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Studies Seeking Healthy Subjects

"Cognitive Control and Obesity"

IRB Number: HUM00067783

Principal Investigators: Dr. Amy Rothberg, John Jonides, Ph.D., and Lynn Ossher, M.S.
Study Coordinator: Marie Yasuda and Xu Li, 734-647-6249

Purpose: The goal of this study is to identify ways people think that may help determine whether they are obese or overweight, and whether they are able to successfully lose weight. We are interested in whether cognitive control, the ability to restrain thought and behavior based on the task at hand, is predictive of successful weight loss. Research has shown that cognitive or mental factors may be important in weight loss efforts, and this study is being done to learn whether there are specific cognitive processes that may be important in this way.

Study Description: In each session of this study, you will be asked to complete a set of computer tasks assessing memory and attention. You will also be asked to complete a set of pencil and paper surveys and questionnaires that assess things like your knowledge of word meanings, and your attitudes and behaviors toward food, eating, hunger, body image, dieting and your weight history. Each participant will complete two testing sessions within one year. We expect each testing session to last approximately two hours, and the spacing between testing sessions will vary for different participants. Participants will also be contacted to complete a third, follow-up session within two years of their first session.

ELIGIBILITY CRITERIA:

* Age Range: 18-65 years
* Gender: Both female and male
* Ethnicity: All
* Race: All
* Smoking: Non-Smoking
* Medication: No Restriction
* Body mass index (BMI) measured as a ratio of weight (in kilograms) divided by height (in meters squared) of at least 18.

EXCLUSIONS:

  • People with significant medical, neurological, psychiatric, or psychological conditions that are known to affect normal cognition.
  • People who are taking a medication that could affect normal cognition.
  • People who have had bariatric surgery for weight loss will also not be included, nor will women who are pregnant.
  • People who are planning to move within the next 2 years should also not participate in this study.
  • Unless individuals are participating as lean control participants, study participants must have been seen in the Weight Management Clinic to participate in this study.
  • A rare risk is that during one of our attention tasks, the computer screen flashes from grey to black, and there is a small risk of seizure or migraine in participants who have a history of these conditions. People who have a history of seizure or migraine should not complete this portion of the experiment, and should tell the experimenter prior to the test.

Location of Study Visits: Ann Arbor, MI

Compensation: Up to $150


"Identification of phenotypic factors that predict success for weight loss and long-term weight maintenance"

IRB Number: HUM00030088
(click on the IRB# to see full study description in the UM Clinical Studies Database)

Principal Investigator: Dr. Amy Rothberg
Study Coordinator: Grace Wu, 734-647-2271 or glwu@umich.edu

Purpose: The study will collect information about how your metabolism works to keep you thin.
Study Description: We are looking for lean, healthy people ONLY. BMI no greater than 25 kg/m2, 30-70 years old who have little to light physical activity. You will be asked to participate in a study which could include: a treadmill test to determine your exercise capacity; a test to determine your body's preference for fat or carbohydrate use as a fuel; a blood draw to measure hormones, metabolites and genes related to metabolism; a psychological test to assess your mood and attitudes to food; an interview to recall food consumption; an x-ray test to look at your body composition; muscle and fat biopsies to measure molecules that may contribute to body weight.

ELIGIBILITY CRITERIA:

* Age Range: From 30 To 70 years
* Gender: Both Female and Male
* Ethnicity: All
* Race: All
* Smoking: Non-Smoking
* Medication: No Restriction
* This study is seeking: Healthy Subjects
* 'Lean' volunteers with healthy BMI only

Location of Study Visits: Ann Arbor, MI

Compensation: Up to $150


"Tissue-Specific Metabolic Reprogramming in Diabetic Complications. Glycemic Clamp Studies to Determine the Real Time Synthesis Rates of Glucose Derived Metabolites in Individuals With Type 1 Diabetes and Healthy Controls"

IRB Number: HUM00060967

Principal Investigator: Dr. Rodica Pop-Busui
Study Coordinator: Cindy Plunkett, 734-936-8065 or cplunket@umich.edu

Purpose: To assess steady state and dynamic metabolite changes in subjects with type 1 diabetes with and without microvascular complications and to understand differences from non-diabetics in metabolite levels and flux.

