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Protease Inhibitors stop HIV replication by preventing the enzyme protease from cutting the virus into shorter pieces that it needs to make copies of itself in newly infected cells. New copies are still made but they are defective and not completely formed so they can't infect other cells.

Kaletra (lopinavir + Norvir)

Form: Capsule containing 133mg of Lopinavir and 33mg of Norvir

Usual Dosage: 3 capsules twice per day (4 capsules twice a day when used with Sustiva or Viramune)

Instructions: Should be taken with food.  Notify your doctor of all medications being taken prior to starting Lopinavir.

Side effects to report to your physician

  • Fatigue
  • Headache
  • Nausea / vomiting/diarrhea
  • High cholesterol or triglycerides

Drug interactions or incompatibility

  • Use with caution if taking Viagra, some antihistamines, anti-fungal medications, or drugs to lower your cholesterol
  • Be aware that drug may increase cholesterol and fats in blood - a diet lower in fats and cholesterol is recommended.

For more information on Lopinavir click here.


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