Schlegel A, Arvan P, Lisanti MP. Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the ER. J. Biol. Chem. 2001; 276: 4398-4408.
Zhang B-Y, Chang A, Kjeldsen T, Arvan P. Intracellular retention of newly-synthesized insulin in yeast is caused by endoproteolytic processing in the Golgi complex. J. Cell Biol. 2001; 153: 1187–1197.
Martin-Belmonte F, Arvan P, Alonso MA. MAL mediates apical transport of secretory proteins in polarized epithelial Madin-Darby Canine Kidney cells. J. Biol. Chem. 2001; 276: 49337-49342.
Zhang X, Reidel C, Carrasco N, Arvan P. Polarized trafficking of thyrocyte proteins in MDCK cells. Mol. Cell. Endo. 2002; 188: 27-36.
Di Jeso B, Ulianich L, Pacifico F, Leonardi A, Vito P, Consiglio E, Formisano S, Arvan P. Folding of thyroglobulin in the calnexin/calreticulin pathway and its alteration by a loss of Ca2+ from the endoplasmic reticulum. Biochem. J. 2003; 370: 449-458.
Zhang, B-y, Liu M, Arvan P. Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations. J. Biol. Chem. 2003; 278: 3687-3693.
Liu M, Ramos-Castañeda J, Arvan P. Role of the connecting peptide in insulin biosynthesis. J. Biol. Chem. 2003; 278: 14798-14805.
Feng L, Arvan P. The trafficking of alpha 1-antitrypsin, a post-Golgi secretory pathway marker, in INS-1 pancreatic beta cells. J. Biol. Chem. 2003; 278: 31486-31494
Kuliawat R, Kalinina E, Bock J, Fricker L, McGraw TE, Kim SR, Zhong J, Scheller RH, Arvan P. Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta cells. Mol. Biol. Cell. 2004; 15: 1690-1701. PMCID: PMC379267
Park Y, Arvan P. The acetylcholinesterase-homology region is essential for normal conformational maturation and secretion of thyroglobulin. J. Biol. Chem. 2004; 279: 17085-17089.
Ramos-Castañeda J, Park Y-N, Liu M, Hauser K, Rudolph H, Shull GE, Jonkman MF, Mori K, Ikeda S, Ogawa H, Arvan P. Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in ER-associated degradation and sensitivity to ER-stress. J. Biol. Chem. 2005; 280: 9467-9473. PMCID: PMC2527542
Liu M, Li Y, Cavener D, Arvan P. Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum. J. Biol. Chem. 2005; 280: 13209-13212. PMCID: PMC2527538
Kuliawat R, Ramos-Castañeda J, Liu Y, Arvan P. Intracellular trafficking of thyroid peroxidase to the cell surface. J. Biol. Chem. 2005; 280: 27713-27718.
Di Jeso B, Park Y-n, Ulianich L, Treglia AS, Urbanas ML, High S, Arvan P. Mixed-disulfide folding intermediates between thyroglobulin and ER resident oxidoreductases ERp57 and PDI. Mol. Cell Biol. 2005; 25: 9793-9805.
Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G et al. Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice. Am. J. Physiol. Cell Physiol. 2006; 290: C1160-C1167.
Lara-Lemus R, Liu M, Turner M, Scherer P, Stenbeck G, Iyengar P, Arvan P. Lumenal protein sorting to the constitutive secretion pathway of a regulated secretory cell. J. Cell Sci. 2006; 119: 1833-1842. PMCID: PMC2547412
Forster ML, Sivick K, Park Y-P, Arvan P, Lencer WI, Tsai B. PDI-like proteins play opposing roles during retro-translocation. J. Cell Biol. 2006; 173: 853-859.
Hua Q-x, Liu M, Hu S-Q, Jia W, Arvan P*, Weiss MA* (*co-corresponding authors). A conserved histidine in insulin is required for the foldability of human proinsulin. Structure and function of an AlaB5 analog. J. Biol. Chem. 2006; 281: 24889-24899.
Zhao X, Chang AY, Toh-e A, Arvan P. A role for Lte1p (a low-temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathway. J. Biol. Chem. 2007; 282: 1670-1678.
Menon S, Lee J, Abplanalp WA, Yoo S-E, Agui T, Furudate S-i, Kim PS, Arvan P. Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf. J. Biol. Chem. 2007; 282: 6183-6191.
Liu M, Hodish I, Rhodes CJ, Arvan P. Proinsulin maturation, misfolding and proteotoxicity.
