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Dr. Powel Kazanjian

Description of Research: Powel Kazanjian


Our group is interested in how OIs have been influenced by antimicrobial prophylaxis and HIV therapy.

Host Defense Defects: Phagocytes
Our work has shown that microbicidal activity in AIDS patients is reduced, possibly due to impaired leukotriene synthesis, and that addition of cytokines augments intracellular killing, possibly by upregulating 5-lipoxegenase metabolism.

Sulfa Prophylaxis and Pneumocystis carinii drug resistant mutations
We have shown that sulfa prophylaxis use in AIDS patients with PCP is associated with mutations in the sulfa binding site of the P carinii DHPS gene, but not yet influenced response to sulfa therapy.

HAART Responses and OI Incidence Rates
We have shown that an incomplete virologic reduction is a significant risk factor for OI, and in patients with multi-resistant HIV, maintaining virologically failing regimens reduces OI rates and maintains CD4 responses.


We are exploring the initial reluctance to accept the scientific finding that bubonic plague was the cause of a 1901 outbreak in San Francisco and the eagerness to accept sterilization procedures to halt the spread of commercial botulism in 1922 to gain a greater understanding of how new ideas become incorporated into the medical profession. This work is used to provide the historic roots to current AIDS, public health, and research trends.

Recent Publications

Gandhi T, Wei W, Amin K, Kazanjian P. Effect of Maintaining HAART on AIDS Events in Late Stage HIV-Infected Patients with Inadequate CD4 and Viral Responses. Clin Infect Dis 2006; 42:878-84.

Weber J, Weberova J, Carobene M, Mirza M, Martinez-Picado J, Kazanjian P, and Quiñones-Mateu ME. Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness. J of Virol Methods 2006; 136(1):102-17.

Riddell J, Kaul D, Karakousis P, Gallant J, Mitty J, and Kazanjian, P. Mycobacterium avium complex immune reconstitution inflammatory syndrome: long term outcomes. J Transl Med 2007; 5(1):50.

Gandhi T, Nagappan V, Cinti S, Wei W, and Kazanjian P. Long-term immunologic and virologic responses in patients with highly resistant HIV infection who are treated with an incompletely suppressive antiretroviral regimen. Clin Infect Dis 2007; 45(8):1085-92.

Markowitz M, Slater L, Schwartz R, Kazanjian P, Hathaway B, Wheeler D, Goldman M, Neubacher D, Mayers D, Valdez H, McCallister S, and the BI 1182.2 Study Team. Long-term efficacy and safety of Tipranavir boosted with Ritonavir in HIV-1-infected patients failing multiple protease inhibitor regimens: 80-week data from a phase 2 study. JAIDS 2007; 45(4) 401-10.

Kazanjian, P. Frederick G. Novy and the Rat Virus. Annals of Internal Medicine. 2012;156:234-237.

Riddell J, Quint D, Kazanjian P. Hematogenous Coagulase Negative Staphylococcal Vertebral Body Osteomyelitis. Infect Dis Clin Pract 20(6):400-403, November 2012.

Kazanjian, P. Frederick Novy and the 1901 San Francisco Plague Commission Investigation. Clinical Infectious Disease 2012 Nov 15;55(10):1373-8

Kazanjian, P. The Origin of AIDS, Book Review. Medical History (In Press).

Kazanjian, P. The AIDS Pandemic in Historic Perspective. Journal of the History of Medicine and Allied Sciences 67 (4) 2012.


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