Description of Research: Daniel Kaul

INFECTIONS IN TRANSPLANT PATIENTS

Dr. Kaul directs the Transplant Infectious Disease Service that provides inpatient and outpatient consultation for patients who have received either solid organ or stem cell transplants. We also work closely with the various transplant groups preparing prophylactic and treatment guidelines. Research interests include the epidemiology of opportunistic infections after solid organ transplantation and the diagnosis and management of viral and other opportunistic infections after stem cell transplantation.

HIV/AIDS

Dr. Kaul is a member of the HIV/AIDS Treatment Program and spent two years training specifically in this area and has been a principal investigator on phase II, III, and IV multi-center trials of antiretroviral agents. Research interests include clinical use of antiretroviral therapies, immune reconstitution disease, and resistance to antiretroviral agents.

RECENT PUBLICATIONS

Kaul DR, Jordan, M. Diffuse Infiltrative Lymphocytosis Syndrome in an HIV-Positive Patient. Infections in Medicine 2006 September, 23 (9): 412-414.

Kaul DR, Flanders SA, Beck JM, Saint S. The incidence, etiology, risk factors, and outcome of hospital-acquired fever: A systematic, evidence-based review. Journal of General Internal Medicine 2006, 21 (11): 1184-87.

Safdar N, Kaul DR, Saint S. Into the Woods. New England Journal of Medicine 2007, 356 (9): 943-947.

Safdar N, Kaul D, Saint S. Into the woods - The authors reply. N Engl J Med 356 (23): 2429-2430, 2007.

Kaul DR, Orringer MB, Saint S, Jones SR. The Drenched Doctor. New England Journal of Medicine 2007, 356 (18): 1871-1876.

Savona MR, Newton D, Frame D, Levine JE, Mineishi S, Kaul DR. Low Dose Cidofovir Treatment of BK Virus Associated Hemorrhagic Cystitis in Recipients of Hematopoietic Stem Cell Transplants. Bone Marrow Transplantation 2007, Jun;39(12):783-7

Riddell J IV, Kaul DR, Karakousis PC, Gallant JE, Mitty J, Kazanjian PH. Mycobacterium avium complex immune reconstitution inflammatory syndrome: Long term outcomes - art. no. 50. J Translat Med 5: 50, 2007.

Safdar N, Abad CL, Kaul DR, Jarrard D, Saint S. An unintended consequence. N Engl J Med 358 (14): 1496-1501, 2008.

Nicolasora N, Kaul DR. Infectious disease emergencies. Med Clin N Amer 92 (2): 427-441, 2008.

Falade OO, Antonarakis ES, Kaul DR, Saint S, Murphy PA. Beware of first impressions (Clinical Problem Solving). New Engl J Med 359 (6): 628-634, 2008.

Nicolasora NP, Reddy P, Kaul DR. Biopsy-proven adenoviral diarrhea responding to low-dose cidofovir. Transpl Infect Dis 10 (5): 346-350, 2008.

Kaul DR, Collins CD, Hyzy RC. New developments in antimicrobial use in sepsis. Curr Pharm Design 14 (19): 1912-1920, 2008.

Kaul DR, Lowe L, Visvesvara GS, Farmen S, Khaled YA, Yanik GA. Acanthamoeba infection in a patient with chronic graft-versus-host disease occurring during treatment with voriconazole. Transpl Infect Dis 10 (6): 437-441, 2008.

Collins CD, Ellis JJ, Kaul DR. Comparative cost-effectiveness of posaconazole versus fluconazole or itraconazole prophylaxis in patients with prolonged neutropenia. Am J Health Syst Pharm 65 (23): 2237-2243, 2008.

Psarros G, Kaul DL, Kauffman CA. Disseminated histoplasmosis in a heart transplant recipient: an uncommon diagnosis even in the Midwest. Infect Dis Clin Pract 16:49-53, 2008.

Segal BH, Freifeld AG, Baden LR, Brown AE, Casper C, Dubberke E, Gelfand M, Greene, JN, Ison MG, Ito JI, Karp JE, Kaul DR, King E, Mackler E, Marcucci G, Montoya JG, Engemann AM, Rolston K. Prevention and Treatment of Cancer Related Infections. Journal of the National Comprehensive Cancer Network 6(2):122-74, 2008.

Safdar N, Abad CL, Narayan S, Kaul DR, Saint S. Keeping an Open Mind. New Engl J Med 360 (1): 72-76, 2009.

Peres E, Khaled Y, Krijanovski OI, Mineishi S, Levine JE, Kaul DR, Riddell J. Mycobacterium chelonae necrotizing pneumonia after allogeneic hematopoietic stem cell transplant: report of clinical response to treatment with tigecycline. Transpl Infect Dis 11:57-63, 2009.

Gandhi T, Flanders SA, Markovitz E, Saint S, Kaul DR. Importance of Urinary Tract Infection to Antibiotic Use Among Hospitalized Patients. Infect Contr Hosp Epidemiol 30 (2): 193-195, 2009.

Cooke DT, Pagani FD, Kaul DR, Cooke KR, Lau CL, Riddell J. Successful treatment of pulmonary zygomycosis in two transplant recipients with liposomal amphotericin B and partial surgical resection followed by posaconazole (Letter). Mycoses eFIRST date: 12 FEB 2009.