Faculty

David Ginsburg, M.D.
Investigator, Howard Hughes Medical Institute
James V. Neel Distinguished University Professor,
Internal Medicine & Human Genetics
Research Professor, Life Sciences Institute
Warner-Lambert/Parke-Davis Professor of Medicine

ginsburg@umich.edu

734/647-4808

Lab address:
5028 LSI
210 Washtenaw
Ann Arbor, MI 48109-2216

Lab website

Research Interests

The Ginsburg lab is interested in understanding the components of the blood-clotting system and how disturbances in their function lead to human bleeding and blood-clotting disorders

Molecular Genetics of Blood Clotting:
von Willebrand factor (VWF)
Coagulation Factor V
Plasminogen Activation


Education and Training

1970-1974 B.A., Yale University, New Haven, Connecticut; (Magna Cum Laude)
1974-1977 M.D., Duke University Medical School, Durham, North Carolina
1977-1978 Resident, Presbyterian Hospital, San Francisco, CA (Pathology)
1978-1981 Intern/Resident, Peter Bent Brigham Hospital, Boston, MA (Internal Medicine)
1981-1984 Fellow, Harvard Medical Area Training Program in Hematology and Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA

Honors & Awards

1999 Distinguished Faculty Lectureship Award in Biomedical Research sponsored by the University of Michigan Medical School Biomedical Research Council
1999 Elected to the Institute of Medicine of the National Academy of Sciences
2000

E. Donnall Thomas Lecture and Prize, 2000 Meeting of the American Society of Hematology (ASH)

2000 Distinguished Faculty Achievement Award, University of Michigan Medical School
2001 Elected to AAAS Fellowship, American Association for the Advancement of Science
2002 ISFP Prize, International Society for Fibrinolysis and Proteolysis
2002 Sol Sherry Distinguished Lecture, Council on Arteriosclerosis, Thrombosis and Vascular Biology, American Heart Association
2003 James V. Neel Distinguished University Professor of Internal Medicine and Human Genetics, University of Michigan
2003 Basic Research Prize, American Heart Association
2004 ASCI Award, American Society for Clinical Investigation
2005 24th Annual Jeanette Piperno Memorial Award, Temple University, September, 2005. He presented a talk, "Disorders of Hemostasis Due to Genes Outside of the Coagulation System."
   
   


Selected Publications

Eitzman DT, Westrick RJ, Shen Y, Bodary PF, Gu S, Manning SL, et al. Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice. Circulation. 2005;111(14):1822-1825.

Ginsburg D. Genetic risk factors for arterial thrombosis and inflammation. Hematology Am Soc Hematol Educ Program. 2005:442-444.

Ginsburg D. Identifying novel genetic determinants of hemostatic balance. J Thromb Haemost. 2005;3(8):1561-1568.

Motto DG, Chauhan AK, Zhu G, Homeister J, Lamb CB, Desch KC, et al. Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest. 2005;115(10):2752-2761. PMC1240119.

Sirachainan N, Zhang B, Chuansumrit A, Pipe S, Sasanakul W, Ginsburg D. Combined factor V and factor VIII deficiency in a Thai patient: a case report of genotype and phenotype characteristics. Haemophilia. 2005;11(3):280-284.

Zhou W, Dong L, Ginsburg D, Bouhassira EE, Tsai HM. Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy? J Biol Chem. 2005;280(48):39934-39941. PMC2582217.

Bernat JA, Crawford GE, Ogurtsov AY, Collins FS, Ginsburg D, Kondrashov AS. Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs. Hum Mol Genet. 2006;15(13):2098-2105.

Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, Plaimauer B, et al.  Systemic antithrombotic effects of ADAMTS13. J Exp Med. 2006;203(3):767-776. PMC2118248.

Cole JN, McArthur JD, McKay FC, Sanderson-Smith ML, Cork AJ, Ranson M, et al. Trigger for group A streptococcal M1T1 invasive disease. FASEB J. 2006;20(10):1745-1747.

Lemmerhirt HL, Shavit JA, Levy GG, Cole SM, Long JC, Ginsburg D. Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene. Blood. 2006;108(9):3061-3067. PMC1895519.

Nyfeler B, Zhang B, Ginsburg D, Kaufman RJ, Hauri HP. Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex. Traffic. 2006;7(11):1473-1481.

Seligsohn U, Ginsburg D. Deciphering the mystery of combined factor V and factor VIII deficiency. J Thromb Haemost. 2006;4(5):927-931.

Zhang B, McGee B, Yamaoka JS, Guglielmone H, Downes KA, Minoldo S, et al. Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2. Blood. 2006;107(5):1903-1907. PMC1895703.

Lemmerhirt HL, Broman KW, Shavit JA, Ginsburg D. Genetic regulation of plasma von Willebrand factor levels: quantitative trait loci analysis in a mouse model. J Thromb Haemost. 2007;5(2):329-335.

Zhu A, Sun H, Raymond RM, Jr., Furie BC, Furie B, Bronstein M, et al. Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 2007;109(12):5270-5275.  PMC1890832.

Tan FL, Ginsburg D. What a polyclonal antibody sees in von Willebrand factor. Thromb Res. 2008;121(4):519-526. PMC2258224.

Shavit JA, Manichaikul A, Lemmerhirt HL, Broman KW, Ginsburg D. Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice. Blood. 2009;114(26):5368-5374. PMC2796139.

Sun H, Wang X, Degen JL, Ginsburg D. Reduced thrombin generation increases host susceptibility to group A streptococcal infection. Blood. 2009;113(6):1358-1364. PMC2637198.

Westrick RJ, Ginsburg D. Modifier genes for disorders of thrombosis and hemostasis. J Thromb Haemost. 2009;7 Suppl 1:132-135.

Chen XW, Leto D, Xiao J, Goss J, Wang Q, Shavit JA, et al. Exocyst function is regulated by effector phosphorylation. Nat Cell Biol. 2011;13(5):580-588.

Desch K, Li J, Kim S, Laventhal N, Metzger K, Siemieniak D, et al. Analysis of informed consent document utilization in a minimal-risk genetic study. Ann Intern Med. 2011;155(5):316-322. PMC3540806.

Ginsburg D. Genetics and genomics to the clinic: a long road ahead. Cell. 2011;147(1):17-19.

Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, et al. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin. Blood. 2011;118(12):3384-3391. PMC3179404.

Khoriaty R, Vasievich MP, Ginsburg D. The COPII pathway and hematologic disease.  Blood. 2012;120(1):31-38. PMC3390960.

 

 

Updated 5/3/13