Description of Research: Powel Kazanjian
MEDICAL RESEARCH: AIDS ASSOCIATED OPPORTUNISTIC INFECTIONS
Our group is interested in how OIs have been influenced
by antimicrobial prophylaxis and HIV therapy.
Host Defense Defects: Phagocytes
Our work has shown that microbicidal activity in AIDS
patients is reduced, possibly due to impaired leukotriene
synthesis, and that addition of cytokines augments
intracellular killing, possibly by upregulating 5-lipoxegenase
Sulfa Prophylaxis and Pneumocystis carinii drug resistant
We have shown that sulfa prophylaxis use in AIDS patients
with PCP is associated with mutations in the sulfa
binding site of the P carinii DHPS gene, but not yet
influenced response to sulfa therapy.
HAART Responses and OI Incidence Rates
We have shown that an incomplete virologic reduction
is a significant risk factor for OI, and in patients
with multi-resistant HIV, maintaining virologically
failing regimens reduces OI rates and maintains CD4
HISTORICAL RESEARCH: EPIDEMIC DISEASES THROUGHOUT
We are exploring the initial reluctance to accept
the scientific finding that bubonic plague was the
cause of a 1901 outbreak in San Francisco and the
eagerness to accept sterilization procedures to halt
the spread of commercial botulism in 1922 to gain
a greater understanding of how new ideas become incorporated
into the medical profession. This work is used to
provide the historic roots to current AIDS, public
health, and research trends.
Gandhi T, Wei W, Amin K, Kazanjian P. Effect of maintaining
highly active antiretroviral therapy on AIDS events
among patients with late-stage HIV infection and inadequate
response to therapy. Clin Infect Dis 42 (6): 878-884,
Markowitz M, Slater LN, Schwartz R, Kazanjian PH,
Hathaway B, Wheeler D, Goldman M, Neubacher D, Mayers
D, Valdez H, McCallister S. Long-term efficacy and
safety of tipranavir boosted with ritonavir in HIV-1-infected
patients failing multiple protease inhibitor regimens
- 80-week data from a phase 2 study. JAIDS 45 (4):
Gandhi T, Nagappan V, Cinti S, Wei W, Kazanjian P.
Long-term immunologic and virologic responses in patients
with highly resistant HIV infection who are treated
with an incompletely suppressive Antiretroviral regimen.
Clin Infect Dis 45 (8): 1085-1092, 2007.
Riddell J IV, Kaul DR, Karakousis PC, Gallant JE,
Mitty J, Kazanjian PH. Mycobacterium avium complex
immune reconstitution inflammatory syndrome: Long
term outcomes - art. no. 50. J Translat Med 5: 50,