Description of Research: James Riddell

HIV/AIDS

Dr. Riddell’s main research focus is to find ways of improving the care of patients living with HIV/AIDS. Dr. Riddell has been the Principal Investigator for a variety of NIH studies evaluating the appropriate use of antiretroviral agents as well as pharmaceutical industry sponsored studies to develop new antiretroviral medications. The future goal of the HIV/AIDS program is to become more involved in large clinical trials to the benefit of patients and to contribute to optimizing the clinical care of patients infected with HIV.

INFECTIONS IN TRANSPLANT PATIENTS

Our group has developed a transplant infectious disease consult service to both better serve the clinical needs of these complex patients and provide a platform for clinical research. Currently, a consult service staffed by physicians with a specific interest in infections in the immunocompromised host is consulting on hematopoietic stem cell recipients with infectious complications of their transplant. In conjunction with the Bone Marrow Transplant service, we are developing clinical protocols to manage and prevent infections in this population. This service has been expanded to include recipients of solid organ transplants. Dr. Riddell is also involved in research efforts to improve the management of the infectious complications that can occur after organ transplantation.

Recent Publications:

Cinti, SK; Gandhi, T; Riddell, J; Non-AIDS- defining cancers: Should HAART be initiated earlier? AIDS Reader, 18:18-33 (2008).

Nicolasora N, Cinti SK, Riddell J, Kauffman CA. A 53-year-old man with a large air bubble in his chest. Diagnosis: Bronchopleural fistula and hydropneumothorax caused by coccidioidomycosis (Photo Quiz). Clin Infect Dis 47 (6): 823-824, 2008.

Chaiyachati K, Cinti SK, Kauffman CA, Riddell J. HIV-Infected patients with anal carcinoma who subsequently developed oral squamous cell carcinoma: Report of 2 cases. J Intl Ass Phys AIDS Care 7:306-11, 2008.

The Strategies for Management of Antiretroviral Therapy (SMART) Study Group; (Riddell, J contributing investigator); Inferior Clinical Outcome of the CD4+ Cell Count–Guided Antiretroviral Treatment Interruption Strategy in the SMART Study: Role of CD4+ Cell Counts and HIV RNA Levels during Follow-up. The Journal of Infectious Diseases, 197:1145–55 (2008).

The Strategies for Management of Antiretroviral Therapy (SMART) Study Group; (Riddell, J contributing investigator); Major Clinical Outcomes in Antiretroviral Therapy (ART)–Naive Participants and in Those Not Receiving ART at Baseline in the SMART Study. The Journal of Infectious Diseases, 197:1133– 44 (2008).

The Strategies for Management of Antiretroviral Therapy (SMART) Study Group; (Riddell, J contributing investigator); Risk for Opportunistic Disease and Death after Reinitiating Continuous Antiretroviral Therapy in Patients with HIV Previously Receiving Episodic Therapy. Annals of Internal Medicine, 149:289-99, (2008).

Peres E, Khaled Y, Krijanovski OI, Mineishi S, Levine JE, Kaul DR, Riddell J. Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant: report of clinical response to treatment with tigecycline. Transpl Infect Dis 11:57-63, 2009.

Cooke DT, Pagani FD, Kaul DR, Cooke KR, Lau CL, Riddell J. Successful treatment of pulmonary zygomycosis in two transplant recipients with liposomal amphotericin B and partial surgical resection followed by posaconazole (Letter). Mycoses eFIRST date: 12 FEB 2009.

Kaul DR, Riddell, J. Approach to the immunocompromised patient with pulmonary nodules. Current Fungal Infection Reports, 3:45-54, (2009). Review.

Riddell J, Kauffman CA. Pharmacotherapy of micafungin: Clinical review. Clin Med Rev Therapeut 1:1-12, 2009.

Cooke DT, Pagani FD, Kaul DR, Cooke KR, Lau CL, Riddell J. Successful treatment of pulmonary zygomycosis in two transplant recipients with liposomal amphotericin B and partial surgical resection followed by posaconazole. Mycoses 53 (2): 163-167, 2010.

Carter CC, Onafuwa-Nuga A, McNamara LA, Riddell J, Bixby D, Savona MR, Collins KL. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nature Med 16 (4): 446-U127, 2010.

Pettit NN, DePestel DD, Malani PN, Riddell J. Factors Associated With Seroconversion After Standard Dose Hepatitis B Vaccination and High-Dose Revaccination Among HIV-Infected Patients. HIV Clin Trials 11 (6): 332-339, 2010.

Riddell J, Comer GM, Kauffman CA. Treatment of Endogenous Fungal Endophthalmitis: Focus on New Antifungal Agents. Clin Infect Dis 52 (5): 648-653, 2011.

Carter CC, McNamara LA, Onafuwa-Nuga A, Shackleton M, Riddell J, Bixby D, Savona MR, Morrison SJ, Collins KL. HIV-1 Utilizes the CXCR4 Chemokine Receptor to Infect Multipotent Hematopoietic Stem and Progenitor Cells. Cell Host Microbe 9 (3): 223-234, 2011.