Faculty

Xiaochun Yu, MD, PhD
Associate Professor, Department of Internal Medicine

xiayu@umich.edu

(734) 615-4945

Campus mail address:

Lab website:

Research Interests

The research interests of our laboratory include the mechanisms of DNA damage response, chromatin remodeling, epigentic modifications and their roles in tumorigenesis and development.


Education

1996 MD, Beijing Medical University, China
2002 PhD, Kurume University, Japan
   

Honors & Awards

1998 Fellowship, Japanese International Education Society
1999 Fellowship, Japanese Department of Education, Culture, Sports, Science and Technology (Monbusho Fellowship Award)
2004 Fellowship, AACR-Cancer Research and Prevention Foundation
2006 Individual Investigator Program, The Ovarian Cancer Research Fund
2006 Idea Award, Department of Defense Breast Cancer Research Program
2006 Biological Science Scholar, the University of Michigan
2007 AACR Susan G. Komen Career Developmental Award
2008 American Cancer Society Research Scholar
2010 Era of Hope Scholar Award, Department of Defense

Selected Publications

Kim H, Chen J, Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science, 2007 May 25; 316(5828):1202-1205. (PMID17525342).

Liu Z, Wu J, Yu X. CCDC98 targets BRCA1 to DNA damage sites. Nat Struct Mol Biol, 2007 Aug; 14(8):716-720. (PMID 17643121).

Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell, 2007 Nov 30; 131(5):901-914. (PMID 18001825)  PMC 2149842.

Privette LM, Weier JF, Nguyen HN, Yu X, Petty EM. Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint. Neoplasia, 2008 Jul; 10(7):643-652. (PMID 18592005)  PMC 2435002.

Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem, 2008 Nov 14; 283(46):31785-31790. (PMID 18801727)  PMC 2581543.

Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol, 2008 Nov; 28(22):6870-6876. (PMID 18794363)  PMC 2573299.

Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol, 2009 Feb; 29(3):849-860. (PMID 19015238)  PMC 2630672.

Zhang F, Ma J, Wu J, Ye L, Cai H, Xia B, Yu X. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. Curr Biol, 2009 Mar 24; 19(6):524-529. (PMID 19268590) PMC 2750839.

Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J. RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol, 2009 May; 11(5):592-603. (PMID 19396164)  PMC 2743127.

Wu J, Prindle MJ, Dressler GR, Yu X. PTIP regulates 53BP1 and SMC1 at the DNA damage sites. J Biol Chem, 2009 Jul 3; 284(27):18078-18084. (PMID 19414588)  PMC 2709350.

Lu LY, Yu X. The balance of Polo-like kinase 1 in tumorigenesis. Cell Div, 2009; 4:4. (PMID 19161615) PMC 2642809.

Zhang F, Wu J, Yu X. Integrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response. J Biol Chem, 2009 Oct 30; 284(44):30408-30415. (PMID 19759019)  PMC 2781595.

Wu J, Lu LY, Yu X. The role of BRCA1 in DNA damage response. Protein Cell, 2010 Feb; 1(2):117-123. (PMID 21203981)  PMC 3078634.

Lu LY, Wu J, Ye L, Gavrilina GB, Saunders TL, Yu X. RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Dev Cell, 2010 Mar 16; 18(3):371-384. (PMID 20153262)  PMC 2840054

Li X, Corsa CA, Pan PW, Wu L, Ferguson D, Yu X, Min J, Dou Y. MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Mol Cell Biol, 2010 Nov; 30(22):5335-5347. (PMID 20837706)  PMC 2976376.

Jia L, Bickel JS, Wu J, Morgan MA, Li H, Yang J, Yu X, Chan RC, Sun Y. RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. J Biol Chem, 2011 Feb 4; 286(5):3379-3386. (PMID 21115485)  PMC 3030344.

Zhang F, Yu X. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. Mol Cell, 2011 Feb 18; 41(4):384-397. (PMID 21329877)  PMC 3062166.

Ma T, Keller JA, Yu X. RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis. Acta Biochim Biophys Sin (Shanghai), 2011 May; 43(5):339-345. (PMID 21444325)  PMC 3080603.

Wu J, Chen Y, Lu LY, Wu Y, Paulsen MT, Ljungman M, Ferguson DO, Yu X. Chfr and RNF8 synergistically regulate ATM activation. Nat Struct Mol Biol, 2011 Jul; 18(7):761-768. (PMID 21706008)  PMC 3130800.

Bian C, Wu R, Cho K, Yu X. Loss of BRCA1-A complex function in RAP80 null tumor cells. PLoS One, 2012; 7(7):e40406. (PMID 22792303)  PMC 3391255.

Fuchs G, Shema E, Vesterman R, Kotler E, Wolchinsky Z, Wilder S, Golomb L, Pribluda A, Zhang F, Haj-Yahya M, Feldmesser E, Brik A, Yu X, Hanna J, Aberdam D, Domany E, Oren M. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Mol Cell, 2012 Jun 8; 46(5):662-673. (PMID 22681888)  PMC 3374598.

Wu J, Liu C, Chen J, Yu X. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem, 2012 Jun 29; 287(27):22919-22926. (PMID 22539352)  PMC 3391110.

Chen Q, Chen Y, Bian C, Fujiki R, Yu X. TET2 promotes histone O-GlcNAcylation during gene transcription. Nature, 2013 Jan 24; 493(7433):561-564. (PMID 23222540).

Liu C, Wu J, Paudyal SC, You Z, Yu X. CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Res, 2013 Feb 1; 41(3):1698-1710. (PMID 23268447) PMC 3561977.

Ma T, Chen Y, Zhang F, Yang CY, Wang S, Yu X. RNF111-dependent neddylation activates DNA damage-induced ubiquitination. Mol Cell, 2013 Mar 7; 49(5):897-907. (PMID 23394999) PMC 3595365.

Liu C, Wang D, Wu J, Keller J, Teng, Yu X. RNF168 forms a functional complex with RAD6 during DNA damage response. J Cell Sci, 2013 Mar 22. (PMID 23525009).

Li W, Katoh H, Wang L, Yu X, Du Z, Yan X, Zheng P, Liu Y. FOXP3 regulates sensitivity of cancer cells to irradiation by transcriptional repression of BRCA1. Cancer Res, 2013 Apr 1; 73(7):2170-2180. (PMID 23319807).

Li M, Yu X. Function of BRCA1 in the DNA Damage Response Is Mediated byADP-Ribosylation. Cancer Cell, 2013 May 13; 23(5):693-704. (PMID 23680151).

 

Updated 5/29/13