Research Faculty

Sean McDermott, Ph.D.
Research Investigator

seanmcde@umich.edu

Phone: 734/647-1590

Campus address:
2800 Plymouth Rd
NCRC Bldg 20-307W
Ann Arbor, MI 48109/2800

Research Interests

1.     Cancer Stem Cells
2.     Drug Discovery
3.     Breast cancer
4.     High-throughput screening

Education and Training

May 2000 B.S., Genetics, Texas A&M University (Research Advisor: Dr. Sumana Datta)
Dec 2005 Ph.D., Cancer Biology, University of Wisconsin-Madison
(Ph.D. Advisor: Dr. Caroline Alexander)
July 2009 Postdoctoral Training, Cell & Molecular Biology, University Health Network, Toronto, ON, Canada (Postdoc Advisor: Dr. John E. Dick)

Memberships in Professional Societies

2001- American Society of Cell Biology
2002- American Association for Cancer Research
2005- International Society for Stem Cell Research
2006-2009 Member, Stem Cell Network

Honors & Awards

2002 Selected to attend AACR Pathobiology of Cancer Workshop, Keystone, CO
2007 AACR-Aflac, Inc Travel Award. AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference
2008 AACR-Aflac, Inc Scholar-in-Training Travel Award. AACR Special Conference: The Role of Stem Cells in the Initiation and Propagation of Tumorigenesis
2009 AACR-Aflac, Inc Travel Award. AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics Conference

Grants Awarded


Single Cell to Spheres in High-Throughput Microfluidics for Cancer Drug Screening.
PI: Euisik Yoon. NIH/NCI. 1 R21 CA175857-01. Role: Co-Investigator.
April 2013-March 2015

Selected Publications

Park Y, Rangel C, Reynolds MM, Caldwell MC, Johns M, Nayak M, Welsh CJ, McDermott S, Datta S. Drosophila perlecan modulates FGF and hedgehog signals to activate neural stem cell division. Dev Biol. 2003 Jan 15;253(2):247-57. PMID: 12645928

Liu BY, McDermott SP, Khwaja SS, Alexander CM. The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc Natl Acad Sci USA. 2004 Mar 23: 101(12):4158-63. PMID: 15020770 (PMC 384711)

McDermott SP, Ranheim EA, Leatherberry VS, Khwaja SS, Klos KS, Alexander CM. Juvenile syndecan-1 null mice are protected from carcinogen-induced tumor development. Oncogene, 2007 Mar 1;26(10):1407-16. PMID: 16953225

Eberhard Y, McDermott SP, Wang X, Gronda M, Venugopal A, Wood TE, Hurren R, Datti A, Batey RA, Wrana J, Antholine WE, Dick J, Schimmer AD. Chelation of intracellular iron with the anti-fungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood, 2009 Oct 1;114(14):3064-73. PMID: 19589922

McDermott SP, Eppert K, Lechman E, Doedens M, Dick JE. Comparison of human cord blood engraftment between immunocompromised mouse strains. Blood, 2010 Jul 15; 116(2):193-200. PMID: 20404133

McDermott SP, Eppert K, Notta F, Isaac M, Datti A, Al-Awar R, Wrana J, Minden M, Dick JE. A small molecule screening strategy targeting human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside. Blood, 2012 Feb 2; 119(5):1200-7. PMID: 22160482

Liu S, Patel SH, Ginestier C, Ibarra I, Martin-Trevino R, Bai S, McDermott SP, Shang L, Ke J, Ou SJ, Heath A, Zhang KJ, Korkaya H, Clouthier SG, Charafe-Jauffret E, Birnbaum D, Hannon GJ, Wicha MS. MicroRNA93 Regulates Proliferation and Differentiation of Normal and Malignant Breast Stem Cells. PLoS Genet, 2012 Jun; 8(6):e1002751. PMID: 22685420 (PMC 369932)

Journal Reviews

McDermott SP and Wicha MS. Breast Tumors: Of Mice and Women, Breast Cancer Res, 2010 May 27;12(3):108-9. (PMC 2917013)

McDermott SP and Wicha MS. Targeting Breast Cancer Stem Cells, Mol Oncol, 2010 Oct; 4(5):404-19
(PMC 3023958)

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