Research Summary:

Link to PubMed Citations

Selected Publications:

Zhang H, Saha J, Byun J, Schin M, Lorenz M, Kennedy RT, Kretzler M, Feldman EL, Pennathur S, Brosius III FC. Rosiglitazone “Reduces Renal and Plasma Markers of Oxidative Injury and Reverses Urinary Metabolite Abnormalities in the Amelioration of Diabetic Nephropathy” Am J Physiol Renal Physiol, July 2008 in Press.

Anuradha Vivekanandan-Giri, Jaeman Byun, and Suburamaniam Pennathur, ’Reactive Oxidants and Diabetic Vascular Disease’, Free Radicals in Biology and Medicine, 2008, 1-30.

Vaisar T, Pennathur S, Green PS, Gharib SA, Cheung MS, Byun J, Vuletic S, Kassim S, Singh P, Vhea H Knopp RH, Bunzell J, Geary R., Chait A Zhao XQ, Elkon K, Marcovina S., Ridker P, Oranm JF, Heinecke JW, “Shotgun proteomics implicates protease inhibition and complement activation in the anti-inflammatory properties of HDL ’, J Clin Invest. 2007 Mar;117(3):746-56.

Gaut JP, Belaaouaj A, Byun J, Roberts LJ 2nd, Maeda N, Frei B, Heinecke JW., ‘ Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation’, Free Radic Biol Med., 2006, 40(9), 1494-1501.

Takeshita J, Byun J, Nhan TQ, Pritchard DK, Pennathur S, Schwartz SM, Chait A, Heinecke JW.‘ Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages’, J. Biol. Chem., 2006, 281(6):3096-104.

Pennathur S, Yasuo I, Heller J, Byun J, Danda R, Pergola P, Williamson JR, Heinecke JW, ‘Reactive Carbonyls and Polyunsaturated Fatty Acids Produce a Hydroxyl Radical-like Species: a potential pathway for oxidative damage of retinal proteins in diabetes’, J. Biol. Chem., 2005, 280(24), 22706-22714.

Bergt C, Pennathur S, Fu X, Byun J, O’Brian K, McDoanld TO, Singh P, Anatharamaiaj GM, Chait A, Brunzell J, Geary RL, Oram JF, Heinecke JW, ‘The Myeloperoxidase Product Hypochlorous Acid Oxidizes HDL in the Human Artery Wall and Impairs ABCA1-dependent Transport’, Proc. Natl. Acad. Sci. U. S. A. 2004, 101(35), 13032-13037.

Pennathur S, Bergt C, Shao B, Byun J, Kassim SY, Singh P, McDonald TO, Brunzell J, Chait A, Oram JF, O’Brien K, Geary RL and Heinecke JW, ‘Human Atherosclerotic Intima and Blood of Patients with Established Coronary Artery Disease Contain High Density Lipoprotein Damaged by Reactive Nitrogen Species’, J. Biol. Chem. 2004 279(41), 42977-42983.