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Description of Research: Suzanne
Bradley
Dr. Bradley has been interested in the prevention
of infectious diseases in older persons, particularly
the frail nursing home resident. Finding out why antibiotic-resistant
pathogens are so common in the nursing home and how
these pathogens emerge and are spread may lead to
improved understanding of how to prevent infections
with these organisms.
Dr. Bradley has shown that mupirocin is effective
in reducing asymptomatic carriage of Staphylococcus
aureus in nursing home residents. However, relapse
with the same strain is common and prevention of infection
has not been proven. Newer studies will assess the
efficacy of intermittent mupirocin treatment in preventing
recurrent infection and its effect on resistance.
In addition, use of molecular techniques in Dr. Bradley’s
laboratory has led to a greater understanding of the
natural history of persistent S. aureus carriage in
nursing home residents and how this organism might
become resistant to mupirocin.
More effective strategies for infection prevention
will reduce antibiotic use, limit the emergence of
antibiotic resistance, and optimize the use of limited
infection control resources in the chronic care setting.
To this end, Dr. Bradley has been involved in national
trials to prevent influenza and other infections in
older adults. She has also been involved in the development
of national guidelines for the diagnosis and treatment
of infections in older adults.
Dr. Bradley is also the Michigan Principal Investigator
for the International Collaboration on Endocarditis
(ICE) group. ICE involves more than 40 centers worldwide
and has published seminal studies on etiologic agents
causing endocarditis and its clinical presentation.
Recent Publications
Fowler VG, Miro JM, Hoen B, Cabell CH, Abrutyn E,
Rubinstein E, Corey GR, Spelman D, Bradley S, Barsic
B, Pappas P, Anstrom K, Wray D, Fortes C, Anguera
I, Athan PJ, Jones P, van der Meer J, Elliott T, Levine
DP, Bayer AS, for the ICE Investigators. Staphylococcus
aureus endocarditis: A consequence of medical progress.
From the International Collaboration on Endocarditis
Prospective Cohort Study. JAMA 293:3012-3021, 2005.
Talbot TR, Bradley SF, Cosgrove SE, Ruef C, Siegel
JD, Weber DJ. Influenza vaccination of healthcare
workers and vaccine allocation for healthcare workers
during vaccine shortages. Infect Contr Hosp Epid 26:
882-890, 2005.
Hurdle JG, O’Neill AJ, Mody L, Chopra I, Bradley
SF. In vivo transfer of resistance elements from coagulase
negative staphylococci to Staphylococcus aureus associated
with high-level mupirocin resistance (mupR) and treatment
failure. J Antimicrob Chemother 26:1166-1168, 2005.
Mody L, Flannery E, , Bielacyzc A, Bradley SF. Molecular
epidemiology of Staphylococcus aureus colonization
in two long-term care facilities. Infect Control Hosp
Epidemiol 27:212-214, 2006.
Mody L, Sun R, Bradley SF. Prospective assessment
of pneumonia in older adults:
Impact of functional status. J Am Geriatr Soc 54:1062-1067,
2006.
Bradley SF. Eradication or decolonization of methicillin-resistant
Staphylococcus aureus carriage: What are we doing
and why are we doing it? Clin Infect Dis 44 (2): 186-189,
2007.
Bradley SF. In the footsteps of the Gods: Janus revisited
and the pursuit of timeliness. Infect Contr Hosp Epidemiol
28 (4): 373-374, 2007.
Mody L, Maheshwari S, Galecki A, Kauffman CA, Bradley
SF. Indwelling device use and antibiotic resistance
in nursing homes: Identifying a high-risk group. J
Am Geriatr Soc 55 (12): 1921-1926, 2007.
Tsan L, Davis C, Langberg R, Hojlo C, Pierce J, Miller
M, Gaynes R, Gibert C, Montgomery O, Bradley S, Richards
C, Danko L, Roselle G. Prevalence of nursing home-associated
infections in the department of Veterans Affairs nursing
home care units. Am J Infect Control 36 (3): 173-179,
2008.
Mody L, Kauffman CA, Donabedian S, Zervos M, Bradley
SF. Epidemiology of Staphylococcus aureus colonization
in nursing home residents. Clin Infect Dis 46 (9):
1368-1373, 2008.
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