Research in Dr. Dressler's laboratory is focused on the molecular genetics of embryonic development. The development of a complex tissue requires the precise orchestration of external cell signalling networks and intrinsic transcription factors. The lab utilizes the developing kidney as a model system to study cell lineage specification, differentiation, and patterning. Strikingly, many of the pathways required for development are associated with renal disease.
Link to PubMed Citations
Dressler GR. Epigenetics, development, and the kidney. J Am Soc Nephrol. 2008 Nov;19(11):2060-7. Epub 2008 Aug 20. Review.
Dressler GR. Another niche for Notch. Kidney Int. 2008 Jun;73(11):1207-9.
Patel SR, Kim D, Levitan I, Dressler GR. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell. 2007 Oct;13(4):580-92.
Viana R, Batourina E, Huang H, Dressler GR, Kobayashi A, Behringer RR, Shapiro E, Hensle T, Lambert S, Mendelsohn C. The development of the bladder trigone, the center of the anti-reflux mechanism. Development. 2007 Oct;134(20):3763-9. Epub 2007 Sep 19.
Gong KQ, Yallowitz AR, Sun H, Dressler GR, Wellik DM. A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol. 2007 Nov;27(21):7661-8. Epub 2007 Sep 4.
Kim D, Dressler GR. PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Dev Biol. 2007 Jul 15;307(2):290-9. Epub 2007 May 8.
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem. 2007 Jul 13;282(28):20395-406. Epub 2007 May 11.
Kim D, Wang M, Cai Q, Brooks H, Dressler GR. Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia. J Am Soc Nephrol. 2007 May;18(5):1458-65. Epub 2007 Apr 11.
Clarke JC, Patel SR, Raymond RM Jr, Andrew S, Robinson BG, Dressler GR, Brophy PD. Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum Mol Genet. 2006 Dec 1;15(23):3420-8. Epub 2006 Oct 17.
Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G. Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28. Epub 2006 Oct 12.
Dressler GR. The cellular basis of kidney development. Annu Rev Cell Dev Biol. 2006;22:509-29. Review.
Lin J, Patel SR, Wang M, Dressler GR. The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia. Mol Cell Biol. 2006 Jun;26(12):4577-85.
Dressler GR. Proposed changes to biomedical funding. Science. 2005 Nov 25;310(5752):1279.
Kim D, Dressler GR. Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia. J Am Soc Nephrol. 2005 Dec;16(12):3527-34. Epub 2005 Nov 2.
Patel SR, Dressler GR. BMP7 signaling in renal development and disease. Trends Mol Med. 2005 Nov;11(11):512-8. Epub 2005 Oct 10. Review.
Lin J, Patel SR, Cheng X, Cho EA, Levitan I, Ullenbruch M, Phan SH, Park JM, Dressler GR. Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease. Nat Med. 2005 Apr;11(4):387-93. Epub 2005 Mar 27.
Patel SR, Dressler GR. Expression of Pax2 in the intermediate mesoderm is regulated by YY1. Dev Biol. 2004 Mar 15;267(2):505-16.