch GM. Adams PL. Wynn JJ. Merion RM. Deierhoi MH. Metzger RA. Cecka JM. Harmon WE. Leichtman AB. Spital A. Blumberg E. Herzog CA. Wolfe RA. Tyan DB. Roberts J. Rohrer R. Port FK. Delmonico FL. The report of a national conference on the wait list for kidney transplantation. American Journal of Transplantation. 3(7):775-85, 2003.

Gaston RS. Alveranga DY. Becker BN. Distant DA. Held PJ. Bragg-Gresham JL. Humar A. Ting A. Wynn JJ. Leichtman AB. Kidney and pancreas transplantation. American Journal of Transplantation. 3 Suppl 4:64-77, 2003.

Merion RM, Wolfe RA, Dykstra DM, Leichtman AB, Gillespie BW, Held PJ: Longitudinal assessment of mortality risk among candidates for liver transplantation. Liver Transpl. 9(1): 12-18, 2003.

Merion RM, Vinokur AD, Couper MP, Jones EG, Dong Y, Wimsatt M, Warren J, Katz S, Leichtman AB, Beyersdorf T. Internet-based intervention to promote organ donor registry participation and family notification. Transplantation. 75(8):1175-9, 2003.

Feng S, Buell JF, Cherikh WS, Deng MC, Hanto DW, Kauffman HM, Leichtman AB, Lorber MI, Maters RG, McBride MA, Metzger RA, Nolte FS, O'Connor KJ, Roth D, Terrault NA, Henry ML. Organ donors with positive viral serology or malignancy: risk of disease transmission by transplantation. Transplantation. 74(12):1657-63, 2002 Dec 27.

Kayler LK, Merion RM, Rudich SM, Punch JD, Magee JC, Maraschio MA, Leichtman AB, Cibrik DM, Ojo AO, Campbell DA Jr., Arenas JD. Evaluation of pancreatic allograft dysfunction by laparoscopic biopsy. Transplantation. 74(9):1287-9, 2002 Nov 15.

Meier-Kriesche H-U, Cibrik DM, Ojo AO, Hanson JA, Leichtman AB, Kaplan B. Interaction between donor and recipient age in determining the risk of chronic renal allograft failure. Journal of the American Geriatrics Society. 50(1): 14-7, 2002.

Kayler LK, Meier-Kriesche H-U, Punch JD, Campbell Jr. DA, Leichtman AB, Magee JC, Rudich SM, Arenas JD, Merion RM. Gender imbalance in living donor renal transplantation. Transplantation, 73(2):248-52, 2002.

Wolf, Jr. JS, Merion RM, Leichtman AB, Campbell DA, Magee JC, Punch JD, Turcotte JG, Konnak JW. Randomized controlled trial of hand-assisted laparoscopic versus open surgical live donor nephrectomy. Transplantation, 72(2): 284-90, 2001.

Arndorfer JA, Meier-Kriesche H-U, Ojo AO, Gruber SA, Cibrik DM, Lake KD, Kaplan B, Leichtman AB. Time to first graft loss as a risk factor for second renal allograft loss. Transplantation Proceedings, 33(1): 1188-1189, 2001.

Ojo AO, Hanson JA, Meier-Kriesche H-U, Okechukwu CN, Wolfe RA, Leichtman AB, Agadoa LY, Kaplan B, Port FK. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol, 12(3): 589-597, 2001.

Ojo AO, Meier-Kriesche H-U, Hanson JA, Leichtman AB, Magee JC, Cibrik DM, Wolfe RA, Port FK, Agadoa LY, Kaufman DB, Kaplan B. The impact of simultaneous pancreas-kidney transplantation on long-term patient survival. Transplantation, 71(1): 82-90, 2001.

Abecassis M, Adams M, Adams P, Arnold RM, Atkins CR, Barr ML, Bennett WM, Bia M, Briscoe DM, Burdick J, Corry RJ, Davis J, Delmonico FL, Gaston RS, Harmon W, Jacobs CL, Kahn J, Leichtman A, Miller C, Moss D, Newmann JM, Rosen LS, Siminoff L, Spital A, Starnes VA, Thomas C, Tyler LS, Williams L, Wright FH, Youngner S. The Live Organ Donor Consensus Group. Consensus statement on the live organ donor. JAMA. 284(22):2919-26, 2000 Dec 13.