Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) work by binding tightly to the enzyme reverse transcriptase. This in turn, prevents viral RNA from being converted to viral DNA which infects healthy cells.
Starting dose: 1 X 200mg tablet once per day for the first 14 days
This lead-in dosing decreases the incidence of developing a rash from nevirapine.
Maintenance dose: 1 X 200mg tablet twice per day after the first 14 days
Tablets should be taken 12 hours apart, for example 7am and 7pm.
Can be taken with or without food.
If a dose is missed take the next as soon as possible. Do not double the next dose.
Side Effects to report to your doctor immediately
- Rash: Most occur within the first 6 weeks of therapy. If you develop a severe rash or a rash accompanied by fever, blisters, oral lesions, conjunctivitis, swelling, muscle or joint aches, or general malaise stop taking Viramune immediately and contact your doctor. Do not increase your dose to twice a day if you develop a rash in the first 14 days.
Drug Interactions and Incompatibility
- Oral Contraceptives: May decrease the effectiveness. Therefore, you should not use these types of birth control while taking Viramune. A latex condom should always be used.
- Notify your doctor of all the medications you are taking
All of your Antiviral Medications must be taken exactly as prescribed, without skipping or altering doses. Please notify you doctor if you have any problems with these or any of your medicines.