Dr. Gandhi is a member of the HIV/AIDS Treatment Program and completed additional training specifically in this area. Research interests include the impact of incompletely suppressive antiretroviral (ARV) regimens on opportunistic infection (OI) rates, immunologic outcomes, virologic outcomes, and occurrence of drug resistant mutations in patients with highly drug resistant HIV. We have found that maintaining an incompletely suppressive ARV regimen reduces OI rates and maintains a durable virologic and immunologic response in many patients. In addition, we have also found that patients with highly drug resistant HIV continue to acquire new drug resistant mutations while on a failing ARV regimen.

Antimicrobial Stewardship

Dr. Gandhi is a member of the Antimicrobial Stewardship Program for the hospital. The goal of our program is to ensure effective and appropriate utilization of antimicrobials for hospitalized patients, while minimizing unintended consequences of antimicrobial use (c.diff infection, selection of drug resistant pathogens, and drug toxicities). In addition, we participate in the development of evidence based guidelines for antimicrobial use. Research interests include the diagnosis and management of urinary tract infections in hospitalized patients.

Recent Publications

Gandhi T, Wei W, Amin K, Kazanjian P. Effect of Maintaining HAART on AIDS Events in Late Stage HIV Infected Patients with Inadequate CD4 and Viral Responses. Clin Infect Dis 2006;42: 878-84

Gandhi T, Nagappan V, Cinti S, Wei W, Kazanjian P. Long-term immunologic and virologic responses in patients with highly resistant HIV infection who are treated with an incompletely suppressive Antiretroviral regimen. Clin Infect Dis 45 (8): 1085-1092, 2007.

Cinti, SK; Gandhi, T; Riddell, J. Non-AIDS-defining cancers: Should antiretroviral therapy be initiated earlier? AIDS Read 18 (1): 18, 2008.

Gandhi T, Wu AH, Aronoff DM. Severe transient cardiomyopathy associated with community-acquired pneumonia caused by Streptococcus pneumoniae. Heart Lung 37 (5): 394-397, 2008.

Gandhi T, Flanders SA, Markovitz E, Saint S, Kaul DR. Importance of Urinary Tract Infection to Antibiotic Use Among Hospitalized Patients. Infect Contr Hosp Epidemiol 30 (2): 193-195, 2009.

Gandhi TN, DePestel DD, Collins CD, Nagel J, Washer LL. Managing antimicrobial resistance in intensive care units. Crit Care Med 38 (8): S315-S323 Suppl. S, 2010.