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PUBLICATIONS

Non-Research Publications

  1. Arvan P. The M.D.-Ph.D. program: inside out. Yale Scientific. 1981; 5:11-13. 

Bibliography (abstracts not included)

  1. Miller C, Arvan P, Telford JM, Racker E.  Ca++-induced fusion of proteoliposomes: dependence on transmembrane osmotic gradient.  J. Membr. Biol.  1976; 30: 271-282.
  2. Dunham P, Arvan P, Falkow S, Hoffstein S, Weissman G.  Inhibitors of membrane transport reduce lysosomal enzyme secretion from dogfish phagocytes and their killing of sea urchin eggs.  Proc. Nat'l Acad. Sci. (USA)  1979; 76: 1873-1877.
  3. Arvan P, Castle JD.  Plasma membrane of the rat parotid gland: preparation and partial characterization of a fraction containing the secretory surface.  J. Cell Biol.  1982; 95: 8-19.
  4. Arvan P, Rudnick G, Castle JD.  Osmotic properties and internal pH of isolated rat parotid secretory granules.  J. Biol. Chem.  1984; 259: 13567-13572.
  5. Arvan P, Rudnick G, Castle JD. Relative lack of ATP-driven H+ translocase activity in isolated parotid secretory granules.  J. Biol. Chem.  1985; 260: 14945-14952.
  6. Arvan P, Castle JD.  Isolated secretion granules from parotid glands of chronically-
    stimulated rats possess an alkaline internal pH and inward-directed H+ pump activity.  J. Cell Biol.  1986; 103: 1257-1267.
  7. Arvan P, Castle JD.  Phasic release of newly-synthesized secretory proteins in the unstimulated rat exocrine pancreas.  J. Cell Biol.  1987; 104: 243-252.
  8. Arvan P, Chang A.  Constitutive protein secretion from the exocrine pancreas of fetal rats.  J. Biol. Chem.  1987; 262: 3886-3890.
  9. Arvan P, Lee JL. Regulated and constitutive protein targeting can be distinguished by secretory polarity in thyroid epithelial cells.  J. Cell Biol.  1991; 112: 365-376.
  10. Kim PS, Arvan P.  Folding and assembly of newly-synthesized thyroglobulin occurs in a pre-Golgi compartment.  J. Biol. Chem.  1991; 266: 12412-12418.
  11. Arvan P, Kuliawat R, Prabakaran D, Zavacki A-M, Elahi D, Wang S, Pilkey D. Protein discharge from immature secretory granules displays both regulated and constitutive characteristics.  J. Biol. Chem.  1991; 266: 14171-14174.
  12. Kuliawat R, Arvan P.  Protein targeting via the "constitutive-like" secretory pathway in isolated pancreatic islets: passive sorting in the immature granule compartment.  J. Cell Biol. 1992;  118: 521-529.
  13. Kim PS, Arvan P.  Transient aggregation of nascent thyroglobulin in the endoplasmic reticulum: relationship to the molecular chaperone, BiP.  J. Cell Biol.  1992; 118: 541-549.
  14. Kim PS, Arvan P.  Hormonal regulation of thyroglobulin export from the endoplasmic reticulum of cultured thyrocytes.  J. Biol. Chem.  1993; 268: 4873-4879.
  15. Prabakaran D, Kim PS, Kim K-R, Arvan P.  Polarized secretion of thrombospondin is opposite to thyroglobulin in thyroid epithelial cells.  J Biol. Chem.  1993; 268: 9041-9048.
  16. Kim PS, Kim K-R, Arvan P.  Disulfide-linked aggregation of thyroglobulin normally occurs during nascent protein folding.  Am. J. Physiol.  1993; 265: C704-C711.
  17. Kuliawat R, Arvan P.  Intracellular iodination of thyroglobulin in filter-polarized thyrocytes leads to the synthesis and basolateral secretion of thyroid hormone.  J. Biol. Chem.  1994; 269: 4922-4927.
