For many years our laboratory has been interested in the pathogenesis of inflammation; particularly the acute inflammatory response. Our studies are centered on the role of neutrophils and macrophages in these reactions including the recruitment of these cells into sites of inflammation, activation of these cells, and the products produced by these cells that are responsible for the tissue injury. Specific areas of study include leukocyte-derived oxidants and proteases and their role in tissue injury, the role of cytokines, and the up-regulation of adhesive interactions between leukocytes and endothelial cells. Much of our research has centered on acute lung injury, but we also have ongoing projects on the mediation of renal glomerular, as well as vascular injury.
Link to PubMed Citations
Warner RL, Bhagavathula N, Nerusu K, Hanosh A, McClintock SD, Naik MK, Johnson KJ, Ginsburg I, Varani J. MDI 301, a nonirritating retinoid, improves abrasion wound healing in damaged/atrophic skin. Wound Repair Regen. 2008 Jan-Feb;16(1):117-24.
Nerusu KC, Warner RL, Bhagavathula N, McClintock SD, Johnson KJ, Varani J. Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury. Exp Mol Pathol. 2007 Oct;83(2):169-76. Epub 2007 May 4.
Williams AR, Wiggins RC, Wharram BL, Goyal M, Dou C, Johnson KJ, Miller DL. Nephron injury induced by diagnostic ultrasound imaging at high mechanical index with gas body contrast agent. Ultrasound Med Biol. 2007 Aug;33(8):1336-44. Epub 2007 May 16.
McClintock SD, Barron AG, Olle EW, Deogracias MP, Warner RL, Opp MR, Johnson KJ. Role of interleukin-6 in a glucan-induced model of granulomatous vasculitis. Exp Mol Pathol. 2007 Apr;82(2):203-9. Epub 2007 Jan 12.
McClintock SD, Barron AG, Olle EW, Deogracias MP, Warner RL, Opp M, Johnson KJ. Role of interleukin-6 in immune complex induced models of vascular injury. Inflammation. 2005 Dec;29(4-6):154-62.
Olle EW, Ren X, McClintock SD, Warner RL, Deogracias MP, Johnson KJ, Colletti LM. Matrix metalloproteinase-9 is an important factor in hepatic regeneration after partial hepatectomy in mice. Hepatology. 2006 Sep;44(3):540-9.
Fligiel SE, Standiford T, Fligiel HM, Tashkin D, Strieter RM, Warner RL, Johnson KJ, Varani J. Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury. Hum Pathol. 2006 Apr;37(4):422-30.
Olle EW, Sreekumar A, Warner RL, McClintock SD, Chinnaiyan AM, Bleavins MR, Anderson TD, Johnson KJ. Development of an internally controlled antibody microarray. Mol Cell Proteomics. 2005 Nov;4(11):1664-72. Epub 2005 Jul 22.
Warner RL, Lukacs NW, Shapiro SD, Bhagarvathula N, Nerusu KC, Varani J, Johnson KJ. Role of metalloelastase in a model of allergic lung responses induced by cockroach allergen. Am J Pathol. 2004 Dec;165(6):1921-30.
Warner RL, Winter HC, Speyer CL, Varani J, Oldstein IJ, Murphy HS, Johnson KJ. Marasmius oreades lectin induces renal thrombotic microangiopathic lesions. Exp Mol Pathol. 2004 Oct;77(2):77-84.
Warner RL, Bhagavathula N, Nerusu KC, Lateef H, Younkin E, Johnson KJ, Varani J. Matrix metalloproteinases in acute inflammation: induction of MMP-3 and MMP-9 in fibroblasts and epithelial cells following exposure to pro-inflammatory mediators in vitro. Exp Mol Pathol. 2004 Jun;76(3):189-95.