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Alan B. Leichtman, M.D.

Research Summary:

Pharmacology of immunosuppresants; Scientific Registry of Transplant Recipients reports on the outcomes of all of the US transplant programs and organ procurement organizations on a twice-yearly basis, makes an annual report on the state of US transplantation, makes a biennial report to congress, and supports the transplant-related research needs of the Organ Procurement and Transplantation Network, the Health Resources and Services Administration, and the Secretary of Health and Human Services; The Impact of an Expedited Allocation System and Pulsatile Preservation Upon the Transplantation of Kidneys from Expanded Criteria Donors (ECD) evaluates the impact of a change in allocation rules by studying the outcomes of ECD kidneys in three participating OPOs encompassing 20 kidney transplant programs; Urine Quantitative PCR in Renal Transplant Patients and GEM and Genomics of Transplantation examines patterns of urinary cytokines as possible indicators of immune activation against renal allografts.

Link to PubMed Citations

Selected Publications:

Gritsch HA. Veale JL. Leichtman AB. Guidinger MK. Magee JC. McDonald RA. Harmon WE. Delmonico FL. Ettenger RB. Cecka JM. Should pediatric patients wait for HLA-DR-matched renal transplants? American Journal of Transplantation. 8(10):2056-61, 2008. [I conceived of and oversaw the analysis of about 1/3 of the data reported. I wrote or revised much of the text of the manuscript.]

Wolfe RA. McCullough KP. Schaubel DE. Kalbfleisch JD. Murray S. Stegall MD. Leichtman AB. Calculating life years from transplant (LYFT): methods for kidney and kidney-pancreas candidates. American Journal of Transplantation. 8(4 Pt 2):997-1011, 2008.

Leichtman AB. Cohen D. Keith D. O'Connor K. Goldstein M. McBride V. Gould CJ. Christensen LL. Ashby VB. Kidney and pancreas transplantation in the United States, 1997-2006: the HRSA Breakthrough Collaboratives and the 58 DSA Challenge. American Journal of Transplantation. 8(4 Pt 2):946-57, 2008.

Sung RS. Christensen LL. Leichtman AB. Greenstein SM. Distant DA. Wynn JJ. Stegall MD. Delmonico FL. Port FK. Determinants of discard of expanded criteria donor kidneys: impact of biopsy and machine perfusion. American Journal of Transplantation. 8(4):783-92, 2008 Apr. [I have worked with these authors on this project for several years. I helped propose, oversee and interpret analyses, and to write and edit the manuscript.]

Abecassis M. Bartlett ST. Collins AJ. Davis CL. Delmonico FL. Friedewald JJ. Hays R. Howard A. Jones E. Leichtman AB. Merion RM. Metzger RA. Pradel F. Schweitzer EJ. Velez RL. Gaston RS. Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQITM) conference. Clinical Journal of the American Society of Nephrology: 3(2):471-80, 2008. [This manuscript summarizes the proceedings of an international conference. I was a member of the steering committee of the conference and proposed the concept for the approximately 25% of the conference’s content that addressed post-transplant care. I chaired the workgroup that developed this concept, wrote approximately 25% of the text of the manuscript, and provided editorial input for the remainder.]

Keith D. Ashby VB. Port FK. Leichtman AB. Insurance type and minority status associated with large disparities in prelisting dialysis among candidates for kidney transplantation. Clinical Journal of the American Society of Nephrology: 3(2):463-70, 2008.

Leichtman AB , Stegall M. A Dynamic Period of Reappraisal and Innovation in Kidney Transplantation Practice and Policies. Nephrology Self Assessment Program (JASN). 7(1), 2008.

Leichtman , AB. Balancing Efficacy and Toxicity in Kidney Transplant Immunosuppression. NEJM. 357(25): 2625-2627, 2007.

Sung RS, Guidinger MK, Leichtman AB, Lake C, Metzger RA, Port FK, Merion RM. Impact of the Expanded Criteria Donor (ECD) Allocation System on Candidates for and Recipients of ECD Kidneys. Transplantation. 84(9):1138-44, 2007.

Stegall MD. Dean PG. Sung R. Guidinger MK. McBride MA. Sommers C. Basadonna G. Stock PG. Leichtman AB. The rationale for the new deceased donor pancreas allocation schema. Transplantation. 83(9):1156-61, 2007.