  18. Huang X-F, Arvan, P.  Formation of the insulin-containing secretory granule core occurs within immature b-granules.  J. Biol. Chem.  1994; 269: 20838-20844.
  19. Kuliawat R, Arvan, P.  Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic b-cells.  J. Cell Biol.  1994; 126: 77-86.
  20. Kim PS, Arvan P.  Calnexin and BiP act as sequential molecular chaperones during thyroglobulin folding in the endoplasmic reticulum.  J. Cell Biol.  1995;  128: 29-38.
  21. Kuliawat R, Lisanti MP, Arvan P.  Polarized distribution and delivery of plasma membrane proteins in thyroid follicular epithelial cells.  J. Biol. Chem.  1995;  270: 2478-2482.
  22. Huang X-F, Arvan, P.  Intracellular transport of proinsulin in pancreatic b-cells:structural maturation probed by disulfide accessibility.  J. Biol. Chem.  1995; 270: 20417-20423.
  23. Kim PS, O-Yu Kwon, Arvan P.  An endoplasmic reticulum storage disease causing congenital goiter with hypothyroidism.  J. Cell Biol.  1996; 133: 517-527.
  24. Prabakaran D, Kim PS, Arvan P.  Protein folding and oligomeric assembly of thrombospondin in the endoplasmic reticulum of thyroid epithelial cells.  Eur. J. Cell Biol.  1996; 70: 134-141. 
  25. Medeiros-Neto G, Kim PS, Yoo SE, Vono J, Targovnik H, Camargo R, Hossain SA,Arvan P.  Congenital hypothyroid goiter with deficient thyroglobulin: identification of an endoplasmic reticulum storage disease (ERSD) with induction of molecular chaperones.  J. Clin. Invest.  1996; 98: 2838-2844.
  26. Kuliawat R, Klumperman J, Ludwig T, Arvan P.  Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic ß-cells.  J. Cell Biol.  1997; 137: 595-608.
  27. Muresan Z, Arvan P.  Thyroglobulin transport along the secretory pathway.  Investigation of the role of molecular chaperone, GRP94, in protein export from the endoplasmic reticulum.  J. Biol. Chem.  1997; 272: 26095-26102.
  28. Huang XF, Compans RW, Chen S, Lamb RA, Arvan P.  Polarized apical targeting directed by the signal/anchor region of simian virus 5 hemagglutinin-neuraminidase.  J. Biol. Chem.  1997; 272: 27598-27604. 
  29. Muresan Z, Arvan P.  Enhanced binding to the molecular chaperone, BiP, slows            thyroglobulin export from the endoplasmic reticulum.  Mol. Endo.  1998; 12: 458-            467.
  30. Klumperman J, Kuliawat R, Griffiths JM, Geuze HJ, Arvan P.  Mannose 6-phosphate   receptors are sorted from immature secretory granules via AP-1, clathrin, and syntaxin 6-  positive vesicles.  J. Cell Biol.  1998; 141: 359-371.
  31. Kim PS, Hossain SA, Park Y-N, Lee I, Yoo S-E, Arvan P.  A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse:  A model of human ER storage diseases.  Proc. Nat'l. Acad. Sci (USA).  1998; 95: 9909-9913. 
  32. Prabakaran D, Ahima RS, Harney JW, Berry MJ, Larsen PR, Arvan P.  Polarized targeting of epithelial cell proteins in thyrocytes and MDCK Cells.  J. Cell. Sci.  1999; 112: 1247-1256.
  33. Gorr S-U, Huang XF,Cowley DJ, Kuliawat R, Arvan P.  Disruption of disulfide bonds exhibits differential effects on the trafficking of regulated secretory proteins.  Am. J. Physiol.: Cell Physiol.  1999; 277: C121-C132. 
  34. Turner M, Arvan P.  Protein traffic from the secretory pathway to the endosomal system in pancreatic ß-cells.  J. Biol. Chem.  2000; 275: 14025-14030.
