Research Faculty


NEED PHOTO

Longchuan Bai, Ph.D.
Research Assistant Professor

lbai@umich.edu
Phone: 734-647-5111

Campus address:
University of Michigan Comprehensive Cancer Center
Room 3131
1500 E. Medical Center Dr./SPC 5934
Ann Arbor, MI 48109

Research Interests


Education and Training

1991 B.S., Beijing Normal University, Beijing, China
1994 M.S., Beijing Normal University, Beijing, China
1997 Ph.D., Peking Union Medical College, Beijing. Dissertation: "Transcriptional regulation of human immunodeficiency vrus type 1 gene expression by Tat transactivator." (Advisor: Boqin Qiang, M.D.)
1997-2000 Postdoctoral Associate, Howard Hughes Medical Institute, Ann Arbor, MI (Mentor: Juanita L. Merchant, M.D., Ph.D.)
2000-2002 Research Fellow, University of Michigan, Ann Arbor, MI (Mentor: Juanita L. Merchant, M.D., Ph.D.)

Honors & Awards

2002 Sigma Xi
2002 Travel award, 14th International Symposium on Regulatory Peptides
2006 Travel award, American Gastroenterological Association Institute


Selected Publications (2008-Present)

Sun H, Nikolovska-Coleska Z, Yang CY, Qian D, Lu J, Qiu S, Bai L, Peng Y, Cai Q, Wang S. Design of small-molecule peptidic and nonpeptidic Smac mimetics. Acc Chem Res, 2008 Oct; 41(10):1264-1277. (PMID 18937395)  PMC 2676167.

Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S.  SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res, 2008 Nov 15; 68(22):9384-9393. (PMID 19010913) PMC 2784911.

Zhang B, Nikolovska-Coleska Z, Zhang Y, Bai L, Qiu S, Yang CY, Sun H, Wang S, Wu Y. Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases. J Med Chem, 2008 Dec 11; 51(23):7352-7355. (PMID 19012392)  PMC 2662380.

Sun W, Nikolovska-Coleska Z, Qin D, Sun H, Yang CY, Bai L, Qiu S, Wang Y, Ma D, Wang S. Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases. J Med Chem, 2009 Feb 12; 52(3):593-596. (PMID 19138149) PMC 2795317.

Gomez C, Bai L, Zhang J, Nikolovska-Coleska Z, Chen J, Yi H, Wang S.  Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors. Bioorg Med Chem Lett, 2009 Mar 15; 19(6):1733-1736. (PMID 19243938).

Chen GG, Chan UP, Bai LC, Fung KY, Tessier A, To AK, Merchant JL, Lai PB.  ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest. Cancer Lett, 2009 Sep 28; 283(1):52-58. (PMID 19362768) PMC 3104054.

Chen J, Bai L, Bernard D, Nikolovska-Coleska Z, Gomez C, Zhang J, Yi H, Wang S. Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors. ACS Med Chem Lett, 2010 May 13; 1(2):85-89. (PMID 20596242)  PMC 2892918.

Yang J, McEachern D, Li W, Davis MA, Li H, Morgan MA, Bai L, Sebolt JT, Sun H, Lawrence TS, Wang S, Sun Y.  Radiosensitization of head and neck squamous cell carcinoma by a SMAC-mimetic compound, SM-164, requires activation of caspases. Mol Cancer Ther, 2011 Apr; 10(4):658-669. (PMID 21282353)  PMC 3073022.

Lu J, McEachern D, Sun H, Bai L, Peng Y, Qiu S, Miller R, Liao J, Yi H, Liu M, Bellail A, Hao C, Sun SY, Ting AT, Wang S.  Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatment. Mol Cancer Ther, 2011 May; 10(5):902-914. (PMID 21372226)  PMC 3091962.

Sun H, Liu L, Lu J, Bai L, Li X, Nikolovska-Coleska Z, McEachern D, Yang CY, Qiu S, Yi H, Sun D, Wang S. Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. J Med Chem, 2011 May 12; 54(9):3306-3318. (PMID 21462933)  PMC 3108148.

Bai L, McEachern D, Yang CY, Lu J, Sun H, Wang S.  LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFalpha expression and receptor tyrosine kinase signaling. Cancer Res, 2012 Mar 1; 72(5):1229-1238. (PMID 22241084)  PMC 3294058.

Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold. J Med Chem, 2012 May 24; 55(10):4664-4682. (PMID 22448988) PMC 3397176.

Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Correction to Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New Scaffold. J Med Chem, 2012 Jun 28; 55(12):5987. (PMID 22676037)  PMC 3417240.

Zhou H, Aguilar A, Chen J, Bai L, Liu L, Meagher JL, Yang CY, McEachern D, Cong X, Stuckey JA, Wang S. Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity. J Med Chem, 2012 Jul 12; 55(13):6149-6161. (PMID 22747598)  PMC 3417242.

Chen J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S. Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. J Med Chem, 2012 Oct 11; 55(19):8502-8514. (PMID 23030453)  PMC 3495162.

Wang S, Bai L, Lu J, Liu L, Yang CY, Sun H.  Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics. J Mammary Gland Biol Neoplasia, 2012 Dec; 17(3-4):217-228. (PMID 23054134)  PMC 3534930.

Aguilar A, Zhou H, Chen J, Liu L, Bai L, McEachern D, Yang CY, Meagher J, Stuckey J, Wang S. A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. J Med Chem, 2013 Apr 11; 56(7):3048-3067. (PMID 23448298).

El-Zaatari M, Kao JY, Tessier A, Bai L, Hayes MM, Fontaine C, Eaton KA, Merchant JL.  Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One, 2013; 8(3):e58935. (PMID 23520544)  PMC 3592845.