ARVAN LAB
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PUBLICATIONS

Kuliawat R, Kalinina E, Bock J, Fricker L, McGraw TE, Kim SR, Zhong J, Scheller RH, Arvan P.  Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta cells.  Mol. Biol. Cell.  2004; 15: 1690-1701.  PMCID: PMC379267

Park Y, Arvan P.  The acetylcholinesterase-homology region is essential for normal conformational maturation and secretion of thyroglobulin.  J. Biol. Chem.  2004; 279: 17085-17089. 

Ramos-Castañeda J, Park Y-N, Liu M, Hauser K, Rudolph H, Shull GE, Jonkman MF, Mori K, Ikeda S, Ogawa H, Arvan P.  Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in ER-associated degradation and sensitivity to ER-stress.  J. Biol. Chem. 2005; 280: 9467-9473.  PMCID: PMC2527542

Liu M, Li Y, Cavener D, Arvan P.  Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum.  J. Biol. Chem. 2005; 280: 13209-13212.  PMCID: PMC2527538

Kuliawat R, Ramos-Castañeda J, Liu Y, Arvan P.  Intracellular trafficking of thyroid peroxidase to the cell surface.  J. Biol. Chem. 2005; 280: 27713-27718.

Di Jeso B, Park Y-n, Ulianich L, Treglia AS, Urbanas ML, High S, Arvan P.   Mixed-disulfide folding intermediates between thyroglobulin and ER resident oxidoreductases ERp57 and PDI.  Mol. Cell Biol. 2005; 25: 9793-9805.

Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G et al.  Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice. Am. J. Physiol. Cell Physiol. 2006; 290: C1160-C1167.  

Lara-Lemus R, Liu M, Turner M, Scherer P, Stenbeck G, Iyengar P, Arvan P.  Lumenal protein sorting to the constitutive secretion pathway of a regulated secretory cell.  J. Cell Sci. 2006; 119: 1833-1842.  PMCID: PMC2547412

Forster ML, Sivick K, Park Y-P, Arvan P, Lencer WI, Tsai B.  PDI-like proteins play opposing roles during retro-translocation.  J. Cell Biol. 2006; 173: 853-859.

Hua Q-x, Liu M, Hu S-Q, Jia W, Arvan P*, Weiss MA* (*co-corresponding authors).  A conserved histidine in insulin is required for the foldability of human proinsulin.  Structure and function of an AlaB5 analog.  J. Biol. Chem. 2006; 281: 24889-24899. 

Zhao X, Chang AY, Toh-e A, Arvan P.  A role for Lte1p (a low-temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathway.  J. Biol. Chem. 2007; 282: 1670-1678. 

Menon S, Lee J, Abplanalp WA, Yoo S-E, Agui T, Furudate S-i, Kim PS, Arvan P.  Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf.  J. Biol. Chem.  2007; 282: 6183-6191. 

Liu M, Hodish I, Rhodes CJ, Arvan P.  Proinsulin maturation, misfolding and proteotoxicity. 
Proc. Nat'l. Acad. Sci (USA; track 2)  2007; 104: 15841-15846.  PMCID: PMC2000385

Zhao X, Nothwehr S, Lara-Lemus R, Zhang B-y, Peter H, Arvan P.  Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly.  Traffic  2007; 8:1829-1840.  PMCID: PMC2532708

Restrepo R, Zhao X, Peter H, Zhang B-y, Arvan P, Nothwehr SF.  Structural features of Vps35p involved in interaction with other subunits of the retromer complex.  Traffic  2007; 8: 1841-1853.  PMCID: PMC2504507

Kim PS, Lee J, Jongsamak P, Menon S, Li B, Hossain SA, Bae J-H, Panijpan B, Arvan P.  Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter.  Mol. Endocrinol.  2008;  22: 477-484.  PMCID: PMC2725791

Yamaguchi Y, Larkin D, Lara-Lemus R, Ramos-Castañeda J, Liu M, Arvan P.  ER chaperone regulation, and survival of cells compensating for deficiency in the ER stress protein kinase, PERK.  J. Biol. Chem.  2008; 283: 17020-17029.  PMCID: PMC2427336