Proc. Nat'l. Acad. Sci (USA; track 2) 2007; 104: 15841-15846. PMCID: PMC2000385
Zhao X, Nothwehr S, Lara-Lemus R, Zhang B-y, Peter H, Arvan P. Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly. Traffic 2007; 8:1829-1840. PMCID: PMC2532708
Restrepo R, Zhao X, Peter H, Zhang B-y, Arvan P, Nothwehr SF. Structural features of Vps35p involved in interaction with other subunits of the retromer complex. Traffic 2007; 8: 1841-1853. PMCID: PMC2504507
Kim PS, Lee J, Jongsamak P, Menon S, Li B, Hossain SA, Bae J-H, Panijpan B, Arvan P. Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter. Mol. Endocrinol. 2008; 22: 477-484. PMCID: PMC2725791
Yamaguchi Y, Larkin D, Lara-Lemus R, Ramos-Castañeda J, Liu M, Arvan P. ER chaperone regulation, and survival of cells compensating for deficiency in the ER stress protein kinase, PERK. J. Biol. Chem. 2008; 283: 17020-17029. PMCID: PMC2427336
Colombo C, Porzio O, Liu M, Massa O, Vasta M, Salardi S, Beccaria L, Monciotti C, Toni S, Pedersen O, Hansen T, Pesavento R, Cadario F, Federici G, Ghirri P, Arvan P, Iafusco D, Barbetti F, and the Early Onset Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (SIEDP). Permanent neonatal diabetes mellitus caused by seven novel mutations of the insulin gene. J. Clin. Invest. 2008; 118: 2148-2156. PMCID: PMC2350430
Lee J, Di Jeso B, Arvan P. The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone. J. Clin. Invest. 2008; 118: 2950-2958. PMCID: PMC2441857
Rajpal G, Liu M, Zhang Y, Arvan P. Single-chain insulins as receptor agonists. Molecular Endocrinology 2009; Mol. Endocrinol. 23: 679-688. PMCID: PMC2675957
Lee J, Wang X, Di Jeso B, Arvan P. The cholinesterase-like domain of thyroglobulin, essential for trafficking in the secretory pathway, is required for protein dimerization. J. Biol. Chem. 2009; 284: 12752-12761. PMCID: PMC2676005
Nicolson TJ, Bellomo EA, Wijesekara N, Loder M, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel, P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PRV, Masseboeufl M, Burcelin R, Baldwin SA, Liu M, Lara- Lemus A, Arvan P, Schuit F, Wheeler MB, Chimienti F, Rutter GA. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 2009; 58: 2070-83. PMCID: PMC2731533
Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP. Targeted induction of Endoplasmic Reticulum stress induces cartilage pathology. PLoS Genetics 2009; 5(10):e1000691. PMCID: PMC2757901
Liu M, Wan Z-L, Chu Y-C, Aladdin H, Klaproth B, Choquette M, Hua Q-X, Mackin RB, Rao S, De Meyts P, Katsoyannis PG, Arvan P1, Weiss MA2. (1,2 co-senior authors). Crystal structure of a "non-foldable" insulin: impaired folding efficiency despite native activity. J. Biol. Chem. 2009; 284: 35259-35272. PMCID: PMC2787385
Hodish I, Liu M, Rajpal G, Larkin D, Holz R, Adams A, Liu L, Arvan P. Misfolded proinsulin affects bystander proinsulin in neonatal diabetes. J Biol Chem. 2010; 285: 685-694. PMCID: PMC2804216
Sohma Y, Hua Q-X, Liu M, Phillips NF, Hu SQ, Whittaker J, Whittaker LJ, Ng A, Roberts CT Jr, Arvan P, Kent SB, Weiss MA.2. Contribution of residue B5 to the folding and function of insulin and IGF-I. Constraints and find-tuning in the evolution of a protein familiy. J Biol Chem. 2010; 285: 5040-55. PMCID: PMC2836107
Wang X, Lee J, Comoletti D, Dubi N, Taylor P, Arvan P. cis and trans actions of the Cholinesterase-Like domain within the thyroglobulin dimer. J. Biol. Chem. 2010; 285: 17564-17573. PMCID: PMC2878521
Liu M, Hua Q-X, Hu S-Q, Jia W, Wan Z-L, Whittaker J, Arvan P Weiss MA. Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible that is dispensable in the mature hormone. J. Biol. Chem. 2010; 285: 30989-31001. PMCID: PMC2945590
Peteiro-Gonzalez D, Lee J, Rodriguez-Fontan J, Castro-Piedras I, Cameselle-Teijeiro JM, Beiras A, Bravo SB, Alvarez CV, Hardy DM, Targovnik HM, Arvan P, Lado-Abeal J. New insights into thyroglobulin pathophysiology revealed by the study of a family with congenital goiter. J. Clin. Endo. Metab. 2010; 95: 3522-3526. PMCID: PMC2928901
Liu M, Haataja L, Wright J, Barbetti F, Weiss MA, Arvan P. Mutant INS-gene induced Diabetes of Youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport. PLoS ONE 2010; 5: e13333. PMCID: PMC2952628
Khoo C, Yang J, Rajpal G, Wang Y, Liu J, Arvan P, Stoffers DA. Endoplasmic reticulum oxidoreducin-1-like ß (ERO1lß) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in ß-cells. Endocrinology 2011 152: 2599-2608. PMCID: PMC3115612
Hodish, I, Absood A, Liu L, Liu M, Haataja L, Larkin D, Arvan P. In vivo misfolding of proinsulin below the threshold of frank diabetes. Diabetes 2011 60: 2092-2101. PMCID: PMC3142084
Lee J, Arvan P. Repeat motif-containing regions within thyroglobulin. J. Biol. Chem. 2011; 286: 26327-26333. PMCID: PMC3143595
Lee J, Di Jeso B, Arvan P. Maturation of thyroglobulin region-I. J. Biol. Chem. 2011; 286: 33045-33052. PMCID: PMC3190886