Abbud-Filho M. Adams PL. Alberu J. Cardella C. Chapman J. Cochat P. Cosio F. Danovitch G. Davis C. Gaston RS. Humar A. Hunsicker LG. Josephson MA. Kasiske B. Kirste G. Leichtman A. Munn S. Obrador GT. Tibell A. Wadstrom J. Zeier M. Delmonico FL. A report of the Lisbon Conference on the care of the kidney transplant recipient. Transplantation. 83(8 Suppl):S1-22, 2007 Apr 27.

Magee JC. Barr ML. Basadonna GP. Johnson MR. Mahadevan S. McBride MA. Schaubel DE . Leichtman AB. Repeat organ transplantation in the United States, 1996-2005. American Journal of Transplantation. 7 Suppl 1:1424-33, 2007 May.

Ashby VB. Kalbfleisch JD. Wolfe RA. Lin MJ. Port FK. Leichtman AB. Geographic variability in access to primary kidney transplantation in the United States, 1996-2005. American Journal of Transplantation. 7 Suppl 1:1412-23, 2007 May.

Wolfe RA. Laporte FB. Rodgers AM. Roys EC. Fant G. Leichtman AB. Developing organ offer and acceptance measures: when 'good' organs are turned down. American Journal of Transplantation. 7 Suppl 1:1404-11, 2007 May.

Danovitch GM. Leichtman AB. Kidney vending: the "Trojan horse" of organ transplantation. Clinical Journal of The American Society of Nephrology: CJASN. 1(6):1133-5, 2006.

Meier-Kriesche HU. Li S. Gruessner RW. Fung JJ. Bustami RT. Barr ML. Leichtman AB. Immunosuppression: evolution in practice and trends, 1994-2004. American Journal of Transplantation. 6:1111-31, 2006.

Bernat JL. D'Alessandro AM. Port FK. Bleck TP. Heard SO. Medina J. Rosenbaum SH. Devita MA. Gaston RS. Merion RM. Barr ML. Marks WH. Nathan H. O'connor K. Rudow DL. Leichtman AB. Schwab P. Ascher NL. Metzger RA. Mc Bride V. Graham W. Wagner D. Warren J. Delmonico FL. Report of a National Conference on Donation after cardiac death. American Journal of Transplantation. 6(2):281-91, 2006 Feb.

Kim SJ, Schaubel DE, Fenton SSA, Leichtman AB, Port FK. Mortality after Kidney Transplantation: A Comparison Between the United States and Canada : Am J Transplant: 6:109-114, 2006.

Sung RS, Guidinger MK, Lake CD , McBride MA, Greenstein SM, Delmonico FL , Port FK, Merion RM, Leichtman AB. Impact of the expanded criteria donor allocation system on the use of expanded criteria donor kidneys. Transplantation 79 (9): 1257-1261, 2005

Shapiro R, Young JB, Milford EL, MD; Trotter JF, Bustami RT, Leichtman AB . Immunosuppression: Evolution in practice and trends. American Journal of Transplantation. 5(4 Pt 2):874-86, 2005 Apr.

Gaston RS, Cosio FG, Davis CL, Basadonna G, Kasiske BL, Larsen J, Leichtman AB , Delmonico FL. Transplantation in the diabetic patient with advanced chronic kidney disease: a task force report. American Journal of Kidney Diseases 44, (3), 2004.

Wynn JJ, Distant DA, Pirsch JD, Norman D, Gaber AO, Ashby VB, Leichtman AB. SRTR Report on the State of Transplantation : Kidney and Pancreas Transplantation. AJT. American Journal of Transplantation. 4 Suppl 9:72-80, 2004.

Axelrod, DA, Guidinger MK,McCullough KP, Leichtman AB, Punch JD, Merion RM. Association of center volume with outcome after liver and kidney transplantation American Journal of Transplantation. 4(6):920-7, 2004.

Busami RT, Ojo AO, Wolfe RA, Merion RM, Bennett WM, McDiarmid SV, Leichtman AB, Held PJ, Port FK. Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients. American Journal of Transplantation. 4(1):87-93, 2004.

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