Description of Research: Daniel Kaul

INFECTIONS IN TRANSPLANT PATIENTS

Dr. Kaul directs the Transplant Infectious Disease Service that provides inpatient and outpatient consultation for patients who have received either solid organ or stem cell transplants. We also work closely with the various transplant groups preparing prophylactic and treatment guidelines. Research interests include the epidemiology of opportunistic infections after solid organ transplantation and the diagnosis and management of viral and other opportunistic infections after stem cell transplantation.

HIV/AIDS

Dr. Kaul is a member of the HIV/AIDS Treatment Program and spent two years training specifically in this area and has been a principal investigator on phase II, III, and IV multi-center trials of antiretroviral agents. Research interests include clinical use of antiretroviral therapies, immune reconstitution disease, and resistance to antiretroviral agents.

Recent Publications

Safdar N, Abad CL, Kaul DR, Jarrard D, Saint S. An unintended consequence. N Engl J Med 358 (14): 1496-1501, 2008.

Nicolasora N, Kaul DR. Infectious disease emergencies. Med Clin N Amer 92 (2): 427-441, 2008.

Falade OO, Antonarakis ES, Kaul DR, Saint S, Murphy PA. Beware of first impressions (Clinical Problem Solving). New Engl J Med 359 (6): 628-634, 2008.

Nicolasora NP, Reddy P, Kaul DR. Biopsy-proven adenoviral diarrhea responding to low-dose cidofovir. Transpl Infect Dis 10 (5): 346-350, 2008.

Kaul DR, Collins CD, Hyzy RC. New developments in antimicrobial use in sepsis. Curr Pharm Design 14 (19): 1912-1920, 2008.

Kaul DR, Lowe L, Visvesvara GS, Farmen S, Khaled YA, Yanik GA. Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole. Transpl Infect Dis 10 (6): 437-441, 2008.

Collins CD, Ellis JJ, Kaul DR. Comparative cost-effectiveness of posaconazole versus fluconazole or itraconazole prophylaxis in patients with prolonged neutropenia. Am J Health Syst Pharm 65 (23): 2237-2243, 2008.

Psarros G, Kaul DL, Kauffman CA. Disseminated histoplasmosis in a heart transplant recipient: an uncommon diagnosis even in the Midwest. Infect Dis Clin Pract 16:49-53, 2008.

Segal BH, Freifeld AG, Baden LR, Brown AE, Casper C, Dubberke E, Gelfand M, Greene, JN, Ison MG, Ito JI, Karp JE, Kaul DR, King E, Mackler E, Marcucci G, Montoya JG, Engemann AM, Rolston K. Prevention and Treatment of Cancer Related Infections. Journal of the National Comprehensive Cancer Network 6(2):122-74, 2008.

Safdar N, Abad CL, Narayan S, Kaul DR, Saint S. Keeping an Open Mind. New Engl J Med 360 (1): 72-76, 2009.

Peres E, Khaled Y, Krijanovski OI, Mineishi S, Levine JE, Kaul DR, Riddell J. Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant: report of clinical response to treatment with tigecycline. Transpl Infect Dis 11:57-63, 2009.

Gandhi T, Flanders SA, Markovitz E, Saint S, Kaul DR. Importance of Urinary Tract Infection to Antibiotic Use Among Hospitalized Patients. Infect Contr Hosp Epidemiol 30 (2): 193-195, 2009.

Cooke DT, Pagani FD, Kaul DR, Cooke KR, Lau CL, Riddell J. Successful treatment of pulmonary zygomycosis in two transplant recipients with liposomal amphotericin B and partial surgical resection followed by posaconazole (Letter). Mycoses eFIRST date: 12 FEB 2009.

Graham BB, Kaul DR, Saint S, Janssen WJ. Kiss of Death. New Engl J Med 360 (24): 2564-2568, 2009.

Pogue JM, DePestel DD, Kaul DR, Khaled Y, Frame DG. Systemic absorption of oral vancomycin in a peripheral blood stem cell transplant patient with severe graft-versus-host disease of the gastrointestinal tract. Transpl Infect Dis 11 (5): 467-470, 2009.