Colombo C, Porzio O, Liu M, Massa O, Vasta M, Salardi S, Beccaria L, Monciotti C, Toni S, Pedersen O, Hansen T, Pesavento R,   Cadario F, Federici G, Ghirri P, Arvan P, Iafusco D, Barbetti F, and the Early Onset Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (SIEDP).  Permanent neonatal diabetes mellitus caused by seven novel mutations of the insulin gene.  J. Clin. Invest.  2008; 118: 2148-2156.   PMCID: PMC2350430

Lee J, Di Jeso B, Arvan P.  The cholinesterase-like domain of thyroglobulin functions as an intramolecular chaperone.  J. Clin. Invest. 2008; 118: 2950-2958.  PMCID: PMC2441857 

Rajpal G, Liu M, Zhang Y, Arvan P.  Single-chain insulins as receptor agonists.  Molecular Endocrinology  2009; Mol. Endocrinol. 23: 679-688.  PMCID: PMC2675957

Lee J, Wang X, Di Jeso B, Arvan P.  The cholinesterase-like domain of thyroglobulin, essential for trafficking in the secretory pathway, is required for protein dimerization.  J. Biol. Chem.  2009; 284: 12752-12761.  PMCID: PMC2676005 

Nicolson TJ, Bellomo EA, Wijesekara N, Loder M, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel, P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PRV, Masseboeufl M, Burcelin R, Baldwin SA, Liu M, Lara-      Lemus A,  Arvan P, Schuit F, Wheeler MB, Chimienti F, Rutter GA.  Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.  Diabetes 2009; 58: 2070-83.  PMCID: PMC2731533

Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP.  Targeted induction of Endoplasmic Reticulum stress induces cartilage pathology.  PLoS Genetics 2009; 5(10):e1000691.  PMCID: PMC2757901

Liu M, Wan Z-L, Chu Y-C, Aladdin H, Klaproth B, Choquette M, Hua Q-X, Mackin RB, Rao S, De Meyts P, Katsoyannis PG, Arvan P1, Weiss MA2. (1,2 co-senior authors).  Crystal structure of a "non-foldable" insulin: impaired folding efficiency despite native activity.  J. Biol. Chem.  2009; 284: 35259-35272.  PMCID: PMC2787385

Hodish I, Liu M, Rajpal G, Larkin D, Holz R, Adams A, Liu L, Arvan P.  Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.  J Biol Chem.  2010; 285: 685-694.  PMCID: PMC2804216

Sohma Y, Hua Q-X, Liu M, Phillips NF, Hu SQ, Whittaker J, Whittaker LJ, Ng A, Roberts CT Jr, Arvan P, Kent SB, Weiss MA.2.  Contribution of residue B5 to the folding and function of insulin and IGF-I.  Constraints and find-tuning in the evolution of a protein familiy.  J Biol Chem. 2010; 285: 5040-55.  PMCID: PMC2836107

Wang X, Lee J, Comoletti D, Dubi N, Taylor P, Arvan P.  cis and trans actions of the Cholinesterase-Like domain within the thyroglobulin dimer.  J. Biol. Chem.  2010; 285: 17564-17573.  PMCID: PMC2878521 

Liu M, Hua Q-X, Hu S-Q, Jia W, Wan Z-L, Whittaker J, Arvan P Weiss MA.  Deciphering the hidden informational content of protein sequences: foldability of proinsulin hinges on a flexible that is dispensable in the mature hormone.  J. Biol. Chem.  2010; 285: 30989-31001.  PMCID: PMC2945590

Peteiro-Gonzalez D, Lee J, Rodriguez-Fontan J, Castro-Piedras I, Cameselle-Teijeiro JM, Beiras A, Bravo SB, Alvarez CV, Hardy DM, Targovnik HM, Arvan P, Lado-Abeal J.  New insights into thyroglobulin pathophysiology revealed by the study of a family with congenital goiter.  J. Clin. Endo. Metab.  2010;  95: 3522-3526.  PMCID: PMC2928901

Liu M, Haataja L, Wright J, Barbetti F, Weiss MA, Arvan P.  Mutant INS-gene induced Diabetes of Youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.  PLoS ONE  2010;  5: e13333. PMCID: PMC2952628