  35. Kuliawat R, Prabakaran D, Arvan P.  Proinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathway.  Mol. Biol. Cell 2000; 11:  1959-1972.
  36. Tokunaga F, Takeuchi S, Omura S, Arvan P, Koide T.  Secretion, gamma-carboxylation, and endoplasmic reticulum-associated degradation of chimeras with mutually exchanged Gla domain between human protein C and prothrombin.  Thrombosis Research  2000; 99: 511-521.
  37. Zhang X, Arvan P.  Cell-type dependent differences in thyroid peroxidase cell surface   expression.  J. Biol. Chem.  2000; 275: 31946-31953.
  38. Tokunaga F, Brostrom C, Koide T, Arvan P.  ER-associated degradation of misfolded N-linked glycoproteins is suppressed upon inhibition of ER mannosidase I.  J. Biol. Chem.  2000; 275: 40757-40764.
  39. Martin-Belmonte F, Alonso MA, Zhang X, Arvan P.  Thyroglobulin is selected as luminal protein cargo for apical transport via detergent-resistant membranes in epithelial cells.  J. Biol. Chem.  2000; 275: 41074-41081.
  40. Schlegel A, Arvan P, Lisanti MP.  Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the ER.  J. Biol. Chem.  2001; 276: 4398-4408.
  41. Zhang B-Y, Chang A, Kjeldsen T, Arvan P.  Intracellular retention of newly-synthesized insulin in yeast is caused by endoproteolytic processing in the Golgi complex.  J. Cell Biol.  2001;    153: 1187–1197.
  42. Martin-Belmonte F, Arvan P, Alonso MA.  MAL mediates apical transport of secretory proteins in polarized epithelial Madin-Darby Canine Kidney cells.  J. Biol. Chem.  2001; 276:           49337-49342.
  43. Zhang X, Reidel C, Carrasco N, Arvan P.  Polarized trafficking of thyrocyte proteins in MDCK cells.  Mol. Cell. Endo.  2002; 188: 27-36.
  44. Di Jeso B, Ulianich L, Pacifico F, Leonardi A, Vito P, Consiglio E, Formisano S, Arvan P.  The folding of thyroglobulin in the calnexin/calreticulin pathway and its alteration by a loss of Ca2+ from the endoplasmic reticulum.  Biochem. J.  2003; 370: 449-458.
  45. Zhang, B-y, Liu M, Arvan P.  Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations.  J. Biol. Chem.  2003; 278: 3687-3693.
  46. Liu M, Ramos-Castañeda J, Arvan P.  Role of the connecting peptide in insulin biosynthesis.  J. Biol. Chem.  2003; 278: 14798-14805.
  47. Feng L, Arvan P.  The trafficking of alpha 1-antitrypsin, a post-Golgi secretory pathway marker, in INS-1 pancreatic beta cells.  J. Biol. Chem.  2003; 278: 31486-31494
  48. Kuliawat R, Kalinina E, Bock J, Fricker L, McGraw TE, Kim SR, Zhong J, Scheller RH, Arvan P.  Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta cells.  Mol. Biol. Cell.  2004; 15: 1690-1701.
  49. Park Y, Arvan P.  The acetylcholinesterase-homology region is essential for normal conformational maturation and secretion of thyroglobulin.  J. Biol. Chem.  2004; 279: 17085-   17089. 
  50. Ramos-Castañeda J, Park Y-N, Liu M, Hauser K, Rudolph H, Shull GE, Jonkman MF, Mori K, Ikeda S, Ogawa H, Arvan P.  Deficiency of ATP2C1, a Golgi ion pump, induces secretory pathway defects in ER-associated degradation and sensitivity to ER-stress.  J. Biol. Chem.  2005; 280: 9467-9473.
  51. Liu M, Li Y, Cavener D, Arvan P.  Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum.  J. Biol. Chem.  2005; 280: 13209-13212.
  52. Kuliawat R, Ramos-Castañeda J, Liu Y, Arvan P.  Intracellular trafficking of thyroid peroxidase to the cell surface.  J. Biol. Chem.  2005; 280: 27713-27718.