Kaul DR, Taranto S, Alexander C, Covington S, Marvin M, Nowicki M, Orlowski J, Pancoska C, Pruett TL, Ison MG. Donor Screening for Human T-cell Lymphotrophic Virus 1 2: Changing Paradigms for Changing Testing Capacity. Am J Transplant eFIRST date: 26 OCT 2009.

Freifeld, AG, Wheat, LJ, Kaul, DR. Histoplasmosis in solid organ transplant recipients: early diagnosis and treatment. Curr Opin Organ Transplant 14 (6): 601-605, 2009.

Luan FL, Stuckey LJ, Park JM, Kaul D, Cibrik D, Ojo A. Six-Month Prophylaxis Is Cost Effective in Transplant Patients at High Risk for Cytomegalovirus Infection. J Am Soc Nephrol 20 (11): 2449-2458, 2009.

Shanahan, A, Malani, PN, Kaul, DR. Relapsing cytomegalovirus infection in solid organ transplant recipients. Transpl Infect Dis 11 (6): 513-518, 2009.

Kaul DR, Riddell, J. Approach to the immunocompromised patient with pulmonary nodules. Current Fungal Infection Reports, 3:45-54, (2009). Review.

Collins CD, Smith J, Kaul DR. Prophylaxis of invasive fungal infections: a review of the use of posaconazole. Clinical Medicine: Therapeutics 2009:1 1399-1408

Kaul DR, Taranto S, Alexander C, Covington S, Marvin M, Nowicki M, Orlowski J, Pancoska C, Pruett TL, Ison MG. HTLV Donor Screening Advisory Grp. Donor Screening for Human T-cell Lymphotrophic Virus 1/2: Changing Paradigms for Changing Testing Capacity. Am J Transplant 10 (2): 207-213, 2010.

Cooke DT, Pagani FD, Kaul DR, Cooke KR, Lau CL, Riddell J. Successful treatment of pulmonary zygomycosis in two transplant recipients with liposomal amphotericin B and partial surgical resection followed by posaconazole. Mycoses 53 (2): 163-167, 2010.

Avery R, Clauss H, Danziger-Isakov L, Davis J, Doucette K, van Duin D, Fishman J, Gunseren F, Humar A, Husain S, Isada C, Julian K, Kaul D, Kumar D, Martin S, Michaels M, Morris M, Silveira F, Subramanian A. Recommended curriculum for subspecialty training in transplant infectious disease on behalf of the American Society of Transplantation Infectious Diseases Community of Practice Educational Initiatives Working Group. Transpl Infect Dis 12 (3): 190-194, 2010.

Jessel P, Safdar N, McCune WJ, Saint S, Kaul DR. Thinking Inside the Box. New Engl J Med 363 (6): 574-579, 2010.

Reznicek JE, Mason WJ, Kaul DR, Saint S, Bloch KC. Avoiding a Rash Diagnosis. New Engl J Med 364 (5): 467-472, 2011.

Jafri SM, Singal AG, Kaul D, Fontana RJ. Detection and Management of Latent Tuberculosis in Liver Transplant Patients. Liver Transplant 17 (3): 306-314, 2011.

Kaul DR, Stoelben S, Cober E, Ojo T, Sandusky E, Lischka P, Zimmermann H, Rubsamen-Schaeff H. First Report of Successful Treatment of Multidrug-Resistant Cytomegalovirus Disease with the Novel Anti-CMV Compound AIC246. Am J Transplant 11 (5): 1079-1084, 2011.

Reznicek JE, Mason WJ, Kaul DR, Saint S, Bloch KC. Avoiding a Rash Diagnosis. New Engl J Med 364 (5): 466-472, 2011.

Anand S, Samaniego M, Kaul DR. Pneumocystis jirovecii pneumonia is rare in renal transplant recipients receiving only one month of prophylaxis. Transplant Infect Dis 13 (6):570-574, 2011.