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Description of Research: Suzanne
Bradley
Dr. Bradley has been interested in the prevention
of infectious diseases in older persons, particularly
the frail nursing home resident. Finding out why antibiotic-resistant
pathogens are so common in the nursing home and how
these pathogens emerge and are spread may lead to
improved understanding of how to prevent infections
with these organisms.
Dr. Bradley has shown that mupirocin is effective
in reducing asymptomatic carriage of Staphylococcus
aureus in nursing home residents. However, relapse
with the same strain is common and prevention of infection
has not been proven. Newer studies will assess the
efficacy of intermittent mupirocin treatment in preventing
recurrent infection and its effect on resistance.
In addition, use of molecular techniques in Dr. Bradley’s
laboratory has led to a greater understanding of the
natural history of persistent S. aureus carriage in
nursing home residents and how this organism might
become resistant to mupirocin.
More effective strategies for infection prevention
will reduce antibiotic use, limit the emergence of
antibiotic resistance, and optimize the use of limited
infection control resources in the chronic care setting.
To this end, Dr. Bradley has been involved in national
trials to prevent influenza and other infections in
older adults. She has also been involved in the development
of national guidelines for the diagnosis and treatment
of infections in older adults.
Dr. Bradley is also the Michigan Principal Investigator
for the International Collaboration on Endocarditis
(ICE) group. ICE involves more than 40 centers worldwide
and has published seminal studies on etiologic agents
causing endocarditis and its clinical presentation.
Recent Publications
Tsan L, Davis C, Langberg R, Hojlo C, Pierce J, Miller
M, Gaynes R, Gibert C, Montgomery O, Bradley S, Richards
C, Danko L, Roselle G. Prevalence of nursing home-associated
infections in the department of Veterans Affairs nursing
home care units. Am J Infect Control 36 (3): 173-179,
2008.
Mody L, Kauffman CA, Donabedian S, Zervos M, Bradley
SF. Epidemiology of Staphylococcus aureus colonization
in nursing home residents. Clin Infect Dis 46 (9):
1368-1373, 2008.
Malani PN, Rana MM, Banerjee M, Bradley SF. Staphylococcus
aureus bloodstream infections: The association between
age and mortality and functional status. J Am Geriatr
Soc 56 (8): 1485-1489, 2008.
Smith PW, Bennett G, Bradley S, Drinka P, Lautenbach
E, Marx J, Mody L, Nicolle L, Stevenson K. SHEA/APIC
guideline: Infection prevention and control in the
long-term care facility. Infect Contr Hosp Epidemiol
29 (9): 785-814, 2008.
Smith PW, Bennett G, Bradley S, Drinka P, Lautenbach
E, Marx J, Mody L, Nicolle L, Stevenson K. SHEA/APIC
guideline: Infection prevention anal control in the
long-term care facility. Am J Infect Contr 36 (7):
504-535, 2008.
Bradley SF. A New Feature: National Healthcare Safety
Network Annual Data (editorial). Infect Contr Hosp
Epidemiol 29 (11): 995-995, 2008.
Bradley SF. Bennett & Brachman’s Hospital
Infections, Fifth Edition (book review). Clin Infect
Dis 47:865, 2008.
Durante-Mangoni, Bradley S, Selton-Suty, Tripodi
M-F, Pappas P, Sexton D, Fowler V, Bouza E, Murdoch
D, Miro JM,Cabell C , Utili R for the International
Collaboration on Endocarditis Prospective Cohort Study
Group. Infective endocarditis in the elderly: An International
Collaboration on Endocarditis Prospective Cohort Study.
Arch Intern Med 168:2095-2103, 2008.
High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello
VJ, Richards C, Yoshikawa TT. Clinical Practice Guideline
for the Evaluation of Fever and Infection in Older
Adult Residents of Long-Term Care Facilities: 2008
Update by the Infectious Diseases Society of America.
Clin Infect Dis 48 (2): 149-171, 2009.
High KP, Bradley SF, Gravenstein S, Mehr DR, Quagliarello
VJ, Richards C, Yoshikawa TT. Clinical Practice Guideline
for the Evaluation of Fever and Infection in Older
Adult Residents of Long-Term Care Facilities: 2008
Update by the Infectious Diseases Society of America
(Reprinted from Clinical Infectious Disease, vol 48,
pg 149-171, 2009). J Am Geriatr Soc 57 (3): 375-394,
2009.
Bae IG, Federspiel JJ, Miro JM, Woods CW, Park L,
Rybak MJ, Rude TH, Bradley S, Bukovski S, de la Maria
CG, Kanj SS, Korman TM, Marco F, Murdoch DR, Plesiat
P, Rodriguez-Creixems M, Reinbott P, Steed L, Tattevin
P, Tripodi MF, Newton KL, Corey GR, Fowler VG. Int
Collaboration Endocarditis-Mic; Int Collaboration
Endocarditis-Mic. Heterogeneous Vancomycin-Intermediate
Susceptibility Phenotype in Bloodstream Methicillin-Resistant
Staphylococcus aureus Isolates from an International
Cohort of Patients with Infective Endocarditis: Prevalence,
Genotype, and Clinical Significance. J Infect Dis
200 (9): 1355-1366, 2009.
Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings
SE, Rice JC, Saint S, Schaeffer AJ, Tambayh PA, Tenke
P, Nicolle LE. Diagnosis, Prevention, and Treatment
of Catheter-Associated Urinary Tract Infection in
Adults: 2009 International Clinical Practice Guidelines
from the Infectious Diseases Society of America. Clin
Infect Dis 50 (5): 625-663, 2010.
Tsan L, Langberg R, Davis C, Phillips Y, Pierce J, Hojlo C, Gibert C, Gaynes R, Montgomery O, Bradley S, Danko L, Roselle G. Nursing home-associated infections in Department of Veterans Affairs community living centers. Am J Infect Contr 38 (6): 461-466, 2010.
Mody L, Bradley SF, Galecki A, Olmsted RN, Fitzgerald JT, Kauffman CA, Saint S, Krein SL. Conceptual Model for Reducing Infections and Antimicrobial Resistance in Skilled Nursing Facilities: Focusing on Residents with Indwelling Devices. Clin Infect Dis 52 (5): 654-661, 2011.
Bradley SF. Five Years Later and the Second Act. Infect Contr Hosp Epidemiol 33 (1):1-2, 2012.
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