  53. Di Jeso B, Park Y-n, Ulianich L, Treglia AS, Urbanas ML, High S, Arvan P.   Mixed-disulfide folding intermediates between thyroglobulin and ER resident oxidoreductases ERp57 and PDI.  Mol. Cell Biol.  2005;25: 9793-9805.
  54. Lisi S, Botta R, Pinchera A, Collins AB, Refetoff S, Arvan P, Bu G, Grasso L, Marshansky V, Bechoua S, Hurtado-Lorenzo A, Marcocci C, Brown D, McCluskey RT, Marinò M.  2006. Defective thyroglobulin storage in LDL receptor-associated protein-deficient mice.  Am. J. Physiol. Cell Physiol.  2006; 290: C1160-C1167.
  55. Lara-Lemus A, Liu M, Turner M, Scherer P, Stenbeck G, Iyengar P, Arvan P.  Lumenal protein sorting to the constitutive secretion pathway of a regulated secretory cell.  J. Cell Sci.  2006; 199: 1833-1842.
  56. Forster, ML, Sivick K, Park Y-P, Arvan P, Lencer WI, Tsai B. PDI-like proteins play opposing roles during retro-translocation.  J. Cell Biol.  2006; 173: 853-859.
  57. Hua Q-x, Liu M, Hu S-Q, Jia W, Arvan P*, Weiss MA* (*co-corresponding authors).  A Conserved Histidine in Insulin is Required for the Foldability of Human Proinsulin.  Structure and Function of an AlaB5 Analog.  J. Biol. Chem.  2006; 281: 24889-24899.
  58. Zhao X, Chang AY, Toh-e A, Arvan P.  A role for Lte1p (a low-temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathway. J. Biol. Chem. 2007; 282: 1670-1678.
  59. Menon S, Abplanalp WA, Yoo S-E, Agui T, Furudate S-i, Kim PS, Arvan P.  Oxidoreductase interactions include a role for ERp72 engagement with mutant thyroglobulin from the rdw/rdw rat dwarf.  J. Biol. Chem.  2007; 282: 6183-6191.
  60. Liu M, Hodish I, Rhodes CJ, Arvan P.  Proinsulin maturation, misfolding and proteotoxicity.  Proc. Nat'l. Acad. Sci (USA; track 2)  2007; 104: 15841-15846.
  61. Zhao X, Nothwehr S, Lara-Lemus R, Zhang BY, Peter H, Arvan P.  Dominant-negative behavior of mammalian Vps35 in yeast requires a conserved PRLYL motif involved in retromer assembly.  Traffic  2007; 8: 1829-40.
  62. Restrepo R, Zhao X, Peter H, Zhang BY, Arvan P, Nothwehr SF.  Structural features of vps35p involved in interaction with other subunits of the retromer complex.  Traffic  2007; 8:1841-1853.
  63. Kim PS, Jongsamak P, Menon S, Li B, Hossain SA, Bae J-H, Panijpan B, Arvan P.  Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter.  Mol. Endocrinol.  2008;  22: 477-484
  64. Colombo C, Porzio O, Liu M, Massa O, Vasta M, Salardi S, Beccaria L, Monciotti C, Toni S, Pedersen O, Hansen T, Federici L, Pesavento R, Cadario F, Federici G, Ghirri P, Arvan P, Iafusco D, Barbetti F; Early Onset Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (SIEDP).  Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus.  J. Clin. Invest.  2008; 118:2148-56.
  65. Yamaguchi Y, Larkin D, Lara-Lemus R, Ramos-Castañeda J, Liu M, Arvan P.  Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK.  J. Biol. Chem.  2008; 283: 17020-9.
  66. Lee J, Di Jeso B, Arvan P.  Defects in intramolecular chaperone and molecular escort function of the cholinesterase-like domain of thyroglobulin.  J. Clin. Invest.  2008; 118: 2950-2958.
