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Puneet Garg, M.D., F.A.S.N.

Research Summary:

Molecular biology of Glomerular Slit Diaphragm; Vascular Calcification in end stage renal disease; Hypertension; HIV Nephropathy.

Link to PubMed Citations

Selected Publications:

Garg P, Holzman LB. Podocytes: Gaining a Foothold.  Experimental Cell Research 2012.

Britta G, Verma R, Soofi A, Garg P, Giardano L, Johnstone B, Wong H, Nihalani D, Ryzhova L, Hanks SK, Park TJ, Curran T, Rastaldi MP and Holzman LB. Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mice. Journal of Clinical Investigation, 2012 doi:10.1172/JCI 600070.

Venkatareddy M, Cook L, Abuarquob K, Verma R, Garg P. Nephrin regulates lamellipodia formation by assembling a protein complex that includes ship2, filamin and lamellipodin. PLoS One Dec 2011; 6 (12): e28710.

Garg, P, Rabelink T. Glomerular Proteinuria: a complex interplay of unique players.  Advances in Chronic Kidney Disease 2011 July; 18(4):233-42

Garg P , Verma R, Cook L, Soofi A, Venkatareddy M, George B, Mizuno K, Gurniak C. Witeke W and Holzman LB. Actin Depolymerizing Factor Cofilin1 is necessary for maintaining mature podocyte architecture. Journal of Biological Chemistry, July 2010: 285(29): 22676-88.

Wagner MC, Rhodes G, Wang E, Pruthi V, Arif E, Saleem M, Wean SE, Garg P, Verma R, Holzman LB, Gattone V, Molitoris BA, and Nihalani D. Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. Journal of Biological Chemistry, 2008 October (Epub ahead of Print)

Garg P, Verma R, Nihalani D, Johnstone D, Holzman LB. Neph1 Cooperates with Nephrin to Transduce a Signal that Induces Actin Polymerization. Molecular Cellular Biology, Dec 2007 27: 8698-8712.

Lomashvili K, Garg P, Narisawa S, Millan JL, O’Neill WC. Upregulation of Smooth Muscle Alkaline Phosphatase and Pyrophosphate Hydrolysis in Renal Failure: Potential Mechanism for Uremic Vascular Calcification. Kidney International, 2008 Feb 20 [Epub ahead of print]

Garg P, Verma R, Holzman LB. Slit Diaphragm Junctional Complex and Regulation of Cytoskeleton. Nephron Experimental Nephrology July 2007;106(2):e67-72

Bernward G. Hinkes, Roger C. Wiggins, Rasheed Gbadegesin, Christopher Vlangos, Dominik Seelow, Puneet Garg, Rakesh Verma, Hassan Chaib, Bethan E. Hoskins, Shazia Ashraf, Grant Kelley, Christian Becker, Hans Christian Hennies, Asher Schachter, Iain Drummond, Fatih Ozaltin, Aysin Bakkaloglu, Jinhong Liu, Massimo Attanasio, Meera Goyal, John F. O'Toole, Katrin Hasselbacher, Bettina Mucha, Edgar A. Otto, Peter Nurnberg, Alan Smrcka, Lawrence B. Holzman, Friedhelm Hildebrandt Positional Cloning Uncovers Mutations in P LCE1 responsible for a Nephrotic Syndrome Variant that may be Reversible. Nature Genetics 2006 Dec; 38(12):1397-1405.

Garg P, Martin C, Elms SC, Gordon FJ, Wall SM, Garland CJ, Sutliff, RL, O’Neill WC. Effect of the Na-K-2Cl Cotransporter NKCC1 on Systemic Blood Pressure and Smooth Muscle Tone. Am J Physiol Heart Circ Physiol, Jan 2007; doi:10.1152/ajpheart.01402.2006.

Garg P, Lomashvilli K, O’Neill WC. Chemical and Harmonal Determinants of vascular Calcification in vitro. Kidney International, 2006; 69: 1464-1470


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