Description of Research: Tejal Gandhi
Dr. Gandhi is a member of the HIV/AIDS Treatment
Program and completed additional training specifically
in this area. Research interests include the impact
of incompletely suppressive antiretroviral (ARV) regimens
on opportunistic infection (OI) rates, immunologic
outcomes, virologic outcomes, and occurrence of drug
resistant mutations in patients with highly drug resistant
HIV. We have found that maintaining an incompletely
suppressive ARV regimen reduces OI rates and maintains
a durable virologic and immunologic response in many
patients. In addition, we have also found that patients
with highly drug resistant HIV continue to acquire
new drug resistant mutations while on a failing ARV
Dr. Gandhi is a member of the Antimicrobial Stewardship
Program for the hospital. The goal of our program
is to ensure effective and appropriate utilization
of antimicrobials for hospitalized patients, while
minimizing unintended consequences of antimicrobial
use (c.diff infection, selection of drug resistant
pathogens, and drug toxicities). In addition, we participate
in the development of evidence based guidelines for
antimicrobial use. Research interests include the
diagnosis and management of urinary tract infections
in hospitalized patients.
Gandhi T, Wei W, Amin K, Kazanjian P. Effect of Maintaining
HAART on AIDS Events in Late Stage HIV Infected Patients
with Inadequate CD4 and Viral Responses. Clin Infect
Dis 2006;42: 878-84
Gandhi T, Nagappan V, Cinti S, Wei W, Kazanjian P.
Long-term immunologic and virologic responses in patients
with highly resistant HIV infection who are treated
with an incompletely suppressive Antiretroviral regimen.
Clin Infect Dis 45 (8): 1085-1092, 2007.
Cinti, SK; Gandhi, T; Riddell, J. Non-AIDS-defining
cancers: Should antiretroviral therapy be initiated
earlier? AIDS Read 18 (1): 18, 2008.
Gandhi T, Wu AH, Aronoff DM. Severe transient cardiomyopathy
associated with community-acquired pneumonia caused
by Streptococcus pneumoniae. Heart Lung 37 (5): 394-397,
Gandhi T, Flanders SA, Markovitz E, Saint S, Kaul
DR. Importance of Urinary Tract Infection to Antibiotic
Use Among Hospitalized Patients. Infect Contr Hosp
Epidemiol 30 (2): 193-195, 2009.
Gandhi TN, DePestel DD, Collins CD, Nagel J, Washer LL. Managing antimicrobial resistance in intensive care units. Crit Care Med 38 (8): S315-S323 Suppl. S, 2010.