Khoo C, Yang J, Rajpal G, Wang Y, Liu J, Arvan P, Stoffers DA. Endoplasmic reticulum oxidoreducin-1-like ß (ERO1lß) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in ß-cells.  Endocrinology 2011  152: 2599-2608.  PMCID: PMC3115612 

Hodish, I, Absood A, Liu L, Liu M, Haataja L, Larkin D, Arvan P.  In vivo misfolding of proinsulin below the threshold of frank diabetes.  Diabetes 2011  60: 2092-2101.  PMCID: PMC3142084 

Lee J, Arvan P.  Repeat motif-containing regions within thyroglobulin.  J. Biol. Chem.  2011; 286: 26327-26333.  PMCID: PMC3143595

Lee J, Di Jeso B, Arvan P.  Maturation of thyroglobulin region-I.   J. Biol. Chem.  2011; 286: 33045-33052. PMCID: PMC3190886

Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ. How does type 1 diabetes develop: the notion of homicide or b-cell suicide revisited. Diabetes 2011; 60: 1370-1379. PMCID: PMC3292309

Rajpal G, Schuiki I, Liu M, Volchuk A, Arvan P. Action of Protein Disulfide Isomerase on proinsulin exit from the endoplasmic reticulum of pancreatic b-cells. J. Biol. Chem. 2012; 287: 43-47. PMCID: PMC3249095

Liu M, Lara-Lemus R, Shan S-o, Wright J, Haataja L, Barbetti F, Guo H, Arvan P. Impaired cleavage of preproinsulin signal peptide linked to autosomal dominant diabetes. Diabetes. 2012; 61: 828-837. PMCID: PMC3314357

Arvan P, Pietropaolo M, Ostrov D, Rhodes CJ. Islet autoantigens: structure, function, localization, and regulation. Cold Spring Harb Perspect Med. 2012; 2(8). pii: a007658. doi: 10.1101/cshperspect.a007658 PMCID: PMC3405822

Haataja L, Snapp E, Wright J, Liu M, Hardy AB, Wheeler MB, Markwardt ML, Rizzo MA, Arvan P. Proinsulin intermolecular interactions during secretory trafficking in pancreatic beta cells. J. Biol. Chem. 2013; 288: 1896-1906. PMCID: PMC3548498

Krokowski D., Han J., Saikia M., Majumder M., Yuan C.L., Guan B.-J., Bevilacqua E., Bussolati O., Bröer S., Arvan P, Tchórzewski M., Kaufman R.J., Snider M.D., Puchowicz M., Croniger C.M., Kimball S. R., Pan T., Koromilas A.E., Hatzoglou M. A self-defeating anabolic program leads to beta-cell loss in ER stress–induced diabetes. J. Biol. Chem. 2013; 288: 17202-17213. PMCID: PMC3682525

Wright J, Wang X, Haataja L, Lee J, Liu M, Kellogg A, Arvan P. Dominant protein interactions that influence the pathogenesis of conformational diseases. J. Clin. Invest. 2013; 123: 3124-3134. PMCID: PMC3696544

Ferris SP, Jaber NS, Molinari M, Arvan P, Kaufman RJ. UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum. Mol. Biol. Cell. 2013; 24: 2597-2608. PMCID: PMC3756913

Gualeni B, Rajpar MH, Kellogg A, Arvan P, Boot- Handford RP, Briggs MD. Reduced chondrocyte proliferation is sufficient to cause decreased bone growth that is independent of apoptosis and extracellular matrix abnormalities in a transgenic mouse model of chondrodysplasia. Disease Models and Mechanisms 2013; 6: 1414-1425 PMCID: PMC3820264

Wright J, Birk J, Haataja L, Liu M, Ramming T, Weiss, MA, Appenzeller-Herzog C, Arvan P. Endoplasmic Reticulum Oxidoreductin-1alpha (Ero1alpha) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced ER stress. J. Biol. Chem. 2013; 288: 31010-31018 PMCID: PMC3829414

Arvan P, Castle D. Regulated secretory cells go to the BAR for a bud. Nat Rev Endocrinol. 2013; 9(8):443-444 PMID: 23797817

Liu M, Wright J, Guo H, Xiong Y, Arvan P. Proinsulin entry and transit through the endoplasmic reticulum in pancreatic beta cells. Vitamins & Hormones 2013; in press.

 

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