  67. Rajpal G, Liu M, Zhang Y, Arvan P.  Single-chain insulins as receptor agonists.  Manuscript submitted. 
  68. Lee J, Wang X, Di Jeso B, Arvan P.  The cholinesterase-like domain of thyroglobulin, essential for trafficking in the secretory pathway, is required for protein dimerization. Manuscript submitted.
  69. Hodish I, Liu M, Rajpal G, Larkin D, Holz R, Adams A, Liu L, Arvan P.  Misfolded proinsulin affects bystander proinsulin in neonatal diabetes.  Manuscript submitted. 

Reviews
*Peer-Reviewed

  1. *Arvan P, Cameron RS, Castle JD. Secretory membranes of the rat parotid gland: preparation and comparative characterization.  Methods in Enzymol.  1983; 98: 75-87.
  2. *Castle JD, Arvan P, Cameron RS.  Protein production and secretion in exocrine cells.  J. Dent. Res.  1987; 66: 633-637 (Special Issue).
  3. Castle JD, Cameron RS, Arvan P, Von Zastrow M, Rudnick G. Similarities and differences between neuroendocrine, exocrine and endocytic vesicles.  Ann. N.Y. Acad. Sci.  1987; 493:448-60.
  4. *Cameron RS, Arvan P, Castle JD.  Secretory membrane and the exocrine storage compartment. In: S.G. Schultz, J.G. Forte, B.B. Rauner (eds): Handbook of Physiology. Oxford University Press, New York, NY.  1989; III: 107-126.
  5. *Arvan P, Castle JD.  Protein sorting and secretion granule formation in regulated secretory cells.  Trends in Cell Biol.  1992; 2: 327-331.
  6. *Arvan P, Kim PS, Kuliawat R, Prabakaran D, Muresan Z, Yoo SE, Hossain SA.  Intracellular protein transport to the thyrocyte plasma membrane: potential implications for thyroid physiology.  Thyroid.  1997; 7: 89-105.
  7. *Kim PS, Arvan P.  Endocrinopathies in the family of endoplasmic reticulum (ER) storage diseases: disorders of protein trafficking and the role of ER molecular chaperones.  Endocrine Reviews.  1998; 19: 173-202.
  8. *Arvan P, Castle JD.  Sorting and storage during secretory granule biogenesis: looking backward and looking forward.  Biochemical Journal.  1998; 332: 593–610.
  9. Shields D, Arvan P.  Disease models provide insights into post-Golgi protein trafficking, localization, and processing.  Curr. Opin. Cell Biol.  1999; 11: 489-494.
  10. *Kuliawat R, Arvan P.  Storage granules of the regulated secretory pathway: structure and function.  The Einstein Quarterly Journal.  1999; 16: 29-40.
  11. *Arvan P, Zhang B-y, Feng L, Liu M, Kuliawat R.  Lumenal protein multimerization in the distal secretory pathway/secretory granules.  Curr. Opin. Cell Biol.  2002; 14: 448-453.
  12. *Arvan P, Zhao X, Ramos-Castañeda J, Chang A.  Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systems.  Traffic.  2002; 3: 771-780.
  13. Arvan P, Halban PA.  Sorting ourselves out: seeking consensus on trafficking in the beta cell.  Traffic.  2004; 5: 53-61.
  14. Arvan P.  Secretory protein trafficking: genetic and biochemical analysis.  Cell Biochemistry and Biophysics.  2004; 40(S): 169-177.
  15. Arvan P, DiJeso B.  Chapter 5: Thyroglobulin structure, function, and biosynthesis.  2005, pps. 77-95.  In Werner and Ingbar's "The Thyroid".  Braverman, L. E., Utiger R., eds., Lippincott Williams & Wilkins, Philadelphia.
  16. Mironov A, Arvan P.  Chapter 3-11: Origins of the regulated secretory pathway.  in "The Golgi apparatus - The state of art after 110 years of Camillo's discovery".  2008;  Mironov A., Pavelka M., Luini A., eds., Springer-VerlagWien/New York.  In press.

 

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