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Research Summary:
Research focuses on understanding defects in vascular biology associated with hypertension and accelerated vascular disease in patients with kidney disease. Currently, studies explore the role of vascular nitric oxide in regulating alpha-adrenergic vasoreactivity and the impact of nitric oxide system defects (associated with kidney disease) on adrenergic vascular responsiveness. All studies are performed using state-of-the-art direct cardiovascular monitoring techniques in the General Clinical Research Center
Research also focuses on the influence of lipid abnormalities associated with kidney disease in disturbances in blood pressure regulation.
Research focuses on recruitment and retention of minority populations into clinical research
Link to PubMed Citations
Selected Publications:
Billecke SS, Platel R, D’Alecy LG, Whitesall S, Perlman RL, Jamerson KA, Gadegbeku CA, Blood Content of Asymmetric Dimethylarginine: New Insights into its dysregulation in renal disease. Nephrol Dial Transplant (accepted).
Fu L, Steffick DE , Gadegbeku CA , Norman SP, Wolfe R, Ojo AO, The impact of steroid-free immunosuppression on graft and patient survival in kidney transplant recipients, American Journal of Transplantation (accepted).
Gadegbeku CA, Jamerson JA, Stillman PK, Huffman M, Jackson JS, Kusek, J. Factors Associated with Enrollment in a Clinical Trial of Blood Pressure Management: Results from Recruitment for the African American Study of Kidney Disease and Hypertension, Contemp Clin Trials (in press).
Gbadegesin R, Kudelka T, Gadegbeku CA, Brophy P, Smoyer WE, Lin JJ, Arterial compliance in adolescents and young adults receiving chronic hemodialysis, Renal Failure 30(6): 591-596, 2008
Gadegbeku CA, Taylor TP, Dhandayuthapani A, Shrayyef MZ, Grekin J, Garvey WT, Egan BM. Insulin’s actions on plasma free fatty acids are normal in stage 2-3 chronic kidney disease. J Am Soc Hypertens 1(6): 414-422, 2007
Gadegbeku CA , Shrayyef MZ, Taylor TP, Egan BM, Mechanisms of lipid enhancement of a 1 -adrenoceptor pressor sensitivity in hypertension. J Hypertens 24(7):1383-1389, 2006.
Lash JP, Wang X, Greene T, Gadegbeku CA , , Hall Y, Jones K, Kusek JW, Sika M, Unruth M, the AASK group, Quality of Life in the African American Study of Kidney Disease and Hypertension: effects of blood pressure management Am J Kid Dis 47:956-964, 2006.
Taylor TP, Wang, W, Hutchison F, Cheek D, Gadegbeku CA, Glomerular filtration rate can be accurately predicted from serum creatinine and quantification of lean mass. Nephrol Dial Transplant 21:84-87,2006
Gadegbeku CA, Lea JP, Jamerson KA, Update on Disparities in Pathophysiology and Management of Hypertension, Med Clin North Am 89(5):921-933, 2005.
Gadegbeku CA, Management of the hypertensive patient with chronic renal disease: What to do and when to refer? In: Hot Topics in Hypertension: A practical TRIP with the experts (*translating research into practice), Editor, Hanley & Belfus, Philadelphia , 2004.
Ullian ME, Gadegbeku CA , Effects of intravenously administered iron on systemic blood pressure in hemodialysis patients. Nephron Clin Prac 98:c83-c86, 2004.
Gadegbeku CA , Dhandayuthapani A, Shrayyef MZ, Egan BM, Lipids enhance a 1 -adrenoceptor pressor sensitivity in patients with chronic kidney disease. Am J Kid Dis 44(3):446-454, 2004.
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