Study Description: The hypothesis is that diabetic complications arise from tissue-specific metabolic reprogramming resulting in alterations in fuel utilization that lead to dysfunction of the tissue. To test this hypothesis, we will use sensitive and specific mass-spectrometer-based metabolomic analysis to measure steady-state metabolite levels in plasma and urine from controls subjects and subjects with T1DM, without and with diabetic complications, during euglycemic and hyperglycemic clamp studies.

Group 1: T1DM subjects without complications
Group 2: T1DM subjects with microalbuminuria (early kidney disease)
Group 3: T1DM subjects with advanced diabetes complications
Group 4: Age-and-sex-matched healthy control subjects

ELIGIBILITY CRITERIA:

  • Must have type 1 diabetes of less than 5 years' duration.
  • 18 years of age or older.
  • Subjects in the microalbuminuria group (Group 2) will have a history of urinary microalbumin to creatinine ratio between 30-300 m/g confirmed on repeat testing while the non-albuminuric group will have a value of less than 30 mg/g.
  • Subjects in the advanced complications group (Group 3) will have confirmed retinopathy, peripheral and/or autonomic neuropathy and nephropathy. 
  • Healthy volunteers will be matched for age and gender and will have normal glucose tolerance, normal lipid metabolism, and normal blood pressure.

EXCLUSION CRITERIA:

Subjects may not:

  • Be less than 18 years old.
  • Be women of child-bearing potential who may be pregnant or lactating
  • Have history of pancreas, kidney or liver transplant
  • Have history of drug or alcohol use.
  • Have history of cancer other than basal cell carcinoma or squamous cell skin cancer.
  • Have the a condition that, in the opinion of the investigator, would make it unlikely for the subject to complete the study.

Compensation: $350 for successful completion of the study.


"Cardiac Autonomic Neuropathy and Myocardial Dysfunction in Type 1 Diabetes"

IRB #: HUM00036408   
(click on the IRB# to see the full study description in the UM Clinical Studies Database)

Principal Investigator: Dr. Rodica Pop-Busui
Study Coordinator: Cindy Plunkett, 734-936-8065 or cplunket@umich.edu

ELIGIBILITY CRITERIA:

  • Age range: 18–65 years old
  • This study is seeking: Patients with specified condition (type 1 diabetes)
  • No complications associated with diabetes
  • Type 1 diabetes diagnosed at least 5 yrs

Other eligibility factors:

  • Gender: Male & Female
  • Ethnicity: All
  • Race: All
  • Smoking: Both Smoking and Non Smoking Volunteers
  • Medication: Taking Medication

Compensation: $50.00 for completed imaging tests, $25 each for all other completed visits


"Type 1 Diabetes TrialNet Natural History Studies"

IRB#: HUM00011027
(click on the IRB# to see full study description in the UM Clinical Studies Database)

Principal Investigator: Massimo T. Pietropaolo, MD
Study Coordinator: Cathy Martin, MS, APRN, BC-ADM, CDE, 734-936-6465 or martinc@umich.edu

ELIGIBILITY CRITERIA:

  • Age range: 1–45 years old
  • This study is seeking: Healthy subjects

Other eligibility factors:

  • Ages 1 to 18 with second-degree relative with type 1 diabetes
  • Ages 1 to 45 with first-degree relative with type 1 diabetes
  • Family history of type 1 diabetes

Compensation: None (over 10,000 people are being recruited for the study)


 

Volunteer for a Clinical Study!

For general questions about our clinical studies, send email to diabetes-studies@umich.edu
or call (734) 647-5400.