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Michael Heung, M.D.

Research Summary:

Pathophysiology and management of acute kidney injury, particularly in the ICU setting; Aspects of continuous renal replacement therapy, including dose, regional citrate anticoagulation, and safety issues; Other extracorporeal therapies; Cardiorenal syndrome and ultrafiltration in the management of heart failure; Identification of biomarkers in the diagnosis and management of acute kidney injury.

Link to PubMed Citations

Selected Publications:

Selewski DT, Cornell TT, Blatt NB, Han YY, Mottes T, Kommareddi M, Gaies MG,
      Annich GM, Kershaw DB, Shanley TP, Heung M. Fluid overload and fluid removal
      in pediatric patients on extracorporeal life support requiring continuous renal
      replacement therapy.  Critical Care Medicine 2012; 40(9):2694-9. Epub Jun 28, 2012.

Eyler RF, Heung M, Pleva M, Sowinski KM, Park PK, Napolitano LM, Mueller BA.
      Pharmacokinetics of oseltamivir and oseltamivir carboxylate in critically ill patients
      receiving continuous veno-venous hemodialysis and/or extracorporeal membrane
      oxygenation. Pharmacotherapy 2012; 32(12):1061-9.

Heung M, Chawla LS. Predicting progression to chronic kidney disease after
      recovery from acute kidney injury. Current Opinion in Nephrology and Hypertension 
      2012; 21:628-34.  Epub Sep 24, 2012.

Talley CL, Wonnacott RO, Schuette JK, Jamieson J, Heung M. Extending the
      benefits of early mobility to critically ill patients undergoing continuous renal
      replacement therapy: the Michigan experience.  Critical Care Nursing Quarterly 
      2013; 36(1):89-100.

Mottes T, Owens T, Niedner M, Juno J, Shanley TP, Heung M. Improving delivery of
      continuous renal replacement therapy: impact of staffing and educational
      interventions. Pediatric Critical Care Medicine 2013;14(8):747-54. Epub Jul 16,

Stevenson JM, Heung M, Vilay AM, Eyler RF, Patel C, Mueller BA. In vitro glucose
      kinetics during continuous renal replacement therapy: implications for caloric balance
      in critically ill patients.  International Journal of Artificial Organs 2013;36(12):861-8.
      Epub Oct 2, 2013.

Eyler RF, Vilay AM, Nader AM, Heung M, Pleva M, Sowinski KM, Depestel DD,
      Sorgel F, Kinzig M, Mueller BA. Pharmacokinetics of ertapenem in critically ill
      patients receiving continuous venovenous hemodialysis or hemodiafiltration.
      Antimicrobial Agents and Chemotherapy 2014;58(3):1320-6. Epub Dec 9, 2013.

Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, DeMuth GE,
      Fitzgerald R, Gong MN, Graham D, Gunnerson K, Heung M, Jortani S, Kleerup E,
      Koyner JL, Krell K, LeTourneau J, Lissauer M, Miner J, Nguyen HB, Ortega LM,
      Self W, Sellman R, Shi J, Straseski J, Szalados J, Wilber S, Walker MG, Wilson J,
      Wunderink R, Zimmerman J, Kellum JA. Validation of cell-cycle arrest biomarkers
      for acute kidney injury using clinical adjudication. American Journal of Respiratory
      and Critical Care Medicine 2014;189(8):932-9. Epub Feb 21, 2014.


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