Description of Research: Laraine
Our research focuses upon the epidemiology of healthcare
associated infections including antibiotic resistant
Dialysis related infections
The major focus of our research has been bloodstream
infections in patients receiving dialysis for acute
renal failure. Our analysis has shown that the rate
of bloodstream infections for patients in ICUs receiving
the continuous renal replacement therapy mode of dialysis
have a high rate of catheter associated bloodstream
infections compared to other ICU patients. We are
analyzing potential risk factors which might be modifiable
to decrease rates of infection.
Emerging antibiotic resistance
We are interested in the emergence of antibiotic resistant
organisms in the hospital and the community. We are
currently evaluating the risk factors associated with
development of extended spectrum beta lactamase producing
gram negative infections in hospitalized patients.
We are also interested in the emergence of carbapenamase
producing gram negative bacteria in hospitalized patients.
Walk ST, Micic D, Jain R, Trivedi I, Liu EW, Almassalha M, Ewing SA, Ring C Galeck AT, Washer L, Newton DW, Malani P, Young VB, Aronoff DM. Clostridium difficile ribotype does not predict severe infection. Clinical Infectious Diseases 2012; 55(12)1661-8
Washer LL, Chenoweth C, Kim H., Rogers M, Malani A, Riddell J, Kuhn L, Noeyack B, Neusius H, Newton D, Saint S, Flanders S. Blood culture contamination: A randomized trial comparing the effectiveness of three skin antiseptic agents. Infection Control and Hospital Epidemiology. 2013; 34(1) 15-21
Antworth, A, Collins C, Kunapali A, Klein K., Carver P., Gandhi T, Washer L, Nagel J. Impact of an Antimicrobial Stewardship Program Comprehensive Care Bundle on the Management of Candidemia. Pharmacotherapy. 2013; 33(2): 137-143
To KB, Washer LL, Varban OA, Haft JW, Fisher-Hubbard A, Napolitano LM. Splenectomy for Splenic Abscess. Surg Infect 2013 Jun;14(3):337-8
Jain R, Walk ST, Aronoff DM, Young VB, Newton DW, Chenoweth, Washer L. Emergence of Carbapenemase-Producing Klebsiella pneumoniae isolates of Sequence Type-258 at a University Hospital in Michigan. Infectious Disease Reports 2013; 5(1); e5
Huang AM, Newton, D, Kunapuli AK, Gandhi TN, Washer LL, Isip J, Collins CD, Nagel JL. Rapid Organism Identification via Matrix-Assisted Laser Desorption Ionization Time-of-Flight Combined with Antimicrobial Stewardship Team Intervention Decreases Mortality and Improves Time to Clinical Response in Adult Patients with Bacteremia and Candidemia. Clinical Infectious Diseases 2013; 57(9):1237-1245
Hartley S, Valley S, Kuhn L, Washer L, Gandhi T, Meddings J, Chenoweth C, Malani A, Saint S, Srinivasan A, Flander SA. Inappropriate Testing for Urinary Tract Infection in Hospitalized Patients: An Oppourtunity for Improvement. Infect Control Hosp Epidemiol 2013; 34(11): 1204-7
Brennan B, Coyle J, Marchaim J, Pogue J, Boehme M, BS, Finks J, Malani A, VerLee K, Buckley B, Mollon N, Sundin D, Washer L, MD, Kaye K. Statewide Surveillance of Carbapenem-Resistant Enterobacteriaceae in Michigan. Infection Control and Hospital Epidemiology. 2014; 35(4): 342-9
Nagel, JL, Huang AM, Kunapuli A, Gandhi TN, Washer LL, Lassiter J, Patel T, Newton DW . Impact of Antimicrobial Stewardship Intervention in Conjunction with Rapid Diagnostic Testing on Management of Patients with Blood Cultures Positive with Coagulase-Negative Staphylococci. Submitted/in revision Journal of Clinical Microbiology.
Marchaim, D, Pogue, JM, Tzuman, O, Hayakawa K, Lephart PR, Salimnia H, Painter T, Zervos MJ, Johnson LE, Perri, MB, Harman, Pm Thygarajan, RV, Major S, Goodell M, Fakih M, Washer LL, Newton DW, Malani A, Wholehan JM, Mody L, Kaye KS. Major Variations in MICs to Tigecycline in Gram Negative Bacilli as a Function of Testing Method. Journal of Clinical Microbiology. 2014; 52(5): 1617-1621